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The map label for this gene is kynA [H]

Identifier: 17545477

GI number: 17545477

Start: 801786

End: 802670

Strand: Reverse

Name: kynA [H]

Synonym: RSc0758

Alternate gene names: 17545477

Gene position: 802670-801786 (Counterclockwise)

Preceding gene: 17545478

Following gene: 17545475

Centisome position: 21.6

GC content: 65.08

Gene sequence:

>885_bases
ATGTCCGAACCGATTCAACCGACCCGGCCCGCGGCATCGGGCTGCCCCATGCACGGCGCGCAGGCCGAAAGCTGGCACGA
CGCGCAGATGGATTTCTCGAAGTCGATGAGCTATGGGGACTACCTCGCCCTCGACCAGATCCTGAACGCGCAGCATCCGC
GCTCGCCGGACCACAACGAGATGCTGTTCATCGTCCAGCACCAGACCACCGAGCTGTGGATGAAGCTGATGCTGCACGAG
CTGCGCGCCGCCCGCGACTGCGTGCGCAACGACGACCTGCCACCCGCCTTCAAGATGCTCGCGCGCGTCTCGCGCATCAT
GGACCAGCTGGTGCAGGCGTGGAACGTGCTCGCCACCATGACGCCGCCGGAATACTCCGCGATGCGCCCGCACCTCGGGC
AATCGTCGGGCTTCCAGTCTTACCAGTACCGCGAGATCGAGTTCATCCTCGGCAACAAGAACGCGGCCATGCTCCAGCCG
CACGCGCACCAGCCCGAACACTACGCGCAGGTGAAGGCCGCGCTGGAAACGCCGTCGCTCTACGACGAGGCCATCCGCTA
CATGGCGCGCCACGGCTTCGCTTTCGATGCCGATTGCATCGAGCGCGACTGGTCGCGCCCGGTCACGTACAACGCGTCGG
TCGAGGCCGCCTGGCTGGAGGTCTATCGCGACCCGACCCACCACTGGGAACTCTATGAACTGGCCGAGAAGTTCGTCGAC
CTGGAAGACGCCTTCCGCCAATGGCGCTTCCGCCATGTGACCACGGTGGAGCGCGTGATCGGCTTCAAGCGCGGCACCGG
CGGCACCGAAGGCGTCAACTACCTGCGCAAGATGCTGGACGTGGTGCTGTTTCCGGAACTGTGGAAGCTGCGCACCGATC
TCTGA

Upstream 100 bases:

>100_bases
TTCGTCGATGTGTGGGATGCGGTCGACGTGCTGCGCGAGGTGCTGGAAACCGGCGCGTGGCAATCCGCCCAATTCAACGA
ACGTACGCTGGTGACCTGAG

Downstream 100 bases:

>100_bases
TCGCTGCGTCTTATCCGGTCGGTTGGGCCAACTGCCCCAGCCGCGCCGCCAGTTCCCGCAAGGCGGGCACCAGTTCGGCG
CGGATGCGCCCGGCATCGGC

Product: oxygenase oxidoreductase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSEPIQPTRPAASGCPMHGAQAESWHDAQMDFSKSMSYGDYLALDQILNAQHPRSPDHNEMLFIVQHQTTELWMKLMLHE
LRAARDCVRNDDLPPAFKMLARVSRIMDQLVQAWNVLATMTPPEYSAMRPHLGQSSGFQSYQYREIEFILGNKNAAMLQP
HAHQPEHYAQVKAALETPSLYDEAIRYMARHGFAFDADCIERDWSRPVTYNASVEAAWLEVYRDPTHHWELYELAEKFVD
LEDAFRQWRFRHVTTVERVIGFKRGTGGTEGVNYLRKMLDVVLFPELWKLRTDL

Sequences:

>Translated_294_residues
MSEPIQPTRPAASGCPMHGAQAESWHDAQMDFSKSMSYGDYLALDQILNAQHPRSPDHNEMLFIVQHQTTELWMKLMLHE
LRAARDCVRNDDLPPAFKMLARVSRIMDQLVQAWNVLATMTPPEYSAMRPHLGQSSGFQSYQYREIEFILGNKNAAMLQP
HAHQPEHYAQVKAALETPSLYDEAIRYMARHGFAFDADCIERDWSRPVTYNASVEAAWLEVYRDPTHHWELYELAEKFVD
LEDAFRQWRFRHVTTVERVIGFKRGTGGTEGVNYLRKMLDVVLFPELWKLRTDL
>Mature_293_residues
SEPIQPTRPAASGCPMHGAQAESWHDAQMDFSKSMSYGDYLALDQILNAQHPRSPDHNEMLFIVQHQTTELWMKLMLHEL
RAARDCVRNDDLPPAFKMLARVSRIMDQLVQAWNVLATMTPPEYSAMRPHLGQSSGFQSYQYREIEFILGNKNAAMLQPH
AHQPEHYAQVKAALETPSLYDEAIRYMARHGFAFDADCIERDWSRPVTYNASVEAAWLEVYRDPTHHWELYELAEKFVDL
EDAFRQWRFRHVTTVERVIGFKRGTGGTEGVNYLRKMLDVVLFPELWKLRTDL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring [H]

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI5032165, Length=148, Percent_Identity=36.4864864864865, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI32564651, Length=167, Percent_Identity=31.7365269461078, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17552370, Length=167, Percent_Identity=31.7365269461078, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI17530891, Length=361, Percent_Identity=26.5927977839335, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017485
- InterPro:   IPR004981 [H]

Pfam domain/function: PF03301 Trp_dioxygenase [H]

EC number: =1.13.11.11 [H]

Molecular weight: Translated: 34155; Mature: 34024

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPIQPTRPAASGCPMHGAQAESWHDAQMDFSKSMSYGDYLALDQILNAQHPRSPDHNE
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCC
MLFIVQHQTTELWMKLMLHELRAARDCVRNDDLPPAFKMLARVSRIMDQLVQAWNVLATM
EEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
TPPEYSAMRPHLGQSSGFQSYQYREIEFILGNKNAAMLQPHAHQPEHYAQVKAALETPSL
CCCCHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHCCCHH
YDEAIRYMARHGFAFDADCIERDWSRPVTYNASVEAAWLEVYRDPTHHWELYELAEKFVD
HHHHHHHHHHCCCCCCHHHHHHHCCCCEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHC
LEDAFRQWRFRHVTTVERVIGFKRGTGGTEGVNYLRKMLDVVLFPELWKLRTDL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEPIQPTRPAASGCPMHGAQAESWHDAQMDFSKSMSYGDYLALDQILNAQHPRSPDHNE
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCC
MLFIVQHQTTELWMKLMLHELRAARDCVRNDDLPPAFKMLARVSRIMDQLVQAWNVLATM
EEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
TPPEYSAMRPHLGQSSGFQSYQYREIEFILGNKNAAMLQPHAHQPEHYAQVKAALETPSL
CCCCHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHCCCHH
YDEAIRYMARHGFAFDADCIERDWSRPVTYNASVEAAWLEVYRDPTHHWELYELAEKFVD
HHHHHHHHHHCCCCCCHHHHHHHCCCCEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHC
LEDAFRQWRFRHVTTVERVIGFKRGTGGTEGVNYLRKMLDVVLFPELWKLRTDL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA