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The map label for this gene is pntAA [H]

Identifier: 17230902

GI number: 17230902

Start: 4120085

End: 4121320

Strand: Reverse

Name: pntAA [H]

Synonym: all3410

Alternate gene names: 17230902

Gene position: 4121320-4120085 (Counterclockwise)

Preceding gene: 17230910

Following gene: 17230901

Centisome position: 64.26

GC content: 45.63

Gene sequence:

>1236_bases
ATGACATTCCTCATAAGCAAAGTTGCAGATTTTGCAGAGATTAGGTATTTATCTTCAGGAGATTTCATGAGAATAGCAGT
TGCTAAAGAAATTGAAGTTTGTGAACGACGTGTAGCCTTAAATCCTGACACTGTTGCCCGATTGGTAAAACAAGGTTTAG
AGGTTTGGGTAGAAGCCGGTGCAGGAGAGCGATCATTTTTTGATGATGCTGCCTATGTAGCAGCAGGCGCGACAATTGTT
GGCGATTCCGGTAAATTATGGGGCGAAACAGATGTTTTGTTGAAAGTTAGCCCACCGCAAGAACGGGAAGATGGACGCTT
AGAGATTGATTTATTACGGGAAGGTGCTGTCTTAATTAGCTTCCTGAATCCCTTGGGTAATCCGGTAGTGGCGCAACAAC
TGGTGAATCGTAAAGTCACAGCCTTGAGTATGGAATTGATCCCCAGAACTACCAGGGCGCAATCGATGGATGCTTTATCT
TCACAAGCGTCACTGGCGGGTTATAAAGCGGTATTAATTGCGGCGGCGGCGTTACCAAAATATTTCCCCATGCTGACAAC
AGCCGCAGGAACAATTGCCCCAGCTAAAGTATTTATTATGGGTGCTGGTGTAGCAGGATTGCAAGCGATCGCCACAGCTA
GACGTTTGGGCGCAGTTGTAGAGGCCTTTGATATTCGTCCGGCTGTCAAAGAAGAAGTGCAGAGTTTAGGGGCAAAATTC
GTCGAAGTCAAACTCGAAGAAGAAACAACCGCCGCCGGTGGTTATGCGAAGGAAATTTCTGAAGCTAGTAAACAGCGCAC
TCAAGAAGTCGTCGCGGAACACGTTAAAAATTCTGATGTAGTCATTACAACTGCTCAAGTACCAGGTAGAAAAGCGCCAG
TGCTAGTCACAGCAGAAATGGTTGCACAAATGAAACCCGGTTCAGTGATTGTCGATTTAGCGGCTGAACAAGGTGGTAAC
TGTGCTTGTACTGATCCTGGTAAAGATATTGTCTGGAACGGGGTGACAATTATCGGCCCCATCAATCTCCCTTCATCAAT
GCCAGTCCACGCCAGCCAATTGTATTCCAAGAACCTCACATCTTTGCTGCAATTGCTAATTAAAGATAAAGCCTTACAAG
TAGATTTTACAGACGACATCATTGATGCTGCTTGCATTACCCACGCTGGAGAAATTCGCAATCAACGCGTCAAGGATGCG
TTACAAGCTTCGACTACTCAACTAGTTAGGGACTAG

Upstream 100 bases:

>100_bases
AAGCTTTGTCTGTTGCATCACCAGAGTTAAGGGGAACGCTCAAGTTTCAATCAAAAAGGAAAATCAATTTTTCATAGCTC
GGCGTAAGAGCCATGAGTGA

Downstream 100 bases:

>100_bases
AGACTAGTCTCTAGCCTCTCAATAATTAAGGAGTTTTAAATGACAGAGGCATTACTTGCAGCTTTGTTTGTATTTGTGTT
GGCATCATTCATTGGCTTTG

Product: nicotinamide nucleotide transhydrogenase, subunit alpha

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MTFLISKVADFAEIRYLSSGDFMRIAVAKEIEVCERRVALNPDTVARLVKQGLEVWVEAGAGERSFFDDAAYVAAGATIV
GDSGKLWGETDVLLKVSPPQEREDGRLEIDLLREGAVLISFLNPLGNPVVAQQLVNRKVTALSMELIPRTTRAQSMDALS
SQASLAGYKAVLIAAAALPKYFPMLTTAAGTIAPAKVFIMGAGVAGLQAIATARRLGAVVEAFDIRPAVKEEVQSLGAKF
VEVKLEEETTAAGGYAKEISEASKQRTQEVVAEHVKNSDVVITTAQVPGRKAPVLVTAEMVAQMKPGSVIVDLAAEQGGN
CACTDPGKDIVWNGVTIIGPINLPSSMPVHASQLYSKNLTSLLQLLIKDKALQVDFTDDIIDAACITHAGEIRNQRVKDA
LQASTTQLVRD

Sequences:

>Translated_411_residues
MTFLISKVADFAEIRYLSSGDFMRIAVAKEIEVCERRVALNPDTVARLVKQGLEVWVEAGAGERSFFDDAAYVAAGATIV
GDSGKLWGETDVLLKVSPPQEREDGRLEIDLLREGAVLISFLNPLGNPVVAQQLVNRKVTALSMELIPRTTRAQSMDALS
SQASLAGYKAVLIAAAALPKYFPMLTTAAGTIAPAKVFIMGAGVAGLQAIATARRLGAVVEAFDIRPAVKEEVQSLGAKF
VEVKLEEETTAAGGYAKEISEASKQRTQEVVAEHVKNSDVVITTAQVPGRKAPVLVTAEMVAQMKPGSVIVDLAAEQGGN
CACTDPGKDIVWNGVTIIGPINLPSSMPVHASQLYSKNLTSLLQLLIKDKALQVDFTDDIIDAACITHAGEIRNQRVKDA
LQASTTQLVRD
>Mature_410_residues
TFLISKVADFAEIRYLSSGDFMRIAVAKEIEVCERRVALNPDTVARLVKQGLEVWVEAGAGERSFFDDAAYVAAGATIVG
DSGKLWGETDVLLKVSPPQEREDGRLEIDLLREGAVLISFLNPLGNPVVAQQLVNRKVTALSMELIPRTTRAQSMDALSS
QASLAGYKAVLIAAAALPKYFPMLTTAAGTIAPAKVFIMGAGVAGLQAIATARRLGAVVEAFDIRPAVKEEVQSLGAKFV
EVKLEEETTAAGGYAKEISEASKQRTQEVVAEHVKNSDVVITTAQVPGRKAPVLVTAEMVAQMKPGSVIVDLAAEQGGNC
ACTDPGKDIVWNGVTIIGPINLPSSMPVHASQLYSKNLTSLLQLLIKDKALQVDFTDDIIDAACITHAGEIRNQRVKDAL
QASTTQLVRD

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=368, Percent_Identity=45.9239130434783, Blast_Score=293, Evalue=1e-79,
Organism=Homo sapiens, GI122939153, Length=368, Percent_Identity=45.9239130434783, Blast_Score=293, Evalue=1e-79,
Organism=Escherichia coli, GI1787887, Length=373, Percent_Identity=47.9892761394102, Blast_Score=328, Evalue=3e-91,
Organism=Caenorhabditis elegans, GI17550456, Length=399, Percent_Identity=43.609022556391, Blast_Score=319, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 43838; Mature: 43707

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00837 ALADH_PNT_2 ; PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFLISKVADFAEIRYLSSGDFMRIAVAKEIEVCERRVALNPDTVARLVKQGLEVWVEAG
CCCHHHHHHHHHHHEEECCCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
AGERSFFDDAAYVAAGATIVGDSGKLWGETDVLLKVSPPQEREDGRLEIDLLREGAVLIS
CCCCCHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCHHHHH
FLNPLGNPVVAQQLVNRKVTALSMELIPRTTRAQSMDALSSQASLAGYKAVLIAAAALPK
HHHHCCCHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YFPMLTTAAGTIAPAKVFIMGAGVAGLQAIATARRLGAVVEAFDIRPAVKEEVQSLGAKF
HHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEE
VEVKLEEETTAAGGYAKEISEASKQRTQEVVAEHVKNSDVVITTAQVPGRKAPVLVTAEM
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEHHH
VAQMKPGSVIVDLAAEQGGNCACTDPGKDIVWNGVTIIGPINLPSSMPVHASQLYSKNLT
HHHCCCCCEEEEEECCCCCCEEECCCCCCEEECCEEEEECCCCCCCCCCHHHHHHHHHHH
SLLQLLIKDKALQVDFTDDIIDAACITHAGEIRNQRVKDALQASTTQLVRD
HHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TFLISKVADFAEIRYLSSGDFMRIAVAKEIEVCERRVALNPDTVARLVKQGLEVWVEAG
CCHHHHHHHHHHHEEECCCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
AGERSFFDDAAYVAAGATIVGDSGKLWGETDVLLKVSPPQEREDGRLEIDLLREGAVLIS
CCCCCHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCHHHHH
FLNPLGNPVVAQQLVNRKVTALSMELIPRTTRAQSMDALSSQASLAGYKAVLIAAAALPK
HHHHCCCHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YFPMLTTAAGTIAPAKVFIMGAGVAGLQAIATARRLGAVVEAFDIRPAVKEEVQSLGAKF
HHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEE
VEVKLEEETTAAGGYAKEISEASKQRTQEVVAEHVKNSDVVITTAQVPGRKAPVLVTAEM
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEHHH
VAQMKPGSVIVDLAAEQGGNCACTDPGKDIVWNGVTIIGPINLPSSMPVHASQLYSKNLT
HHHCCCCCEEEEEECCCCCCEEECCCCCCEEECCEEEEECCCCCCCCCCHHHHHHHHHHH
SLLQLLIKDKALQVDFTDDIIDAACITHAGEIRNQRVKDALQASTTQLVRD
HHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]