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The map label for this gene is irlR [H]

Identifier: 17227925

GI number: 17227925

Start: 506544

End: 507374

Strand: Direct

Name: irlR [H]

Synonym: alr0429

Alternate gene names: 17227925

Gene position: 506544-507374 (Clockwise)

Preceding gene: 17227924

Following gene: 17227926

Centisome position: 7.9

GC content: 41.4

Gene sequence:

>831_bases
ATGCAGGAATCATTAAATACAATTCTGGTCATTGAAGATGATACAGTTACCCGCAATCTCTACTTAAAGGGACTGAAAAT
TGAAGGGTTTAATGTCATAGGTGCTGAAAATGGTGTGGTGGGTGTTCAAAAGGCACAAGAACATCTGCCAGATATAATTA
TTTGCGATATTATGATGCCTCAGATGGATGGTTATAGTGTTCTCACCATCCTACGCCAAGACTCTTTAACAGCAGGTATT
CCCTTCATTTTTCTGACTGCTAGCGATATGAGGGGAGATCTTCGTAAGGGTATGGAGTTGGGTGCTGATGATTATATTAC
CAAACCATCTACCCTAGACGAATTACTCAAAGCGATCGCCACCCGTTTACGCAAGCAAGCATCTGTGAAAAACTGGTGTA
ATAATCTCCTCCAGAAAACTGCAAAACCAGCCTCTACAGCTAGTGCTGTACAAAAAACTCCTCCTGATTCTCAATCCATT
TTTCCGGCTGTTCCTCAGTTAAAAGAGGTTTTCGACTTTATTGAAGCTTATTTTCACCAAGGGATTACTCTCTGTGACGT
AGCGGCTGCGGTGGGTTATTCCCCTGCTTATTTGACTAATCGCGTAGCCAAGCAGACAGGAGATACTATCAATAACTGGA
TTGTCAAACGTCGGATGGCGGAAGCTCGTCGTTTACTTCAAAATAGCGATGAGACTGTAGAGCAAATTTCTAGATTATTG
GGATATCAACACGTTTGTCATTTCTCCCGTCAATTTCGTCAACATCACGGGTTACCTCCCCATGCTTGGCGATTATGTTC
TAAAAATAAGGAAGAATTAGTAAAAGTTTAA

Upstream 100 bases:

>100_bases
AATTTCTGTAACTTAACGTTTATCAGTTGGAATAAATAGACTCTGCTGAATTCTGAACGCAGAGATTGGTAAGAACCAAA
CTTATATTCACGGAAAAACA

Downstream 100 bases:

>100_bases
AGCCGCCACGATAGTACGACGTAAAAATTTCATATAATGCCTATAGTGCTGTTAAATCAAGGCAAGTGCTAAATTATTCC
ATATGTTATGAATTACAGAT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MQESLNTILVIEDDTVTRNLYLKGLKIEGFNVIGAENGVVGVQKAQEHLPDIIICDIMMPQMDGYSVLTILRQDSLTAGI
PFIFLTASDMRGDLRKGMELGADDYITKPSTLDELLKAIATRLRKQASVKNWCNNLLQKTAKPASTASAVQKTPPDSQSI
FPAVPQLKEVFDFIEAYFHQGITLCDVAAAVGYSPAYLTNRVAKQTGDTINNWIVKRRMAEARRLLQNSDETVEQISRLL
GYQHVCHFSRQFRQHHGLPPHAWRLCSKNKEELVKV

Sequences:

>Translated_276_residues
MQESLNTILVIEDDTVTRNLYLKGLKIEGFNVIGAENGVVGVQKAQEHLPDIIICDIMMPQMDGYSVLTILRQDSLTAGI
PFIFLTASDMRGDLRKGMELGADDYITKPSTLDELLKAIATRLRKQASVKNWCNNLLQKTAKPASTASAVQKTPPDSQSI
FPAVPQLKEVFDFIEAYFHQGITLCDVAAAVGYSPAYLTNRVAKQTGDTINNWIVKRRMAEARRLLQNSDETVEQISRLL
GYQHVCHFSRQFRQHHGLPPHAWRLCSKNKEELVKV
>Mature_276_residues
MQESLNTILVIEDDTVTRNLYLKGLKIEGFNVIGAENGVVGVQKAQEHLPDIIICDIMMPQMDGYSVLTILRQDSLTAGI
PFIFLTASDMRGDLRKGMELGADDYITKPSTLDELLKAIATRLRKQASVKNWCNNLLQKTAKPASTASAVQKTPPDSQSI
FPAVPQLKEVFDFIEAYFHQGITLCDVAAAVGYSPAYLTNRVAKQTGDTINNWIVKRRMAEARRLLQNSDETVEQISRLL
GYQHVCHFSRQFRQHHGLPPHAWRLCSKNKEELVKV

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=122, Percent_Identity=40.9836065573771, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1786599, Length=118, Percent_Identity=37.2881355932203, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI87082012, Length=124, Percent_Identity=35.4838709677419, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790860, Length=120, Percent_Identity=32.5, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1786911, Length=124, Percent_Identity=31.4516129032258, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1790863, Length=108, Percent_Identity=37.962962962963, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI2367329, Length=157, Percent_Identity=33.7579617834395, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789809, Length=128, Percent_Identity=36.71875, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788550, Length=135, Percent_Identity=31.1111111111111, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI145693157, Length=121, Percent_Identity=33.8842975206612, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787375, Length=129, Percent_Identity=28.6821705426357, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1789402, Length=145, Percent_Identity=32.4137931034483, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790552, Length=119, Percent_Identity=31.0924369747899, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788394, Length=125, Percent_Identity=30.4, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 30968; Mature: 30968

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQESLNTILVIEDDTVTRNLYLKGLKIEGFNVIGAENGVVGVQKAQEHLPDIIICDIMMP
CCCCCCEEEEEECCCEEHHHEEEEEEECCEEEECCCCCEEHHHHHHHHCCCEEEEHHHCC
QMDGYSVLTILRQDSLTAGIPFIFLTASDMRGDLRKGMELGADDYITKPSTLDELLKAIA
CCCCHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
TRLRKQASVKNWCNNLLQKTAKPASTASAVQKTPPDSQSIFPAVPQLKEVFDFIEAYFHQ
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
GITLCDVAAAVGYSPAYLTNRVAKQTGDTINNWIVKRRMAEARRLLQNSDETVEQISRLL
CCHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GYQHVCHFSRQFRQHHGLPPHAWRLCSKNKEELVKV
HHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHCC
>Mature Secondary Structure
MQESLNTILVIEDDTVTRNLYLKGLKIEGFNVIGAENGVVGVQKAQEHLPDIIICDIMMP
CCCCCCEEEEEECCCEEHHHEEEEEEECCEEEECCCCCEEHHHHHHHHCCCEEEEHHHCC
QMDGYSVLTILRQDSLTAGIPFIFLTASDMRGDLRKGMELGADDYITKPSTLDELLKAIA
CCCCHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
TRLRKQASVKNWCNNLLQKTAKPASTASAVQKTPPDSQSIFPAVPQLKEVFDFIEAYFHQ
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
GITLCDVAAAVGYSPAYLTNRVAKQTGDTINNWIVKRRMAEARRLLQNSDETVEQISRLL
CCHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GYQHVCHFSRQFRQHHGLPPHAWRLCSKNKEELVKV
HHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]