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The map label for this gene is pdxA

Identifier: 17545236

GI number: 17545236

Start: 555147

End: 556163

Strand: Direct

Name: pdxA

Synonym: RSc0517

Alternate gene names: 17545236

Gene position: 555147-556163 (Clockwise)

Preceding gene: 17545235

Following gene: 17545237

Centisome position: 14.94

GC content: 72.57

Gene sequence:

>1017_bases
ATGCTGAACATTGCCATCACGACCGGCGAACCGGCCGGCATCGGTCCGGACATCACCGTGACGGCGCTGCTGCGCCTGCT
GCGGCAGCCCGCCCCGCGCCATGCCGACGTGCGCTGGCACGTGATCGGCGATGCCGCGCTGCTGCAGGCGCGCGCCGATG
CCATCGGCCTGGGCGACGCCTGGCGGGACGCAGCGGCGGCGCTCACCGTGGTCGCGCGTCCGCTGGGGGCGCCGGTGCGC
ACCGGCGTGCTCGATGCCGCCAATGGCCGCTATGTGCTCGACCTGCTCGATGCCGCCATCGACGGCTGCCTGCCAGATGC
CGCGGGCATGGCGCGCTACGACGCGATGGTGACGGCCCCGGTGCAGAAGAGCACCATCAACGACGCCGGCGTGCCGTTCA
CCGGCCATACCGAATACCTGGCCGAGCGCAGCCGCACGCCGCGCGTGGTGATGATGCTGGCCGGCCCGCAGCCCGCGCAT
GGCAACGCCATGCTGCGCGTGGCGCTGGCCACCACGCACCTGCCGCTGCGCGAGGTGCCGGATGCCATCACGCCCGCCGT
GCTGGACGAGACGCTGGACATCGTGCAGCGGGACCTGCGCGCCCGCTTCGGCATGGCCGCGCCTCGCATCCTGGTCACCG
GGCTGAATCCGCATGCCGGCGAGGCGGGCCACCTGGGCCGCGAGGAGATCGAGGTGATCGAACCCGCCGTTGTCCGGGCC
CGTGCGCGCGGCATCGACGCCCGCGGGCCGTATCCCGCCGACACGCTGTTCCAGCCGCGCCTGCTGGCCGATGCCGATTG
CGTGCTGGCGATGTATCACGACCAGGGCCTGGCGCCGCTCAAGTACGGCACCTTCGGCCATGGCGTCAACATCACGCTGG
GGTTGCCGTTCGTGCGCACCTCCGTCGACCACGGCACCGCGCTGGATCTTGCCGGCACCGGCCGCGCGGAGGCGGGCAGC
CTGCTCGAGGCGATCGATACCGCTGTCGAGATGGCCCGCCACGCGGCGCATTCCTGA

Upstream 100 bases:

>100_bases
TAAGTCGGGTACGCTGTCGGGACGCTTGCTTCCCGGTTCACGGCCGCCCGCGGGCGGCCGTTCCATTTCCGATGCCACCG
CAGTCACTGAAAGGCGCCGC

Downstream 100 bases:

>100_bases
TTCCATTTCTTCCGTTTTCCGAGCTTCGCTATGGCGCGATCCACTTCCGGCGTTCACCAGGGGCACCAGGCCCGCAAGCG
TTTCGGCCAGAACTTCCTGG

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MLNIAITTGEPAGIGPDITVTALLRLLRQPAPRHADVRWHVIGDAALLQARADAIGLGDAWRDAAAALTVVARPLGAPVR
TGVLDAANGRYVLDLLDAAIDGCLPDAAGMARYDAMVTAPVQKSTINDAGVPFTGHTEYLAERSRTPRVVMMLAGPQPAH
GNAMLRVALATTHLPLREVPDAITPAVLDETLDIVQRDLRARFGMAAPRILVTGLNPHAGEAGHLGREEIEVIEPAVVRA
RARGIDARGPYPADTLFQPRLLADADCVLAMYHDQGLAPLKYGTFGHGVNITLGLPFVRTSVDHGTALDLAGTGRAEAGS
LLEAIDTAVEMARHAAHS

Sequences:

>Translated_338_residues
MLNIAITTGEPAGIGPDITVTALLRLLRQPAPRHADVRWHVIGDAALLQARADAIGLGDAWRDAAAALTVVARPLGAPVR
TGVLDAANGRYVLDLLDAAIDGCLPDAAGMARYDAMVTAPVQKSTINDAGVPFTGHTEYLAERSRTPRVVMMLAGPQPAH
GNAMLRVALATTHLPLREVPDAITPAVLDETLDIVQRDLRARFGMAAPRILVTGLNPHAGEAGHLGREEIEVIEPAVVRA
RARGIDARGPYPADTLFQPRLLADADCVLAMYHDQGLAPLKYGTFGHGVNITLGLPFVRTSVDHGTALDLAGTGRAEAGS
LLEAIDTAVEMARHAAHS
>Mature_338_residues
MLNIAITTGEPAGIGPDITVTALLRLLRQPAPRHADVRWHVIGDAALLQARADAIGLGDAWRDAAAALTVVARPLGAPVR
TGVLDAANGRYVLDLLDAAIDGCLPDAAGMARYDAMVTAPVQKSTINDAGVPFTGHTEYLAERSRTPRVVMMLAGPQPAH
GNAMLRVALATTHLPLREVPDAITPAVLDETLDIVQRDLRARFGMAAPRILVTGLNPHAGEAGHLGREEIEVIEPAVVRA
RARGIDARGPYPADTLFQPRLLADADCVLAMYHDQGLAPLKYGTFGHGVNITLGLPFVRTSVDHGTALDLAGTGRAEAGS
LLEAIDTAVEMARHAAHS

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=338, Percent_Identity=53.5502958579882, Blast_Score=329, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA_RALSO (P58714)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_518638.1
- ProteinModelPortal:   P58714
- SMR:   P58714
- GeneID:   1219321
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc0517
- NMPDR:   fig|267608.1.peg.517
- HOGENOM:   HBG451136
- OMA:   LETAYQM
- ProtClustDB:   PRK01909
- BioCyc:   RSOL267608:RSC0517-MONOMER
- BRENDA:   1.1.1.262
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR005255
- TIGRFAMs:   TIGR00557

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 35592; Mature: 35592

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: BINDING 136-136 BINDING 137-137 BINDING 281-281 BINDING 290-290 BINDING 299-299

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNIAITTGEPAGIGPDITVTALLRLLRQPAPRHADVRWHVIGDAALLQARADAIGLGDA
CEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHCCCCCCHH
WRDAAAALTVVARPLGAPVRTGVLDAANGRYVLDLLDAAIDGCLPDAAGMARYDAMVTAP
HHHHHHHHHHHHHHCCCCHHHCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHEEECC
VQKSTINDAGVPFTGHTEYLAERSRTPRVVMMLAGPQPAHGNAMLRVALATTHLPLREVP
CHHCCCCCCCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEEEHHCCCCHHHCC
DAITPAVLDETLDIVQRDLRARFGMAAPRILVTGLNPHAGEAGHLGREEIEVIEPAVVRA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
RARGIDARGPYPADTLFQPRLLADADCVLAMYHDQGLAPLKYGTFGHGVNITLGLPFVRT
HHCCCCCCCCCCCCCCCCCHHHCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCHHEE
SVDHGTALDLAGTGRAEAGSLLEAIDTAVEMARHAAHS
CCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLNIAITTGEPAGIGPDITVTALLRLLRQPAPRHADVRWHVIGDAALLQARADAIGLGDA
CEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHCCCCCCHH
WRDAAAALTVVARPLGAPVRTGVLDAANGRYVLDLLDAAIDGCLPDAAGMARYDAMVTAP
HHHHHHHHHHHHHHCCCCHHHCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHEEECC
VQKSTINDAGVPFTGHTEYLAERSRTPRVVMMLAGPQPAHGNAMLRVALATTHLPLREVP
CHHCCCCCCCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEEEHHCCCCHHHCC
DAITPAVLDETLDIVQRDLRARFGMAAPRILVTGLNPHAGEAGHLGREEIEVIEPAVVRA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
RARGIDARGPYPADTLFQPRLLADADCVLAMYHDQGLAPLKYGTFGHGVNITLGLPFVRT
HHCCCCCCCCCCCCCCCCCHHHCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCHHEE
SVDHGTALDLAGTGRAEAGSLLEAIDTAVEMARHAAHS
CCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852