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The map label for this gene is gpwA [H]

Identifier: 17545026

GI number: 17545026

Start: 338893

End: 339594

Strand: Reverse

Name: gpwA [H]

Synonym: RSc0307

Alternate gene names: 17545026

Gene position: 339594-338893 (Counterclockwise)

Preceding gene: 17545029

Following gene: 17545021

Centisome position: 9.14

GC content: 69.94

Gene sequence:

>702_bases
ATGTCGTCGCCTTCCCTCGCCGCGCCTGCCCTTGCCCGCGCACGCGACCGGCTCGCCCGCCGGCGCACTGCGGGCGTGCT
GAGCCGGCATCACCTGCTGATCATCGCGATCGCCATCGTCATTGCGATCATCGCGCTGCTGCTGCCGCGCACCTGCCACG
CGGCCGCCGGCGCCCAGGCCGCCCCGGCACCACAGCCCGCCGCCGCGGGCCCCTGCCCGACCGCCCTCGATTTCCGCGTC
AGGCGCCTGCAGGACGACGCACCGCAGAACCTGTGCCAGTACGCCGGCCGCGTGGTGCTGGTGGTCAACACCGCCAGCTA
TTGCGGCTATACCTACCAGTACGAAGGGCTCGAAGCGCTGTACGCCAGGTTCCGCGACAAGGGACTGACCGTGCTGGGCT
TCCCCTCCAACGACTTCGAGCAGGAGCCGGGCACCGGCAAGCAGATCGCCGACTTCTGCTACAACACGTACGGCGTGAAG
TTCCCGATGTTCTCGAAGACCTCGGTGGTGGGGCCGGCGGCGTCGCCGCTCTATCACTGGCTCGCCCAGCAGACCGGGCA
GCCGCCCAAGTGGAACTTCCACAAGTACCTGCTGGACCGCAGCGGCCGCGTAGTGGCGGTGTACCCGAGCAAGGTCGAGC
CGGGCGATCCGGCCCTCATCAAGCGCATCGACGCCCTGCTCGCCGAACCGGCGCCCCGCTGA

Upstream 100 bases:

>100_bases
ACAAGCAACGCCTGGCGCACTTCGGCTGCGGCAGGCTCCGCGAGCGTTATACCCTAGACTGAAGACATTCCATGCACTGC
CCGCGATTCCGGAGACTGCC

Downstream 100 bases:

>100_bases
GCGCCGGCTCAGGCCGCCATCGTGTCCGGCACCACGCCGTACAGGAAGGCGGCCAGTTCGTCGCGGCGGGCCAGCGCATC
GCGCTCGCCGAGGTCGATCA

Product: glutathione peroxidase transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MSSPSLAAPALARARDRLARRRTAGVLSRHHLLIIAIAIVIAIIALLLPRTCHAAAGAQAAPAPQPAAAGPCPTALDFRV
RRLQDDAPQNLCQYAGRVVLVVNTASYCGYTYQYEGLEALYARFRDKGLTVLGFPSNDFEQEPGTGKQIADFCYNTYGVK
FPMFSKTSVVGPAASPLYHWLAQQTGQPPKWNFHKYLLDRSGRVVAVYPSKVEPGDPALIKRIDALLAEPAPR

Sequences:

>Translated_233_residues
MSSPSLAAPALARARDRLARRRTAGVLSRHHLLIIAIAIVIAIIALLLPRTCHAAAGAQAAPAPQPAAAGPCPTALDFRV
RRLQDDAPQNLCQYAGRVVLVVNTASYCGYTYQYEGLEALYARFRDKGLTVLGFPSNDFEQEPGTGKQIADFCYNTYGVK
FPMFSKTSVVGPAASPLYHWLAQQTGQPPKWNFHKYLLDRSGRVVAVYPSKVEPGDPALIKRIDALLAEPAPR
>Mature_232_residues
SSPSLAAPALARARDRLARRRTAGVLSRHHLLIIAIAIVIAIIALLLPRTCHAAAGAQAAPAPQPAAAGPCPTALDFRVR
RLQDDAPQNLCQYAGRVVLVVNTASYCGYTYQYEGLEALYARFRDKGLTVLGFPSNDFEQEPGTGKQIADFCYNTYGVKF
PMFSKTSVVGPAASPLYHWLAQQTGQPPKWNFHKYLLDRSGRVVAVYPSKVEPGDPALIKRIDALLAEPAPR

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI15618997, Length=147, Percent_Identity=42.1768707482993, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI90903240, Length=165, Percent_Identity=39.3939393939394, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI75709200, Length=175, Percent_Identity=39.4285714285714, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI192455698, Length=137, Percent_Identity=37.956204379562, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI90903238, Length=173, Percent_Identity=36.9942196531792, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI4557629, Length=194, Percent_Identity=27.8350515463918, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1788003, Length=170, Percent_Identity=38.8235294117647, Blast_Score=117, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI71993584, Length=160, Percent_Identity=37.5, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17535473, Length=149, Percent_Identity=36.9127516778523, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17506887, Length=162, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17550320, Length=186, Percent_Identity=29.5698924731183, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI193210707, Length=163, Percent_Identity=33.7423312883436, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI193209493, Length=183, Percent_Identity=29.5081967213115, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322228, Length=143, Percent_Identity=46.1538461538462, Blast_Score=129, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6319721, Length=143, Percent_Identity=44.0559440559441, Blast_Score=128, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6322826, Length=141, Percent_Identity=36.8794326241135, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI85726443, Length=144, Percent_Identity=36.8055555555556, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24656772, Length=202, Percent_Identity=33.1683168316832, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24656777, Length=144, Percent_Identity=38.1944444444444, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24656767, Length=144, Percent_Identity=38.1944444444444, Blast_Score=81, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 25326; Mature: 25195

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPSLAAPALARARDRLARRRTAGVLSRHHLLIIAIAIVIAIIALLLPRTCHAAAGAQA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCC
APAPQPAAAGPCPTALDFRVRRLQDDAPQNLCQYAGRVVLVVNTASYCGYTYQYEGLEAL
CCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCEEEEEEECHHHHCEEEEECCHHHH
YARFRDKGLTVLGFPSNDFEQEPGTGKQIADFCYNTYGVKFPMFSKTSVVGPAASPLYHW
HHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
LAQQTGQPPKWNFHKYLLDRSGRVVAVYPSKVEPGDPALIKRIDALLAEPAPR
HHHHCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SSPSLAAPALARARDRLARRRTAGVLSRHHLLIIAIAIVIAIIALLLPRTCHAAAGAQA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCC
APAPQPAAAGPCPTALDFRVRRLQDDAPQNLCQYAGRVVLVVNTASYCGYTYQYEGLEAL
CCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCEEEEEEECHHHHCEEEEECCHHHH
YARFRDKGLTVLGFPSNDFEQEPGTGKQIADFCYNTYGVKFPMFSKTSVVGPAASPLYHW
HHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
LAQQTGQPPKWNFHKYLLDRSGRVVAVYPSKVEPGDPALIKRIDALLAEPAPR
HHHHCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA