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The map label for this gene is dmsA [H]

Identifier: 16765850

GI number: 16765850

Start: 2662913

End: 2665318

Strand: Reverse

Name: dmsA [H]

Synonym: STM2530

Alternate gene names: 16765850

Gene position: 2665318-2662913 (Counterclockwise)

Preceding gene: 16765851

Following gene: 16765849

Centisome position: 54.87

GC content: 54.61

Gene sequence:

>2406_bases
ATGGGTTTTTATTTGACGAGTCGGATCATGAAAAATATAAAAAGCCAGGGAAATGGCGAACAGCCCGCTATTTCTCGCCG
CCACTTTATCCAGGCCAGCTCCGCGCTTATTGCGTTACCGTTTGTCTCCTCGCCAGCTACCGCTCAGGCGCGCGCTGTGA
CGGCAACTGAAAACAGGCCTGCGGAAAAAGTCGTTCAGACATGCAGCACTTTTGACTGCGGGGGCAAATGCGATATTCGG
GCGCATGTTAGTGACGGTATCGTGACGCGAATTTCAACGCGACCGGATAATGCGCTGGATGCGCAAATGCCGGTGATGCG
TGCCTGTGTTCGTGGACGCGCATACCGTAAATTTGTTTATCATCCTGACAGACTTAAATATCCCATGAAGCGCGTAGGAA
AACGCGGTGAAGGAAAATTTGAGCGAATTTCCTGGGATGAAGCGACAACCTTAATCGCCGATAATTTAAAATCGATTACT
GAAAAATATGGCCCGGCTTCGCGCTATGTTCATGTTGGTACCGCCGTTTCCGGCGGCACCTTTTCCGGCGATAAAATGGC
ACGTCGCCTGTTGAATCTGACCGGCGGATATCTCGAAAGCTACCATTCTGTGAGTATGGGCAACACGGCGGCCGCGACGC
CTTATACTTACGGCATTGCCGCCAGCGGCAGTTCACTGGATACGCTTTTGGACACCAAACTGGTGATTCTGTGGGGCCAT
AACCCGACGGAGACCATTTTTGGTCATACCAACTATTTCTTGCAGAAGATGAAGCAGAACGGTACGCGGTTTATCGTGGT
TGATCCGCGCTATTCCGACACCGTTTCGTCGCTGGCGGATCAGTGGATCCCGCTGCTGCCCACCACCGACAATGCGCTGA
TGGACGCGATGATGTACGTCATCATCAGCGAGAATCTGCACGATCGCGCATTTATTGCGCGTTACGCTATCGGTTTTGAT
GAAGACTCAATGCCGGAAGGCGTACCGGCTAACGAATCGCTGGTGGCGTATCTGACCGGCGCCAAAGACGGTGTCGTTAA
GTCCCCCGAGTGGGCGGAAAAGATCACCCATGTGCCGGCGCAAACCATTCGCCAGTTAGCGCGTGATTACGCGAATACCA
AACCCGCCGCGTTGATTCAGGGGTGGGGACCACAGCGCCACAACTGCGGCGAGCGCACCGCGCGCGGTTCGACTCTACTG
GCGACCATTACCGGTAATGTCGGCATCAAAGGCGGTTGGGCTGCGGGTTACGGCGGCTGCGCTAACCGTAAATTCGCCGC
GGGTCCGGAGATGCCGGATAACCCGGTAAAAGCCAAAATTTCGGTGATGAACTGGGTGCAGGCCGCAGACGACGCCAGCA
AAGTGACGCCGGATATGGGGCTGAAAGATGCCGATAAGCTGGACAGTAACATCCGTATTCTGTTCTCGCTGGCCGGGAAC
TATCTGGCGAATCAGAACCCCGATCTGCACCAGGCGGTACGCGTACTGGAGGATGAATCAAAGATCCAGTTTATTGTCGC
CAGCGATCTGTTTATGACGCCGAGCGCGAAATACGCTGATCTACTGCTGCCGGAAACCAGCTTTATGGAACGCTGGAACA
TCGGTGAAACCTGGGGCACGGCAAGCTACCTGATACTCTCTGAAAAACTGATTGAGCCTGAATTTGAGCGGCGCTCCGAC
TACGACTGGCTACGTGAGGTGGCGGCGAAATTAGGCATTGAGAATGAATTTAGCCAGGGGCGCGATGAGAAAGCGTGGAT
TGAACACATCTGGGAACAGACGCGCCTGGCGATGCCGGACGAAAATCTGCCGGATTTCGCCACGCTGCAAAAGACCCGTC
AGCATCTGTTCAAAAGCGCGCCATTTATCGCCTTTGAAGACAATATTCGCGATCCGGAAAATCATCCGTTCCCGACGCCG
TCAGGGAAAATAGAGATCTTCTCGAAGCGCCTCTACGACATGCAGCATCCGGAAATCCCGGCGTTATCGCACTACGTTCC
CGCGCATGAAGGCCCGGAGGATGCGCTGGCGAAAGATTTTCCGCTCCAGTTAATTACGTGGAAAGGAAAAAACCGCGCCA
ACTCAACGCAATACGCTAACCCGTGGCTGATTGAAGTGCAGCAGCAGACATTGTGGATCAACCCGCAGGATGCGCAAAAG
CGCGGCATTACGCATGGCGACATGGTGCGCATTCATAACTCACGCGGGATTTGCGAAATCCCGGCGGAAGTGACGCCGCG
CATTATTCCCGGCGTTGTCGCGATGCAGGCTGGCGCCTGGTGGCAGCCGGATGAAAACGGCGTTGATAAAGGCGGCTGTG
CGAACGTCCTCAGCTCGGCCCGTATTACCGCGCTGGCGAAGGGAAATTCACATCAAACCATGCTGGTGGAGGTGGCTAAA
GCATGA

Upstream 100 bases:

>100_bases
ATTTAATTTAAAGTTAATGAGAATTATTAATTTTTCCGGAATTACCCTTAATGAGGGAGCTTGATAAATATCAAGAGAAC
CAGCGCATAAAAACGTGAGA

Downstream 100 bases:

>100_bases
GTCAGTTTACACATTACCCGCCGGTGAGCGATAAACAACTGGGATTTTTCATCGACTCCTCACGCTGCTCCGGTTGTAAA
GCCTGCCAGGTGGCCTGCAA

Product: anaerobic dimethylsulfoxide reductase

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 801; Mature: 800

Protein sequence:

>801_residues
MGFYLTSRIMKNIKSQGNGEQPAISRRHFIQASSALIALPFVSSPATAQARAVTATENRPAEKVVQTCSTFDCGGKCDIR
AHVSDGIVTRISTRPDNALDAQMPVMRACVRGRAYRKFVYHPDRLKYPMKRVGKRGEGKFERISWDEATTLIADNLKSIT
EKYGPASRYVHVGTAVSGGTFSGDKMARRLLNLTGGYLESYHSVSMGNTAAATPYTYGIAASGSSLDTLLDTKLVILWGH
NPTETIFGHTNYFLQKMKQNGTRFIVVDPRYSDTVSSLADQWIPLLPTTDNALMDAMMYVIISENLHDRAFIARYAIGFD
EDSMPEGVPANESLVAYLTGAKDGVVKSPEWAEKITHVPAQTIRQLARDYANTKPAALIQGWGPQRHNCGERTARGSTLL
ATITGNVGIKGGWAAGYGGCANRKFAAGPEMPDNPVKAKISVMNWVQAADDASKVTPDMGLKDADKLDSNIRILFSLAGN
YLANQNPDLHQAVRVLEDESKIQFIVASDLFMTPSAKYADLLLPETSFMERWNIGETWGTASYLILSEKLIEPEFERRSD
YDWLREVAAKLGIENEFSQGRDEKAWIEHIWEQTRLAMPDENLPDFATLQKTRQHLFKSAPFIAFEDNIRDPENHPFPTP
SGKIEIFSKRLYDMQHPEIPALSHYVPAHEGPEDALAKDFPLQLITWKGKNRANSTQYANPWLIEVQQQTLWINPQDAQK
RGITHGDMVRIHNSRGICEIPAEVTPRIIPGVVAMQAGAWWQPDENGVDKGGCANVLSSARITALAKGNSHQTMLVEVAK
A

Sequences:

>Translated_801_residues
MGFYLTSRIMKNIKSQGNGEQPAISRRHFIQASSALIALPFVSSPATAQARAVTATENRPAEKVVQTCSTFDCGGKCDIR
AHVSDGIVTRISTRPDNALDAQMPVMRACVRGRAYRKFVYHPDRLKYPMKRVGKRGEGKFERISWDEATTLIADNLKSIT
EKYGPASRYVHVGTAVSGGTFSGDKMARRLLNLTGGYLESYHSVSMGNTAAATPYTYGIAASGSSLDTLLDTKLVILWGH
NPTETIFGHTNYFLQKMKQNGTRFIVVDPRYSDTVSSLADQWIPLLPTTDNALMDAMMYVIISENLHDRAFIARYAIGFD
EDSMPEGVPANESLVAYLTGAKDGVVKSPEWAEKITHVPAQTIRQLARDYANTKPAALIQGWGPQRHNCGERTARGSTLL
ATITGNVGIKGGWAAGYGGCANRKFAAGPEMPDNPVKAKISVMNWVQAADDASKVTPDMGLKDADKLDSNIRILFSLAGN
YLANQNPDLHQAVRVLEDESKIQFIVASDLFMTPSAKYADLLLPETSFMERWNIGETWGTASYLILSEKLIEPEFERRSD
YDWLREVAAKLGIENEFSQGRDEKAWIEHIWEQTRLAMPDENLPDFATLQKTRQHLFKSAPFIAFEDNIRDPENHPFPTP
SGKIEIFSKRLYDMQHPEIPALSHYVPAHEGPEDALAKDFPLQLITWKGKNRANSTQYANPWLIEVQQQTLWINPQDAQK
RGITHGDMVRIHNSRGICEIPAEVTPRIIPGVVAMQAGAWWQPDENGVDKGGCANVLSSARITALAKGNSHQTMLVEVAK
A
>Mature_800_residues
GFYLTSRIMKNIKSQGNGEQPAISRRHFIQASSALIALPFVSSPATAQARAVTATENRPAEKVVQTCSTFDCGGKCDIRA
HVSDGIVTRISTRPDNALDAQMPVMRACVRGRAYRKFVYHPDRLKYPMKRVGKRGEGKFERISWDEATTLIADNLKSITE
KYGPASRYVHVGTAVSGGTFSGDKMARRLLNLTGGYLESYHSVSMGNTAAATPYTYGIAASGSSLDTLLDTKLVILWGHN
PTETIFGHTNYFLQKMKQNGTRFIVVDPRYSDTVSSLADQWIPLLPTTDNALMDAMMYVIISENLHDRAFIARYAIGFDE
DSMPEGVPANESLVAYLTGAKDGVVKSPEWAEKITHVPAQTIRQLARDYANTKPAALIQGWGPQRHNCGERTARGSTLLA
TITGNVGIKGGWAAGYGGCANRKFAAGPEMPDNPVKAKISVMNWVQAADDASKVTPDMGLKDADKLDSNIRILFSLAGNY
LANQNPDLHQAVRVLEDESKIQFIVASDLFMTPSAKYADLLLPETSFMERWNIGETWGTASYLILSEKLIEPEFERRSDY
DWLREVAAKLGIENEFSQGRDEKAWIEHIWEQTRLAMPDENLPDFATLQKTRQHLFKSAPFIAFEDNIRDPENHPFPTPS
GKIEIFSKRLYDMQHPEIPALSHYVPAHEGPEDALAKDFPLQLITWKGKNRANSTQYANPWLIEVQQQTLWINPQDAQKR
GITHGDMVRIHNSRGICEIPAEVTPRIIPGVVAMQAGAWWQPDENGVDKGGCANVLSSARITALAKGNSHQTMLVEVAKA

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=809, Percent_Identity=42.5216316440049, Blast_Score=611, Evalue=1e-176,
Organism=Escherichia coli, GI171474008, Length=805, Percent_Identity=42.4844720496894, Blast_Score=585, Evalue=1e-168,
Organism=Escherichia coli, GI1787870, Length=812, Percent_Identity=40.5172413793103, Blast_Score=571, Evalue=1e-164,
Organism=Escherichia coli, GI145693196, Length=734, Percent_Identity=29.8365122615804, Blast_Score=267, Evalue=2e-72,
Organism=Escherichia coli, GI1787231, Length=750, Percent_Identity=28.4, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI87081994, Length=722, Percent_Identity=28.808864265928, Blast_Score=233, Evalue=3e-62,
Organism=Escherichia coli, GI3868721, Length=790, Percent_Identity=26.2025316455696, Blast_Score=176, Evalue=6e-45,
Organism=Escherichia coli, GI1787741, Length=284, Percent_Identity=27.4647887323944, Blast_Score=89, Evalue=2e-18,
Organism=Escherichia coli, GI3868720, Length=455, Percent_Identity=22.8571428571429, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI3868719, Length=463, Percent_Identity=22.8941684665227, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788534, Length=557, Percent_Identity=22.4416517055655, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 88758; Mature: 88626

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00490 MOLYBDOPTERIN_PROK_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFYLTSRIMKNIKSQGNGEQPAISRRHFIQASSALIALPFVSSPATAQARAVTATENRP
CCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCC
AEKVVQTCSTFDCGGKCDIRAHVSDGIVTRISTRPDNALDAQMPVMRACVRGRAYRKFVY
HHHHHHHHCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHCC
HPDRLKYPMKRVGKRGEGKFERISWDEATTLIADNLKSITEKYGPASRYVHVGTAVSGGT
CCHHHCCHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCC
FSGDKMARRLLNLTGGYLESYHSVSMGNTAAATPYTYGIAASGSSLDTLLDTKLVILWGH
CCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHCCEEEEEECC
NPTETIFGHTNYFLQKMKQNGTRFIVVDPRYSDTVSSLADQWIPLLPTTDNALMDAMMYV
CCCCCEECCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
IISENLHDRAFIARYAIGFDEDSMPEGVPANESLVAYLTGAKDGVVKSPEWAEKITHVPA
HHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHCCCH
QTIRQLARDYANTKPAALIQGWGPQRHNCGERTARGSTLLATITGNVGIKGGWAAGYGGC
HHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHCCCCEEEEEEECCCCCCCCCCCCCCCC
ANRKFAAGPEMPDNPVKAKISVMNWVQAADDASKVTPDMGLKDADKLDSNIRILFSLAGN
CCCCCCCCCCCCCCCCCEEHHHHHHHHHCCCHHHCCCCCCCCCHHHCCCCCEEEEEECCC
YLANQNPDLHQAVRVLEDESKIQFIVASDLFMTPSAKYADLLLPETSFMERWNIGETWGT
HHCCCCCCHHHHHHHHCCCCCEEEEEECCEEECCCCCHHHEECCCHHHHHHCCCCCCCCC
ASYLILSEKLIEPEFERRSDYDWLREVAAKLGIENEFSQGRDEKAWIEHIWEQTRLAMPD
EEEEEEHHHHCCCHHHCCCCHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHCCCCC
ENLPDFATLQKTRQHLFKSAPFIAFEDNIRDPENHPFPTPSGKIEIFSKRLYDMQHPEIP
CCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHCCCCCCC
ALSHYVPAHEGPEDALAKDFPLQLITWKGKNRANSTQYANPWLIEVQQQTLWINPQDAQK
CHHHCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCEEEECCCHHHH
RGITHGDMVRIHNSRGICEIPAEVTPRIIPGVVAMQAGAWWQPDENGVDKGGCANVLSSA
CCCCCCCEEEEECCCCEEECCHHCCCCHHCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
RITALAKGNSHQTMLVEVAKA
HEEEEECCCCCCEEEEEEECC
>Mature Secondary Structure 
GFYLTSRIMKNIKSQGNGEQPAISRRHFIQASSALIALPFVSSPATAQARAVTATENRP
CCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCC
AEKVVQTCSTFDCGGKCDIRAHVSDGIVTRISTRPDNALDAQMPVMRACVRGRAYRKFVY
HHHHHHHHCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHCC
HPDRLKYPMKRVGKRGEGKFERISWDEATTLIADNLKSITEKYGPASRYVHVGTAVSGGT
CCHHHCCHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCC
FSGDKMARRLLNLTGGYLESYHSVSMGNTAAATPYTYGIAASGSSLDTLLDTKLVILWGH
CCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHCCEEEEEECC
NPTETIFGHTNYFLQKMKQNGTRFIVVDPRYSDTVSSLADQWIPLLPTTDNALMDAMMYV
CCCCCEECCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
IISENLHDRAFIARYAIGFDEDSMPEGVPANESLVAYLTGAKDGVVKSPEWAEKITHVPA
HHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHCCCH
QTIRQLARDYANTKPAALIQGWGPQRHNCGERTARGSTLLATITGNVGIKGGWAAGYGGC
HHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHCCCCEEEEEEECCCCCCCCCCCCCCCC
ANRKFAAGPEMPDNPVKAKISVMNWVQAADDASKVTPDMGLKDADKLDSNIRILFSLAGN
CCCCCCCCCCCCCCCCCEEHHHHHHHHHCCCHHHCCCCCCCCCHHHCCCCCEEEEEECCC
YLANQNPDLHQAVRVLEDESKIQFIVASDLFMTPSAKYADLLLPETSFMERWNIGETWGT
HHCCCCCCHHHHHHHHCCCCCEEEEEECCEEECCCCCHHHEECCCHHHHHHCCCCCCCCC
ASYLILSEKLIEPEFERRSDYDWLREVAAKLGIENEFSQGRDEKAWIEHIWEQTRLAMPD
EEEEEEHHHHCCCHHHCCCCHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHCCCCC
ENLPDFATLQKTRQHLFKSAPFIAFEDNIRDPENHPFPTPSGKIEIFSKRLYDMQHPEIP
CCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHCCCCCCC
ALSHYVPAHEGPEDALAKDFPLQLITWKGKNRANSTQYANPWLIEVQQQTLWINPQDAQK
CHHHCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCEEEECCCHHHH
RGITHGDMVRIHNSRGICEIPAEVTPRIIPGVVAMQAGAWWQPDENGVDKGGCANVLSSA
CCCCCCCEEEEECCCCEEECCHHCCCCHHCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
RITALAKGNSHQTMLVEVAKA
HEEEEECCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]