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The map label for this gene is atoB [H]

Identifier: 17544995

GI number: 17544995

Start: 307801

End: 308982

Strand: Reverse

Name: atoB [H]

Synonym: RSc0276

Alternate gene names: 17544995

Gene position: 308982-307801 (Counterclockwise)

Preceding gene: 17544996

Following gene: 17544994

Centisome position: 8.31

GC content: 70.98

Gene sequence:

>1182_bases
ATGTCCGACCGCATCATCATCGCCTCCGCCGCCCGCACCCCCATGGGCGCTTTCCAGGGCGAGCTCGCCAGCCTGACCGC
GCCGCAGCTCGGCGCGACCGCCATCCGCGCGGCGGTGGAGCGCGCAGGCCTGAAGCCCGAGCAGATCGAGGAGGTCATCA
TGGGCTGCGTGCTGCCGGCCGGCCAGGGCCAGGCGCCGGCGCGCCAGGCGGCGCTGGGCGCGGGCCTGCCGCTGTCGGTG
GGCTGCACGACGGTCAACAAGATGTGCGGCTCGGGCATGCGCGCGGCGATGAACGCCTACGACGCGCTGCTGGCCGGATC
GGTGGACGTGGTGGTGGCCGGCGGCATGGAGAGCATGACCAACGCGCCCTACCTGATCCCGAAGGGCCGCGGCGGCTACC
GCATCGGCCACGGCATGATCTACGACCACATGATGCTCGACGGCCTGGAAGACGCCTATGACAAGGGCCGCGCCATGGGC
ACCTTCGGCGAGGACTGTGCCGAGAAGTACGGCTTCACGCGCGAGGCGCAGGATGCCTTCGCGATGGACTCCGTGCGGCG
CGCGCAGGCAGCCACCGAATCGGGCGCGTTCCGCTGGGAGATCGCGCCGGTGACAGTGCCGGGCAAAGCCGGCGACACCG
TGGTCGACACCGACGAAGGCCCGCGCCGCATCAAGGTCGACAAGATTCCCTCGCTCAAGCCCGCGTTCAAGAAGGACGGC
ACGGTGACGGCCGCTTCGTCCTCGTCGATCAACGACGGCGCCGCCGCGCTGGTGATGATGCGCGAATCGACCGCCAGGCA
GCTCGGCATCGCGCCGCTGGCGGTCATGCTGGGCCACACCACGCACGCGCAGGCGCCGGGCTGGTTCACCACCGCGCCGG
TCACGGCGATCGACAAGCTGTTCAAAAAGCTCGGCTGGAGCGCCGACAGCGTGGACCTGTTCGAGATCAACGAAGCGTTT
GCCGTGGTGCCGATGGCGGCCATGCACGACCTGCGCATCCCGCACGAGAAGGTGAACGTGAACGGCGGCGCGTGTGCGCT
GGGCCATCCGATCGGCGCGTCGGGCGCGCGCCTGATCGCCACGCTGCTGGGCGCGCTGCGCCACCGCGGCGGCAAGCGCG
GCGTGGCCAGCCTGTGCATCGGCGGCGGCGAGGCCACCGCGGTCGGCATCGAACTGCTGTGA

Upstream 100 bases:

>100_bases
ACAAGGGTTGCACCACAAGTGCCAGGCCCTGGCGGAAGCCAAAACAGGTAATGCACCACCAGTGCTGAACGCAAGAGAAA
AAACCGGAGACCTATCACCC

Downstream 100 bases:

>100_bases
GGCGCGCACGATGACGAACGCGTCTTCCCGCTCCCGTACCGCCCTCGTCCTGGGCGCCTCGCGCGGCATCGGCCTGGAAA
CGGTCAGGCAATACCTGGCC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSDRIIIASAARTPMGAFQGELASLTAPQLGATAIRAAVERAGLKPEQIEEVIMGCVLPAGQGQAPARQAALGAGLPLSV
GCTTVNKMCGSGMRAAMNAYDALLAGSVDVVVAGGMESMTNAPYLIPKGRGGYRIGHGMIYDHMMLDGLEDAYDKGRAMG
TFGEDCAEKYGFTREAQDAFAMDSVRRAQAATESGAFRWEIAPVTVPGKAGDTVVDTDEGPRRIKVDKIPSLKPAFKKDG
TVTAASSSSINDGAAALVMMRESTARQLGIAPLAVMLGHTTHAQAPGWFTTAPVTAIDKLFKKLGWSADSVDLFEINEAF
AVVPMAAMHDLRIPHEKVNVNGGACALGHPIGASGARLIATLLGALRHRGGKRGVASLCIGGGEATAVGIELL

Sequences:

>Translated_393_residues
MSDRIIIASAARTPMGAFQGELASLTAPQLGATAIRAAVERAGLKPEQIEEVIMGCVLPAGQGQAPARQAALGAGLPLSV
GCTTVNKMCGSGMRAAMNAYDALLAGSVDVVVAGGMESMTNAPYLIPKGRGGYRIGHGMIYDHMMLDGLEDAYDKGRAMG
TFGEDCAEKYGFTREAQDAFAMDSVRRAQAATESGAFRWEIAPVTVPGKAGDTVVDTDEGPRRIKVDKIPSLKPAFKKDG
TVTAASSSSINDGAAALVMMRESTARQLGIAPLAVMLGHTTHAQAPGWFTTAPVTAIDKLFKKLGWSADSVDLFEINEAF
AVVPMAAMHDLRIPHEKVNVNGGACALGHPIGASGARLIATLLGALRHRGGKRGVASLCIGGGEATAVGIELL
>Mature_392_residues
SDRIIIASAARTPMGAFQGELASLTAPQLGATAIRAAVERAGLKPEQIEEVIMGCVLPAGQGQAPARQAALGAGLPLSVG
CTTVNKMCGSGMRAAMNAYDALLAGSVDVVVAGGMESMTNAPYLIPKGRGGYRIGHGMIYDHMMLDGLEDAYDKGRAMGT
FGEDCAEKYGFTREAQDAFAMDSVRRAQAATESGAFRWEIAPVTVPGKAGDTVVDTDEGPRRIKVDKIPSLKPAFKKDGT
VTAASSSSINDGAAALVMMRESTARQLGIAPLAVMLGHTTHAQAPGWFTTAPVTAIDKLFKKLGWSADSVDLFEINEAFA
VVPMAAMHDLRIPHEKVNVNGGACALGHPIGASGARLIATLLGALRHRGGKRGVASLCIGGGEATAVGIELL

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4557237, Length=392, Percent_Identity=46.9387755102041, Blast_Score=342, Evalue=4e-94,
Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=44.7837150127226, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=37.5321336760925, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=37.2151898734177, Blast_Score=221, Evalue=7e-58,
Organism=Homo sapiens, GI4504327, Length=433, Percent_Identity=29.0993071593533, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=30.2564102564103, Blast_Score=138, Evalue=7e-33,
Organism=Escherichia coli, GI1788554, Length=390, Percent_Identity=49.2307692307692, Blast_Score=327, Evalue=1e-90,
Organism=Escherichia coli, GI87082165, Length=388, Percent_Identity=42.5257731958763, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI1787663, Length=396, Percent_Identity=35.8585858585859, Blast_Score=214, Evalue=6e-57,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=36.9077306733167, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1788683, Length=416, Percent_Identity=29.0865384615385, Blast_Score=155, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI25147385, Length=388, Percent_Identity=43.5567010309278, Blast_Score=314, Evalue=6e-86,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=44.4444444444444, Blast_Score=308, Evalue=4e-84,
Organism=Caenorhabditis elegans, GI133906874, Length=388, Percent_Identity=38.4020618556701, Blast_Score=270, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI17535917, Length=395, Percent_Identity=34.9367088607595, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=422, Percent_Identity=31.2796208530806, Blast_Score=175, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=47.25, Blast_Score=340, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6322031, Length=393, Percent_Identity=34.0966921119593, Blast_Score=196, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24655093, Length=398, Percent_Identity=46.2311557788945, Blast_Score=338, Evalue=3e-93,
Organism=Drosophila melanogaster, GI24640423, Length=392, Percent_Identity=47.1938775510204, Blast_Score=332, Evalue=2e-91,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=36.1323155216285, Blast_Score=231, Evalue=9e-61,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=29.9528301886792, Blast_Score=156, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40716; Mature: 40585

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRIIIASAARTPMGAFQGELASLTAPQLGATAIRAAVERAGLKPEQIEEVIMGCVLPA
CCCCEEEEECCCCCCHHHHCHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
GQGQAPARQAALGAGLPLSVGCTTVNKMCGSGMRAAMNAYDALLAGSVDVVVAGGMESMT
CCCCCCHHHHHHCCCCCCEECHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCHHHHC
NAPYLIPKGRGGYRIGHGMIYDHMMLDGLEDAYDKGRAMGTFGEDCAEKYGFTREAQDAF
CCCEEEECCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHH
AMDSVRRAQAATESGAFRWEIAPVTVPGKAGDTVVDTDEGPRRIKVDKIPSLKPAFKKDG
HHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCEEECCCCCCEEEECCCCCCCCCCCCCC
TVTAASSSSINDGAAALVMMRESTARQLGIAPLAVMLGHTTHAQAPGWFTTAPVTAIDKL
CEEECCCCCCCCCCEEEEEEHHHHHHHHCHHHHHHHHCCCCCCCCCCCEECCHHHHHHHH
FKKLGWSADSVDLFEINEAFAVVPMAAMHDLRIPHEKVNVNGGACALGHPIGASGARLIA
HHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCHHHEECCCCEEECCCCCCCCHHHHHH
TLLGALRHRGGKRGVASLCIGGGEATAVGIELL
HHHHHHHHCCCCCCHHHEEECCCCEEEEEEEEC
>Mature Secondary Structure 
SDRIIIASAARTPMGAFQGELASLTAPQLGATAIRAAVERAGLKPEQIEEVIMGCVLPA
CCCEEEEECCCCCCHHHHCHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
GQGQAPARQAALGAGLPLSVGCTTVNKMCGSGMRAAMNAYDALLAGSVDVVVAGGMESMT
CCCCCCHHHHHHCCCCCCEECHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCHHHHC
NAPYLIPKGRGGYRIGHGMIYDHMMLDGLEDAYDKGRAMGTFGEDCAEKYGFTREAQDAF
CCCEEEECCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHH
AMDSVRRAQAATESGAFRWEIAPVTVPGKAGDTVVDTDEGPRRIKVDKIPSLKPAFKKDG
HHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCEEECCCCCCEEEECCCCCCCCCCCCCC
TVTAASSSSINDGAAALVMMRESTARQLGIAPLAVMLGHTTHAQAPGWFTTAPVTAIDKL
CEEECCCCCCCCCCEEEEEEHHHHHHHHCHHHHHHHHCCCCCCCCCCCEECCHHHHHHHH
FKKLGWSADSVDLFEINEAFAVVPMAAMHDLRIPHEKVNVNGGACALGHPIGASGARLIA
HHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCHHHEECCCCEEECCCCCCCCHHHHHH
TLLGALRHRGGKRGVASLCIGGGEATAVGIELL
HHHHHHHHCCCCCCHHHEEECCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]