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The map label for this gene is apaH

Identifier: 17545400

GI number: 17545400

Start: 729078

End: 729929

Strand: Reverse

Name: apaH

Synonym: RSc0681

Alternate gene names: 17545400

Gene position: 729929-729078 (Counterclockwise)

Preceding gene: 17545414

Following gene: 17545385

Centisome position: 19.64

GC content: 69.95

Gene sequence:

>852_bases
ATGACAGTCGCGTCGATCCCTCCTCACGCCATCGGCGATCTCCAAGGCTGCTGCTCTCCCCTCCAGACCCTGCTGACCGC
ACTGCCGGCCAACGCCCCGCTGCGCTTCGTCGGCGACCTGGTCAACCGCGGGCCGGATTCGCTCGGCACGCTGCGACGGG
TCATCATGCTGTGCGAGGGCGGACGGGCCCGCGCGGTGTTGGGCAACCACGACATCCACCTGCTGGCGGTCGCCGCCGGC
GTGCGCAAGCTGGGCAAGCGGGACACCCTCGACGACATCCTCGGCGCCCCCGACTGCGATGCGCTGATCCACTGGCTGCG
GCACCAGCCGCTGGCGATCTTCGAGAACGGTTTCCTGATGGTCCATGCCGGCGTGCTGCCTCAGTGGACGACGGGCGATG
TGCTGGAGCTGGCCGGCGCGGTCGAGCGCGAACTGCGCAGCCCGCACTGGAAGACGTTCCTGACCGATGCCTTCGGCAAT
CAGCCCGCCAAGTGGAGCAGCGATCTTATCGGCATCGACCGCCTGCGACTGACGATCAACGCCCTGACCCGCCTGCGCTT
CTGTACGCCGGACGGCGCCATGGAGTTCGAGACCACCGATGCCGACGGCGCGCCGGACGGCCACGTGCCGTGGTTCGACG
TCCCCGGCCGCCGCACGCGCGGCACGCCGATCGCCTTCGGCCACTGGTCAACACGCGGACTGGTGATGCGGGATGACCTG
CTGGGCCTGGACACCGGCTGTGTATGGGGCGGCAAGCTGACCGCCGCGCGCATGACGCTGGCCCCGGCCGGCCGCGAGGT
GATCCAGGTCGCCTGCGAGCAGGCCCAGGACCCGCTCGCCCACAAGAAGTAG

Upstream 100 bases:

>100_bases
CAGGGTAAGCCCTGCCAATACGGTCGATCTTTTTGTAGCGCGTTGTAACAGTTGAGACGCCACCGTCCCAACCCGTTGCA
ATGAGTGATCCACAACACAC

Downstream 100 bases:

>100_bases
GGCGGAATCCGGCGGGCTACCCGGCCCGCTCCATCAGCGTGGCGACAGCCTGGCGGCTGTGCTCGGCCAGCGCACGGCGA
TCCATTTCCGGGGACACGGC

Product: diadenosine tetraphosphatase

Products: NA

Alternate protein names: Ap4A hydrolase; Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase; Diadenosine tetraphosphatase

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MTVASIPPHAIGDLQGCCSPLQTLLTALPANAPLRFVGDLVNRGPDSLGTLRRVIMLCEGGRARAVLGNHDIHLLAVAAG
VRKLGKRDTLDDILGAPDCDALIHWLRHQPLAIFENGFLMVHAGVLPQWTTGDVLELAGAVERELRSPHWKTFLTDAFGN
QPAKWSSDLIGIDRLRLTINALTRLRFCTPDGAMEFETTDADGAPDGHVPWFDVPGRRTRGTPIAFGHWSTRGLVMRDDL
LGLDTGCVWGGKLTAARMTLAPAGREVIQVACEQAQDPLAHKK

Sequences:

>Translated_283_residues
MTVASIPPHAIGDLQGCCSPLQTLLTALPANAPLRFVGDLVNRGPDSLGTLRRVIMLCEGGRARAVLGNHDIHLLAVAAG
VRKLGKRDTLDDILGAPDCDALIHWLRHQPLAIFENGFLMVHAGVLPQWTTGDVLELAGAVERELRSPHWKTFLTDAFGN
QPAKWSSDLIGIDRLRLTINALTRLRFCTPDGAMEFETTDADGAPDGHVPWFDVPGRRTRGTPIAFGHWSTRGLVMRDDL
LGLDTGCVWGGKLTAARMTLAPAGREVIQVACEQAQDPLAHKK
>Mature_282_residues
TVASIPPHAIGDLQGCCSPLQTLLTALPANAPLRFVGDLVNRGPDSLGTLRRVIMLCEGGRARAVLGNHDIHLLAVAAGV
RKLGKRDTLDDILGAPDCDALIHWLRHQPLAIFENGFLMVHAGVLPQWTTGDVLELAGAVERELRSPHWKTFLTDAFGNQ
PAKWSSDLIGIDRLRLTINALTRLRFCTPDGAMEFETTDADGAPDGHVPWFDVPGRRTRGTPIAFGHWSTRGLVMRDDLL
GLDTGCVWGGKLTAARMTLAPAGREVIQVACEQAQDPLAHKK

Specific function: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Ap4A hydrolase family

Homologues:

Organism=Escherichia coli, GI1786234, Length=256, Percent_Identity=43.75, Blast_Score=192, Evalue=3e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APAH_RALSO (Q8Y1K9)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_518802.1
- ProteinModelPortal:   Q8Y1K9
- SMR:   Q8Y1K9
- GeneID:   1219486
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc0681
- NMPDR:   fig|267608.1.peg.681
- HOGENOM:   HBG724457
- OMA:   LVFGHWA
- ProtClustDB:   PRK00166
- BioCyc:   RSOL267608:RSC0681-MONOMER
- BRENDA:   3.6.1.41
- HAMAP:   MF_00199
- InterPro:   IPR004617
- InterPro:   IPR004843
- PIRSF:   PIRSF000903
- TIGRFAMs:   TIGR00668

Pfam domain/function: PF00149 Metallophos

EC number: =3.6.1.41

Molecular weight: Translated: 30661; Mature: 30529

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVASIPPHAIGDLQGCCSPLQTLLTALPANAPLRFVGDLVNRGPDSLGTLRRVIMLCEG
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCC
GRARAVLGNHDIHLLAVAAGVRKLGKRDTLDDILGAPDCDALIHWLRHQPLAIFENGFLM
CCEEEEECCCCEEEHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHCCCEEEEECCEEE
VHAGVLPQWTTGDVLELAGAVERELRSPHWKTFLTDAFGNQPAKWSSDLIGIDRLRLTIN
EEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
ALTRLRFCTPDGAMEFETTDADGAPDGHVPWFDVPGRRTRGTPIAFGHWSTRGLVMRDDL
HHHHHEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEECCC
LGLDTGCVWGGKLTAARMTLAPAGREVIQVACEQAQDPLAHKK
CCCCCCCEECCCCHHHHEEECCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TVASIPPHAIGDLQGCCSPLQTLLTALPANAPLRFVGDLVNRGPDSLGTLRRVIMLCEG
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCC
GRARAVLGNHDIHLLAVAAGVRKLGKRDTLDDILGAPDCDALIHWLRHQPLAIFENGFLM
CCEEEEECCCCEEEHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHCCCEEEEECCEEE
VHAGVLPQWTTGDVLELAGAVERELRSPHWKTFLTDAFGNQPAKWSSDLIGIDRLRLTIN
EEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
ALTRLRFCTPDGAMEFETTDADGAPDGHVPWFDVPGRRTRGTPIAFGHWSTRGLVMRDDL
HHHHHEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEECCC
LGLDTGCVWGGKLTAARMTLAPAGREVIQVACEQAQDPLAHKK
CCCCCCCEECCCCHHHHEEECCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852