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The map label for this gene is surA [H]

Identifier: 17545235

GI number: 17545235

Start: 553553

End: 555049

Strand: Direct

Name: surA [H]

Synonym: RSc0516

Alternate gene names: 17545235

Gene position: 553553-555049 (Clockwise)

Preceding gene: 17545234

Following gene: 17545236

Centisome position: 14.89

GC content: 69.81

Gene sequence:

>1497_bases
ATGACTATGGCTTGCAAATCGACTGCTGTCCGCTCTGCCACGCGCGTGGCGCCCACCCGCCGGCTGGGCATGGTGACCGG
TGCGCTGGTTGCGCTGATGGCTGGTGCGGCGCTGCTGCCCGCCGCCCATGCGCAGCAGACGCAGAAGAAGAGCGCGCCGC
TGCGCGGCATCTTCACCACGCCCGATGCATCGCCCAGCCAGCCGCTGCTGCGGGGCACGCTGCCGGGGCCGTCGACGGCC
TCCGGCGCGGCGCGCAGCCAGCTGGTCGACGAAGTGGTGGCGGTGGTCAATACCGACATCATCACGCGCCGCGAGCTGCT
GGATCGCGCCGACCTGGTCGAACGCACCCTGCAGTCGCAGAATCGCCAGGTACCGGTGCGCGCCGACCTGCTCGGCGAAG
TGCTGGAGCAGCTGATCCTGGAGCGGGTGCAGGCGCAGACGGCCAAGGAAAGCGGCATCCGCGTGTCGGATGCCGACGTG
GACCGCGCGGTGGAGAGCGTGGCCCAGCGCAACAACCTGTCGGTATCGCAGCTCAAGTCCAAGCTGGCCCAGTCCGGGCT
GGCCTACGACAAGTACCGTGAAGACCTGCGGCAGGAGATCCTGCTGGCCCGCCTGCGCGATCGCGAGGTGGATTCCAAGG
TGCAGGTGTTCGACGGCGAGATCGACAACTTCCTCGCCCAGCAGGGCGGCAGCGCCGCATCGAGCGGTGTGCAGGAATAC
AACGTCGCCCAGATCCTGGTGCCGGTGGCCGAGGATGCCTCCGCCGAGCAGAAGGCGGCCGCGCGCGGCAAGGCCGAAAG
CCTGCTGAAGCAGGTCCAGGGCGGCGCGGACTTTGCCAAGCTGGCGCGCGACAGTTCCGGCGCGCCCGAGGCTGCGCAGG
GCGGCGAGCTCGGCTTGCGCCCGATCGGCCGCCTGCCGGCGCAGTTCGCCAACGCCGTGGTCGATCTGAAGCCGGGCCAG
GTGGTGGACCAGGTGATCGAGAGCCCCGCCGGCTTCCATGTGCTGAAGCTGGTGGACAAGCGTGCGCAGGGCACCGCCAT
CACGGCCAAGGTGGCGCAGACGCAGGTCCGCCATATCCTGATCAAGACCGGCCCGACCATGTCGGCCGACGACGCGCGCC
GCCAGCTGGCCGGCCTGCGTGACCGCATCGTCCACGGCTACGATTTCGGCGATGCGGCGCGCCGCTATTCGCAGGATACC
TCGGCCAGCGCGGGCGGCGAGCTGGGCTGGGTGTCGCCCGGCCAGCTGGTGCCGGAGTTCGAGCAGGCGATGGGCCTGCT
CAAGCCGGGCGAGGTTTCGCAGCCGGTGCAGAGCCAGTTCGGCCTGCACCTGATCCAGGTGGAAGGCCGCCGCGAAGCCG
AAGTGCCGGTGGACCGCCAGCGTGACTACGCGCGCTCGGTGATCCGCGAGCAGAAAGTCCAGGCCGCGTACGAAGACTGG
CTGCGCCAGCTGCGCGACAGCGCCCACGTGGAATACCGCGTGAACCGCCAGCAGTAA

Upstream 100 bases:

>100_bases
AGGTGGGGAACAATCCGATCGACGTGATCCGACTCAACGTGCCCGGCTACCAGCCGGTCACCGCGCAGCCGGTCACGCCG
TCCGTGCTGGATCAATACGA

Downstream 100 bases:

>100_bases
GTCGGGTACGCTGTCGGGACGCTTGCTTCCCGGTTCACGGCCGCCCGCGGGCGGCCGTTCCATTTCCGATGCCACCGCAG
TCACTGAAAGGCGCCGCATG

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase surA; PPIase surA; Rotamase surA [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MTMACKSTAVRSATRVAPTRRLGMVTGALVALMAGAALLPAAHAQQTQKKSAPLRGIFTTPDASPSQPLLRGTLPGPSTA
SGAARSQLVDEVVAVVNTDIITRRELLDRADLVERTLQSQNRQVPVRADLLGEVLEQLILERVQAQTAKESGIRVSDADV
DRAVESVAQRNNLSVSQLKSKLAQSGLAYDKYREDLRQEILLARLRDREVDSKVQVFDGEIDNFLAQQGGSAASSGVQEY
NVAQILVPVAEDASAEQKAAARGKAESLLKQVQGGADFAKLARDSSGAPEAAQGGELGLRPIGRLPAQFANAVVDLKPGQ
VVDQVIESPAGFHVLKLVDKRAQGTAITAKVAQTQVRHILIKTGPTMSADDARRQLAGLRDRIVHGYDFGDAARRYSQDT
SASAGGELGWVSPGQLVPEFEQAMGLLKPGEVSQPVQSQFGLHLIQVEGRREAEVPVDRQRDYARSVIREQKVQAAYEDW
LRQLRDSAHVEYRVNRQQ

Sequences:

>Translated_498_residues
MTMACKSTAVRSATRVAPTRRLGMVTGALVALMAGAALLPAAHAQQTQKKSAPLRGIFTTPDASPSQPLLRGTLPGPSTA
SGAARSQLVDEVVAVVNTDIITRRELLDRADLVERTLQSQNRQVPVRADLLGEVLEQLILERVQAQTAKESGIRVSDADV
DRAVESVAQRNNLSVSQLKSKLAQSGLAYDKYREDLRQEILLARLRDREVDSKVQVFDGEIDNFLAQQGGSAASSGVQEY
NVAQILVPVAEDASAEQKAAARGKAESLLKQVQGGADFAKLARDSSGAPEAAQGGELGLRPIGRLPAQFANAVVDLKPGQ
VVDQVIESPAGFHVLKLVDKRAQGTAITAKVAQTQVRHILIKTGPTMSADDARRQLAGLRDRIVHGYDFGDAARRYSQDT
SASAGGELGWVSPGQLVPEFEQAMGLLKPGEVSQPVQSQFGLHLIQVEGRREAEVPVDRQRDYARSVIREQKVQAAYEDW
LRQLRDSAHVEYRVNRQQ
>Mature_497_residues
TMACKSTAVRSATRVAPTRRLGMVTGALVALMAGAALLPAAHAQQTQKKSAPLRGIFTTPDASPSQPLLRGTLPGPSTAS
GAARSQLVDEVVAVVNTDIITRRELLDRADLVERTLQSQNRQVPVRADLLGEVLEQLILERVQAQTAKESGIRVSDADVD
RAVESVAQRNNLSVSQLKSKLAQSGLAYDKYREDLRQEILLARLRDREVDSKVQVFDGEIDNFLAQQGGSAASSGVQEYN
VAQILVPVAEDASAEQKAAARGKAESLLKQVQGGADFAKLARDSSGAPEAAQGGELGLRPIGRLPAQFANAVVDLKPGQV
VDQVIESPAGFHVLKLVDKRAQGTAITAKVAQTQVRHILIKTGPTMSADDARRQLAGLRDRIVHGYDFGDAARRYSQDTS
ASAGGELGWVSPGQLVPEFEQAMGLLKPGEVSQPVQSQFGLHLIQVEGRREAEVPVDRQRDYARSVIREQKVQAAYEDWL
RQLRDSAHVEYRVNRQQ

Specific function: Chaperone involved in the correct folding and assembly of outer membrane proteins. It recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Periplasm. Note=Is capable of associating with the outer membrane (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PpiC domains [H]

Homologues:

Organism=Escherichia coli, GI1786238, Length=411, Percent_Identity=33.5766423357664, Blast_Score=223, Evalue=2e-59,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR023034
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 53843; Mature: 53711

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMACKSTAVRSATRVAPTRRLGMVTGALVALMAGAALLPAAHAQQTQKKSAPLRGIFTT
CCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
PDASPSQPLLRGTLPGPSTASGAARSQLVDEVVAVVNTDIITRRELLDRADLVERTLQSQ
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NRQVPVRADLLGEVLEQLILERVQAQTAKESGIRVSDADVDRAVESVAQRNNLSVSQLKS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
KLAQSGLAYDKYREDLRQEILLARLRDREVDSKVQVFDGEIDNFLAQQGGSAASSGVQEY
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHEECCCHHHHHHHHCCCCHHHCCHHHH
NVAQILVPVAEDASAEQKAAARGKAESLLKQVQGGADFAKLARDSSGAPEAAQGGELGLR
CHHHHEEECCCCCCHHHHHHHCCHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCC
PIGRLPAQFANAVVDLKPGQVVDQVIESPAGFHVLKLVDKRAQGTAITAKVAQTQVRHIL
CHHCCHHHHHHHEECCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IKTGPTMSADDARRQLAGLRDRIVHGYDFGDAARRYSQDTSASAGGELGWVSPGQLVPEF
EECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHH
EQAMGLLKPGEVSQPVQSQFGLHLIQVEGRREAEVPVDRQRDYARSVIREQKVQAAYEDW
HHHHCCCCCCCCCCHHHHHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LRQLRDSAHVEYRVNRQQ
HHHHHHCCCEEEEECCCC
>Mature Secondary Structure 
TMACKSTAVRSATRVAPTRRLGMVTGALVALMAGAALLPAAHAQQTQKKSAPLRGIFTT
CCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
PDASPSQPLLRGTLPGPSTASGAARSQLVDEVVAVVNTDIITRRELLDRADLVERTLQSQ
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NRQVPVRADLLGEVLEQLILERVQAQTAKESGIRVSDADVDRAVESVAQRNNLSVSQLKS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
KLAQSGLAYDKYREDLRQEILLARLRDREVDSKVQVFDGEIDNFLAQQGGSAASSGVQEY
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHEECCCHHHHHHHHCCCCHHHCCHHHH
NVAQILVPVAEDASAEQKAAARGKAESLLKQVQGGADFAKLARDSSGAPEAAQGGELGLR
CHHHHEEECCCCCCHHHHHHHCCHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCC
PIGRLPAQFANAVVDLKPGQVVDQVIESPAGFHVLKLVDKRAQGTAITAKVAQTQVRHIL
CHHCCHHHHHHHEECCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IKTGPTMSADDARRQLAGLRDRIVHGYDFGDAARRYSQDTSASAGGELGWVSPGQLVPEF
EECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHH
EQAMGLLKPGEVSQPVQSQFGLHLIQVEGRREAEVPVDRQRDYARSVIREQKVQAAYEDW
HHHHCCCCCCCCCCHHHHHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LRQLRDSAHVEYRVNRQQ
HHHHHHCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]