Click here to switch to the map view.

The map label for this gene is hilD

Identifier: 16766181

GI number: 16766181

Start: 3017836

End: 3018765

Strand: Direct

Name: hilD

Synonym: STM2875

Alternate gene names: 16766181

Gene position: 3017836-3018765 (Clockwise)

Preceding gene: 16766170

Following gene: 16766182

Centisome position: 62.13

GC content: 40.97

Gene sequence:

>930_bases
ATGGAAAATGTAACCTTTGTAAGTAATAGTCATCAGCGTCCTGCCGCAGATAACTTACAGAAATTAAAATCACTTTTGAC
AAATACCCGGCAGCAAATTAAAAGTCAGACTCAGCAGGTTACCATCAAAAATCTTTATGTAAGCAGTTTCACTTTAGTTT
GCTTTCGGAGCGGTAAACTGACGATTAGCAATAATCACGATACGATTTACTGTGACGAACCTGGGATGTTGGTGCTCAAA
AAAGAGCAGGTAGTTAACGTGACGCTTGAAGAGGTCAATGGCCACATGGATTTCGATATACTCGAGATACCGACGCAACG
ACTTGGCGCTCTCTATGCACTTATCCCAAACGAGCAGCAAACCAAAATGGCGGTACCCACAGAGAAAGCGCAGAAGATCT
TCTATACGCCTGACTTTCCTGCCAGAAGAGAGGTATTTGAACATCTGAAAACGGCGTTCTCCTGTACGAAGGATACAAGC
AAAGGTTGCAGTAACTGTAACAACAAAAGTTGTATTGAAAATGAAGAGTTAATTCCTTATTTTCTGCTGTTCCTGCTTAC
TGCTTTTCTCCGACTCCCGGAGAGTTATGAGATCATCCTTAGCTCGGCTCAGATAACGTTAAAGGAGCGCGTTTACAACA
TTATATCTTCGTCACCCAGTAGACAGTGGAAGCTTACGGATGTTGCCGATCATATATTTATGAGTACGTCAACGCTCAAA
CGGAAACTTGCAGAAGAAGGTACCAGCTTTAGCGACATCTACTTATCGGCAAGAATGAATCAGGCAGCAAAACTTTTACG
CATAGGCAACCATAATGTTAATGCTGTAGCATTAAAATGTGGTTATGATAGCACGTCCTACTTCATTCAATGTTTCAAAA
AATATTTTAAAACTACGCCATCGACATTCATAAAAATGGCGAACCATTAA

Upstream 100 bases:

>100_bases
GACCATTGCCAACACACGCTAATAAAGAGCATTTACAACTCAGATTTTTTCAGTAGGATACCAGTAAGGAACATTAAAAT
AACATCAACAAAGGGATAAT

Downstream 100 bases:

>100_bases
CATTTTTTGTATCTGTCACTTAAGTAAAGATTTTTATTAAAATTGTAATAATTTAAAATTCAGACTGCGCATTAACACGC
TCTATCAGGATGGGAGGCTA

Product: invasion protein regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MENVTFVSNSHQRPAADNLQKLKSLLTNTRQQIKSQTQQVTIKNLYVSSFTLVCFRSGKLTISNNHDTIYCDEPGMLVLK
KEQVVNVTLEEVNGHMDFDILEIPTQRLGALYALIPNEQQTKMAVPTEKAQKIFYTPDFPARREVFEHLKTAFSCTKDTS
KGCSNCNNKSCIENEELIPYFLLFLLTAFLRLPESYEIILSSAQITLKERVYNIISSSPSRQWKLTDVADHIFMSTSTLK
RKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPSTFIKMANH

Sequences:

>Translated_309_residues
MENVTFVSNSHQRPAADNLQKLKSLLTNTRQQIKSQTQQVTIKNLYVSSFTLVCFRSGKLTISNNHDTIYCDEPGMLVLK
KEQVVNVTLEEVNGHMDFDILEIPTQRLGALYALIPNEQQTKMAVPTEKAQKIFYTPDFPARREVFEHLKTAFSCTKDTS
KGCSNCNNKSCIENEELIPYFLLFLLTAFLRLPESYEIILSSAQITLKERVYNIISSSPSRQWKLTDVADHIFMSTSTLK
RKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPSTFIKMANH
>Mature_309_residues
MENVTFVSNSHQRPAADNLQKLKSLLTNTRQQIKSQTQQVTIKNLYVSSFTLVCFRSGKLTISNNHDTIYCDEPGMLVLK
KEQVVNVTLEEVNGHMDFDILEIPTQRLGALYALIPNEQQTKMAVPTEKAQKIFYTPDFPARREVFEHLKTAFSCTKDTS
KGCSNCNNKSCIENEELIPYFLLFLLTAFLRLPESYEIILSSAQITLKERVYNIISSSPSRQWKLTDVADHIFMSTSTLK
RKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPSTFIKMANH

Specific function: Induces The Expression Of Gade And Yhiuv. Could Also Regulate The Expression Of Other Genes Involved In Acid Resistance. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1787776, Length=120, Percent_Identity=39.1666666666667, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1786776, Length=119, Percent_Identity=42.0168067226891, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1789933, Length=137, Percent_Identity=35.7664233576642, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1789932, Length=98, Percent_Identity=40.8163265306122, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790557, Length=124, Percent_Identity=36.2903225806452, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786778, Length=129, Percent_Identity=35.6589147286822, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1786758, Length=103, Percent_Identity=33.9805825242718, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): HILD_SALTY (P41782)

Other databases:

- EMBL:   AF124398
- EMBL:   AE006468
- EMBL:   U21676
- PIR:   S69787
- RefSeq:   NP_461796.1
- ProteinModelPortal:   P41782
- SMR:   P41782
- PRIDE:   P41782
- GeneID:   1254398
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM2875
- HOGENOM:   HBG673544
- OMA:   GNHNVNS
- ProtClustDB:   PRK15185
- BioCyc:   STYP99287:STM2875-MONOMER
- GO:   GO:0005622
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR020449
- InterPro:   IPR018060
- Gene3D:   G3DSA:1.10.10.60
- PRINTS:   PR00032
- SMART:   SM00342

Pfam domain/function: PF00165 HTH_AraC; SSF46689 Homeodomain_like

EC number: NA

Molecular weight: Translated: 35219; Mature: 35219

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS00041 HTH_ARAC_FAMILY_1; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENVTFVSNSHQRPAADNLQKLKSLLTNTRQQIKSQTQQVTIKNLYVSSFTLVCFRSGKL
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCEE
TISNNHDTIYCDEPGMLVLKKEQVVNVTLEEVNGHMDFDILEIPTQRLGALYALIPNEQQ
EEECCCCEEEECCCCEEEEECCHHEEEEHHHCCCCCCEEHEECCHHHHCEEEEECCCCCC
TKMAVPTEKAQKIFYTPDFPARREVFEHLKTAFSCTKDTSKGCSNCNNKSCIENEELIPY
CEEECCCHHCCEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCHHHH
FLLFLLTAFLRLPESYEIILSSAQITLKERVYNIISSSPSRQWKLTDVADHIFMSTSTLK
HHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHH
RKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTP
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCC
STFIKMANH
HHHHEECCC
>Mature Secondary Structure
MENVTFVSNSHQRPAADNLQKLKSLLTNTRQQIKSQTQQVTIKNLYVSSFTLVCFRSGKL
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCEE
TISNNHDTIYCDEPGMLVLKKEQVVNVTLEEVNGHMDFDILEIPTQRLGALYALIPNEQQ
EEECCCCEEEECCCCEEEEECCHHEEEEHHHCCCCCCEEHEECCHHHHCEEEEECCCCCC
TKMAVPTEKAQKIFYTPDFPARREVFEHLKTAFSCTKDTSKGCSNCNNKSCIENEELIPY
CEEECCCHHCCEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCHHHH
FLLFLLTAFLRLPESYEIILSSAQITLKERVYNIISSSPSRQWKLTDVADHIFMSTSTLK
HHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHH
RKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTP
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCC
STFIKMANH
HHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10320584; 11677609; 7476203