Click here to switch to the map view.

The map label for this gene is luxQ [H]

Identifier: 17227924

GI number: 17227924

Start: 504500

End: 506413

Strand: Direct

Name: luxQ [H]

Synonym: alr0428

Alternate gene names: 17227924

Gene position: 504500-506413 (Clockwise)

Preceding gene: 17227898

Following gene: 17227925

Centisome position: 7.87

GC content: 37.1

Gene sequence:

>1914_bases
ATGAATATACAGTCAGAATTGGAGTTTAAATTTGCCCATTACCTGATCAACAATGCCGTAGAAGCATCCTTTTGTTTGGG
AGACAACTGGCAATTTCTCTACGTCAATGATGCAACTTGTCGTATGACTGAGTATTCTCGTGAACAGTTGTTATCGATGA
ATTTGCAAGATATAGATGTAGATTTTGCGTTACATGATTGGGAGGAAATCAGACAAAAGAATAACTACACATTTAAAACT
AGATATCGTTCTCAGAGTGGAAGAATATTTTTAGTAGAAATGTCTTTAACATTTTTAGAAGACCAAGAGAGGCGATTTAG
CTGTGTTTTTGTGCGAGAGAAAAGTAATGAGATCGTAGAATTAAGTGTACAAAAGTGGATTAATGAATTAAGAGATGCCA
ATAATAAATTGCAGCAAGAAGTTTCTGAACTCAAGAAAAAGGAGGTTAATCTAGAAAGTTCCCTATCTTTACTTAGCTCA
ACTCTCGAATCTACTGCTATCGGCATTGTGGCGATTAATTTTGAAGGCGATATTCTCAATTATAATCAAAAGTTTGCTGA
GATGTGGAAGCTCCCACAGCAACTAATATTGTCTAAAAAATGCCCTCGCTGTAAAGCTTTTTTTGAGGGTCAAATGAAAG
ACCCTGAAACATTTAATAGACTAATTTGGGCAGTTTCTAGTACATCCAATATTGAGAGTTATGATGTTTTGGAATTGAAA
GATGGTAGGGTTTTTGCTCACTATTCGCAACCGCAGTGGCTGGGACAAAAAATAATTGGTAGAGTCTGGAGTATTTGGGA
CATTACTGAATCTAAGCAAACAGAGGAAGCATTAAGACTAAATGAGGCTAGGTTTCGAGCTTTAGCGGAGACTAGCGACG
CTAGCACTTTTCTGGTTCAAGATACACAGTTTTGTTATGTTAATCCTGCTGTAGAGGTGCTTACAGGCTACACGAGAACC
GAACTGCTCAATGGGTTCGATATTCGGCGGCTGATCAAATATCGAAAAGGTAGACAGATACGTAATTCGGCTACAGCTAC
TAACTTTGAATATCAAGAAATCAGTATTTTAACCAAAAACGGTGCAGAGCGTTGGTTATCTTGTGCAGTCACAATACTTG
ATAGCACGATAGATTTTCAAGGTAAATCTGTAGAAATGATTACGGCTATTGATATTACCGATTATAAACAGGCAGAATCA
GAGCTTACCCAGGCTTTAGAACAGGCAAAACATCTCGGTGAATTAAGAGCAAGTTTCCTTTCTATGGTGTGTCATCAATT
CCGTAATCCGTTAAATATTGTCTCTTTTTCCAATAGCTTGCTTAAGCGATATCTTAATGCACAGACAGAAGAGACTATAC
AACCATTACTCGATCAAGTGCAATTATCTATTCAACAACTTAACCAGATGTTGGACGATATGTTGCTCTTTGCTAAAACA
GAAGCAGCCAAACTTAAATTTGAGCCTAGTCGATTTGAAATAGTGGAGTTTTGCAACGATGTGATTTCACAAATGCAGAT
GGCACACTTTCCTAATTATATTAATTTTATTAGCCAGACTGAATATCTAACAGTTTGGATGGATAAAAATATATTAGATT
CGATTCTCAAGAATTTGATTGATAATGCAATTAAGTATTCTCCCTTAGGGAGTATGGTAGAACTGAGGCTTTTAGGTAAC
AATGAAAAGATAATTTTTCAGGTCAAAGATGATGGAATTGGGATTTCAACATTAGACCAGAAACGACTTTTTGAACCGTT
TTACCGAGGCAAGAATGTTGATAATATTCCTGGGACTGGACTGGGGTTGTCGATTGTGAAAACCCTGGTAGATTTACATG
GTGGTCAGGTTGCAGTAGAAAGTAAAGTTGGCGTAGGTACGACATTTACTGTAGTGCTGCCACACAAGATATAG

Upstream 100 bases:

>100_bases
TAAACCTATAGATAATTTCACGCCAAATTCAATTAAGTATCAGTTTGTTGTTATGTAAATAGGTGAAAGTAGGAGATTTT
TCTTGGAGTTACAGCAAGTA

Downstream 100 bases:

>100_bases
AACCTCATTTGCTCCAAGTTATAAATGTTAAATTTCTGTAACTTAACGTTTATCAGTTGGAATAAATAGACTCTGCTGAA
TTCTGAACGCAGAGATTGGT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MNIQSELEFKFAHYLINNAVEASFCLGDNWQFLYVNDATCRMTEYSREQLLSMNLQDIDVDFALHDWEEIRQKNNYTFKT
RYRSQSGRIFLVEMSLTFLEDQERRFSCVFVREKSNEIVELSVQKWINELRDANNKLQQEVSELKKKEVNLESSLSLLSS
TLESTAIGIVAINFEGDILNYNQKFAEMWKLPQQLILSKKCPRCKAFFEGQMKDPETFNRLIWAVSSTSNIESYDVLELK
DGRVFAHYSQPQWLGQKIIGRVWSIWDITESKQTEEALRLNEARFRALAETSDASTFLVQDTQFCYVNPAVEVLTGYTRT
ELLNGFDIRRLIKYRKGRQIRNSATATNFEYQEISILTKNGAERWLSCAVTILDSTIDFQGKSVEMITAIDITDYKQAES
ELTQALEQAKHLGELRASFLSMVCHQFRNPLNIVSFSNSLLKRYLNAQTEETIQPLLDQVQLSIQQLNQMLDDMLLFAKT
EAAKLKFEPSRFEIVEFCNDVISQMQMAHFPNYINFISQTEYLTVWMDKNILDSILKNLIDNAIKYSPLGSMVELRLLGN
NEKIIFQVKDDGIGISTLDQKRLFEPFYRGKNVDNIPGTGLGLSIVKTLVDLHGGQVAVESKVGVGTTFTVVLPHKI

Sequences:

>Translated_637_residues
MNIQSELEFKFAHYLINNAVEASFCLGDNWQFLYVNDATCRMTEYSREQLLSMNLQDIDVDFALHDWEEIRQKNNYTFKT
RYRSQSGRIFLVEMSLTFLEDQERRFSCVFVREKSNEIVELSVQKWINELRDANNKLQQEVSELKKKEVNLESSLSLLSS
TLESTAIGIVAINFEGDILNYNQKFAEMWKLPQQLILSKKCPRCKAFFEGQMKDPETFNRLIWAVSSTSNIESYDVLELK
DGRVFAHYSQPQWLGQKIIGRVWSIWDITESKQTEEALRLNEARFRALAETSDASTFLVQDTQFCYVNPAVEVLTGYTRT
ELLNGFDIRRLIKYRKGRQIRNSATATNFEYQEISILTKNGAERWLSCAVTILDSTIDFQGKSVEMITAIDITDYKQAES
ELTQALEQAKHLGELRASFLSMVCHQFRNPLNIVSFSNSLLKRYLNAQTEETIQPLLDQVQLSIQQLNQMLDDMLLFAKT
EAAKLKFEPSRFEIVEFCNDVISQMQMAHFPNYINFISQTEYLTVWMDKNILDSILKNLIDNAIKYSPLGSMVELRLLGN
NEKIIFQVKDDGIGISTLDQKRLFEPFYRGKNVDNIPGTGLGLSIVKTLVDLHGGQVAVESKVGVGTTFTVVLPHKI
>Mature_637_residues
MNIQSELEFKFAHYLINNAVEASFCLGDNWQFLYVNDATCRMTEYSREQLLSMNLQDIDVDFALHDWEEIRQKNNYTFKT
RYRSQSGRIFLVEMSLTFLEDQERRFSCVFVREKSNEIVELSVQKWINELRDANNKLQQEVSELKKKEVNLESSLSLLSS
TLESTAIGIVAINFEGDILNYNQKFAEMWKLPQQLILSKKCPRCKAFFEGQMKDPETFNRLIWAVSSTSNIESYDVLELK
DGRVFAHYSQPQWLGQKIIGRVWSIWDITESKQTEEALRLNEARFRALAETSDASTFLVQDTQFCYVNPAVEVLTGYTRT
ELLNGFDIRRLIKYRKGRQIRNSATATNFEYQEISILTKNGAERWLSCAVTILDSTIDFQGKSVEMITAIDITDYKQAES
ELTQALEQAKHLGELRASFLSMVCHQFRNPLNIVSFSNSLLKRYLNAQTEETIQPLLDQVQLSIQQLNQMLDDMLLFAKT
EAAKLKFEPSRFEIVEFCNDVISQMQMAHFPNYINFISQTEYLTVWMDKNILDSILKNLIDNAIKYSPLGSMVELRLLGN
NEKIIFQVKDDGIGISTLDQKRLFEPFYRGKNVDNIPGTGLGLSIVKTLVDLHGGQVAVESKVGVGTTFTVVLPHKI

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=328, Percent_Identity=26.219512195122, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788549, Length=343, Percent_Identity=27.4052478134111, Blast_Score=96, Evalue=9e-21,
Organism=Escherichia coli, GI1789149, Length=239, Percent_Identity=30.9623430962343, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI48994928, Length=387, Percent_Identity=26.3565891472868, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1786912, Length=241, Percent_Identity=25.3112033195021, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1790346, Length=232, Percent_Identity=26.7241379310345, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786600, Length=368, Percent_Identity=25.5434782608696, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788393, Length=239, Percent_Identity=23.0125523012552, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI87081816, Length=248, Percent_Identity=26.2096774193548, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789808, Length=235, Percent_Identity=25.1063829787234, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1788713, Length=233, Percent_Identity=24.8927038626609, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790551, Length=218, Percent_Identity=28.4403669724771, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788279, Length=262, Percent_Identity=22.9007633587786, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786783, Length=227, Percent_Identity=25.5506607929515, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1787894, Length=217, Percent_Identity=24.4239631336406, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 73376; Mature: 73376

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIQSELEFKFAHYLINNAVEASFCLGDNWQFLYVNDATCRMTEYSREQLLSMNLQDIDV
CCCCHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEECCEEEHHHHHHHHHHHCCCHHCEE
DFALHDWEEIRQKNNYTFKTRYRSQSGRIFLVEMSLTFLEDQERRFSCVFVREKSNEIVE
EEEECCHHHHHHCCCCEEEEEEECCCCCEEEEEEEEHHHCCCCCCEEEEEEEECCCCEEE
LSVQKWINELRDANNKLQQEVSELKKKEVNLESSLSLLSSTLESTAIGIVAINFEGDILN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCEEEEEEEEECCCEEC
YNQKFAEMWKLPQQLILSKKCPRCKAFFEGQMKDPETFNRLIWAVSSTSNIESYDVLELK
CHHHHHHHHHCHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHEEEECCCCCCCCEEEEEEE
DGRVFAHYSQPQWLGQKIIGRVWSIWDITESKQTEEALRLNEARFRALAETSDASTFLVQ
CCEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
DTQFCYVNPAVEVLTGYTRTELLNGFDIRRLIKYRKGRQIRNSATATNFEYQEISILTKN
CCCEEEECCHHHHHHCCHHHHHHCCHHHHHHHHHHCCCCHHCCCCCCCCCEEEEEEEECC
GAERWLSCAVTILDSTIDFQGKSVEMITAIDITDYKQAESELTQALEQAKHLGELRASFL
CHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SMVCHQFRNPLNIVSFSNSLLKRYLNAQTEETIQPLLDQVQLSIQQLNQMLDDMLLFAKT
HHHHHHHCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EAAKLKFEPSRFEIVEFCNDVISQMQMAHFPNYINFISQTEYLTVWMDKNILDSILKNLI
CHHEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEEECHHHHHHHHHHHH
DNAIKYSPLGSMVELRLLGNNEKIIFQVKDDGIGISTLDQKRLFEPFYRGKNVDNIPGTG
HHHHEECCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
LGLSIVKTLVDLHGGQVAVESKVGVGTTFTVVLPHKI
HHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCC
>Mature Secondary Structure
MNIQSELEFKFAHYLINNAVEASFCLGDNWQFLYVNDATCRMTEYSREQLLSMNLQDIDV
CCCCHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEECCEEEHHHHHHHHHHHCCCHHCEE
DFALHDWEEIRQKNNYTFKTRYRSQSGRIFLVEMSLTFLEDQERRFSCVFVREKSNEIVE
EEEECCHHHHHHCCCCEEEEEEECCCCCEEEEEEEEHHHCCCCCCEEEEEEEECCCCEEE
LSVQKWINELRDANNKLQQEVSELKKKEVNLESSLSLLSSTLESTAIGIVAINFEGDILN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCEEEEEEEEECCCEEC
YNQKFAEMWKLPQQLILSKKCPRCKAFFEGQMKDPETFNRLIWAVSSTSNIESYDVLELK
CHHHHHHHHHCHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHEEEECCCCCCCCEEEEEEE
DGRVFAHYSQPQWLGQKIIGRVWSIWDITESKQTEEALRLNEARFRALAETSDASTFLVQ
CCEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
DTQFCYVNPAVEVLTGYTRTELLNGFDIRRLIKYRKGRQIRNSATATNFEYQEISILTKN
CCCEEEECCHHHHHHCCHHHHHHCCHHHHHHHHHHCCCCHHCCCCCCCCCEEEEEEEECC
GAERWLSCAVTILDSTIDFQGKSVEMITAIDITDYKQAESELTQALEQAKHLGELRASFL
CHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SMVCHQFRNPLNIVSFSNSLLKRYLNAQTEETIQPLLDQVQLSIQQLNQMLDDMLLFAKT
HHHHHHHCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EAAKLKFEPSRFEIVEFCNDVISQMQMAHFPNYINFISQTEYLTVWMDKNILDSILKNLI
CHHEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEEECHHHHHHHHHHHH
DNAIKYSPLGSMVELRLLGNNEKIIFQVKDDGIGISTLDQKRLFEPFYRGKNVDNIPGTG
HHHHEECCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
LGLSIVKTLVDLHGGQVAVESKVGVGTTFTVVLPHKI
HHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]