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The map label for this gene is purE [H]

Identifier: 17545294

GI number: 17545294

Start: 619330

End: 619839

Strand: Direct

Name: purE [H]

Synonym: RSc0575

Alternate gene names: 17545294

Gene position: 619330-619839 (Clockwise)

Preceding gene: 17545293

Following gene: 17545295

Centisome position: 16.66

GC content: 69.8

Gene sequence:

>510_bases
ATGACCGCATCGCAATCCGCGCCGCTCGTCGGCGTCGTCATGGGTTCCAGCTCCGACTGGGACGTCATGCAGCACGCCGT
GGTCCTGCTCAAGGAATTCGACATTCCGTTCGAGGCGCAGGTGGTCTCGGCGCACCGCATGCCGGACGACATGTTCCGCT
ACGCCGAGGCCGCACGCGGCCGGGGCCTGCGCGCCATCATCGCCGGTGCCGGCGGCGCGGCGCACCTGCCGGGCATGATC
GCCGCCAAGACCATCGTGCCGGTGTTCGGCGTGCCGGTGCCGTCCAAGTACCTGCGCGGCGAAGACTCGCTGCTGTCCAT
CGTGCAGATGCCCAAGGGCATTCCGGTGGCGACCTTTGCCATCGGCGAGGCGGGCGCGGCCAACGCGGCGCTGTCGGCCA
TCGCCATGCTGGCGACCACCGACGATGCGCTGGCGGCCAAGCTCGAAGCCTTCCGCGCCCGGCAGACCGAAGTGGCGCGC
GGCATGACGCTGCCCGTGCACAGTGCTTAA

Upstream 100 bases:

>100_bases
CCGCAGCTGCCCGCCGACATCATCGAGAAGACCGCGGACAAGTACCGCGAAGCACTGACCCGCCTGACCGGCGAGACGCT
GCGCTGAGGGAGCGACGACG

Downstream 100 bases:

>100_bases
GTCCTTCGCCCAACCGCCCATGGCCGACGACCTGAATCCGCGCCTCGCGCAGGCCCACACGCCCGAATCCCGCGCGCTGA
ACGTTCCCGACGCGATCCTG

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit protein

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MTASQSAPLVGVVMGSSSDWDVMQHAVVLLKEFDIPFEAQVVSAHRMPDDMFRYAEAARGRGLRAIIAGAGGAAHLPGMI
AAKTIVPVFGVPVPSKYLRGEDSLLSIVQMPKGIPVATFAIGEAGAANAALSAIAMLATTDDALAAKLEAFRARQTEVAR
GMTLPVHSA

Sequences:

>Translated_169_residues
MTASQSAPLVGVVMGSSSDWDVMQHAVVLLKEFDIPFEAQVVSAHRMPDDMFRYAEAARGRGLRAIIAGAGGAAHLPGMI
AAKTIVPVFGVPVPSKYLRGEDSLLSIVQMPKGIPVATFAIGEAGAANAALSAIAMLATTDDALAAKLEAFRARQTEVAR
GMTLPVHSA
>Mature_168_residues
TASQSAPLVGVVMGSSSDWDVMQHAVVLLKEFDIPFEAQVVSAHRMPDDMFRYAEAARGRGLRAIIAGAGGAAHLPGMIA
AKTIVPVFGVPVPSKYLRGEDSLLSIVQMPKGIPVATFAIGEAGAANAALSAIAMLATTDDALAAKLEAFRARQTEVARG
MTLPVHSA

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=157, Percent_Identity=57.3248407643312, Blast_Score=148, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324702, Length=150, Percent_Identity=55.3333333333333, Blast_Score=158, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17555; Mature: 17423

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASQSAPLVGVVMGSSSDWDVMQHAVVLLKEFDIPFEAQVVSAHRMPDDMFRYAEAARG
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHCC
RGLRAIIAGAGGAAHLPGMIAAKTIVPVFGVPVPSKYLRGEDSLLSIVQMPKGIPVATFA
CCEEEEEECCCCCHHCCCHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHCCCCCCEEEEE
IGEAGAANAALSAIAMLATTDDALAAKLEAFRARQTEVARGMTLPVHSA
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TASQSAPLVGVVMGSSSDWDVMQHAVVLLKEFDIPFEAQVVSAHRMPDDMFRYAEAARG
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHCC
RGLRAIIAGAGGAAHLPGMIAAKTIVPVFGVPVPSKYLRGEDSLLSIVQMPKGIPVATFA
CCEEEEEECCCCCHHCCCHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHCCCCCCEEEEE
IGEAGAANAALSAIAMLATTDDALAAKLEAFRARQTEVARGMTLPVHSA
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]