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The map label for this gene is thrB [H]

Identifier: 17227842

GI number: 17227842

Start: 397530

End: 398114

Strand: Direct

Name: thrB [H]

Synonym: alr0346

Alternate gene names: 17227842

Gene position: 397530-398114 (Clockwise)

Preceding gene: 17227840

Following gene: 17227843

Centisome position: 6.2

GC content: 50.94

Gene sequence:

>585_bases
GTGGCGGCGAATCGATTGGCTGGTGAGCCTTTGTCTCAGGCGCAGGTGATGGCATTAGCGATCGCCATCGAAGGACATCC
TGATAATGTCGTACCCGCTTTGTTGGGGGGATGTCGTCTGGCGGCTACTGGTGCTAGTGGTTGGGAAATTTGTGATGTTC
CCTGGCATAGTCATATTGTCCCAGTACTGGCAATTCCCGATTTTGAATTGTCCACCTCAGAGGCGCGGCGAGTTTTACCA
ACAGAATATAGTCGTGCAGATGCGATTTTTAATACTGCCCATTTGGGGTTATTGTTGCGCGGCTTGGAAACAGGTAAGGG
AGAATGGTTAAGGGCAGCTTTACAAGATAAGTTACATCAGCCTTATCGCCAAGCTTTAATTCCTGGTTACGATGCTGTGA
ATACTGCGGCTGTAGCTGCTGGTGCTTACGGTATGGTGATTAGTGGCGCGGGGCCGACTTTGTTGGCTTTAGCGGATGTG
TCTCATGCGGCAGCTGTTGAGGCGGCAATGTCCACAGCTTGGCAAGAAGCAGGAATTACGGCTGTAGTGCGATCGCTTGC
TCTCGATACTCATGGCGCAACTTAA

Upstream 100 bases:

>100_bases
TATAGATCAGCCAGCGCCAGGGGTAAAAATCGAAATTGAGTTGGGTGTACCACTGGCGAGGGGTTTGGGTAGTTCAGCCA
CGGCGATTGTTGGGGGTTTG

Downstream 100 bases:

>100_bases
CAATTCAAAATTCAACATGAAAGAACTTAATCCCAGCTTGCCTTTAAAGCAAATTCAGTCGGAGATGACAGCACTCAAGT
CGCAAATTCAAGTGCTGGAG

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MAANRLAGEPLSQAQVMALAIAIEGHPDNVVPALLGGCRLAATGASGWEICDVPWHSHIVPVLAIPDFELSTSEARRVLP
TEYSRADAIFNTAHLGLLLRGLETGKGEWLRAALQDKLHQPYRQALIPGYDAVNTAAVAAGAYGMVISGAGPTLLALADV
SHAAAVEAAMSTAWQEAGITAVVRSLALDTHGAT

Sequences:

>Translated_194_residues
MAANRLAGEPLSQAQVMALAIAIEGHPDNVVPALLGGCRLAATGASGWEICDVPWHSHIVPVLAIPDFELSTSEARRVLP
TEYSRADAIFNTAHLGLLLRGLETGKGEWLRAALQDKLHQPYRQALIPGYDAVNTAAVAAGAYGMVISGAGPTLLALADV
SHAAAVEAAMSTAWQEAGITAVVRSLALDTHGAT
>Mature_193_residues
AANRLAGEPLSQAQVMALAIAIEGHPDNVVPALLGGCRLAATGASGWEICDVPWHSHIVPVLAIPDFELSTSEARRVLPT
EYSRADAIFNTAHLGLLLRGLETGKGEWLRAALQDKLHQPYRQALIPGYDAVNTAAVAAGAYGMVISGAGPTLLALADVS
HAAAVEAAMSTAWQEAGITAVVRSLALDTHGAT

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=202, Percent_Identity=33.6633663366337, Blast_Score=97, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321814, Length=195, Percent_Identity=31.2820512820513, Blast_Score=90, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 20134; Mature: 20003

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAANRLAGEPLSQAQVMALAIAIEGHPDNVVPALLGGCRLAATGASGWEICDVPWHSHIV
CCCCCCCCCCCHHHHEEEEEEEEECCCCCHHHHHHCCCEEEECCCCCCEEECCCCCCCEE
PVLAIPDFELSTSEARRVLPTEYSRADAIFNTAHLGLLLRGLETGKGEWLRAALQDKLHQ
EEEEECCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
PYRQALIPGYDAVNTAAVAAGAYGMVISGAGPTLLALADVSHAAAVEAAMSTAWQEAGIT
HHHHHHCCCCCHHHHHHHHCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHCCHH
AVVRSLALDTHGAT
HHHHHHHHHCCCCC
>Mature Secondary Structure 
AANRLAGEPLSQAQVMALAIAIEGHPDNVVPALLGGCRLAATGASGWEICDVPWHSHIV
CCCCCCCCCCHHHHEEEEEEEEECCCCCHHHHHHCCCEEEECCCCCCEEECCCCCCCEE
PVLAIPDFELSTSEARRVLPTEYSRADAIFNTAHLGLLLRGLETGKGEWLRAALQDKLHQ
EEEEECCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
PYRQALIPGYDAVNTAAVAAGAYGMVISGAGPTLLALADVSHAAAVEAAMSTAWQEAGIT
HHHHHHCCCCCHHHHHHHHCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHCCHH
AVVRSLALDTHGAT
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA