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The map label for this gene is ppiB [H]

Identifier: 17545883

GI number: 17545883

Start: 1222542

End: 1223081

Strand: Reverse

Name: ppiB [H]

Synonym: RSc1164

Alternate gene names: 17545883

Gene position: 1223081-1222542 (Counterclockwise)

Preceding gene: 17545884

Following gene: 17545882

Centisome position: 32.91

GC content: 62.59

Gene sequence:

>540_bases
TTGCTTTTGCGCTTTTCCGCCAAGGAACTCACCATGACCCAAGTCAAGCTGCACACCAACCACGGCGACATCACGCTGGC
CCTGGACGCCGAGAAGGCGCCCAAGAGCGTCGCCAACTTCGTCCACTACGTCAAGAAGGGCCACTACAACGGCACGGTGT
TCCACCGCGTCATCAAGGGCTTCATGATCCAGGGCGGCGGTTTCGAGCCGGGCGCCGACATGAAGCAGAAGCCGACCGAC
GCACCGATCGACAACGAAGCCAACAACGGCCTGAAGAACGAGCGCGGCTCGATCGCCATGGCGCGCACCAACGACCCGCA
TTCGGCCACGGCCCAGTTCTTCATCAACGTGGTCGACAACGACTTCCTGAACCACACCTCGCCGACGCCGCAAGGCTGGG
GCTATGCCGTGTTCGGCAAGGTGACCGAGGGCCTGGACGTGGTCGACAAGATCCGCGCCGTGCGCACCGGCAACCGCGGC
TACCACCAGGACGTGCCGATGGAAGACGTGGTGATCGAAAGCGCCGAAGTGATCGAATGA

Upstream 100 bases:

>100_bases
AGATCAAGGGCGTGGAGACCACCAGCAAGCTCCCGCACCAAAACGTGCCCGTCACGCCGATCGTGATCGAATCGGTCACC
CTCGTCACCAAGTAACGCTT

Downstream 100 bases:

>100_bases
GCGATGCGCCGACGGCGTCCGCACTGAAGACACCGGTCCGGGTTTCCGGGCCGGTGTTTTTCATTTCGGACCTGCACCTG
AGCGCCGGCATGCCCGCCAC

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MLLRFSAKELTMTQVKLHTNHGDITLALDAEKAPKSVANFVHYVKKGHYNGTVFHRVIKGFMIQGGGFEPGADMKQKPTD
APIDNEANNGLKNERGSIAMARTNDPHSATAQFFINVVDNDFLNHTSPTPQGWGYAVFGKVTEGLDVVDKIRAVRTGNRG
YHQDVPMEDVVIESAEVIE

Sequences:

>Translated_179_residues
MLLRFSAKELTMTQVKLHTNHGDITLALDAEKAPKSVANFVHYVKKGHYNGTVFHRVIKGFMIQGGGFEPGADMKQKPTD
APIDNEANNGLKNERGSIAMARTNDPHSATAQFFINVVDNDFLNHTSPTPQGWGYAVFGKVTEGLDVVDKIRAVRTGNRG
YHQDVPMEDVVIESAEVIE
>Mature_179_residues
MLLRFSAKELTMTQVKLHTNHGDITLALDAEKAPKSVANFVHYVKKGHYNGTVFHRVIKGFMIQGGGFEPGADMKQKPTD
APIDNEANNGLKNERGSIAMARTNDPHSATAQFFINVVDNDFLNHTSPTPQGWGYAVFGKVTEGLDVVDKIRAVRTGNRG
YHQDVPMEDVVIESAEVIE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=164, Percent_Identity=32.9268292682927, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI22547212, Length=165, Percent_Identity=32.1212121212121, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI7657473, Length=165, Percent_Identity=32.1212121212121, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI22547215, Length=165, Percent_Identity=32.1212121212121, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI24308049, Length=157, Percent_Identity=34.3949044585987, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI7706339, Length=168, Percent_Identity=34.5238095238095, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI64276486, Length=133, Percent_Identity=34.5864661654135, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI4758950, Length=162, Percent_Identity=35.1851851851852, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI310110104, Length=152, Percent_Identity=30.2631578947368, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1786736, Length=165, Percent_Identity=66.6666666666667, Blast_Score=231, Evalue=3e-62,
Organism=Escherichia coli, GI1789763, Length=164, Percent_Identity=59.1463414634146, Blast_Score=182, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=34.2465753424658, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71980594, Length=146, Percent_Identity=34.2465753424658, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17506311, Length=159, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17532641, Length=165, Percent_Identity=33.9393939393939, Blast_Score=83, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17552780, Length=158, Percent_Identity=34.8101265822785, Blast_Score=73, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17539496, Length=144, Percent_Identity=30.5555555555556, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17506307, Length=158, Percent_Identity=32.9113924050633, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71997782, Length=134, Percent_Identity=32.089552238806, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320510, Length=177, Percent_Identity=32.7683615819209, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19922376, Length=175, Percent_Identity=30.2857142857143, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI19922912, Length=164, Percent_Identity=35.3658536585366, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17986117, Length=163, Percent_Identity=29.4478527607362, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24652460, Length=164, Percent_Identity=29.8780487804878, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17136360, Length=161, Percent_Identity=32.2981366459627, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21357249, Length=172, Percent_Identity=31.9767441860465, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 19721; Mature: 19721

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLRFSAKELTMTQVKLHTNHGDITLALDAEKAPKSVANFVHYVKKGHYNGTVFHRVIKG
CEEECCCCCEEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHH
FMIQGGGFEPGADMKQKPTDAPIDNEANNGLKNERGSIAMARTNDPHSATAQFFINVVDN
HEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCC
DFLNHTSPTPQGWGYAVFGKVTEGLDVVDKIRAVRTGNRGYHQDVPMEDVVIESAEVIE
CHHCCCCCCCCCCCEEEECCHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHCC
>Mature Secondary Structure
MLLRFSAKELTMTQVKLHTNHGDITLALDAEKAPKSVANFVHYVKKGHYNGTVFHRVIKG
CEEECCCCCEEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHH
FMIQGGGFEPGADMKQKPTDAPIDNEANNGLKNERGSIAMARTNDPHSATAQFFINVVDN
HEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCC
DFLNHTSPTPQGWGYAVFGKVTEGLDVVDKIRAVRTGNRGYHQDVPMEDVVIESAEVIE
CHHCCCCCCCCCCCEEEECCHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2007139; 9278503; 1864365; 9298646; 9600841; 1606970; 8601841 [H]