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The map label for this gene is purK [H]

Identifier: 17545295

GI number: 17545295

Start: 619859

End: 621100

Strand: Direct

Name: purK [H]

Synonym: RSc0576

Alternate gene names: 17545295

Gene position: 619859-621100 (Clockwise)

Preceding gene: 17545294

Following gene: 17545296

Centisome position: 16.68

GC content: 70.21

Gene sequence:

>1242_bases
ATGGCCGACGACCTGAATCCGCGCCTCGCGCAGGCCCACACGCCCGAATCCCGCGCGCTGAACGTTCCCGACGCGATCCT
GCCCGACAGCTGGCTGGGCATGCTCGGCGGCGGCCAGCTCGGCCGCATGTTCACGCACGCCGCACAGGCGATGGGCTACA
AGGTGTGCGTGCTGGACCCCGACCCGAACAGCCCCGCCGGCACCGTCGCCGAGCGCCACCTGTGCGCGGCCTACACGGAT
GAGGCCGCGCTGGCCGAGCTGGCCGCGCTGTGCCCGGCGGTCACCACCGAATTCGAGAACGTGCCGGCACAGGCGCTCGA
CCGCCTCGAGCACCTCGGCGCCTTCGTCGCGCCGCGCGCCCACTGCGTGTCGATCGCGCAGAACCGCATCGCCGAGAAGA
AATTCTTTGCGCTGTGCGCCGCCCGCACCGGCATCCACCCGGCGCCGAGCTGGGTGATCGAGCACGACGCCGACATCGAC
CAGCTGCCGGCCGACCTGCTGCCCGGCATCCTGAAGATCGCCCGCATGGGCTACGACGGCAAGGGCCAGGCGCGCGTCTC
CACGGTCGGCGAGCTGCGCGCGGCCTGGGGCGCGATGCAGCACGTGCCGTGCGTGCTGGAGAAGATGCTGCCGCTGGCCT
ACGAAGTGTCCGTGCTGGCCGCCCGCGCCGCCGACGGCAGCACCGTTACCTGGCCGCTGGCCGAGAACATTCACCGCGAC
GGCATCCTGTTCTCCACGGTCATGCCCTCGCGCAGCGTGTCGGACGACATCGCCACGCGCACCCGCGCCGCCGCCGCAAT
GATCACCGAGGAGATGGGCTACGTGGGCGTGCTGTGCATCGAGTTCTTCGTGCTGCAGGACGGTTCGCTGATCGCCAACG
AGATGGCGCCGCGCCCGCACAACTCGGGCCATATCACTATGGATGTGTGCGAGACCAGCCAGTTCGAGCAGCAGGTGCGT
ACCATGGCCCGCCTGCCGCTGGGCAGCACGCGCCAGCATTCGCCGGGGCGCATGCTCAACGTGCTGGGCGACGTGTGGTT
CGAGTACGGCCTGGAACGCACGCCCGCGTGGCACGATGTGATGCGGCATTCCGGCACCAAGGTGCACCTGTACGGCAAGG
CCGACGCGCGTCCGGGCCGCAAGATGGGCCATGTCAATTGCGTCGGCACGTCGCCCGAGGTGGCGGACGAGGCGTTCCAC
CATGCCGTGCAGGTGCTCGGCCTGCAATCGGCCCCGGCCTGA

Upstream 100 bases:

>100_bases
CTGGCGGCCAAGCTCGAAGCCTTCCGCGCCCGGCAGACCGAAGTGGCGCGCGGCATGACGCTGCCCGTGCACAGTGCTTA
AGTCCTTCGCCCAACCGCCC

Downstream 100 bases:

>100_bases
CGGCCGCCACATCCGAAGCCATGCACAAGTCGACCACGCCCTTCGTCATGCCTCCCGCCGCGCGCCTCGATGAGGCCGCG
CGCCGGCTGGAAGCGGGCGA

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MADDLNPRLAQAHTPESRALNVPDAILPDSWLGMLGGGQLGRMFTHAAQAMGYKVCVLDPDPNSPAGTVAERHLCAAYTD
EAALAELAALCPAVTTEFENVPAQALDRLEHLGAFVAPRAHCVSIAQNRIAEKKFFALCAARTGIHPAPSWVIEHDADID
QLPADLLPGILKIARMGYDGKGQARVSTVGELRAAWGAMQHVPCVLEKMLPLAYEVSVLAARAADGSTVTWPLAENIHRD
GILFSTVMPSRSVSDDIATRTRAAAAMITEEMGYVGVLCIEFFVLQDGSLIANEMAPRPHNSGHITMDVCETSQFEQQVR
TMARLPLGSTRQHSPGRMLNVLGDVWFEYGLERTPAWHDVMRHSGTKVHLYGKADARPGRKMGHVNCVGTSPEVADEAFH
HAVQVLGLQSAPA

Sequences:

>Translated_413_residues
MADDLNPRLAQAHTPESRALNVPDAILPDSWLGMLGGGQLGRMFTHAAQAMGYKVCVLDPDPNSPAGTVAERHLCAAYTD
EAALAELAALCPAVTTEFENVPAQALDRLEHLGAFVAPRAHCVSIAQNRIAEKKFFALCAARTGIHPAPSWVIEHDADID
QLPADLLPGILKIARMGYDGKGQARVSTVGELRAAWGAMQHVPCVLEKMLPLAYEVSVLAARAADGSTVTWPLAENIHRD
GILFSTVMPSRSVSDDIATRTRAAAAMITEEMGYVGVLCIEFFVLQDGSLIANEMAPRPHNSGHITMDVCETSQFEQQVR
TMARLPLGSTRQHSPGRMLNVLGDVWFEYGLERTPAWHDVMRHSGTKVHLYGKADARPGRKMGHVNCVGTSPEVADEAFH
HAVQVLGLQSAPA
>Mature_412_residues
ADDLNPRLAQAHTPESRALNVPDAILPDSWLGMLGGGQLGRMFTHAAQAMGYKVCVLDPDPNSPAGTVAERHLCAAYTDE
AALAELAALCPAVTTEFENVPAQALDRLEHLGAFVAPRAHCVSIAQNRIAEKKFFALCAARTGIHPAPSWVIEHDADIDQ
LPADLLPGILKIARMGYDGKGQARVSTVGELRAAWGAMQHVPCVLEKMLPLAYEVSVLAARAADGSTVTWPLAENIHRDG
ILFSTVMPSRSVSDDIATRTRAAAAMITEEMGYVGVLCIEFFVLQDGSLIANEMAPRPHNSGHITMDVCETSQFEQQVRT
MARLPLGSTRQHSPGRMLNVLGDVWFEYGLERTPAWHDVMRHSGTKVHLYGKADARPGRKMGHVNCVGTSPEVADEAFHH
AVQVLGLQSAPA

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=367, Percent_Identity=34.8773841961853, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788155, Length=386, Percent_Identity=25.3886010362694, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6324702, Length=372, Percent_Identity=31.4516129032258, Blast_Score=187, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 44581; Mature: 44450

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADDLNPRLAQAHTPESRALNVPDAILPDSWLGMLGGGQLGRMFTHAAQAMGYKVCVLDP
CCCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCEEEEECC
DPNSPAGTVAERHLCAAYTDEAALAELAALCPAVTTEFENVPAQALDRLEHLGAFVAPRA
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHH
HCVSIAQNRIAEKKFFALCAARTGIHPAPSWVIEHDADIDQLPADLLPGILKIARMGYDG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHCCHHHHHHHHHHHHCCCCC
KGQARVSTVGELRAAWGAMQHVPCVLEKMLPLAYEVSVLAARAADGSTVTWPLAENIHRD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCCC
GILFSTVMPSRSVSDDIATRTRAAAAMITEEMGYVGVLCIEFFVLQDGSLIANEMAPRPH
CEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHCCCCCC
NSGHITMDVCETSQFEQQVRTMARLPLGSTRQHSPGRMLNVLGDVWFEYGLERTPAWHDV
CCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHH
MRHSGTKVHLYGKADARPGRKMGHVNCVGTSPEVADEAFHHAVQVLGLQSAPA
HHCCCCEEEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ADDLNPRLAQAHTPESRALNVPDAILPDSWLGMLGGGQLGRMFTHAAQAMGYKVCVLDP
CCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCEEEEECC
DPNSPAGTVAERHLCAAYTDEAALAELAALCPAVTTEFENVPAQALDRLEHLGAFVAPRA
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHH
HCVSIAQNRIAEKKFFALCAARTGIHPAPSWVIEHDADIDQLPADLLPGILKIARMGYDG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHCCHHHHHHHHHHHHCCCCC
KGQARVSTVGELRAAWGAMQHVPCVLEKMLPLAYEVSVLAARAADGSTVTWPLAENIHRD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCCC
GILFSTVMPSRSVSDDIATRTRAAAAMITEEMGYVGVLCIEFFVLQDGSLIANEMAPRPH
CEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHCCCCCC
NSGHITMDVCETSQFEQQVRTMARLPLGSTRQHSPGRMLNVLGDVWFEYGLERTPAWHDV
CCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHH
MRHSGTKVHLYGKADARPGRKMGHVNCVGTSPEVADEAFHHAVQVLGLQSAPA
HHCCCCEEEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]