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The map label for this gene is rtcR [H]

Identifier: 17544941

GI number: 17544941

Start: 243896

End: 245503

Strand: Reverse

Name: rtcR [H]

Synonym: RSc0222

Alternate gene names: 17544941

Gene position: 245503-243896 (Counterclockwise)

Preceding gene: 17544949

Following gene: 17544939

Centisome position: 6.61

GC content: 69.47

Gene sequence:

>1608_bases
ATGCAAAAAACCGTGGCCATCGGCTTTGTCGGCACCGTGCTGGACTATGCCGGCAAGGGCAACCAGCGCTGGGAGCGCTG
GCGCCCGTCCGTCGGACTGTGCCAGCAGGAAGACCTGGTCATCCACCGGCTGGAATTGCTGCACGACGCGCGCAGCCGTG
GCCTGTTCGAGCGCCTGCGGGACGACATCGCCGCCGTCTCGCCGGAAACCGAGGTGCGCAGCGTCGAGATCGCGCTGCGC
GATCCCTGGGATTTCGAGGAGGTCTACGGCATGCTGCACGACTTCGCCCGGGGCTACGCATTCGACACCGACGCCGAGGA
CTACCTGATCCACATCACCACGGGCACCCACGTCGCGCAGATCTGCTGGTTCCTGCTGGCCGAGGCGCGCTATCTGCCGG
CCCGGCTGGTGCAGACCTCGCCGCCGCGCAAGAAGGCGCCGGGCAACATCGCGGGCAGCTATGCCCTGATCGATCTCGAC
CTGTCCCGCTACGACAGGATCGCCACGCGCTTCGCGCGCGAGCGCGAAGACACGGTGTCGCGGCTGAAGTCCGGCATTGC
CACGCGCAACCCCGCGTTCAACCGCATGATCGAGCAGATCGAGCGCGTGGCATCGCGGTCGCGCTCGCCGATGCTGCTGT
TCGGCCCGACCGGCGCCGGCAAGTCGTTCCTGGCGCGGCGCGTGTACGAGATGAAGAAGGCGCGCCACCAACTGAGCGGC
CGCTTTGTCGAGGTGAACTGCGCCACGCTGCGCGGCGACAGCGCGATGTCGGCGCTGTTCGGCCACGTCAAGGGCGCCTT
CACCGGCGCGCAGACCGACCGCGCCGGGCTGCTACGCAGCGCGGACGGCGGCCTGCTGTTCCTGGATGAGATCGGGGAGC
TCGGGCTGGACGAGCAGGCCATGCTACTCAAGGCCATCGAAGAGAAGCGCTTCCTGCCGTTCGGCAGCGACCGCGAGGCG
CAGAGCGATTTCCAGCTGATCGCGGGCACGGTGCGCGACCTGCGGCAATGGGTGGCCGAGGGACGCTTTCGCGAAGACCT
GTTCGCGCGCATCAACCTGTGGACCTTCGATCTGCCCGGCCTGGCCCAGCGCCCGGAAGACATCGAGCCCAACCTCGATT
ACGAACTGGTCCGCTTTGCCCGCGAGCACGGCGAGCAGGTGCGCTTCCATACCGAGGCGCGGCGCGCTTACCTGCGGTTT
GTCGCCTCGCCCCAGGCGCGCTGGAGCGGCAACTTCCGCGAGCTGTCGGCGTCGGTCACGCGCCTGGCCACGCTGGCCGA
AGGCGGCCGCATCACCGAGGCCGGCGTGGAGGCGGAAATCGGCCGGCTGCGGCGCGCCTGGTCCGGCGCCGAGGCGCCCG
CCGGCGACGACACCCTCGCCGGGCTGCTGGGTGACGGCGCGGCCGCGCTCGATCGGTTCGACCGGATGCAGCTGGAGAGC
GTCGTCCGGATCTGCCGGGAATCGGCATCGCTGTCGGATGCGGGGCGGCGGCTGTTCGATGTGTCGCGGCTGGAGAAAGC
CAAGGTCAACGATGCGGACCGGCTGCGCAAGTACCTCGCCCGGTTCGGCCTGGACTGGCAGCAGGTGCGCGGCCAGGCGG
CGAACTAG

Upstream 100 bases:

>100_bases
GACTTCTCCCGAGCCGGAACTCCGGAGGCATCGATCCGTCATTTCGCCCAATTTTCCGATCCTGTAAGATCGCTACTTAT
CTATTTTTATAGCCACACTC

Downstream 100 bases:

>100_bases
CGGCGCTGGCGCCGGCCTCGCCCGGCCGTCCGGCGGGTGCCGCGCTCACGGCGCCGGCATCGCGTGGAGATCGGCGCTGC
AACCCGCGTGTCCGTCGTCG

Product: sigma-54 interacting transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MQKTVAIGFVGTVLDYAGKGNQRWERWRPSVGLCQQEDLVIHRLELLHDARSRGLFERLRDDIAAVSPETEVRSVEIALR
DPWDFEEVYGMLHDFARGYAFDTDAEDYLIHITTGTHVAQICWFLLAEARYLPARLVQTSPPRKKAPGNIAGSYALIDLD
LSRYDRIATRFAREREDTVSRLKSGIATRNPAFNRMIEQIERVASRSRSPMLLFGPTGAGKSFLARRVYEMKKARHQLSG
RFVEVNCATLRGDSAMSALFGHVKGAFTGAQTDRAGLLRSADGGLLFLDEIGELGLDEQAMLLKAIEEKRFLPFGSDREA
QSDFQLIAGTVRDLRQWVAEGRFREDLFARINLWTFDLPGLAQRPEDIEPNLDYELVRFAREHGEQVRFHTEARRAYLRF
VASPQARWSGNFRELSASVTRLATLAEGGRITEAGVEAEIGRLRRAWSGAEAPAGDDTLAGLLGDGAAALDRFDRMQLES
VVRICRESASLSDAGRRLFDVSRLEKAKVNDADRLRKYLARFGLDWQQVRGQAAN

Sequences:

>Translated_535_residues
MQKTVAIGFVGTVLDYAGKGNQRWERWRPSVGLCQQEDLVIHRLELLHDARSRGLFERLRDDIAAVSPETEVRSVEIALR
DPWDFEEVYGMLHDFARGYAFDTDAEDYLIHITTGTHVAQICWFLLAEARYLPARLVQTSPPRKKAPGNIAGSYALIDLD
LSRYDRIATRFAREREDTVSRLKSGIATRNPAFNRMIEQIERVASRSRSPMLLFGPTGAGKSFLARRVYEMKKARHQLSG
RFVEVNCATLRGDSAMSALFGHVKGAFTGAQTDRAGLLRSADGGLLFLDEIGELGLDEQAMLLKAIEEKRFLPFGSDREA
QSDFQLIAGTVRDLRQWVAEGRFREDLFARINLWTFDLPGLAQRPEDIEPNLDYELVRFAREHGEQVRFHTEARRAYLRF
VASPQARWSGNFRELSASVTRLATLAEGGRITEAGVEAEIGRLRRAWSGAEAPAGDDTLAGLLGDGAAALDRFDRMQLES
VVRICRESASLSDAGRRLFDVSRLEKAKVNDADRLRKYLARFGLDWQQVRGQAAN
>Mature_535_residues
MQKTVAIGFVGTVLDYAGKGNQRWERWRPSVGLCQQEDLVIHRLELLHDARSRGLFERLRDDIAAVSPETEVRSVEIALR
DPWDFEEVYGMLHDFARGYAFDTDAEDYLIHITTGTHVAQICWFLLAEARYLPARLVQTSPPRKKAPGNIAGSYALIDLD
LSRYDRIATRFAREREDTVSRLKSGIATRNPAFNRMIEQIERVASRSRSPMLLFGPTGAGKSFLARRVYEMKKARHQLSG
RFVEVNCATLRGDSAMSALFGHVKGAFTGAQTDRAGLLRSADGGLLFLDEIGELGLDEQAMLLKAIEEKRFLPFGSDREA
QSDFQLIAGTVRDLRQWVAEGRFREDLFARINLWTFDLPGLAQRPEDIEPNLDYELVRFAREHGEQVRFHTEARRAYLRF
VASPQARWSGNFRELSASVTRLATLAEGGRITEAGVEAEIGRLRRAWSGAEAPAGDDTLAGLLGDGAAALDRFDRMQLES
VVRICRESASLSDAGRRLFDVSRLEKAKVNDADRLRKYLARFGLDWQQVRGQAAN

Specific function: Transcriptional repressor of the rtcAB genes. Interacts with sigma-54 [H]

COG id: COG4650

COG function: function code KT; Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1789828, Length=535, Percent_Identity=73.0841121495327, Blast_Score=785, Evalue=0.0,
Organism=Escherichia coli, GI1788905, Length=262, Percent_Identity=37.7862595419847, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI1789233, Length=248, Percent_Identity=39.5161290322581, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1789087, Length=249, Percent_Identity=38.1526104417671, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI1788550, Length=276, Percent_Identity=36.9565217391304, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI1790437, Length=250, Percent_Identity=38.8, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI87082117, Length=310, Percent_Identity=33.5483870967742, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1790299, Length=289, Percent_Identity=35.2941176470588, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI87082152, Length=248, Percent_Identity=37.9032258064516, Blast_Score=140, Evalue=3e-34,
Organism=Escherichia coli, GI1787583, Length=336, Percent_Identity=29.1666666666667, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI87081872, Length=232, Percent_Identity=35.7758620689655, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1786524, Length=237, Percent_Identity=35.0210970464135, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI87081858, Length=254, Percent_Identity=28.740157480315, Blast_Score=86, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR002078
- InterPro:   IPR009715
- InterPro:   IPR017183 [H]

Pfam domain/function: PF06956 RtcR; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 60239; Mature: 60239

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKTVAIGFVGTVLDYAGKGNQRWERWRPSVGLCQQEDLVIHRLELLHDARSRGLFERLR
CCCEEEEHHHHHHHHHCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DDIAAVSPETEVRSVEIALRDPWDFEEVYGMLHDFARGYAFDTDAEDYLIHITTGTHVAQ
HHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHH
ICWFLLAEARYLPARLVQTSPPRKKAPGNIAGSYALIDLDLSRYDRIATRFAREREDTVS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHH
RLKSGIATRNPAFNRMIEQIERVASRSRSPMLLFGPTGAGKSFLARRVYEMKKARHQLSG
HHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
RFVEVNCATLRGDSAMSALFGHVKGAFTGAQTDRAGLLRSADGGLLFLDEIGELGLDEQA
CEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEEHHCCCCCCHHH
MLLKAIEEKRFLPFGSDREAQSDFQLIAGTVRDLRQWVAEGRFREDLFARINLWTFDLPG
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEEEEECCCC
LAQRPEDIEPNLDYELVRFAREHGEQVRFHTEARRAYLRFVASPQARWSGNFRELSASVT
CCCCCCCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHH
RLATLAEGGRITEAGVEAEIGRLRRAWSGAEAPAGDDTLAGLLGDGAAALDRFDRMQLES
HHHHHHCCCCEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHH
VVRICRESASLSDAGRRLFDVSRLEKAKVNDADRLRKYLARFGLDWQQVRGQAAN
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHCCCCCC
>Mature Secondary Structure
MQKTVAIGFVGTVLDYAGKGNQRWERWRPSVGLCQQEDLVIHRLELLHDARSRGLFERLR
CCCEEEEHHHHHHHHHCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DDIAAVSPETEVRSVEIALRDPWDFEEVYGMLHDFARGYAFDTDAEDYLIHITTGTHVAQ
HHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHH
ICWFLLAEARYLPARLVQTSPPRKKAPGNIAGSYALIDLDLSRYDRIATRFAREREDTVS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHH
RLKSGIATRNPAFNRMIEQIERVASRSRSPMLLFGPTGAGKSFLARRVYEMKKARHQLSG
HHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
RFVEVNCATLRGDSAMSALFGHVKGAFTGAQTDRAGLLRSADGGLLFLDEIGELGLDEQA
CEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEEHHCCCCCCHHH
MLLKAIEEKRFLPFGSDREAQSDFQLIAGTVRDLRQWVAEGRFREDLFARINLWTFDLPG
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEEEEECCCC
LAQRPEDIEPNLDYELVRFAREHGEQVRFHTEARRAYLRFVASPQARWSGNFRELSASVT
CCCCCCCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHH
RLATLAEGGRITEAGVEAEIGRLRRAWSGAEAPAGDDTLAGLLGDGAAALDRFDRMQLES
HHHHHHCCCCEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHH
VVRICRESASLSDAGRRLFDVSRLEKAKVNDADRLRKYLARFGLDWQQVRGQAAN
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 3045764; 7984428; 7920643; 9738023 [H]