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The map label for this gene is lpxH

Identifier: 17545882

GI number: 17545882

Start: 1221739

End: 1222545

Strand: Reverse

Name: lpxH

Synonym: RSc1163

Alternate gene names: 17545882

Gene position: 1222545-1221739 (Counterclockwise)

Preceding gene: 17545883

Following gene: 17545879

Centisome position: 32.9

GC content: 71.75

Gene sequence:

>807_bases
ATGAGCGATGCGCCGACGGCGTCCGCACTGAAGACACCGGTCCGGGTTTCCGGGCCGGTGTTTTTCATTTCGGACCTGCA
CCTGAGCGCCGGCATGCCCGCCACGGCCGCCGCGTTCGAGCGCTTCGTGCGCACACGGGCGCGCGAGGCCCGCACGCTCG
TCATCCTGGGCGACTTCTTCGAATACTGGGTCGGCGATGAGGAACTCGCCGATCCGTTCCACCGGCATGTCGCCGCGCTG
CTCGCCGAGCTGGCGCAGGCCGGCACGCGCGTGCTGCTCATGCACGGCAACCGCGATTTCCTGCTGGGCAAGCGCTTCCT
GGCAACCACGCAGGCGACGCTGCTGCCCGATCCGAGCGTGCTGGAAGCCGATGGCCTGCGCATCGTGCTGGCCCACGGCG
ATGCGCTGTGCACGCGCGACGCGGCCTACATGCGGTTCCGCCGCTGGACGCGCAAGCGCTGGGTGCAGCGGCTGTTCCTG
GCGATGCCGCTGCGCTGGCGGCTGCGGATCGCGCAGAAGATGCGCGCCGACAGCGAAGCCGGCCGCGCCCTGTCCGCCAA
CGTGGCGGGCGAGCCGCGCGCGGCTGCGATGATGGGCGACGTGGCGCCCGAGGCGGTGGACGCGCTGTTCAAGGCCGCCG
GCATCCCGCTGCTGATCCACGGCCACACGCACCGCCCCCGGCTGCACCACGAGCCCGGCGGCGAGCGCTGGGTCCTCTCC
GACTGGGATTTCGACCATGCGCAGCCGCGCGGCAGCTTCCTCAGGCTGCAGGACGGCGTGCTGACGGCCGAGCCGGTGAC
GGCGTAA

Upstream 100 bases:

>100_bases
ACGTGGTCGACAAGATCCGCGCCGTGCGCACCGGCAACCGCGGCTACCACCAGGACGTGCCGATGGAAGACGTGGTGATC
GAAAGCGCCGAAGTGATCGA

Downstream 100 bases:

>100_bases
TCCGCCGCCACGGCCCTGCCCTCACTTCAGCATCCGCTTGAGCTCGCTGGCATCGAACGGATCGTTCGGCGAGTTCTCGA
GATGCGCGCCCAGGCGGTCC

Product: UDP-2,3-diacylglucosamine hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MSDAPTASALKTPVRVSGPVFFISDLHLSAGMPATAAAFERFVRTRAREARTLVILGDFFEYWVGDEELADPFHRHVAAL
LAELAQAGTRVLLMHGNRDFLLGKRFLATTQATLLPDPSVLEADGLRIVLAHGDALCTRDAAYMRFRRWTRKRWVQRLFL
AMPLRWRLRIAQKMRADSEAGRALSANVAGEPRAAAMMGDVAPEAVDALFKAAGIPLLIHGHTHRPRLHHEPGGERWVLS
DWDFDHAQPRGSFLRLQDGVLTAEPVTA

Sequences:

>Translated_268_residues
MSDAPTASALKTPVRVSGPVFFISDLHLSAGMPATAAAFERFVRTRAREARTLVILGDFFEYWVGDEELADPFHRHVAAL
LAELAQAGTRVLLMHGNRDFLLGKRFLATTQATLLPDPSVLEADGLRIVLAHGDALCTRDAAYMRFRRWTRKRWVQRLFL
AMPLRWRLRIAQKMRADSEAGRALSANVAGEPRAAAMMGDVAPEAVDALFKAAGIPLLIHGHTHRPRLHHEPGGERWVLS
DWDFDHAQPRGSFLRLQDGVLTAEPVTA
>Mature_267_residues
SDAPTASALKTPVRVSGPVFFISDLHLSAGMPATAAAFERFVRTRAREARTLVILGDFFEYWVGDEELADPFHRHVAALL
AELAQAGTRVLLMHGNRDFLLGKRFLATTQATLLPDPSVLEADGLRIVLAHGDALCTRDAAYMRFRRWTRKRWVQRLFLA
MPLRWRLRIAQKMRADSEAGRALSANVAGEPRAAAMMGDVAPEAVDALFKAAGIPLLIHGHTHRPRLHHEPGGERWVLSD
WDFDHAQPRGSFLRLQDGVLTAEPVTA

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family

Homologues:

Organism=Escherichia coli, GI1786735, Length=226, Percent_Identity=44.6902654867257, Blast_Score=178, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXH_RALSO (Q8Y081)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519284.1
- ProteinModelPortal:   Q8Y081
- GeneID:   1219978
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1163
- NMPDR:   fig|267608.1.peg.1163
- HOGENOM:   HBG288883
- OMA:   CHGDTLC
- ProtClustDB:   PRK05340
- BioCyc:   RSOL267608:RSC1163-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00575
- InterPro:   IPR004843
- InterPro:   IPR010138
- TIGRFAMs:   TIGR01854

Pfam domain/function: PF00149 Metallophos

EC number: 3.6.1.-

Molecular weight: Translated: 29769; Mature: 29637

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAPTASALKTPVRVSGPVFFISDLHLSAGMPATAAAFERFVRTRAREARTLVILGDFF
CCCCCCCHHHCCCEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEHHH
EYWVGDEELADPFHRHVAALLAELAQAGTRVLLMHGNRDFLLGKRFLATTQATLLPDPSV
HHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEHHHHHHHHHHHHCCCCCCE
LEADGLRIVLAHGDALCTRDAAYMRFRRWTRKRWVQRLFLAMPLRWRLRIAQKMRADSEA
ECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
GRALSANVAGEPRAAAMMGDVAPEAVDALFKAAGIPLLIHGHTHRPRLHHEPGGERWVLS
CCEEECCCCCCCHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEE
DWDFDHAQPRGSFLRLQDGVLTAEPVTA
CCCCCCCCCCCCEEEEECCEECCCCCCC
>Mature Secondary Structure 
SDAPTASALKTPVRVSGPVFFISDLHLSAGMPATAAAFERFVRTRAREARTLVILGDFF
CCCCCCHHHCCCEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEHHH
EYWVGDEELADPFHRHVAALLAELAQAGTRVLLMHGNRDFLLGKRFLATTQATLLPDPSV
HHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEHHHHHHHHHHHHCCCCCCE
LEADGLRIVLAHGDALCTRDAAYMRFRRWTRKRWVQRLFLAMPLRWRLRIAQKMRADSEA
ECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
GRALSANVAGEPRAAAMMGDVAPEAVDALFKAAGIPLLIHGHTHRPRLHHEPGGERWVLS
CCEEECCCCCCCHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEE
DWDFDHAQPRGSFLRLQDGVLTAEPVTA
CCCCCCCCCCCCEEEEECCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852