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The map label for this gene is sigC

Identifier: 17229184

GI number: 17229184

Start: 2021083

End: 2022333

Strand: Reverse

Name: sigC

Synonym: all1692

Alternate gene names: 17229184

Gene position: 2022333-2021083 (Counterclockwise)

Preceding gene: 17229185

Following gene: 17229183

Centisome position: 31.53

GC content: 43.49

Gene sequence:

>1251_bases
ATGCCAGCAACATCTTTTTACGCAGATGCCGCCTACAATACCCAAAAATCCCGCCAGGCTTTAGACCCTGATATCGCCAT
TGATGACAGTGATTTGTCGGTGGATGAGATCCAAGAATTAGAGATAGCTGCTGCTGATCCCGCTACTTTTGGTGCTAGCG
CTAACCGTCGTAGTACAGACTTAGTACGTCTATACCTTCAGGAAATCGGTCGAGTCCGTTTGTTAGGACGGGACGAAGAA
GTTTCTGAAGCTCAAAAAGTCCAGCGTTACTTAAAGTTGCGGATAGTGCTAGCTAATGCTGTCAAACAGGGAGATGAAGT
TGCTACTCCTTATCTACATTTAATCGAAGTTCAAGAGCGTCTAGCATCAGAACTTGGCCATCGTCCTTCCTTGGAAAGAT
GGGCTGCTACTGCTGGTATCAACTTATGTGACCTGAAGCCAATTTTATCGGAAGGTAAACGTCGCTGGGCAGAAATTGCC
AAGATGACGGTGGAAGAATTGGAGAAAATGCAATCTCAAGGTCTTCAGTCAAAAGAACACATGATTAAGGCTAATCTGCG
CTTAGTCGTGTCTGTTGCCAAAAAATACCAAAATCGTGGTTTAGAATTATTAGACTTAGTTCAAGAAGGCACTCTCGGCT
TAGAACGAGCTGTAGAGAAATTTGATCCAACTAAAGGATATCGTTTTAGTACCTATGCCTACTGGTGGATTCGCCAAGGG
ATCACAAGAGCGATCGCTACTTCTAGTCGCACAATTCGCCTCCCTGTTCATATTACAGAAAAATTAAACAAAATTAAAAA
GGCTCAACGCAAAATCGCTCAAGAAAAAGGTCGCACTCCTACTTTAGAAGACCTAGCAATTGAGTTAGATATGACCCCTA
CCCAAGTGCGGGAAGTTTTACTAAGAGTACCCCGTTCTGTTTCTTTGGAAACCAAGGTAGGTAAAGATAAAGACACTGAG
TTGGGAGAATTATTAGAGACTGACGGTGTAACTCCTGAAGAAATGTTAATGCGAGAATCTTTACAAAGAGACTTGCAACA
TTTATTAGCTGATTTAACTAGCCGTGAACGTGATGTCATCTTGATGCGTTTCGGTTTAGCTGATGGTCATCCTTACTCAT
TGGCAGAAATTGGCCGCGCTCTGGATTTATCACGGGAGCGAGTACGCCAAATTGAATCTAAGGCCTTGCAAAAACTCCGC
CAACCCAAGCGTCGCAACCTTATCCGTGACTATTTGGAATCTCTGAGTTAG

Upstream 100 bases:

>100_bases
AACCTTAACCGTGTTAGTTCATCTAGAATCACGGGAACAATAGCAACAGTTAAATAGCTGACCGCAATCTATTGTTACCT
GGAGCCATAGAGACGATCTT

Downstream 100 bases:

>100_bases
ATAGTTAATAGTCAATAGTCAATAGTCAATAGTCAATAATCAATAGTAAACAAAATCCATACTATAGATTATTGACTCTG
GACTATTTATTTCATCACAA

Product: RNA polymerase sigma factor SigC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MPATSFYADAAYNTQKSRQALDPDIAIDDSDLSVDEIQELEIAAADPATFGASANRRSTDLVRLYLQEIGRVRLLGRDEE
VSEAQKVQRYLKLRIVLANAVKQGDEVATPYLHLIEVQERLASELGHRPSLERWAATAGINLCDLKPILSEGKRRWAEIA
KMTVEELEKMQSQGLQSKEHMIKANLRLVVSVAKKYQNRGLELLDLVQEGTLGLERAVEKFDPTKGYRFSTYAYWWIRQG
ITRAIATSSRTIRLPVHITEKLNKIKKAQRKIAQEKGRTPTLEDLAIELDMTPTQVREVLLRVPRSVSLETKVGKDKDTE
LGELLETDGVTPEEMLMRESLQRDLQHLLADLTSRERDVILMRFGLADGHPYSLAEIGRALDLSRERVRQIESKALQKLR
QPKRRNLIRDYLESLS

Sequences:

>Translated_416_residues
MPATSFYADAAYNTQKSRQALDPDIAIDDSDLSVDEIQELEIAAADPATFGASANRRSTDLVRLYLQEIGRVRLLGRDEE
VSEAQKVQRYLKLRIVLANAVKQGDEVATPYLHLIEVQERLASELGHRPSLERWAATAGINLCDLKPILSEGKRRWAEIA
KMTVEELEKMQSQGLQSKEHMIKANLRLVVSVAKKYQNRGLELLDLVQEGTLGLERAVEKFDPTKGYRFSTYAYWWIRQG
ITRAIATSSRTIRLPVHITEKLNKIKKAQRKIAQEKGRTPTLEDLAIELDMTPTQVREVLLRVPRSVSLETKVGKDKDTE
LGELLETDGVTPEEMLMRESLQRDLQHLLADLTSRERDVILMRFGLADGHPYSLAEIGRALDLSRERVRQIESKALQKLR
QPKRRNLIRDYLESLS
>Mature_415_residues
PATSFYADAAYNTQKSRQALDPDIAIDDSDLSVDEIQELEIAAADPATFGASANRRSTDLVRLYLQEIGRVRLLGRDEEV
SEAQKVQRYLKLRIVLANAVKQGDEVATPYLHLIEVQERLASELGHRPSLERWAATAGINLCDLKPILSEGKRRWAEIAK
MTVEELEKMQSQGLQSKEHMIKANLRLVVSVAKKYQNRGLELLDLVQEGTLGLERAVEKFDPTKGYRFSTYAYWWIRQGI
TRAIATSSRTIRLPVHITEKLNKIKKAQRKIAQEKGRTPTLEDLAIELDMTPTQVREVLLRVPRSVSLETKVGKDKDTEL
GELLETDGVTPEEMLMRESLQRDLQHLLADLTSRERDVILMRFGLADGHPYSLAEIGRALDLSRERVRQIESKALQKLRQ
PKRRNLIRDYLESLS

Specific function: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released

COG id: COG0568

COG function: function code K; DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sigma-70 factor family

Homologues:

Organism=Escherichia coli, GI1789448, Length=244, Percent_Identity=47.5409836065574, Blast_Score=241, Evalue=8e-65,
Organism=Escherichia coli, GI1789098, Length=226, Percent_Identity=42.9203539823009, Blast_Score=187, Evalue=8e-49,
Organism=Escherichia coli, GI1789871, Length=251, Percent_Identity=28.6852589641434, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788231, Length=234, Percent_Identity=26.0683760683761, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 700 (log & stationary phase) [C]

Swissprot (AC and ID): RPSC_NOSS1 (Q03066)

Other databases:

- EMBL:   M95759
- EMBL:   BA000019
- PIR:   AF2017
- PIR:   C47017
- RefSeq:   NP_485732.1
- ProteinModelPortal:   Q03066
- SMR:   Q03066
- STRING:   Q03066
- GeneID:   1105284
- GenomeReviews:   BA000019_GR
- KEGG:   ana:all1692
- NMPDR:   fig|103690.1.peg.1999
- eggNOG:   COG0568
- HOGENOM:   HBG745096
- OMA:   LQDIGRV
- ProtClustDB:   PRK07598
- BioCyc:   NSP103690:ALL1692-MONOMER
- InterPro:   IPR014284
- InterPro:   IPR000943
- InterPro:   IPR009042
- InterPro:   IPR007627
- InterPro:   IPR007624
- InterPro:   IPR007630
- InterPro:   IPR013325
- InterPro:   IPR013324
- InterPro:   IPR017848
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00046
- TIGRFAMs:   TIGR02997
- TIGRFAMs:   TIGR02937

Pfam domain/function: PF00140 Sigma70_r1_2; PF04542 Sigma70_r2; PF04539 Sigma70_r3; PF04545 Sigma70_r4; SSF88946 Sigma_r2; SSF88659 Sigma_r3_r4

EC number: NA

Molecular weight: Translated: 47375; Mature: 47244

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS00715 SIGMA70_1; PS00716 SIGMA70_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPATSFYADAAYNTQKSRQALDPDIAIDDSDLSVDEIQELEIAAADPATFGASANRRSTD
CCCCCHHHHHHHCCHHHHHHCCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHH
LVRLYLQEIGRVRLLGRDEEVSEAQKVQRYLKLRIVLANAVKQGDEVATPYLHLIEVQER
HHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LASELGHRPSLERWAATAGINLCDLKPILSEGKRRWAEIAKMTVEELEKMQSQGLQSKEH
HHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
MIKANLRLVVSVAKKYQNRGLELLDLVQEGTLGLERAVEKFDPTKGYRFSTYAYWWIRQG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHCCCCCCCEEHHHHHHHHHHH
ITRAIATSSRTIRLPVHITEKLNKIKKAQRKIAQEKGRTPTLEDLAIELDMTPTQVREVL
HHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEEECCCHHHHHHHH
LRVPRSVSLETKVGKDKDTELGELLETDGVTPEEMLMRESLQRDLQHLLADLTSRERDVI
HHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LMRFGLADGHPYSLAEIGRALDLSRERVRQIESKALQKLRQPKRRNLIRDYLESLS
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PATSFYADAAYNTQKSRQALDPDIAIDDSDLSVDEIQELEIAAADPATFGASANRRSTD
CCCCHHHHHHHCCHHHHHHCCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHH
LVRLYLQEIGRVRLLGRDEEVSEAQKVQRYLKLRIVLANAVKQGDEVATPYLHLIEVQER
HHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LASELGHRPSLERWAATAGINLCDLKPILSEGKRRWAEIAKMTVEELEKMQSQGLQSKEH
HHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
MIKANLRLVVSVAKKYQNRGLELLDLVQEGTLGLERAVEKFDPTKGYRFSTYAYWWIRQG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHCCCCCCCEEHHHHHHHHHHH
ITRAIATSSRTIRLPVHITEKLNKIKKAQRKIAQEKGRTPTLEDLAIELDMTPTQVREVL
HHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEEECCCHHHHHHHH
LRVPRSVSLETKVGKDKDTELGELLETDGVTPEEMLMRESLQRDLQHLLADLTSRERDVI
HHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LMRFGLADGHPYSLAEIGRALDLSRERVRQIESKALQKLRQPKRRNLIRDYLESLS
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1385387; 11759840