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The map label for this gene is ywlC [H]

Identifier: 17545296

GI number: 17545296

Start: 621121

End: 622131

Strand: Direct

Name: ywlC [H]

Synonym: RSc0577

Alternate gene names: 17545296

Gene position: 621121-622131 (Clockwise)

Preceding gene: 17545295

Following gene: 17545299

Centisome position: 16.71

GC content: 72.7

Gene sequence:

>1011_bases
ATGCACAAGTCGACCACGCCCTTCGTCATGCCTCCCGCCGCGCGCCTCGATGAGGCCGCGCGCCGGCTGGAAGCGGGCGA
GCTGGTCGCCTTCCCGACCGAGACCGTCTACGGCCTCGGCGCCGATGCCGAGAACCCTCAGGCCATTGCCCGGATCTACG
CGCTGAAGGGCCGGCCGTCGAACCATCCGGTGATCGTGCACGTGGTCGACGGCGCGGACCTGACGTACTGGGCCGACGAC
GTGCCCGGCATCGCGCTGCAGCTGGTCGAGGCGTTCTGGCCGGGCCCGCTCACGCTGATCCTCAAGCGCGCGCCGCACAT
CCCGGCGGCGGTCGCGGGCGGGCAGGACAGCGTCGGATTGCGCTGTCCGTCGCATCCGGTGGCGCAGGCGCTGCTGTCGC
GCTTCAAGCGCGGTCGCGGCGGCATCGCGGCGCCGTCGGCCAACAAGTTTGGCCAGGTCAGCCCGACCACCGCGCAGCAT
GTGCGCGACGAGTTCGGCGATGCCGTGTTCGTGCTCGAAGGTGATGGGGTGGATGTCGGCATCGAGTCCACCATCGTCGA
CCTGTCGCGGCTGGACCAGGGCGTCGGGCCGGTGCTGCTGCGCCCCGGCGCCATCACGCCGGAGGACATCGGGCGCGTGA
CCGGCGTGATGCCGTTGCTGCCCGATGCCGCCGCGCCGCGCGCGTCCGGAACGCTGCGCGCGCATTACGCGCCGCGCACG
CCGCTGTATCTGCTGGCCGCTGCCGATGTGCCCGCGCGGCTGGCCGCGCTGCCGGCCGGTCGGCGCATCGTGTGGGTGGG
GGCGCCTGTCGACCTGCCGCCCGGCTGCGACCAGCATGCCGCACCCGCCACGCCGGCGGCCTACGCCAATGCGCTGTACG
CCTTGCTGCGCGAACTGGATCGCGGCGGCTATCACGCCATCTGGGTGGAAACCCTGCCTGACACCTCCGCCTGGGCGGCG
GTCAACGACCGCCTGCGTCGCGCTGCCGCCGCGTTCGAAGCCGGCCTCTAA

Upstream 100 bases:

>100_bases
TCGGCACGTCGCCCGAGGTGGCGGACGAGGCGTTCCACCATGCCGTGCAGGTGCTCGGCCTGCAATCGGCCCCGGCCTGA
CGGCCGCCACATCCGAAGCC

Downstream 100 bases:

>100_bases
TTCGGGCCGGGCACGGCGCCGCCGCATGGGCGGCAACCTCGCTACACTTGCCCCTGTGCGTCGGCCCGCGTCTGCCTGAA
TTGCACGCCGGCATCGCAAC

Product: hypothetical protein

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MHKSTTPFVMPPAARLDEAARRLEAGELVAFPTETVYGLGADAENPQAIARIYALKGRPSNHPVIVHVVDGADLTYWADD
VPGIALQLVEAFWPGPLTLILKRAPHIPAAVAGGQDSVGLRCPSHPVAQALLSRFKRGRGGIAAPSANKFGQVSPTTAQH
VRDEFGDAVFVLEGDGVDVGIESTIVDLSRLDQGVGPVLLRPGAITPEDIGRVTGVMPLLPDAAAPRASGTLRAHYAPRT
PLYLLAAADVPARLAALPAGRRIVWVGAPVDLPPGCDQHAAPATPAAYANALYALLRELDRGGYHAIWVETLPDTSAWAA
VNDRLRRAAAAFEAGL

Sequences:

>Translated_336_residues
MHKSTTPFVMPPAARLDEAARRLEAGELVAFPTETVYGLGADAENPQAIARIYALKGRPSNHPVIVHVVDGADLTYWADD
VPGIALQLVEAFWPGPLTLILKRAPHIPAAVAGGQDSVGLRCPSHPVAQALLSRFKRGRGGIAAPSANKFGQVSPTTAQH
VRDEFGDAVFVLEGDGVDVGIESTIVDLSRLDQGVGPVLLRPGAITPEDIGRVTGVMPLLPDAAAPRASGTLRAHYAPRT
PLYLLAAADVPARLAALPAGRRIVWVGAPVDLPPGCDQHAAPATPAAYANALYALLRELDRGGYHAIWVETLPDTSAWAA
VNDRLRRAAAAFEAGL
>Mature_336_residues
MHKSTTPFVMPPAARLDEAARRLEAGELVAFPTETVYGLGADAENPQAIARIYALKGRPSNHPVIVHVVDGADLTYWADD
VPGIALQLVEAFWPGPLTLILKRAPHIPAAVAGGQDSVGLRCPSHPVAQALLSRFKRGRGGIAAPSANKFGQVSPTTAQH
VRDEFGDAVFVLEGDGVDVGIESTIVDLSRLDQGVGPVLLRPGAITPEDIGRVTGVMPLLPDAAAPRASGTLRAHYAPRT
PLYLLAAADVPARLAALPAGRRIVWVGAPVDLPPGCDQHAAPATPAAYANALYALLRELDRGGYHAIWVETLPDTSAWAA
VNDRLRRAAAAFEAGL

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=181, Percent_Identity=32.5966850828729, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI2367210, Length=155, Percent_Identity=30.3225806451613, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87081864, Length=124, Percent_Identity=30.6451612903226, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17537239, Length=176, Percent_Identity=30.6818181818182, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6321269, Length=380, Percent_Identity=30.7894736842105, Blast_Score=126, Evalue=6e-30,
Organism=Drosophila melanogaster, GI78707274, Length=204, Percent_Identity=27.9411764705882, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 35327; Mature: 35327

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKSTTPFVMPPAARLDEAARRLEAGELVAFPTETVYGLGADAENPQAIARIYALKGRPS
CCCCCCCEEECCHHHHHHHHHHHCCCCEEEECCHHEEECCCCCCCHHHHHHHHEECCCCC
NHPVIVHVVDGADLTYWADDVPGIALQLVEAFWPGPLTLILKRAPHIPAAVAGGQDSVGL
CCCEEEEEECCCCEEEECCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCEEECCCCCCCCC
RCPSHPVAQALLSRFKRGRGGIAAPSANKFGQVSPTTAQHVRDEFGDAVFVLEGDGVDVG
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEECCCCEEC
IESTIVDLSRLDQGVGPVLLRPGAITPEDIGRVTGVMPLLPDAAAPRASGTLRAHYAPRT
HHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCC
PLYLLAAADVPARLAALPAGRRIVWVGAPVDLPPGCDQHAAPATPAAYANALYALLRELD
CEEEEEECCCCHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
RGGYHAIWVETLPDTSAWAAVNDRLRRAAAAFEAGL
CCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHKSTTPFVMPPAARLDEAARRLEAGELVAFPTETVYGLGADAENPQAIARIYALKGRPS
CCCCCCCEEECCHHHHHHHHHHHCCCCEEEECCHHEEECCCCCCCHHHHHHHHEECCCCC
NHPVIVHVVDGADLTYWADDVPGIALQLVEAFWPGPLTLILKRAPHIPAAVAGGQDSVGL
CCCEEEEEECCCCEEEECCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCEEECCCCCCCCC
RCPSHPVAQALLSRFKRGRGGIAAPSANKFGQVSPTTAQHVRDEFGDAVFVLEGDGVDVG
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEECCCCEEC
IESTIVDLSRLDQGVGPVLLRPGAITPEDIGRVTGVMPLLPDAAAPRASGTLRAHYAPRT
HHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCC
PLYLLAAADVPARLAALPAGRRIVWVGAPVDLPPGCDQHAAPATPAAYANALYALLRELD
CEEEEEECCCCHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
RGGYHAIWVETLPDTSAWAAVNDRLRRAAAAFEAGL
CCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]