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The map label for this gene is devB

Identifier: 17229094

GI number: 17229094

Start: 1883375

End: 1884097

Strand: Direct

Name: devB

Synonym: alr1602

Alternate gene names: 17229094

Gene position: 1883375-1884097 (Clockwise)

Preceding gene: 17229092

Following gene: 17229095

Centisome position: 29.36

GC content: 47.3

Gene sequence:

>723_bases
ATGAAAAAAACGGTTGAAGTCCTACCGGATCAAACAGCGCTAATTGCGCGATCGCTCGATTTGATCCTGACTAAGTTAGA
TACTGCCATAAAACAGCAGGGGCGATTTACCATTGCCTTATCCGGCGGTAGCACACCTAAGCCGTTGTATGAAGCGATCG
CTGCCCAAAAATTACCTTGGGATAAAATTCATGTTTTCTGGGGAGATGAGCGTTATGTCTCACCAGATCATCCCGATAGT
AATGAACTGATGGCACGTACTGCATGGCTAGACCGCGTTGATATCCCCGCCGAGAATATTCATGCTGTCCCCACCTTAGA
TAATAATCCGGCAGTATCGGCTGCTAAGTATGAACAGCACTTGCAAACATTTTTTAACTCTGCACCCGGAGAGTTTCCCG
CTTTGGATGTGGTATTGCTAGGAATGGGTGATGATGCCCATACTGCATCTTTGTTTCCCCACACAGAAGCTTTACAAGTA
CGCGATCGCTTAATTACTGTGGGTAATAAAGACGGTAATCCCCGCATAACCTTCACATACCCATTCATTAACGCTGCTAG
CAGTGTAATTTTTGTGGTTGCAGGTGCTAACAAACGGCCAGCCCTTGCTCAAGTATTTGCTCCGAGTGCAGATGACTTAG
CTTATCCATCCCGCTTCATCCAGCCCCAAGGTGAACTTTTGTGGCTACTGGATGCAGCCGCAGGCGCGGAACTCTCAGTT
TGA

Upstream 100 bases:

>100_bases
CCACCTAATTTTTGATGTTAAGAGTTTCAAAAGTTAAAAAGGGGGGTTGTCAGAAGTTAGGTATTGTATTGCTGGAAGCA
GGCAATGTGATGATGAAGCC

Downstream 100 bases:

>100_bases
TTTTCCCATCACGAGTAATTGTTAAAATCGGAAGCTAGAGTCACCGCCTTGCTGCATTTCTCATAAAAACAAGTCTAACC
TTTGGGTGTCTACTGCAAAA

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MKKTVEVLPDQTALIARSLDLILTKLDTAIKQQGRFTIALSGGSTPKPLYEAIAAQKLPWDKIHVFWGDERYVSPDHPDS
NELMARTAWLDRVDIPAENIHAVPTLDNNPAVSAAKYEQHLQTFFNSAPGEFPALDVVLLGMGDDAHTASLFPHTEALQV
RDRLITVGNKDGNPRITFTYPFINAASSVIFVVAGANKRPALAQVFAPSADDLAYPSRFIQPQGELLWLLDAAAGAELSV

Sequences:

>Translated_240_residues
MKKTVEVLPDQTALIARSLDLILTKLDTAIKQQGRFTIALSGGSTPKPLYEAIAAQKLPWDKIHVFWGDERYVSPDHPDS
NELMARTAWLDRVDIPAENIHAVPTLDNNPAVSAAKYEQHLQTFFNSAPGEFPALDVVLLGMGDDAHTASLFPHTEALQV
RDRLITVGNKDGNPRITFTYPFINAASSVIFVVAGANKRPALAQVFAPSADDLAYPSRFIQPQGELLWLLDAAAGAELSV
>Mature_240_residues
MKKTVEVLPDQTALIARSLDLILTKLDTAIKQQGRFTIALSGGSTPKPLYEAIAAQKLPWDKIHVFWGDERYVSPDHPDS
NELMARTAWLDRVDIPAENIHAVPTLDNNPAVSAAKYEQHLQTFFNSAPGEFPALDVVLLGMGDDAHTASLFPHTEALQV
RDRLITVGNKDGNPRITFTYPFINAASSVIFVVAGANKRPALAQVFAPSADDLAYPSRFIQPQGELLWLLDAAAGAELSV

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily

Homologues:

Organism=Homo sapiens, GI52145310, Length=210, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI6912586, Length=221, Percent_Identity=31.6742081447964, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI115533060, Length=254, Percent_Identity=29.5275590551181, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI115533058, Length=254, Percent_Identity=29.5275590551181, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321957, Length=221, Percent_Identity=29.4117647058824, Blast_Score=90, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6321687, Length=246, Percent_Identity=29.6747967479675, Blast_Score=86, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6324362, Length=209, Percent_Identity=32.0574162679426, Blast_Score=83, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319918, Length=212, Percent_Identity=30.6603773584906, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24641119, Length=244, Percent_Identity=33.1967213114754, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): 6PGL_NOSS1 (P46016)

Other databases:

- EMBL:   U14553
- EMBL:   BA000019
- PIR:   AD2006
- RefSeq:   NP_485642.1
- ProteinModelPortal:   P46016
- STRING:   P46016
- GeneID:   1105194
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr1602
- NMPDR:   fig|103690.1.peg.1909
- eggNOG:   COG0363
- HOGENOM:   HBG725991
- OMA:   PAICLTG
- PhylomeDB:   P46016
- ProtClustDB:   CLSK2302142
- BioCyc:   NSP103690:ALR1602-MONOMER
- InterPro:   IPR005900
- InterPro:   IPR006148
- PANTHER:   PTHR11054
- TIGRFAMs:   TIGR01198

Pfam domain/function: PF01182 Glucosamine_iso

EC number: =3.1.1.31

Molecular weight: Translated: 26183; Mature: 26183

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTVEVLPDQTALIARSLDLILTKLDTAIKQQGRFTIALSGGSTPKPLYEAIAAQKLPW
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCC
DKIHVFWGDERYVSPDHPDSNELMARTAWLDRVDIPAENIHAVPTLDNNPAVSAAKYEQH
CEEEEEECCCEECCCCCCCCHHHHHHHHHHHCCCCCHHHEEECCCCCCCCCCCHHHHHHH
LQTFFNSAPGEFPALDVVLLGMGDDAHTASLFPHTEALQVRDRLITVGNKDGNPRITFTY
HHHHHHCCCCCCCEEEEEEEECCCCCCEEECCCCHHHHHHHHEEEEECCCCCCCEEEEEE
PFINAASSVIFVVAGANKRPALAQVFAPSADDLAYPSRFIQPQGELLWLLDAAAGAELSV
CCCCCCCEEEEEEECCCCCCCCCEEECCCCCCCCCCHHHCCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MKKTVEVLPDQTALIARSLDLILTKLDTAIKQQGRFTIALSGGSTPKPLYEAIAAQKLPW
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCC
DKIHVFWGDERYVSPDHPDSNELMARTAWLDRVDIPAENIHAVPTLDNNPAVSAAKYEQH
CEEEEEECCCEECCCCCCCCHHHHHHHHHHHCCCCCHHHEEECCCCCCCCCCCHHHHHHH
LQTFFNSAPGEFPALDVVLLGMGDDAHTASLFPHTEALQVRDRLITVGNKDGNPRITFTY
HHHHHHCCCCCCCEEEEEEEECCCCCCEEECCCCHHHHHHHHEEEEECCCCCCCEEEEEE
PFINAASSVIFVVAGANKRPALAQVFAPSADDLAYPSRFIQPQGELLWLLDAAAGAELSV
CCCCCCCEEEEEEECCCCCCCCCEEECCCCCCCCCCHHHCCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840