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The map label for this gene is prpA [H]

Identifier: 17231223

GI number: 17231223

Start: 4503856

End: 4506432

Strand: Direct

Name: prpA [H]

Synonym: alr3731

Alternate gene names: 17231223

Gene position: 4503856-4506432 (Clockwise)

Preceding gene: 17231222

Following gene: 17231224

Centisome position: 70.22

GC content: 45.21

Gene sequence:

>2577_bases
ATGAAAATTACTATTCCTGAATTATCTTTAGTTGTCTTGATTGGTGCTTCTGGTGCAGGTAAATCAACATTCGCACGTAA
GCACTTTCAACCGTTTGAAGTAATATCTTCTGATTTTTGTCGTGGGTTAGTTTCCAATGATGAAAATAGCCAGTCTGCTT
CCAGAGATGCTTTTGATGTTCTGCACTATATAACGACTAAACGCCTAGCCGCAGGCAAATTAACAGTAATAGATGCAACT
AACGTCCAGCCAGAAGACCGCAAGACTTTACTGCAAATGGCCAAGCAGTATCATTGCTTTACAGTGGCCATAGTTTTTGA
CCTACCAGAAGAATTATGTCATGAACGTAACCAACAAAGAAGTGACAGACAATTCGGCTCCCATGTAGTCCGTCGTCATA
CCCAAATGTTACGGCGTTCTTTGCGTAGTTTAGAAAAAGAGGGTTTCCGCTACGTCTACACCCTCAAATCACCAGAGGAA
ATCGCCAACGTCGCAATTGAACTTCAACCCTTATGGAATAACAAAAAACACGAACACGGCCCCTTTGACATCATCGGCGA
TATTCACGGTTGTTGTGATGAGCTGGAAACTTTACTCCAGCAATTAGGCTATGAAAAAAGCACAGGAATTGAAGATACAA
TCTGGAACGCTCCCATCTACTACCACCCCCAAGGACGCAAAGCGGTCTTTCTTGGTGATTTGGTAGACAGAGGGACACGT
ATTTTAGATACAGTCAAGCTAGTACGCAACATGGTGACAGCAGATACAGCCATTTGTGTTCCTGGTAATCATGAAAACAA
GCTCTTGCGGAAATTACGAGGTAAAAATGTCAAGGTAAATCATGGGTTACAGCAAAGCCTTGATGAAATTGCAGCGTTAC
CAGAAGCAATCCGCACACTATTCACTAAGGAACTCACAGACTTTTTAGATTCCCTTGTCAGCCACTACTTACTTGATGAC
GGACGCTTGGTAGTAGCACACGCAGGGATGAAACAGGAAATGCAGGGACGGGGTTCTGGTGCGGTGCGGGAGTTTGCCCT
GTACGGTGAAAGTACGGGTGAAATTGACGAGTTTGGTTTACCAGTCCGTTATAACTGGGCTGGAGATTATCGGGGTGAGG
CGCTGGTAGTTTATGGACATACACCCATACCTGAGGCGGAATGGCTGAATAATACTATTGATATTGATACAGGTTGTGTG
TTTGGTGGCAAACTTACCGCCCTACGTTATCCCGAAAAGGAATTGGTGAGTGTTCCGGCGGCGCGGGTTTACTGTGAACC
CGTGAAACCTTTAGTTGAGAATAGTATTACGCGGACATCCCAACAGGAATTTGATGATGTTCTCAACATTGAGGATGTAT
TAGGTAAGCGCATCATCAATACCAAGCTACAACCAAATATCACCATTAGAGAAGAAAATGCGATCGCTGCTTTAGAAATT
ATGAGCCGTTTTGCTGCTAATCCCAAATGGCTGATTTACCTCCCTCCTACCATGTCCCCAGTAGAAACCTCTTCAGCCCC
TGGATACCTGGAACACCCATCCCAAGCCTTCGTCTACTACCAAAAGCAAGGAATTACGGAGGTTATATGTGAAGAAAAGC
ATATGGGTTCACGCGCCATTGTGGTTGTTTGTCGGGATTTAGCAACAGCCGAGAAACGGTTTGGTGTAGTGGATGAAGGT
ATTGGTATTTGTTATACCCGCACAGGTAGGAGATTTTTTGATGAGCCAACATTAGAAACGCAACTTTTGGCACGGGTAAA
TGCTGCTCTGACTGCAAGTAGATTTTGGGAAAGATTTAATACAGACTGGGTGTGCTTAGACTGTGAACTCATGCCTTGGT
CAGCAAAAGCACAAGGATTAATAAAAGGGCAATATGCACCAGTGGGTGTGGCATCACGCCTAGCTTGCAATGATGCCGTA
GAATTACTGCAACAAGCAAGCGAGCGCGGCCTCAATATTACTACCCAACTCACTCGCTACCAACAACGAGCAGAGATGGC
AAATCAGTACATCACTGCTTACCGTCGCTACTGCTGGAATGTCACCGATATTGGAGACTTAAAACTAGCCCCCTTTCATA
TCCTCGCTACAGAGGAAGCTGTGCATATCGACAAAGACCATCGTTGGCACATAGAACAAATTACCCAAATCTGCCAATCA
GACCCGGATTTACTCCTGTCAACGGCTTACAAAGTAATAGATTTAACCGACCCTAGCAGCCAAGCTGAAGGGGTGCATTG
GTGGGAAAAACTCACCCAAGTTGGGGGTGAGGGTATGGTTGTCAAATCTATGCAATTTCTGGTCAAGGGTAGTCGGGGTA
TTGTGCAGCCTGCGGTGAAATGTCGTGGACAAGAATATCTGCGAATTATCTATGGCCCTGAATATTCAGCCCTAGAGAAC
TTGCAACGTCTACGCCAACGAGGGTTATCTCTGAAACGTTCTTTGGCCATGCGAGAGTTCGCCCTGGGTGTGGAAGCATT
AGAGCGATTTGTTGCCCATGCTCCTTTACGTCATGTACATGAATGCGTATTTGGAATTTTGGCTCTAGAAAGTGAACCCG
TAGATCCACGACTGTAG

Upstream 100 bases:

>100_bases
TTGGTTCACCGACACAAATGGCACGTTTTTGTCAATAAGTAAGGGACTGGGGAGCAGGGGGAGAAAAGAACTGTTGACTG
TTGACCAATGACTAATAACT

Downstream 100 bases:

>100_bases
CGCCTATGATAAAGACAGCCAGCAGGGCTTAAACTTGACTTTAATTCATTTTTTTTGCAATGAGATCGCGATCGCTAAAA
TCTTTGTAAGACAATAGTCT

Product: protein serine-threonine phosphatase

Products: NA

Alternate protein names: Ap4A hydrolase; Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase; Diadenosine tetraphosphatase [H]

Number of amino acids: Translated: 858; Mature: 858

Protein sequence:

>858_residues
MKITIPELSLVVLIGASGAGKSTFARKHFQPFEVISSDFCRGLVSNDENSQSASRDAFDVLHYITTKRLAAGKLTVIDAT
NVQPEDRKTLLQMAKQYHCFTVAIVFDLPEELCHERNQQRSDRQFGSHVVRRHTQMLRRSLRSLEKEGFRYVYTLKSPEE
IANVAIELQPLWNNKKHEHGPFDIIGDIHGCCDELETLLQQLGYEKSTGIEDTIWNAPIYYHPQGRKAVFLGDLVDRGTR
ILDTVKLVRNMVTADTAICVPGNHENKLLRKLRGKNVKVNHGLQQSLDEIAALPEAIRTLFTKELTDFLDSLVSHYLLDD
GRLVVAHAGMKQEMQGRGSGAVREFALYGESTGEIDEFGLPVRYNWAGDYRGEALVVYGHTPIPEAEWLNNTIDIDTGCV
FGGKLTALRYPEKELVSVPAARVYCEPVKPLVENSITRTSQQEFDDVLNIEDVLGKRIINTKLQPNITIREENAIAALEI
MSRFAANPKWLIYLPPTMSPVETSSAPGYLEHPSQAFVYYQKQGITEVICEEKHMGSRAIVVVCRDLATAEKRFGVVDEG
IGICYTRTGRRFFDEPTLETQLLARVNAALTASRFWERFNTDWVCLDCELMPWSAKAQGLIKGQYAPVGVASRLACNDAV
ELLQQASERGLNITTQLTRYQQRAEMANQYITAYRRYCWNVTDIGDLKLAPFHILATEEAVHIDKDHRWHIEQITQICQS
DPDLLLSTAYKVIDLTDPSSQAEGVHWWEKLTQVGGEGMVVKSMQFLVKGSRGIVQPAVKCRGQEYLRIIYGPEYSALEN
LQRLRQRGLSLKRSLAMREFALGVEALERFVAHAPLRHVHECVFGILALESEPVDPRL

Sequences:

>Translated_858_residues
MKITIPELSLVVLIGASGAGKSTFARKHFQPFEVISSDFCRGLVSNDENSQSASRDAFDVLHYITTKRLAAGKLTVIDAT
NVQPEDRKTLLQMAKQYHCFTVAIVFDLPEELCHERNQQRSDRQFGSHVVRRHTQMLRRSLRSLEKEGFRYVYTLKSPEE
IANVAIELQPLWNNKKHEHGPFDIIGDIHGCCDELETLLQQLGYEKSTGIEDTIWNAPIYYHPQGRKAVFLGDLVDRGTR
ILDTVKLVRNMVTADTAICVPGNHENKLLRKLRGKNVKVNHGLQQSLDEIAALPEAIRTLFTKELTDFLDSLVSHYLLDD
GRLVVAHAGMKQEMQGRGSGAVREFALYGESTGEIDEFGLPVRYNWAGDYRGEALVVYGHTPIPEAEWLNNTIDIDTGCV
FGGKLTALRYPEKELVSVPAARVYCEPVKPLVENSITRTSQQEFDDVLNIEDVLGKRIINTKLQPNITIREENAIAALEI
MSRFAANPKWLIYLPPTMSPVETSSAPGYLEHPSQAFVYYQKQGITEVICEEKHMGSRAIVVVCRDLATAEKRFGVVDEG
IGICYTRTGRRFFDEPTLETQLLARVNAALTASRFWERFNTDWVCLDCELMPWSAKAQGLIKGQYAPVGVASRLACNDAV
ELLQQASERGLNITTQLTRYQQRAEMANQYITAYRRYCWNVTDIGDLKLAPFHILATEEAVHIDKDHRWHIEQITQICQS
DPDLLLSTAYKVIDLTDPSSQAEGVHWWEKLTQVGGEGMVVKSMQFLVKGSRGIVQPAVKCRGQEYLRIIYGPEYSALEN
LQRLRQRGLSLKRSLAMREFALGVEALERFVAHAPLRHVHECVFGILALESEPVDPRL
>Mature_858_residues
MKITIPELSLVVLIGASGAGKSTFARKHFQPFEVISSDFCRGLVSNDENSQSASRDAFDVLHYITTKRLAAGKLTVIDAT
NVQPEDRKTLLQMAKQYHCFTVAIVFDLPEELCHERNQQRSDRQFGSHVVRRHTQMLRRSLRSLEKEGFRYVYTLKSPEE
IANVAIELQPLWNNKKHEHGPFDIIGDIHGCCDELETLLQQLGYEKSTGIEDTIWNAPIYYHPQGRKAVFLGDLVDRGTR
ILDTVKLVRNMVTADTAICVPGNHENKLLRKLRGKNVKVNHGLQQSLDEIAALPEAIRTLFTKELTDFLDSLVSHYLLDD
GRLVVAHAGMKQEMQGRGSGAVREFALYGESTGEIDEFGLPVRYNWAGDYRGEALVVYGHTPIPEAEWLNNTIDIDTGCV
FGGKLTALRYPEKELVSVPAARVYCEPVKPLVENSITRTSQQEFDDVLNIEDVLGKRIINTKLQPNITIREENAIAALEI
MSRFAANPKWLIYLPPTMSPVETSSAPGYLEHPSQAFVYYQKQGITEVICEEKHMGSRAIVVVCRDLATAEKRFGVVDEG
IGICYTRTGRRFFDEPTLETQLLARVNAALTASRFWERFNTDWVCLDCELMPWSAKAQGLIKGQYAPVGVASRLACNDAV
ELLQQASERGLNITTQLTRYQQRAEMANQYITAYRRYCWNVTDIGDLKLAPFHILATEEAVHIDKDHRWHIEQITQICQS
DPDLLLSTAYKVIDLTDPSSQAEGVHWWEKLTQVGGEGMVVKSMQFLVKGSRGIVQPAVKCRGQEYLRIIYGPEYSALEN
LQRLRQRGLSLKRSLAMREFALGVEALERFVAHAPLRHVHECVFGILALESEPVDPRL

Specific function: Asymmetrically hydrolyzes Ap4p to yield AMP and ATP [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prpE family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR006186 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: =3.6.1.17 [H]

Molecular weight: Translated: 96871; Mature: 96871

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITIPELSLVVLIGASGAGKSTFARKHFQPFEVISSDFCRGLVSNDENSQSASRDAFDV
CEEECCCEEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LHYITTKRLAAGKLTVIDATNVQPEDRKTLLQMAKQYHCFTVAIVFDLPEELCHERNQQR
HHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEEEEEECCHHHHHHHHHHHH
SDRQFGSHVVRRHTQMLRRSLRSLEKEGFRYVYTLKSPEEIANVAIELQPLWNNKKHEHG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHCEEEEEEECCCCCCCCCC
PFDIIGDIHGCCDELETLLQQLGYEKSTGIEDTIWNAPIYYHPQGRKAVFLGDLVDRGTR
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEECCCCCCEEEEHHHHHCCHH
ILDTVKLVRNMVTADTAICVPGNHENKLLRKLRGKNVKVNHGLQQSLDEIAALPEAIRTL
HHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHH
FTKELTDFLDSLVSHYLLDDGRLVVAHAGMKQEMQGRGSGAVREFALYGESTGEIDEFGL
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHCCCCCCCHHHHHEECCCCCCHHHCCC
PVRYNWAGDYRGEALVVYGHTPIPEAEWLNNTIDIDTGCVFGGKLTALRYPEKELVSVPA
CEEEECCCCCCCCEEEEECCCCCCCHHHCCCCEECCCCEEECCEEEEEECCHHHHHHCCH
ARVYCEPVKPLVENSITRTSQQEFDDVLNIEDVLGKRIINTKLQPNITIREENAIAALEI
HHHEECCCHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHH
MSRFAANPKWLIYLPPTMSPVETSSAPGYLEHPSQAFVYYQKQGITEVICEEKHMGSRAI
HHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEHHCCHHHHHHHHHCCCCCEE
VVVCRDLATAEKRFGVVDEGIGICYTRTGRRFFDEPTLETQLLARVNAALTASRFWERFN
EEEEHHHHHHHHHCCCCCCCCCEEEEECCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHC
TDWVCLDCELMPWSAKAQGLIKGQYAPVGVASRLACNDAVELLQQASERGLNITTQLTRY
CCEEEEEEEECCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
QQRAEMANQYITAYRRYCWNVTDIGDLKLAPFHILATEEAVHIDKDHRWHIEQITQICQS
HHHHHHHHHHHHHHHHHHCCCCCCCCCEECCEEEEECCCEEECCCCCCCCHHHHHHHHCC
DPDLLLSTAYKVIDLTDPSSQAEGVHWWEKLTQVGGEGMVVKSMQFLVKGSRGIVQPAVK
CCCHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCCCCHHHH
CRGQEYLRIIYGPEYSALENLQRLRQRGLSLKRSLAMREFALGVEALERFVAHAPLRHVH
HCCCEEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ECVFGILALESEPVDPRL
HHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKITIPELSLVVLIGASGAGKSTFARKHFQPFEVISSDFCRGLVSNDENSQSASRDAFDV
CEEECCCEEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LHYITTKRLAAGKLTVIDATNVQPEDRKTLLQMAKQYHCFTVAIVFDLPEELCHERNQQR
HHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEEEEEECCHHHHHHHHHHHH
SDRQFGSHVVRRHTQMLRRSLRSLEKEGFRYVYTLKSPEEIANVAIELQPLWNNKKHEHG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHCEEEEEEECCCCCCCCCC
PFDIIGDIHGCCDELETLLQQLGYEKSTGIEDTIWNAPIYYHPQGRKAVFLGDLVDRGTR
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEECCCCCCEEEEHHHHHCCHH
ILDTVKLVRNMVTADTAICVPGNHENKLLRKLRGKNVKVNHGLQQSLDEIAALPEAIRTL
HHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHH
FTKELTDFLDSLVSHYLLDDGRLVVAHAGMKQEMQGRGSGAVREFALYGESTGEIDEFGL
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHCCCCCCCHHHHHEECCCCCCHHHCCC
PVRYNWAGDYRGEALVVYGHTPIPEAEWLNNTIDIDTGCVFGGKLTALRYPEKELVSVPA
CEEEECCCCCCCCEEEEECCCCCCCHHHCCCCEECCCCEEECCEEEEEECCHHHHHHCCH
ARVYCEPVKPLVENSITRTSQQEFDDVLNIEDVLGKRIINTKLQPNITIREENAIAALEI
HHHEECCCHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHH
MSRFAANPKWLIYLPPTMSPVETSSAPGYLEHPSQAFVYYQKQGITEVICEEKHMGSRAI
HHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEHHCCHHHHHHHHHCCCCCEE
VVVCRDLATAEKRFGVVDEGIGICYTRTGRRFFDEPTLETQLLARVNAALTASRFWERFN
EEEEHHHHHHHHHCCCCCCCCCEEEEECCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHC
TDWVCLDCELMPWSAKAQGLIKGQYAPVGVASRLACNDAVELLQQASERGLNITTQLTRY
CCEEEEEEEECCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
QQRAEMANQYITAYRRYCWNVTDIGDLKLAPFHILATEEAVHIDKDHRWHIEQITQICQS
HHHHHHHHHHHHHHHHHHCCCCCCCCCEECCEEEEECCCEEECCCCCCCCHHHHHHHHCC
DPDLLLSTAYKVIDLTDPSSQAEGVHWWEKLTQVGGEGMVVKSMQFLVKGSRGIVQPAVK
CCCHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCCCCHHHH
CRGQEYLRIIYGPEYSALENLQRLRQRGLSLKRSLAMREFALGVEALERFVAHAPLRHVH
HCCCEEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ECVFGILALESEPVDPRL
HHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA