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The map label for this gene is spkB [H]

Identifier: 17227840

GI number: 17227840

Start: 393531

End: 395921

Strand: Direct

Name: spkB [H]

Synonym: alr0344

Alternate gene names: 17227840

Gene position: 393531-395921 (Clockwise)

Preceding gene: 17227836

Following gene: 17227842

Centisome position: 6.14

GC content: 41.74

Gene sequence:

>2391_bases
GTGGTTTTAGAATACGTATATTGTTTGTTGGCTTTTTGTCTTTACTTTATGGCGTACTGCATCAATCCCGATTGTTCGCA
GCGAGAAAATCCTGATACTAGTGCAGTATGTCAAAACTGTGGAACGCCACTCATACTTCAAAATCGCTACCGACTTAGGC
ATTTCCTACGAACTGATAGAGGTAGCTATACAGAAGTATTTGCAATCGAAGATTTAGTTAACCGAGATCAACCTAAAGTT
CTCAAGTCTCTGAAAGAGGTAACGCCACAACTAGAACGACTTTTTCAGCAAGAAGCATCAATATTGAACACGTTGCGACA
TCCTGGGTTACCTATTGGCGAAGCACTATTTCCCCTGGTTTTAAACACAGGTCGTCAATTGTGGTGTTTTGTGATGGAGA
AAATTCCTGGTGAAGATTTACAGACTTGGTTATCTCACCATCAATATGTAACATCTTATAAAACAGCATTAGATTGGCTA
AAACAACTAACGCAGATTCTCCAATTCGTACATGAGGAAAAGTTTTTCCATCGGGATATCAAGCCAGCAAATATTATGGT
TTGTCCTGATGGAAAACTGGTGTTAATTGATTTTGGTGCGGCGCGTAAAGTGACACAGACAATCATCAACCGTGAGTCCG
TCACCATAGTTCATTCCCTTGGTTATACTGCACCCGAACAACGTGATGGTCACGCCGTTGTGCAGTCAGATTTTTATGCA
CTGGGTCGGACTTTGATCTATTTACTCACAGGCATTGACCCAACAGGCGATCGCGCTCAAGATTTACTCAATTGGTCTAA
ATATATTCAAGACCCAAAAACTCCCAAAAAATTCATCTCTTTGCTTCAGGTAATGACAGATTCTCATCCCTACCACCGTC
CGCCTACAGCACAAGCAATTCTCGAAAAGATTGAAAAAATTGACCAGCATTCGCACCAATGGCCAAAATTATTGCTGAGT
GCTACTTGTGGTGTGTTATTGCTGTTCGCGGGAAAATCCTTATACCAGGAAATTACATTACCTCGGACTTGTGACAACAT
ACTCAACGATTATCTTAGTTGTGGAGAAGAAAGCCTCACTCCCAGTAGCTTTTGGGGTAATAGTCAGCCGCCACCAGCAA
AGCAATTAGGAATGGAACAGTATCGTAATCGAAATTTCGGCGCAGCCGTGAATTTCCTAGAAACTGCTTTCCAGCAAGAA
TCAGACCCAGAAACGTTAATTTACCTCAACAATGCCAAAATTCACCAGCAATTTCCCGCAAATCAAATTTATACTATCGC
CGTTGCAGTCCCCCTGGAACGACGCACAGATATAGGTCGGGAAATACTCAGAGGTGTAGCGCAAGCTCAAACTGAAGCAC
TAAAAAAAGGTCGAGCTTTACGCATTATCATTGCTGATGATAGTAATCGGGAAGATAGCAAAACGGGTAATAATGCCCGT
AAAATTGCCCAGCATTTAGTAAAATATCGTGATTTACTGGCTGTTTTGGGTCACTATAGCAGCGAAGCCACCAAAAATTC
TTTACCAATTTATAGCCAAGCCAGAGTAGTCTTAATTTCTGCTACTAGCACTTCTCAAAATCTCAAAGACCCTTTTTTCT
TTCGTACTGTCCCTAGCGATCGCATCGCAGCCCAAAAAATGGTAACTTACTTGTTGTCTGCATTGAAACAGAATCAAGTA
GCTATCTTTTATAGTCGAGGTAGTGAGTATGCTGAATCTCTTTCCCAGGCTGTTCGAGAAAGCACAAAATCACTTCCTCT
AAAGGTGATTGATCATCAAGCAGCTTTTAATTTAGCCAGCGATCGCTTCAACGCCATAACAGCGCTAAATCAAGCTCAAA
CCCAAGGTGCAAAGGCAATTGTCCTGATCCCCGATGCCGGAGTAGGGTTGTATAATGCAATTCCCAATGCCTTACGAGTG
ATTCAGTCGAATATCAATCAAGTTTGGATTGTTGCAGGTGACAGCCTCTATAGTTCTGATTCGTTCACATCAGAGAAAGC
TTTCTCTTCACCCGAAATCAAATACACAGCTTGGGCAGTTTTTTGGCATCCCCTCAATGAGATAAATTCAACGTTTGTCA
AGGAAGTCCAAAACCTCTGGAAAATTGATATACTGTCAATCCTCAGCAACACAAACATTACATGGCGAACAGCAACTAGC
TACGATGCAACATTAGTTTTGAGTCAAGCCATCACCCAAAATCCTACTCGCCTCGGCATTAAAAAAACACTCAGCCAACC
TCAATTTTCCGTTACAGGTGCAACAGGAGTAATTCAATTTGCCGGAAGCGATCGCCAAAATGGAAAAATTACGATGGTAA
GAGTCCAGCGTAATTGTGATGATAATGGTTTTTTCTTTATTCCTAGCGATCGCTCTTTACAATGCCAGTAG

Upstream 100 bases:

>100_bases
TCTCTTCTCTCCTGCTCCTCTGCCTCTTCCCCTTCCCCATTCCCTGCCATTAGTAAAAACTCTGAAATAAAGTGTTGGAA
AAGGCTTTTTTTAACAGGTT

Downstream 100 bases:

>100_bases
TTGGTATATCAAGCTTGAGCTACTGGAAACTGTAGTTCTGTTACATAGGAATCATTATTCTGCTCATTGCCACCAATGAT
ATAAACTTCGCGGTTAGGAG

Product: serine/threonine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 796; Mature: 796

Protein sequence:

>796_residues
MVLEYVYCLLAFCLYFMAYCINPDCSQRENPDTSAVCQNCGTPLILQNRYRLRHFLRTDRGSYTEVFAIEDLVNRDQPKV
LKSLKEVTPQLERLFQQEASILNTLRHPGLPIGEALFPLVLNTGRQLWCFVMEKIPGEDLQTWLSHHQYVTSYKTALDWL
KQLTQILQFVHEEKFFHRDIKPANIMVCPDGKLVLIDFGAARKVTQTIINRESVTIVHSLGYTAPEQRDGHAVVQSDFYA
LGRTLIYLLTGIDPTGDRAQDLLNWSKYIQDPKTPKKFISLLQVMTDSHPYHRPPTAQAILEKIEKIDQHSHQWPKLLLS
ATCGVLLLFAGKSLYQEITLPRTCDNILNDYLSCGEESLTPSSFWGNSQPPPAKQLGMEQYRNRNFGAAVNFLETAFQQE
SDPETLIYLNNAKIHQQFPANQIYTIAVAVPLERRTDIGREILRGVAQAQTEALKKGRALRIIIADDSNREDSKTGNNAR
KIAQHLVKYRDLLAVLGHYSSEATKNSLPIYSQARVVLISATSTSQNLKDPFFFRTVPSDRIAAQKMVTYLLSALKQNQV
AIFYSRGSEYAESLSQAVRESTKSLPLKVIDHQAAFNLASDRFNAITALNQAQTQGAKAIVLIPDAGVGLYNAIPNALRV
IQSNINQVWIVAGDSLYSSDSFTSEKAFSSPEIKYTAWAVFWHPLNEINSTFVKEVQNLWKIDILSILSNTNITWRTATS
YDATLVLSQAITQNPTRLGIKKTLSQPQFSVTGATGVIQFAGSDRQNGKITMVRVQRNCDDNGFFFIPSDRSLQCQ

Sequences:

>Translated_796_residues
MVLEYVYCLLAFCLYFMAYCINPDCSQRENPDTSAVCQNCGTPLILQNRYRLRHFLRTDRGSYTEVFAIEDLVNRDQPKV
LKSLKEVTPQLERLFQQEASILNTLRHPGLPIGEALFPLVLNTGRQLWCFVMEKIPGEDLQTWLSHHQYVTSYKTALDWL
KQLTQILQFVHEEKFFHRDIKPANIMVCPDGKLVLIDFGAARKVTQTIINRESVTIVHSLGYTAPEQRDGHAVVQSDFYA
LGRTLIYLLTGIDPTGDRAQDLLNWSKYIQDPKTPKKFISLLQVMTDSHPYHRPPTAQAILEKIEKIDQHSHQWPKLLLS
ATCGVLLLFAGKSLYQEITLPRTCDNILNDYLSCGEESLTPSSFWGNSQPPPAKQLGMEQYRNRNFGAAVNFLETAFQQE
SDPETLIYLNNAKIHQQFPANQIYTIAVAVPLERRTDIGREILRGVAQAQTEALKKGRALRIIIADDSNREDSKTGNNAR
KIAQHLVKYRDLLAVLGHYSSEATKNSLPIYSQARVVLISATSTSQNLKDPFFFRTVPSDRIAAQKMVTYLLSALKQNQV
AIFYSRGSEYAESLSQAVRESTKSLPLKVIDHQAAFNLASDRFNAITALNQAQTQGAKAIVLIPDAGVGLYNAIPNALRV
IQSNINQVWIVAGDSLYSSDSFTSEKAFSSPEIKYTAWAVFWHPLNEINSTFVKEVQNLWKIDILSILSNTNITWRTATS
YDATLVLSQAITQNPTRLGIKKTLSQPQFSVTGATGVIQFAGSDRQNGKITMVRVQRNCDDNGFFFIPSDRSLQCQ
>Mature_796_residues
MVLEYVYCLLAFCLYFMAYCINPDCSQRENPDTSAVCQNCGTPLILQNRYRLRHFLRTDRGSYTEVFAIEDLVNRDQPKV
LKSLKEVTPQLERLFQQEASILNTLRHPGLPIGEALFPLVLNTGRQLWCFVMEKIPGEDLQTWLSHHQYVTSYKTALDWL
KQLTQILQFVHEEKFFHRDIKPANIMVCPDGKLVLIDFGAARKVTQTIINRESVTIVHSLGYTAPEQRDGHAVVQSDFYA
LGRTLIYLLTGIDPTGDRAQDLLNWSKYIQDPKTPKKFISLLQVMTDSHPYHRPPTAQAILEKIEKIDQHSHQWPKLLLS
ATCGVLLLFAGKSLYQEITLPRTCDNILNDYLSCGEESLTPSSFWGNSQPPPAKQLGMEQYRNRNFGAAVNFLETAFQQE
SDPETLIYLNNAKIHQQFPANQIYTIAVAVPLERRTDIGREILRGVAQAQTEALKKGRALRIIIADDSNREDSKTGNNAR
KIAQHLVKYRDLLAVLGHYSSEATKNSLPIYSQARVVLISATSTSQNLKDPFFFRTVPSDRIAAQKMVTYLLSALKQNQV
AIFYSRGSEYAESLSQAVRESTKSLPLKVIDHQAAFNLASDRFNAITALNQAQTQGAKAIVLIPDAGVGLYNAIPNALRV
IQSNINQVWIVAGDSLYSSDSFTSEKAFSSPEIKYTAWAVFWHPLNEINSTFVKEVQNLWKIDILSILSNTNITWRTATS
YDATLVLSQAITQNPTRLGIKKTLSQPQFSVTGATGVIQFAGSDRQNGKITMVRVQRNCDDNGFFFIPSDRSLQCQ

Specific function: Protein kinase required for cell motility, but not for phototaxis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI4502557, Length=239, Percent_Identity=26.7782426778243, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193203107, Length=201, Percent_Identity=27.8606965174129, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71989911, Length=208, Percent_Identity=27.4038461538462, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71989893, Length=201, Percent_Identity=27.8606965174129, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71989905, Length=201, Percent_Identity=27.8606965174129, Blast_Score=72, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71989900, Length=201, Percent_Identity=27.8606965174129, Blast_Score=72, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI72000588, Length=246, Percent_Identity=27.2357723577236, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17564376, Length=246, Percent_Identity=27.2357723577236, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17564378, Length=246, Percent_Identity=27.2357723577236, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319502, Length=211, Percent_Identity=29.3838862559242, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161077455, Length=179, Percent_Identity=31.8435754189944, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161077453, Length=179, Percent_Identity=31.8435754189944, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001646
- InterPro:   IPR020636
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017441
- InterPro:   IPR017442
- InterPro:   IPR016252 [H]

Pfam domain/function: PF00805 Pentapeptide; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 89758; Mature: 89758

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS00108 PROTEIN_KINASE_ST ; PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLEYVYCLLAFCLYFMAYCINPDCSQRENPDTSAVCQNCGTPLILQNRYRLRHFLRTDR
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCEEECCHHHHHHHHHCCC
GSYTEVFAIEDLVNRDQPKVLKSLKEVTPQLERLFQQEASILNTLRHPGLPIGEALFPLV
CCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LNTGRQLWCFVMEKIPGEDLQTWLSHHQYVTSYKTALDWLKQLTQILQFVHEEKFFHRDI
HHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KPANIMVCPDGKLVLIDFGAARKVTQTIINRESVTIVHSLGYTAPEQRDGHAVVQSDFYA
CCCEEEECCCCCEEEEECCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHH
LGRTLIYLLTGIDPTGDRAQDLLNWSKYIQDPKTPKKFISLLQVMTDSHPYHRPPTAQAI
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHH
LEKIEKIDQHSHQWPKLLLSATCGVLLLFAGKSLYQEITLPRTCDNILNDYLSCGEESLT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
PSSFWGNSQPPPAKQLGMEQYRNRNFGAAVNFLETAFQQESDPETLIYLNNAKIHQQFPA
CCCCCCCCCCCCHHHHCHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHCCCCC
NQIYTIAVAVPLERRTDIGREILRGVAQAQTEALKKGRALRIIIADDSNREDSKTGNNAR
CCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHH
KIAQHLVKYRDLLAVLGHYSSEATKNSLPIYSQARVVLISATSTSQNLKDPFFFRTVPSD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCH
RIAAQKMVTYLLSALKQNQVAIFYSRGSEYAESLSQAVRESTKSLPLKVIDHQAAFNLAS
HHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHH
DRFNAITALNQAQTQGAKAIVLIPDAGVGLYNAIPNALRVIQSNINQVWIVAGDSLYSSD
HHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCEECCC
SFTSEKAFSSPEIKYTAWAVFWHPLNEINSTFVKEVQNLWKIDILSILSNTNITWRTATS
CCCCHHCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
YDATLVLSQAITQNPTRLGIKKTLSQPQFSVTGATGVIQFAGSDRQNGKITMVRVQRNCD
CCHHHHHHHHHHCCCHHHHHHHHHCCCCEEECCCCEEEEECCCCCCCCCEEEEEEECCCC
DNGFFFIPSDRSLQCQ
CCCEEEEECCCCCCCC
>Mature Secondary Structure
MVLEYVYCLLAFCLYFMAYCINPDCSQRENPDTSAVCQNCGTPLILQNRYRLRHFLRTDR
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCEEECCHHHHHHHHHCCC
GSYTEVFAIEDLVNRDQPKVLKSLKEVTPQLERLFQQEASILNTLRHPGLPIGEALFPLV
CCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LNTGRQLWCFVMEKIPGEDLQTWLSHHQYVTSYKTALDWLKQLTQILQFVHEEKFFHRDI
HHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KPANIMVCPDGKLVLIDFGAARKVTQTIINRESVTIVHSLGYTAPEQRDGHAVVQSDFYA
CCCEEEECCCCCEEEEECCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHH
LGRTLIYLLTGIDPTGDRAQDLLNWSKYIQDPKTPKKFISLLQVMTDSHPYHRPPTAQAI
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHH
LEKIEKIDQHSHQWPKLLLSATCGVLLLFAGKSLYQEITLPRTCDNILNDYLSCGEESLT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
PSSFWGNSQPPPAKQLGMEQYRNRNFGAAVNFLETAFQQESDPETLIYLNNAKIHQQFPA
CCCCCCCCCCCCHHHHCHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHCCCCC
NQIYTIAVAVPLERRTDIGREILRGVAQAQTEALKKGRALRIIIADDSNREDSKTGNNAR
CCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHH
KIAQHLVKYRDLLAVLGHYSSEATKNSLPIYSQARVVLISATSTSQNLKDPFFFRTVPSD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCH
RIAAQKMVTYLLSALKQNQVAIFYSRGSEYAESLSQAVRESTKSLPLKVIDHQAAFNLAS
HHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHH
DRFNAITALNQAQTQGAKAIVLIPDAGVGLYNAIPNALRVIQSNINQVWIVAGDSLYSSD
HHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCEECCC
SFTSEKAFSSPEIKYTAWAVFWHPLNEINSTFVKEVQNLWKIDILSILSNTNITWRTATS
CCCCHHCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
YDATLVLSQAITQNPTRLGIKKTLSQPQFSVTGATGVIQFAGSDRQNGKITMVRVQRNCD
CCHHHHHHHHHHCCCHHHHHHHHHCCCCEEECCCCEEEEECCCCCCCCCEEEEEEECCCC
DNGFFFIPSDRSLQCQ
CCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12732981; 8905231 [H]