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The map label for this gene is ndhA [H]

Identifier: 17227719

GI number: 17227719

Start: 239773

End: 240891

Strand: Direct

Name: ndhA [H]

Synonym: alr0223

Alternate gene names: 17227719

Gene position: 239773-240891 (Clockwise)

Preceding gene: 17227718

Following gene: 17227720

Centisome position: 3.74

GC content: 46.11

Gene sequence:

>1119_bases
ATGAATTCAGGAATTGACCTCCAAGGAACGTTTATTAAATCCCTAATCGATTTAGGAATCCCACCCGGAACGGCTAAAGC
GATTTGGATGCCTCTGCCCATGATCCTGATGCTGATTGGGGCGACGGTGGGCGTGCTGGTTTGTGTTTGGCTAGAACGGA
AGATTTCGGCAGCCGCACAGCAACGGATTGGCCCTGAATACATTGGGCCTTTGGGCTTGCTAGCTCCGGTAGCCGATGGT
CTCAAGCTGGTATTTAAAGAAGATATTGTACCGGCTCAGGCTGACCCTTGGCTATTTACTCTCGGCCCGATTCTTGTAGT
CTTGCCAGTATTTTTGTCTTATTTGATTGTTCCTTTCGGACAGAATATTGTCATTACTAATGTAGGTACAGGGATATTTC
TGTGGATTGCTTTATCTAGCATCCAACCCATTGGCTTGTTGATGGCTGGCTACTCTTCCAATAACAAGTATTCCCTACTA
GGGGGTTTGCGAGCAGCAGCACAATCAATTAGTTACGAAATTCCCTTGGCGCTGAGTGTGTTGGCGATCGTTATGATGTC
TAACAGCCTCAGTACTGTAGATATTGTTAACCAACAATCTGACTACGGTATTCTGGGCTGGAACATTTGGCGACAACCCC
TTGGTTTTATGATCTTTTGGATAGCCGCCCTTGCAGAATGCGAACGTTTGCCCTTCGACTTACCGGAAGCGGAAGAAGAA
CTAGTAGCAGGCTATCAAACTGAATACTCAGGGATGAAATTTGCGCTGTTCTACCTCAGTTCCTACGTTAACCTAATCCT
GTCGGCTCTTTTGGTGGCAGTATTGTACTTGGGTGGTTGGGATTTTCCCATTCCCATCAATGTCTTAGCTAATTTGGTGG
GAGTCAGTGAAGCAAATCCTGTATTACAGGTGGTCAGCGCTGCCTTAGGTATCACCATGACCTTAGTCAAGGCTTACTTT
TTAGTATTTATTGCCATCCTCTTGCGTTGGACAGTACCAAGGGTAAGGATTGACCAGTTGTTAGATTTAGGATGGAAGTT
TTTGTTACCAGTTGGTTTAGTGAACCTACTTTTAACCGCAGCCCTGAAACTGGCTTTTCCCGTCGCCTTCGGCGGGTAA

Upstream 100 bases:

>100_bases
AGGTGTCATCTCAGCAGAGATATTAATGGGTGTGGTTGCAGGTATTAGTTTAACTAATGTTTGAGCTTCACCATGACTTG
ATGACTTAAAGAGCGAAAAC

Downstream 100 bases:

>100_bases
TCGGTAATCGGTAATCGGTAATGGAAAAATCATTACCAATTACCTGTTACCAATTACCAATTACCTCAAAAGAGTAGAGA
GACACAAAATGCTAAAGTTC

Product: NADH dehydrogenase subunit H

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I subunit 1; NDH-1 subunit 1; NDH-A [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MNSGIDLQGTFIKSLIDLGIPPGTAKAIWMPLPMILMLIGATVGVLVCVWLERKISAAAQQRIGPEYIGPLGLLAPVADG
LKLVFKEDIVPAQADPWLFTLGPILVVLPVFLSYLIVPFGQNIVITNVGTGIFLWIALSSIQPIGLLMAGYSSNNKYSLL
GGLRAAAQSISYEIPLALSVLAIVMMSNSLSTVDIVNQQSDYGILGWNIWRQPLGFMIFWIAALAECERLPFDLPEAEEE
LVAGYQTEYSGMKFALFYLSSYVNLILSALLVAVLYLGGWDFPIPINVLANLVGVSEANPVLQVVSAALGITMTLVKAYF
LVFIAILLRWTVPRVRIDQLLDLGWKFLLPVGLVNLLLTAALKLAFPVAFGG

Sequences:

>Translated_372_residues
MNSGIDLQGTFIKSLIDLGIPPGTAKAIWMPLPMILMLIGATVGVLVCVWLERKISAAAQQRIGPEYIGPLGLLAPVADG
LKLVFKEDIVPAQADPWLFTLGPILVVLPVFLSYLIVPFGQNIVITNVGTGIFLWIALSSIQPIGLLMAGYSSNNKYSLL
GGLRAAAQSISYEIPLALSVLAIVMMSNSLSTVDIVNQQSDYGILGWNIWRQPLGFMIFWIAALAECERLPFDLPEAEEE
LVAGYQTEYSGMKFALFYLSSYVNLILSALLVAVLYLGGWDFPIPINVLANLVGVSEANPVLQVVSAALGITMTLVKAYF
LVFIAILLRWTVPRVRIDQLLDLGWKFLLPVGLVNLLLTAALKLAFPVAFGG
>Mature_372_residues
MNSGIDLQGTFIKSLIDLGIPPGTAKAIWMPLPMILMLIGATVGVLVCVWLERKISAAAQQRIGPEYIGPLGLLAPVADG
LKLVFKEDIVPAQADPWLFTLGPILVVLPVFLSYLIVPFGQNIVITNVGTGIFLWIALSSIQPIGLLMAGYSSNNKYSLL
GGLRAAAQSISYEIPLALSVLAIVMMSNSLSTVDIVNQQSDYGILGWNIWRQPLGFMIFWIAALAECERLPFDLPEAEEE
LVAGYQTEYSGMKFALFYLSSYVNLILSALLVAVLYLGGWDFPIPINVLANLVGVSEANPVLQVVSAALGITMTLVKAYF
LVFIAILLRWTVPRVRIDQLLDLGWKFLLPVGLVNLLLTAALKLAFPVAFGG

Specific function: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=306, Percent_Identity=33.9869281045752, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1788618, Length=332, Percent_Identity=37.9518072289157, Blast_Score=224, Evalue=5e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: 1.6.5.3

Molecular weight: Translated: 40321; Mature: 40321

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00667 COMPLEX1_ND1_1 ; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSGIDLQGTFIKSLIDLGIPPGTAKAIWMPLPMILMLIGATVGVLVCVWLERKISAAAQ
CCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRIGPEYIGPLGLLAPVADGLKLVFKEDIVPAQADPWLFTLGPILVVLPVFLSYLIVPFG
HCCCHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
QNIVITNVGTGIFLWIALSSIQPIGLLMAGYSSNNKYSLLGGLRAAAQSISYEIPLALSV
CCEEEEECCCHHHHHHHHHCCCHHHHHEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHH
LAIVMMSNSLSTVDIVNQQSDYGILGWNIWRQPLGFMIFWIAALAECERLPFDLPEAEEE
HHHHHHCCCCCCEEEECCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LVAGYQTEYSGMKFALFYLSSYVNLILSALLVAVLYLGGWDFPIPINVLANLVGVSEANP
HHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCH
VLQVVSAALGITMTLVKAYFLVFIAILLRWTVPRVRIDQLLDLGWKFLLPVGLVNLLLTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALKLAFPVAFGG
HHHHHHHHCCCC
>Mature Secondary Structure
MNSGIDLQGTFIKSLIDLGIPPGTAKAIWMPLPMILMLIGATVGVLVCVWLERKISAAAQ
CCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRIGPEYIGPLGLLAPVADGLKLVFKEDIVPAQADPWLFTLGPILVVLPVFLSYLIVPFG
HCCCHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
QNIVITNVGTGIFLWIALSSIQPIGLLMAGYSSNNKYSLLGGLRAAAQSISYEIPLALSV
CCEEEEECCCHHHHHHHHHCCCHHHHHEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHH
LAIVMMSNSLSTVDIVNQQSDYGILGWNIWRQPLGFMIFWIAALAECERLPFDLPEAEEE
HHHHHHCCCCCCEEEECCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LVAGYQTEYSGMKFALFYLSSYVNLILSALLVAVLYLGGWDFPIPINVLANLVGVSEANP
HHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCH
VLQVVSAALGITMTLVKAYFLVFIAILLRWTVPRVRIDQLLDLGWKFLLPVGLVNLLLTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALKLAFPVAFGG
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA