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The map label for this gene is hilA [H]

Identifier: 16766182

GI number: 16766182

Start: 3019856

End: 3021517

Strand: Direct

Name: hilA [H]

Synonym: STM2876

Alternate gene names: 16766182

Gene position: 3019856-3021517 (Clockwise)

Preceding gene: 16766181

Following gene: 16766183

Centisome position: 62.17

GC content: 43.14

Gene sequence:

>1662_bases
ATGCCACATTTTAATCCTGTTCCTGTATCGAATAAAAAATTCGTCTTTGATGATTTCATACTCAACATGGACGGCTCCCT
GCTACGCTCAGAAAAGAAAGTCAATATTCCGCCAAAAGAATATGCCGTTCTGGTCATCCTGCTCGAAGCCGCCGGCGAGA
TTGTGAGTAAAAACACCTTACTGGACCAGGTATGGGGCGACGCGGAAGTTAACGAAGAATCTCTTACCCGCTGTATTTAT
GCCTTACGACGTATTCTGTCGGAAGATAAAGAGCATCGTTACATTGAAACACTGTACGGACAGGGCTATCGGTTTAATCG
TCCGGTCGTAGTGGTGTCTCCGCCAGCGCCGCAACCTACGACTCATACATTGGCGATACTTCCTTTTCAGATGCAGGATC
AGGTTCAATCCGAGAGTCTGCATTACTCTATCGTGAAGGGATTATCGCAGTATGCGCCCTTTGGCCTGAGCGTGCTGCCG
GTGACCATTACGAAGAACTGCCGCAGTGTTAAGGATATTCTTGAGCTCATGGATCAATTACGCCCCGATTATTATATCTC
CGGGCAGATGATACCCGATGGTAATGATAATATTGTACAGATTGAGATAGTTCGGGTTAAAGGTTATCACCTGCTGCACC
AGGAAAGCATTAAGTTGATAGAACACCAACCCGCTTCTCTCTTGCAAAACAAAATTGCGAATCTTTTGCTCAGATGTATT
CCCGGACTTCGCTGGGACACAAAGCAGATTAGCGAGCTAAATTCGATTGACAGTACTATGGTTTACTTACGCGGTAAGCA
TGAGTTAAATCAATACACCCCCTATAGCTTACAGCAAGCGCTTAAATTGCTGACTCAATGCGTTAACATGTCGCCAAACA
GCATTGCGCCTTACTGTGCGCTGGCAGAATGCTACCTCAGCATGGCGCAAATGGGGATTTTTGATAAACAAAACGCTATG
ATCAAAGCTAAAGAACATGCGATTAAGGCGACAGAGCTGGACCACAATAATCCACAAGCTTTAGGATTACTGGGGCTAAT
TAATACGATTCACTCAGAATACATCGTCGGGAGTTTGCTATTCAAACAAGCTAACTTACTTTCGCCCATTTCTGCAGATA
TTAAATATTATTATGGCTGGAATCTTTTCATGGCTGGTCAGTTGGAGGAGGCCTTACAAACGATTAACGAGTGTTTAAAA
TTGGACCCAACGCGCGCAGCCGCAGGGATCACTAAGCTGTGGATTACCTATTATCATACCGGTATTGATGATGCTATACG
TTTAGGCGATGAATTACGCTCACAACACCTGCAGGATAATCCAATATTATTAAGTATGCAGGTTATGTTTCTTTCGCTTA
AAGGTAAACATGAACTGGCACGAAAATTAACTAAAGAAATATCCACGCAGGAAATAACAGGACTTATTGCTGTTAATCTT
CTTTACGCTGAATATTGTCAGAATAGTGAGCGTGCCTTACCGACGATAAGAGAATTTCTGGAAAGTGAACAGCGTATAGA
TAATAATCCGGGATTATTACCGTTAGTGCTGGTTGCCCACGGCGAAGCTATTGCCGAGAAAATGTGGAATAAATTTAAAA
ACGAAGACAATATTTGGTTCAAAAGATGGAAACAGGATCCCCGCTTGATTAAATTACGGTAA

Upstream 100 bases:

>100_bases
GTTAGTACTAACAGCAGAATTACTGAAACAGTAGATTCTATCCTAACGACTTGTATTAGTTATTATAACTTTTCACCCTG
TAAGAGAATACACTATTATC

Downstream 100 bases:

>100_bases
AATCTGAGAGAGGAGATATGCATTATTTTTTTATCATCGTAATCTGGTTGCTTAGCATAAATACGGCATGGGCTGATTGC
TGGCTTCAGGCTGAAAAAAT

Product: invasion protein regulator

Products: NA

Alternate protein names: Protein iagA [H]

Number of amino acids: Translated: 553; Mature: 552

Protein sequence:

>553_residues
MPHFNPVPVSNKKFVFDDFILNMDGSLLRSEKKVNIPPKEYAVLVILLEAAGEIVSKNTLLDQVWGDAEVNEESLTRCIY
ALRRILSEDKEHRYIETLYGQGYRFNRPVVVVSPPAPQPTTHTLAILPFQMQDQVQSESLHYSIVKGLSQYAPFGLSVLP
VTITKNCRSVKDILELMDQLRPDYYISGQMIPDGNDNIVQIEIVRVKGYHLLHQESIKLIEHQPASLLQNKIANLLLRCI
PGLRWDTKQISELNSIDSTMVYLRGKHELNQYTPYSLQQALKLLTQCVNMSPNSIAPYCALAECYLSMAQMGIFDKQNAM
IKAKEHAIKATELDHNNPQALGLLGLINTIHSEYIVGSLLFKQANLLSPISADIKYYYGWNLFMAGQLEEALQTINECLK
LDPTRAAAGITKLWITYYHTGIDDAIRLGDELRSQHLQDNPILLSMQVMFLSLKGKHELARKLTKEISTQEITGLIAVNL
LYAEYCQNSERALPTIREFLESEQRIDNNPGLLPLVLVAHGEAIAEKMWNKFKNEDNIWFKRWKQDPRLIKLR

Sequences:

>Translated_553_residues
MPHFNPVPVSNKKFVFDDFILNMDGSLLRSEKKVNIPPKEYAVLVILLEAAGEIVSKNTLLDQVWGDAEVNEESLTRCIY
ALRRILSEDKEHRYIETLYGQGYRFNRPVVVVSPPAPQPTTHTLAILPFQMQDQVQSESLHYSIVKGLSQYAPFGLSVLP
VTITKNCRSVKDILELMDQLRPDYYISGQMIPDGNDNIVQIEIVRVKGYHLLHQESIKLIEHQPASLLQNKIANLLLRCI
PGLRWDTKQISELNSIDSTMVYLRGKHELNQYTPYSLQQALKLLTQCVNMSPNSIAPYCALAECYLSMAQMGIFDKQNAM
IKAKEHAIKATELDHNNPQALGLLGLINTIHSEYIVGSLLFKQANLLSPISADIKYYYGWNLFMAGQLEEALQTINECLK
LDPTRAAAGITKLWITYYHTGIDDAIRLGDELRSQHLQDNPILLSMQVMFLSLKGKHELARKLTKEISTQEITGLIAVNL
LYAEYCQNSERALPTIREFLESEQRIDNNPGLLPLVLVAHGEAIAEKMWNKFKNEDNIWFKRWKQDPRLIKLR
>Mature_552_residues
PHFNPVPVSNKKFVFDDFILNMDGSLLRSEKKVNIPPKEYAVLVILLEAAGEIVSKNTLLDQVWGDAEVNEESLTRCIYA
LRRILSEDKEHRYIETLYGQGYRFNRPVVVVSPPAPQPTTHTLAILPFQMQDQVQSESLHYSIVKGLSQYAPFGLSVLPV
TITKNCRSVKDILELMDQLRPDYYISGQMIPDGNDNIVQIEIVRVKGYHLLHQESIKLIEHQPASLLQNKIANLLLRCIP
GLRWDTKQISELNSIDSTMVYLRGKHELNQYTPYSLQQALKLLTQCVNMSPNSIAPYCALAECYLSMAQMGIFDKQNAMI
KAKEHAIKATELDHNNPQALGLLGLINTIHSEYIVGSLLFKQANLLSPISADIKYYYGWNLFMAGQLEEALQTINECLKL
DPTRAAAGITKLWITYYHTGIDDAIRLGDELRSQHLQDNPILLSMQVMFLSLKGKHELARKLTKEISTQEITGLIAVNLL
YAEYCQNSERALPTIREFLESEQRIDNNPGLLPLVLVAHGEAIAEKMWNKFKNEDNIWFKRWKQDPRLIKLR

Specific function: The main transcriptional regulator of the Salmonella pathogenicity island 1 (SPI1) gene expression. Activates the expression of invasion genes by a direct action at their promoters and also indirectly by increasing the level of invF. Also binds upstream o

COG id: COG0457

COG function: function code R; FOG: TPR repeat

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TPR repeat [H]

Homologues:

Organism=Escherichia coli, GI1789216, Length=403, Percent_Identity=29.2803970223325, Blast_Score=167, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 63042; Mature: 62911

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS50005 TPR ; PS50293 TPR_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHFNPVPVSNKKFVFDDFILNMDGSLLRSEKKVNIPPKEYAVLVILLEAAGEIVSKNTL
CCCCCCCCCCCCCEEEEHHHCCCCCHHHHCCCCCCCCCHHHEEHEEEHHHHHHHHHHHHH
LDQVWGDAEVNEESLTRCIYALRRILSEDKEHRYIETLYGQGYRFNRPVVVVSPPAPQPT
HHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEECCCEEEECCCCCCCC
THTLAILPFQMQDQVQSESLHYSIVKGLSQYAPFGLSVLPVTITKNCRSVKDILELMDQL
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHH
RPDYYISGQMIPDGNDNIVQIEIVRVKGYHLLHQESIKLIEHQPASLLQNKIANLLLRCI
CCCEEEECEECCCCCCCEEEEEEEEECCEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
PGLRWDTKQISELNSIDSTMVYLRGKHELNQYTPYSLQQALKLLTQCVNMSPNSIAPYCA
CCCCCCHHHHHHHHCCCCEEEEEECCHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHH
LAECYLSMAQMGIFDKQNAMIKAKEHAIKATELDHNNPQALGLLGLINTIHSEYIVGSLL
HHHHHHHHHHHCCCCCCCCEEEHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
FKQANLLSPISADIKYYYGWNLFMAGQLEEALQTINECLKLDPTRAAAGITKLWITYYHT
HHHHHHCCCCCCCEEEEECCEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
GIDDAIRLGDELRSQHLQDNPILLSMQVMFLSLKGKHELARKLTKEISTQEITGLIAVNL
CHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LYAEYCQNSERALPTIREFLESEQRIDNNPGLLPLVLVAHGEAIAEKMWNKFKNEDNIWF
HHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCHHH
KRWKQDPRLIKLR
HHHCCCCCEEEEC
>Mature Secondary Structure 
PHFNPVPVSNKKFVFDDFILNMDGSLLRSEKKVNIPPKEYAVLVILLEAAGEIVSKNTL
CCCCCCCCCCCCEEEEHHHCCCCCHHHHCCCCCCCCCHHHEEHEEEHHHHHHHHHHHHH
LDQVWGDAEVNEESLTRCIYALRRILSEDKEHRYIETLYGQGYRFNRPVVVVSPPAPQPT
HHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEECCCEEEECCCCCCCC
THTLAILPFQMQDQVQSESLHYSIVKGLSQYAPFGLSVLPVTITKNCRSVKDILELMDQL
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHH
RPDYYISGQMIPDGNDNIVQIEIVRVKGYHLLHQESIKLIEHQPASLLQNKIANLLLRCI
CCCEEEECEECCCCCCCEEEEEEEEECCEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
PGLRWDTKQISELNSIDSTMVYLRGKHELNQYTPYSLQQALKLLTQCVNMSPNSIAPYCA
CCCCCCHHHHHHHHCCCCEEEEEECCHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHH
LAECYLSMAQMGIFDKQNAMIKAKEHAIKATELDHNNPQALGLLGLINTIHSEYIVGSLL
HHHHHHHHHHHCCCCCCCCEEEHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
FKQANLLSPISADIKYYYGWNLFMAGQLEEALQTINECLKLDPTRAAAGITKLWITYYHT
HHHHHHCCCCCCCEEEEECCEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
GIDDAIRLGDELRSQHLQDNPILLSMQVMFLSLKGKHELARKLTKEISTQEITGLIAVNL
CHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LYAEYCQNSERALPTIREFLESEQRIDNNPGLLPLVLVAHGEAIAEKMWNKFKNEDNIWF
HHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCHHH
KRWKQDPRLIKLR
HHHCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA