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The map label for this gene is kynU [H]

Identifier: 17545478

GI number: 17545478

Start: 802672

End: 803925

Strand: Reverse

Name: kynU [H]

Synonym: RSc0759

Alternate gene names: 17545478

Gene position: 803925-802672 (Counterclockwise)

Preceding gene: 17545479

Following gene: 17545477

Centisome position: 21.63

GC content: 69.62

Gene sequence:

>1254_bases
ATGCCCCTCACCCGCAACACCTGCCTCGAACGCGACGCGGCCGACCCGATCGCTCCGCTGCGCGATGCCTTCGCGCTGCC
CGACGGCGTGATCTACCTGGACGGCAACTCGCTCGGCGCCCGCCCCCATGCCGCGCTCGCCCGTGCCCAACAGGTCATCG
CCGACGAATGGGGCGAGGGCCTGATCCGCAGCTGGAACCAGGCTGGCTGGTTCGAGCTGCCGCGACGCCTGGGCAACAAG
CTCGCCCCGCTGATCGGCGCGCGCGCGGACGAGGTGGTCATCACCGACACCACCTCGATCAACCTGTTCAAGGTGCTGGC
CGCCGCCCTGCGCGTGCAGCGCGAGGATGCGCCGGAACGCAGGATCATCGTCTCGGAAGCGCACAACTTCCCGACCGACC
TCTACATCGCCGAGGGCCTGGCCGACCTGCTGCGCGACGGCTACAAGCTGCGCCTGATCGATGCGCCGGACGCGCTGGAA
ACCGCGCTGGGCGACGACGTGGCCGTCACCATGCTCACGCACGTCAACTACAAGAGCGGCCACATGTACGACATGGCAGC
CGTCTCGGCATTGGCGCACAGGCACGGCGCGCTGGCCGTCTGGGACCTCGCGCACTCGGCCGGCGCCGTGCCCGTGGACC
TTCACACCGGCGGCGCCGACTACGCCATCGGCTGCACCTACAAATACCTGAACGGCGGCCCGGGTTCGCCGGCCTTCGTG
TGGGCCTCGCCCGCGCTGCGCGAGCGCTTCTGGCAGCCGCTGTCGGGCTGGTGGGGCCACGCGCGGCCGTTCGCGATGGC
GTCACACTACGATGCCGGCGCCGGCATCGGGCGCTTCCTGTGCGGCACCCAGCCGATCACGTCGATGGCGATGGTCGAAT
GCGGGCTGGACATCTTCGCCCAGACCTCGATGACCGCGCTGCGCGCCAAGTCGCTCGCGCTGACCGATCTCTTCATCGAA
CTGGTCGAGGCCCGCTGCGCCGGCTACCCGCTGACGCTCGCCACCCCGCGCGACCACGCGGTGCGCGGCAGCCACGTCAG
CTATGCGCACCCGGACGGCTTTGCCGTGATGCAGGCGCTGATCGCGCGCGGCGTGATCGGCGACTACCGCGAACCGAGCA
TCATGCGCTTCGGCTTCACGCCGCTGTACACGCGCTTCGTCGATGTGTGGGATGCGGTCGACGTGCTGCGCGAGGTGCTG
GAAACCGGCGCGTGGCAATCCGCCCAATTCAACGAACGTACGCTGGTGACCTGA

Upstream 100 bases:

>100_bases
CTGCCGCTCAAGTTCGCCACGCTCGACGCCAGCCCGGTGCGCGCCGTACTGCGCCGCCTGCCCTGACCGGCTCCACCGCT
TTCACTGCCCCACAGTCGCC

Downstream 100 bases:

>100_bases
GATGTCCGAACCGATTCAACCGACCCGGCCCGCGGCATCGGGCTGCCCCATGCACGGCGCGCAGGCCGAAAGCTGGCACG
ACGCGCAGATGGATTTCTCG

Product: hydrolase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MPLTRNTCLERDAADPIAPLRDAFALPDGVIYLDGNSLGARPHAALARAQQVIADEWGEGLIRSWNQAGWFELPRRLGNK
LAPLIGARADEVVITDTTSINLFKVLAAALRVQREDAPERRIIVSEAHNFPTDLYIAEGLADLLRDGYKLRLIDAPDALE
TALGDDVAVTMLTHVNYKSGHMYDMAAVSALAHRHGALAVWDLAHSAGAVPVDLHTGGADYAIGCTYKYLNGGPGSPAFV
WASPALRERFWQPLSGWWGHARPFAMASHYDAGAGIGRFLCGTQPITSMAMVECGLDIFAQTSMTALRAKSLALTDLFIE
LVEARCAGYPLTLATPRDHAVRGSHVSYAHPDGFAVMQALIARGVIGDYREPSIMRFGFTPLYTRFVDVWDAVDVLREVL
ETGAWQSAQFNERTLVT

Sequences:

>Translated_417_residues
MPLTRNTCLERDAADPIAPLRDAFALPDGVIYLDGNSLGARPHAALARAQQVIADEWGEGLIRSWNQAGWFELPRRLGNK
LAPLIGARADEVVITDTTSINLFKVLAAALRVQREDAPERRIIVSEAHNFPTDLYIAEGLADLLRDGYKLRLIDAPDALE
TALGDDVAVTMLTHVNYKSGHMYDMAAVSALAHRHGALAVWDLAHSAGAVPVDLHTGGADYAIGCTYKYLNGGPGSPAFV
WASPALRERFWQPLSGWWGHARPFAMASHYDAGAGIGRFLCGTQPITSMAMVECGLDIFAQTSMTALRAKSLALTDLFIE
LVEARCAGYPLTLATPRDHAVRGSHVSYAHPDGFAVMQALIARGVIGDYREPSIMRFGFTPLYTRFVDVWDAVDVLREVL
ETGAWQSAQFNERTLVT
>Mature_416_residues
PLTRNTCLERDAADPIAPLRDAFALPDGVIYLDGNSLGARPHAALARAQQVIADEWGEGLIRSWNQAGWFELPRRLGNKL
APLIGARADEVVITDTTSINLFKVLAAALRVQREDAPERRIIVSEAHNFPTDLYIAEGLADLLRDGYKLRLIDAPDALET
ALGDDVAVTMLTHVNYKSGHMYDMAAVSALAHRHGALAVWDLAHSAGAVPVDLHTGGADYAIGCTYKYLNGGPGSPAFVW
ASPALRERFWQPLSGWWGHARPFAMASHYDAGAGIGRFLCGTQPITSMAMVECGLDIFAQTSMTALRAKSLALTDLFIEL
VEARCAGYPLTLATPRDHAVRGSHVSYAHPDGFAVMQALIARGVIGDYREPSIMRFGFTPLYTRFVDVWDAVDVLREVLE
TGAWQSAQFNERTLVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=449, Percent_Identity=25.8351893095768, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI74101437, Length=262, Percent_Identity=24.8091603053435, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17550466, Length=429, Percent_Identity=27.2727272727273, Blast_Score=150, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6323261, Length=454, Percent_Identity=29.0748898678414, Blast_Score=150, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 45468; Mature: 45337

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00630 IMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTRNTCLERDAADPIAPLRDAFALPDGVIYLDGNSLGARPHAALARAQQVIADEWGEG
CCCCCCHHHCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCH
LIRSWNQAGWFELPRRLGNKLAPLIGARADEVVITDTTSINLFKVLAAALRVQREDAPER
HHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCC
RIIVSEAHNFPTDLYIAEGLADLLRDGYKLRLIDAPDALETALGDDVAVTMLTHVNYKSG
EEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCCCCEEEHHHHCCCCCC
HMYDMAAVSALAHRHGALAVWDLAHSAGAVPVDLHTGGADYAIGCTYKYLNGGPGSPAFV
CCHHHHHHHHHHHHCCCEEEEEHHHCCCCCEEEEECCCCCEEEEEEEEECCCCCCCCEEE
WASPALRERFWQPLSGWWGHARPFAMASHYDAGAGIGRFLCGTQPITSMAMVECGLDIFA
ECCHHHHHHHHCHHHCCCCCCCCCHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHCHHHHH
QTSMTALRAKSLALTDLFIELVEARCAGYPLTLATPRDHAVRGSHVSYAHPDGFAVMQAL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHH
IARGVIGDYREPSIMRFGFTPLYTRFVDVWDAVDVLREVLETGAWQSAQFNERTLVT
HHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PLTRNTCLERDAADPIAPLRDAFALPDGVIYLDGNSLGARPHAALARAQQVIADEWGEG
CCCCCHHHCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCH
LIRSWNQAGWFELPRRLGNKLAPLIGARADEVVITDTTSINLFKVLAAALRVQREDAPER
HHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCC
RIIVSEAHNFPTDLYIAEGLADLLRDGYKLRLIDAPDALETALGDDVAVTMLTHVNYKSG
EEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCCCCEEEHHHHCCCCCC
HMYDMAAVSALAHRHGALAVWDLAHSAGAVPVDLHTGGADYAIGCTYKYLNGGPGSPAFV
CCHHHHHHHHHHHHCCCEEEEEHHHCCCCCEEEEECCCCCEEEEEEEEECCCCCCCCEEE
WASPALRERFWQPLSGWWGHARPFAMASHYDAGAGIGRFLCGTQPITSMAMVECGLDIFA
ECCHHHHHHHHCHHHCCCCCCCCCHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHCHHHHH
QTSMTALRAKSLALTDLFIELVEARCAGYPLTLATPRDHAVRGSHVSYAHPDGFAVMQAL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHH
IARGVIGDYREPSIMRFGFTPLYTRFVDVWDAVDVLREVLETGAWQSAQFNERTLVT
HHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA