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The map label for this gene is luxQ [H]

Identifier: 17231256

GI number: 17231256

Start: 4550134

End: 4551243

Strand: Reverse

Name: luxQ [H]

Synonym: all3764

Alternate gene names: 17231256

Gene position: 4551243-4550134 (Counterclockwise)

Preceding gene: 17231257

Following gene: 17231251

Centisome position: 70.96

GC content: 40.45

Gene sequence:

>1110_bases
ATGTCTGTTGTGGAAAATCATCAAATTGATCGAATTTTGGCTGTTGACGACACTAGAGATAATCTGATTTTAGTGCAAAC
AATTTTAGAAAGTGAAGGCTATGAAATTGATTTAGCCAGTGATGGCATTTCAGCTTTGCAAAAAGTAGAACAGTCTCCAC
CAGATTTAATCTTATTAGATGTAATGATGCCGGGGATGGATGGTTATGAAGTGACGCGACGCATTCGCAATAACCCAGCC
CTCAGTTATATACCAATATTGTTGATTACAGCTTTTCACGAATCGAGTGTTGTGGAAGGTTTGGACGTAGGCGCGGATGA
TTTCATTCGCAAACCATTTGATACAGATGAACTATTGGCTAGAGTGCGATCGCTCCTACGCCTCAAGCACAGTCTGGACG
AACAAAAGAAAATGGCACGCCAAAGGGAAGACTTTGTGTCACGCCTGACCCACGATTTACGCACACCGCTAGTAGCAGCC
GATCGGATGTTGGACTTGTTTCAACAAGAAGCTTTTTGCAAAATTTCGCCAGAAATGAAACAGGCGATCGCTGTCATGAT
TCGCAGCAATCAAAATTTGATGCAGATGGTTAATACCTTACTAGAAGTTTATCGCTTTGAAGCCGGTAAGAAAACATTAA
ATTATGAAAGCTGTAACTTAAAAGAAATCGCTCAAGAAGTGGTTAGCGAACTCACAACTCTAACTAATGAAAAAGGTATC
GCCTTAAAAATAGATAGCAGTCAGATAGATAACTTAGGAGAAAAAGCAGGTATAGTCATGGGCGATACCCTCGAACTACG
CCGCGTGTTGTACAACTTAGTAGCAAATGCCATCAAGTTTACAGATACTGGCGGCATTGAAATTCGCTTTTTTGAACCCA
ATAATCATTGGTTAACAATTGAAATTGAAGATACTGGTTATGGTATTGCTCCCGAAGACCAAGTAACCATTTTTGAGCGC
TTTCGACAGGGAAGGAATAAACGTTCAGGTAGTGGTTTAGGTCTGCATTTGTCCAGTCGTATTGTTGAAGCCCACGAAGG
TATGATTAGCTTGGTTTCTGAAGTAGGTAAAGGTAGTAAATTCACAGTCAAACTGCCTAAAAATATTTGA

Upstream 100 bases:

>100_bases
ATCACAAAGTACACCACCCTACGGCTAAATCCAACCCAACCGCCAGAAAATATCATAATCTTAAGTTATAAATTTATATA
TATAAAACAAATTTATTATC

Downstream 100 bases:

>100_bases
GGAAGAATTTCTCGGACTTCTGAAATTAAGTTATTGTAATTTAAAAAAAAGAATGCAATAAATACGATAGTAGAAGGATA
ATTCCATACCCTTCTACTAT

Product: two-component hybrid sensor and regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MSVVENHQIDRILAVDDTRDNLILVQTILESEGYEIDLASDGISALQKVEQSPPDLILLDVMMPGMDGYEVTRRIRNNPA
LSYIPILLITAFHESSVVEGLDVGADDFIRKPFDTDELLARVRSLLRLKHSLDEQKKMARQREDFVSRLTHDLRTPLVAA
DRMLDLFQQEAFCKISPEMKQAIAVMIRSNQNLMQMVNTLLEVYRFEAGKKTLNYESCNLKEIAQEVVSELTTLTNEKGI
ALKIDSSQIDNLGEKAGIVMGDTLELRRVLYNLVANAIKFTDTGGIEIRFFEPNNHWLTIEIEDTGYGIAPEDQVTIFER
FRQGRNKRSGSGLGLHLSSRIVEAHEGMISLVSEVGKGSKFTVKLPKNI

Sequences:

>Translated_369_residues
MSVVENHQIDRILAVDDTRDNLILVQTILESEGYEIDLASDGISALQKVEQSPPDLILLDVMMPGMDGYEVTRRIRNNPA
LSYIPILLITAFHESSVVEGLDVGADDFIRKPFDTDELLARVRSLLRLKHSLDEQKKMARQREDFVSRLTHDLRTPLVAA
DRMLDLFQQEAFCKISPEMKQAIAVMIRSNQNLMQMVNTLLEVYRFEAGKKTLNYESCNLKEIAQEVVSELTTLTNEKGI
ALKIDSSQIDNLGEKAGIVMGDTLELRRVLYNLVANAIKFTDTGGIEIRFFEPNNHWLTIEIEDTGYGIAPEDQVTIFER
FRQGRNKRSGSGLGLHLSSRIVEAHEGMISLVSEVGKGSKFTVKLPKNI
>Mature_368_residues
SVVENHQIDRILAVDDTRDNLILVQTILESEGYEIDLASDGISALQKVEQSPPDLILLDVMMPGMDGYEVTRRIRNNPAL
SYIPILLITAFHESSVVEGLDVGADDFIRKPFDTDELLARVRSLLRLKHSLDEQKKMARQREDFVSRLTHDLRTPLVAAD
RMLDLFQQEAFCKISPEMKQAIAVMIRSNQNLMQMVNTLLEVYRFEAGKKTLNYESCNLKEIAQEVVSELTTLTNEKGIA
LKIDSSQIDNLGEKAGIVMGDTLELRRVLYNLVANAIKFTDTGGIEIRFFEPNNHWLTIEIEDTGYGIAPEDQVTIFERF
RQGRNKRSGSGLGLHLSSRIVEAHEGMISLVSEVGKGSKFTVKLPKNI

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=236, Percent_Identity=32.2033898305085, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI87081816, Length=238, Percent_Identity=30.672268907563, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI145693157, Length=258, Percent_Identity=29.0697674418605, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788713, Length=240, Percent_Identity=27.0833333333333, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1786912, Length=246, Percent_Identity=32.1138211382114, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082128, Length=233, Percent_Identity=27.8969957081545, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1786600, Length=252, Percent_Identity=29.7619047619048, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI48994928, Length=257, Percent_Identity=26.4591439688716, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786783, Length=250, Percent_Identity=25.2, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788394, Length=118, Percent_Identity=44.0677966101695, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788549, Length=243, Percent_Identity=27.5720164609054, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082012, Length=140, Percent_Identity=38.5714285714286, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1786784, Length=141, Percent_Identity=36.8794326241135, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786599, Length=118, Percent_Identity=38.135593220339, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790437, Length=126, Percent_Identity=38.8888888888889, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788279, Length=296, Percent_Identity=26.6891891891892, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788550, Length=122, Percent_Identity=36.8852459016393, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790860, Length=102, Percent_Identity=39.2156862745098, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788393, Length=271, Percent_Identity=26.9372693726937, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790436, Length=261, Percent_Identity=27.9693486590038, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789809, Length=120, Percent_Identity=36.6666666666667, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789808, Length=253, Percent_Identity=26.8774703557312, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790552, Length=120, Percent_Identity=40, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI2367329, Length=129, Percent_Identity=39.5348837209302, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789402, Length=144, Percent_Identity=34.0277777777778, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790863, Length=122, Percent_Identity=34.4262295081967, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1786911, Length=145, Percent_Identity=33.7931034482759, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787375, Length=129, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790551, Length=245, Percent_Identity=27.3469387755102, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787374, Length=287, Percent_Identity=26.1324041811847, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790346, Length=235, Percent_Identity=25.9574468085106, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788191, Length=105, Percent_Identity=31.4285714285714, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790861, Length=211, Percent_Identity=26.5402843601896, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 41591; Mature: 41460

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVVENHQIDRILAVDDTRDNLILVQTILESEGYEIDLASDGISALQKVEQSPPDLILLD
CCCCCCCCCCEEEEECCCCCCEEEEEEHHHCCCCEEEECCHHHHHHHHHHCCCCCEEEEE
VMMPGMDGYEVTRRIRNNPALSYIPILLITAFHESSVVEGLDVGADDFIRKPFDTDELLA
ECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHH
RVRSLLRLKHSLDEQKKMARQREDFVSRLTHDLRTPLVAADRMLDLFQQEAFCKISPEMK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHH
QAIAVMIRSNQNLMQMVNTLLEVYRFEAGKKTLNYESCNLKEIAQEVVSELTTLTNEKGI
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCE
ALKIDSSQIDNLGEKAGIVMGDTLELRRVLYNLVANAIKFTDTGGIEIRFFEPNNHWLTI
EEEECCHHHHCCHHHCCEEECCHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCEEEE
EIEDTGYGIAPEDQVTIFERFRQGRNKRSGSGLGLHLSSRIVEAHEGMISLVSEVGKGSK
EEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCE
FTVKLPKNI
EEEECCCCC
>Mature Secondary Structure 
SVVENHQIDRILAVDDTRDNLILVQTILESEGYEIDLASDGISALQKVEQSPPDLILLD
CCCCCCCCCEEEEECCCCCCEEEEEEHHHCCCCEEEECCHHHHHHHHHHCCCCCEEEEE
VMMPGMDGYEVTRRIRNNPALSYIPILLITAFHESSVVEGLDVGADDFIRKPFDTDELLA
ECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHH
RVRSLLRLKHSLDEQKKMARQREDFVSRLTHDLRTPLVAADRMLDLFQQEAFCKISPEMK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHH
QAIAVMIRSNQNLMQMVNTLLEVYRFEAGKKTLNYESCNLKEIAQEVVSELTTLTNEKGI
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCE
ALKIDSSQIDNLGEKAGIVMGDTLELRRVLYNLVANAIKFTDTGGIEIRFFEPNNHWLTI
EEEECCHHHHCCHHHCCEEECCHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCEEEE
EIEDTGYGIAPEDQVTIFERFRQGRNKRSGSGLGLHLSSRIVEAHEGMISLVSEVGKGSK
EEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCE
FTVKLPKNI
EEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]