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The map label for this gene is mprA [H]

Identifier: 17231251

GI number: 17231251

Start: 4540614

End: 4541804

Strand: Reverse

Name: mprA [H]

Synonym: all3759

Alternate gene names: 17231251

Gene position: 4541804-4540614 (Counterclockwise)

Preceding gene: 17231256

Following gene: 17231245

Centisome position: 70.81

GC content: 37.62

Gene sequence:

>1191_bases
ATGGTAAAAATTTTAGTTATTGATGATGATCCGGTTGTACGGACGGTGCTAAAAAGAACTCTTGAGAATCAGGGTTATGA
AACTACTGTTGTCAACAATGGGAAGGAAGGAATTATTCAAGCAGAACTGCTCCGTCCCGCATTGATTATCTGTGATTGGG
TAATGTCTCCGTTAGATGGATTGGAAGTATGTCGTCAAATTAAAGCAAATCCAGAGTTAGCAACTAGTTTTTTTATTTTG
TTAACGGCTAAGGGAGCAGCGCCAGGAGAAGAGAAAGACAGAGTTAAAGGACTGGATGCTGGAGCTGATGAGTTTATCTC
TAAACCAATCGAAATGATTGAATTAAAAGCGCGGGTAAGAGCCGGACTCAGGTTACATCAGCTCAATCAGGATTTACAAA
CCCAAAAGCAAACTTTAGAAATACTCAACCATGATTTACAAACCCAAAAGCAAACTTTAGAAGCAGACTTAGCCGAGGCT
GCTGATTATGTGCGATCGCTTCTACCTAAACCTCTAGAAGGAAGAGTAAATACAGAAGCCTTATTTATTCCTTCAACCCA
GTTGGGGGGTGATTGCTTCGATTATTACTGGCTGGATGACGAGCATTTAGCAATTTATCTATTGGATGTATCAGGACATG
GAATAGGTTCTGCCCTATTATCTGTCTCTATCTTGAATATTCTGCGATCGCAATCTTTACCTAATACTAATTTCTACAAG
CCTAGAGAAGTTCTCAAGGCACTAAATCATGCTTTCCAGATGACAAACCACGGTGATAAATACTTCACAATTTGGTATGG
AGTTTATCACTGTATTCAACATCAACTCGTCTATGCTAGCGCCGGACATCCCCCGGCTGTAATTTTATCTGGTACATCTG
AAACTGGTTTTCAAGTTAAACAACTCAATTCTTTAGATTTACCCATAGGATTTTTACCTGATGTGCAGTTTGAAGATGCT
GCCTGGGAAGTAAAAAAAGACAGTACTCTGTACATATTTAGTGATGGCATTTATGAAATTAGAGAGCCAGATGGCAAGAT
TTTAGGACTCGATGCTTTTATTGAAATACTAATTAAATCTAGCCAGGCAGAACCCTGTAATATTCATTACATATTAATGC
AAATAATGACATTAAATATTCAACAAATAATTGAAGATGATTTGTCATTATTAAAAATTACTTTGGGTTAA

Upstream 100 bases:

>100_bases
TTTAATTTGAGTATTTTCACTGTACATTATCAACTCGATTATAGTTAATTTGAAATAAATACAATACTCAATTGAGATTA
TATTTATTAGCCCATCACTT

Downstream 100 bases:

>100_bases
TAGAGTTATATTGATTCTTTTTAATTAGGAAATAACCCTTGTGGCTGTCAGTACTTGCCGTTTAAAGTCATCTTGATCGA
TAAAGGTTTGAAAAATCCTA

Product: two-component response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MVKILVIDDDPVVRTVLKRTLENQGYETTVVNNGKEGIIQAELLRPALIICDWVMSPLDGLEVCRQIKANPELATSFFIL
LTAKGAAPGEEKDRVKGLDAGADEFISKPIEMIELKARVRAGLRLHQLNQDLQTQKQTLEILNHDLQTQKQTLEADLAEA
ADYVRSLLPKPLEGRVNTEALFIPSTQLGGDCFDYYWLDDEHLAIYLLDVSGHGIGSALLSVSILNILRSQSLPNTNFYK
PREVLKALNHAFQMTNHGDKYFTIWYGVYHCIQHQLVYASAGHPPAVILSGTSETGFQVKQLNSLDLPIGFLPDVQFEDA
AWEVKKDSTLYIFSDGIYEIREPDGKILGLDAFIEILIKSSQAEPCNIHYILMQIMTLNIQQIIEDDLSLLKITLG

Sequences:

>Translated_396_residues
MVKILVIDDDPVVRTVLKRTLENQGYETTVVNNGKEGIIQAELLRPALIICDWVMSPLDGLEVCRQIKANPELATSFFIL
LTAKGAAPGEEKDRVKGLDAGADEFISKPIEMIELKARVRAGLRLHQLNQDLQTQKQTLEILNHDLQTQKQTLEADLAEA
ADYVRSLLPKPLEGRVNTEALFIPSTQLGGDCFDYYWLDDEHLAIYLLDVSGHGIGSALLSVSILNILRSQSLPNTNFYK
PREVLKALNHAFQMTNHGDKYFTIWYGVYHCIQHQLVYASAGHPPAVILSGTSETGFQVKQLNSLDLPIGFLPDVQFEDA
AWEVKKDSTLYIFSDGIYEIREPDGKILGLDAFIEILIKSSQAEPCNIHYILMQIMTLNIQQIIEDDLSLLKITLG
>Mature_396_residues
MVKILVIDDDPVVRTVLKRTLENQGYETTVVNNGKEGIIQAELLRPALIICDWVMSPLDGLEVCRQIKANPELATSFFIL
LTAKGAAPGEEKDRVKGLDAGADEFISKPIEMIELKARVRAGLRLHQLNQDLQTQKQTLEILNHDLQTQKQTLEADLAEA
ADYVRSLLPKPLEGRVNTEALFIPSTQLGGDCFDYYWLDDEHLAIYLLDVSGHGIGSALLSVSILNILRSQSLPNTNFYK
PREVLKALNHAFQMTNHGDKYFTIWYGVYHCIQHQLVYASAGHPPAVILSGTSETGFQVKQLNSLDLPIGFLPDVQFEDA
AWEVKKDSTLYIFSDGIYEIREPDGKILGLDAFIEILIKSSQAEPCNIHYILMQIMTLNIQQIIEDDLSLLKITLG

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG2208

COG function: function code TK; Serine phosphatase RsbU, regulator of sigma subunit

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=132, Percent_Identity=40.1515151515151, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1786911, Length=126, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786599, Length=160, Percent_Identity=28.125, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082012, Length=149, Percent_Identity=34.2281879194631, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788394, Length=133, Percent_Identity=32.3308270676692, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI2367329, Length=148, Percent_Identity=34.4594594594595, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 44330; Mature: 44330

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKILVIDDDPVVRTVLKRTLENQGYETTVVNNGKEGIIQAELLRPALIICDWVMSPLDG
CEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHH
LEVCRQIKANPELATSFFILLTAKGAAPGEEKDRVKGLDAGADEFISKPIEMIELKARVR
HHHHHHHCCCCCHHHEEEEEEEECCCCCCCHHHHHCCCCCCHHHHHHCCHHHHHHHHHHH
AGLRLHQLNQDLQTQKQTLEILNHDLQTQKQTLEADLAEAADYVRSLLPKPLEGRVNTEA
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
LFIPSTQLGGDCFDYYWLDDEHLAIYLLDVSGHGIGSALLSVSILNILRSQSLPNTNFYK
EEECCCCCCCCEEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
PREVLKALNHAFQMTNHGDKYFTIWYGVYHCIQHQLVYASAGHPPAVILSGTSETGFQVK
HHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCEEE
QLNSLDLPIGFLPDVQFEDAAWEVKKDSTLYIFSDGIYEIREPDGKILGLDAFIEILIKS
ECCCCCCCCCCCCCCCCCCCCEEECCCCEEEEEECCCEEEECCCCCEEEHHHHHHHHHHC
SQAEPCNIHYILMQIMTLNIQQIIEDDLSLLKITLG
CCCCCCHHHHHHHHHHHHHHHHHHHCCHHHEEEECC
>Mature Secondary Structure
MVKILVIDDDPVVRTVLKRTLENQGYETTVVNNGKEGIIQAELLRPALIICDWVMSPLDG
CEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHH
LEVCRQIKANPELATSFFILLTAKGAAPGEEKDRVKGLDAGADEFISKPIEMIELKARVR
HHHHHHHCCCCCHHHEEEEEEEECCCCCCCHHHHHCCCCCCHHHHHHCCHHHHHHHHHHH
AGLRLHQLNQDLQTQKQTLEILNHDLQTQKQTLEADLAEAADYVRSLLPKPLEGRVNTEA
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
LFIPSTQLGGDCFDYYWLDDEHLAIYLLDVSGHGIGSALLSVSILNILRSQSLPNTNFYK
EEECCCCCCCCEEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
PREVLKALNHAFQMTNHGDKYFTIWYGVYHCIQHQLVYASAGHPPAVILSGTSETGFQVK
HHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCEEE
QLNSLDLPIGFLPDVQFEDAAWEVKKDSTLYIFSDGIYEIREPDGKILGLDAFIEILIKS
ECCCCCCCCCCCCCCCCCCCCEEECCCCEEEEEECCCEEEECCCCCEEEHHHHHHHHHHC
SQAEPCNIHYILMQIMTLNIQQIIEDDLSLLKITLG
CCCCCCHHHHHHHHHHHHHHHHHHHCCHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA