| Definition | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome. |
|---|---|
| Accession | NC_003197 |
| Length | 4,857,432 |
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The map label for this gene is pbpC [H]
Identifier: 16765851
GI number: 16765851
Start: 2665447
End: 2667762
Strand: Reverse
Name: pbpC [H]
Synonym: STM2531
Alternate gene names: 16765851
Gene position: 2667762-2665447 (Counterclockwise)
Preceding gene: 16765852
Following gene: 16765850
Centisome position: 54.92
GC content: 61.27
Gene sequence:
>2316_bases ATGAACGGTTGGCGTGGTAAACGTGGCCGCTGGCTGTGGCTGGCGGGCGCGCCGCTTTTTATTTTCCTGGCGTTATGGGC AGCGGATAAACTCTGGCCGCTGCCGCTCAATGAGGTCCATCCTGCGCGGGTCGTGGTAGCCCATGACGGTACGCCGCTGT GGCGCTTTGCCGACGCCGGGGGGATCTGGCGTTATCCGGTGACGATTGAAGAGGTCTCTCCCCGCTACCTGGAGGCCCTA ATCAATTACGAAGATCGCTGGTTCTGGCGGCACCCTGGCGTTAACCCTTTCTCCGTCGCGCGCGCGGCATGGCAGGATCT TACCGCCGGGCGCGTTATTTCCGGCGGCAGTACGCTGACTATGCAGGTGGCGAGACTGCTGGACCCGCATTCGCGCACGT TCGGCGGTAAAATCCGCCAGCTTTGGCGCGCCCTCCAGCTTGAATGGCATTTGTCCAAGCGCGATATCCTGACGCTGTAC CTGAACCGCGCGCCGTTCGGCGGCACGCTACAGGGTATTGGCGCTGCAAGCTGGGCCTACTTCGGCAAGCCGCCCGCGCG CCTGAGCTACGCTGACGCGGCGCTGCTGGCCGTATTGCCGCAGGCGCCGAGCCGGTTACGCCCCGACCGCTGGCCTGCGA GAGCCGAAGCGGCACGAAATAAAGTGCTGGATCGGATGGCGGCGCAGGGCGTCTGGCCTGCCGAAACGGTACGCGAGTCG CGTGAAGAACCGGTCTGGCTGGCGCCGCGTCAAATGCCGCAACTGGCGCCGCTTTTTGCCCGAATGATGTTGAGTAAAAG CCAGAACGACAAAATTGTGACCACGCTGGACGCCGGGTTGCAGCGGCAACTGGAAGATCTGGCGCGGGCATGGAAAGGGC GGCTGCCTGCACGCAGTTCGTTGGCGATGATCGTCGTCGATCATACCGATATGAGCGTGCGCGGCTGGGTAGGATCGGTA GACCTTAATGACGACAGCCGTTTTGGTCATGTCGACATGGTAACGGCGATCCGATCGCCGGGATCGGTACTCAAACCCTT TGTGTATGGTCTGGCGCTGGATGACGGCTTGATCCATCCCGCATCATTATTACAGGACGTTCCGCGCCGTACCGGAGATT ACCGCCCGGGAAACTTCGACAGCGGATTTCACGGCCCGGTCAGCATGAGCGACGCGCTGGTACGCTCGCTGAATCTGCCA GCCGTTCAGGTGCTTGAAGCCTATGGGCCGAAACGATTTGCGGCAAAACTGCGTAACGTCGGCCTGCCGCTATATTTGCC TGCTGGCGCGGCGCCCAATCTTTCGCTGATTCTGGGCGGCGCGGGCGCGCGGCTTGACGAGATGGCGGCGGCATACAGCG CGTTCGCTCGTCATGGGAAAGCGGCGAAACTACGGTTACAGCCGGACGATCCGCTGTCGGAAAGACCATTAATGTCGCCG GGAGCGGCGTGGATCATTCGACGGATTATGGCGGATGAAGCGCAACCCTTGCCGGATAACGCGCTGCCGCGCATTGTGCC GTTGGCGTGGAAAACCGGCACCAGTTACGGCTATCGCGATGCGTGGGCTATTGGCGTTAACGCGCGCTATATCATCGGTA TCTGGACAGGCAGACCCGACGGCACGCCTGTGGTGGGGCAATTTGGTTTTGCCAGCGCGGTGCCATTGCTTAACCAGGTC AATAATCTGTTACTGGCGCATACGGGACGCCTGCCGGAAGATCCGCGTCCGCAGGCGGTAAGCCGCGGCGTCATTTGCTG GCCGGGCGGACAGACTCTGCCTGCCGGAGACAGCAACTGTCGCCGCCGACTGGCGACATGGCTGCTCGATGACAGCCAGC CGCCCACGCTGCTGTTACCTGAGCAGGAAGACATCAACGGTATTCGTTTCCCGGTCTGGCTGGATGATACGGGGCGGCGT GTCGCTGCCGACTGTCCGCAGGCGCGTGCGCATACGTTTATCGTCTGGCCGCGGCCGCTGGAGCCGTGGCTGCCGCCTGC GGAAAGACGTAGCGCCCGCTTGCCCGCGGCGTCCGACCACTGTCCGCCGCTACAGGGCAATGACGCCGCGCCGTTAATGC TGTCAGGAGTGAGGGATGGCGCGGTGATCAGGCAATTGCCAGGCCAGGAAAACGTCACGCTGCCCGTCTCGACTACCGGC GGCAAAGGGCGTCGCTGGTGGTTTTTAAATGGCGAACCTGTTAATGGCGAAAATAATCGCCTTTCTTTATTACTCAATAT CGCTGGACGTTATCAACTTGTCGTAATGGATGAGTCCGGTCAGGTTGCAGCGGTTAATTTTGAATTAATACGTTAA
Upstream 100 bases:
>100_bases GGGGACGTACCAGCTTGCGCAACCGCAGGTGGAATCGATGTATGCGCCTCAGTGGCGGGCAACCGGCGCGAGCGAGGGGC TGCTGATTGTGACGCCTTAA
Downstream 100 bases:
>100_bases CAACTCTTCAGAATAAATTATGAATTTCATTTAATTTAAAGTTAATGAGAATTATTAATTTTTCCGGAATTACCCTTAAT GAGGGAGCTTGATAAATATC
Product: penicillin-binding protein 1C
Products: NA
Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]
Number of amino acids: Translated: 771; Mature: 771
Protein sequence:
>771_residues MNGWRGKRGRWLWLAGAPLFIFLALWAADKLWPLPLNEVHPARVVVAHDGTPLWRFADAGGIWRYPVTIEEVSPRYLEAL INYEDRWFWRHPGVNPFSVARAAWQDLTAGRVISGGSTLTMQVARLLDPHSRTFGGKIRQLWRALQLEWHLSKRDILTLY LNRAPFGGTLQGIGAASWAYFGKPPARLSYADAALLAVLPQAPSRLRPDRWPARAEAARNKVLDRMAAQGVWPAETVRES REEPVWLAPRQMPQLAPLFARMMLSKSQNDKIVTTLDAGLQRQLEDLARAWKGRLPARSSLAMIVVDHTDMSVRGWVGSV DLNDDSRFGHVDMVTAIRSPGSVLKPFVYGLALDDGLIHPASLLQDVPRRTGDYRPGNFDSGFHGPVSMSDALVRSLNLP AVQVLEAYGPKRFAAKLRNVGLPLYLPAGAAPNLSLILGGAGARLDEMAAAYSAFARHGKAAKLRLQPDDPLSERPLMSP GAAWIIRRIMADEAQPLPDNALPRIVPLAWKTGTSYGYRDAWAIGVNARYIIGIWTGRPDGTPVVGQFGFASAVPLLNQV NNLLLAHTGRLPEDPRPQAVSRGVICWPGGQTLPAGDSNCRRRLATWLLDDSQPPTLLLPEQEDINGIRFPVWLDDTGRR VAADCPQARAHTFIVWPRPLEPWLPPAERRSARLPAASDHCPPLQGNDAAPLMLSGVRDGAVIRQLPGQENVTLPVSTTG GKGRRWWFLNGEPVNGENNRLSLLLNIAGRYQLVVMDESGQVAAVNFELIR
Sequences:
>Translated_771_residues MNGWRGKRGRWLWLAGAPLFIFLALWAADKLWPLPLNEVHPARVVVAHDGTPLWRFADAGGIWRYPVTIEEVSPRYLEAL INYEDRWFWRHPGVNPFSVARAAWQDLTAGRVISGGSTLTMQVARLLDPHSRTFGGKIRQLWRALQLEWHLSKRDILTLY LNRAPFGGTLQGIGAASWAYFGKPPARLSYADAALLAVLPQAPSRLRPDRWPARAEAARNKVLDRMAAQGVWPAETVRES REEPVWLAPRQMPQLAPLFARMMLSKSQNDKIVTTLDAGLQRQLEDLARAWKGRLPARSSLAMIVVDHTDMSVRGWVGSV DLNDDSRFGHVDMVTAIRSPGSVLKPFVYGLALDDGLIHPASLLQDVPRRTGDYRPGNFDSGFHGPVSMSDALVRSLNLP AVQVLEAYGPKRFAAKLRNVGLPLYLPAGAAPNLSLILGGAGARLDEMAAAYSAFARHGKAAKLRLQPDDPLSERPLMSP GAAWIIRRIMADEAQPLPDNALPRIVPLAWKTGTSYGYRDAWAIGVNARYIIGIWTGRPDGTPVVGQFGFASAVPLLNQV NNLLLAHTGRLPEDPRPQAVSRGVICWPGGQTLPAGDSNCRRRLATWLLDDSQPPTLLLPEQEDINGIRFPVWLDDTGRR VAADCPQARAHTFIVWPRPLEPWLPPAERRSARLPAASDHCPPLQGNDAAPLMLSGVRDGAVIRQLPGQENVTLPVSTTG GKGRRWWFLNGEPVNGENNRLSLLLNIAGRYQLVVMDESGQVAAVNFELIR >Mature_771_residues MNGWRGKRGRWLWLAGAPLFIFLALWAADKLWPLPLNEVHPARVVVAHDGTPLWRFADAGGIWRYPVTIEEVSPRYLEAL INYEDRWFWRHPGVNPFSVARAAWQDLTAGRVISGGSTLTMQVARLLDPHSRTFGGKIRQLWRALQLEWHLSKRDILTLY LNRAPFGGTLQGIGAASWAYFGKPPARLSYADAALLAVLPQAPSRLRPDRWPARAEAARNKVLDRMAAQGVWPAETVRES REEPVWLAPRQMPQLAPLFARMMLSKSQNDKIVTTLDAGLQRQLEDLARAWKGRLPARSSLAMIVVDHTDMSVRGWVGSV DLNDDSRFGHVDMVTAIRSPGSVLKPFVYGLALDDGLIHPASLLQDVPRRTGDYRPGNFDSGFHGPVSMSDALVRSLNLP AVQVLEAYGPKRFAAKLRNVGLPLYLPAGAAPNLSLILGGAGARLDEMAAAYSAFARHGKAAKLRLQPDDPLSERPLMSP GAAWIIRRIMADEAQPLPDNALPRIVPLAWKTGTSYGYRDAWAIGVNARYIIGIWTGRPDGTPVVGQFGFASAVPLLNQV NNLLLAHTGRLPEDPRPQAVSRGVICWPGGQTLPAGDSNCRRRLATWLLDDSQPPTLLLPEQEDINGIRFPVWLDDTGRR VAADCPQARAHTFIVWPRPLEPWLPPAERRSARLPAASDHCPPLQGNDAAPLMLSGVRDGAVIRQLPGQENVTLPVSTTG GKGRRWWFLNGEPVNGENNRLSLLLNIAGRYQLVVMDESGQVAAVNFELIR
Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]
COG id: COG4953
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1788867, Length=763, Percent_Identity=82.175622542595, Blast_Score=1285, Evalue=0.0, Organism=Escherichia coli, GI87082258, Length=249, Percent_Identity=34.136546184739, Blast_Score=127, Evalue=3e-30, Organism=Escherichia coli, GI1786343, Length=515, Percent_Identity=28.3495145631068, Blast_Score=124, Evalue=2e-29, Organism=Escherichia coli, GI1789601, Length=144, Percent_Identity=34.7222222222222, Blast_Score=67, Evalue=5e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011815 - InterPro: IPR009647 - InterPro: IPR001460 [H]
Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-
Molecular weight: Translated: 85106; Mature: 85106
Theoretical pI: Translated: 10.27; Mature: 10.27
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNGWRGKRGRWLWLAGAPLFIFLALWAADKLWPLPLNEVHPARVVVAHDGTPLWRFADAG CCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCC GIWRYPVTIEEVSPRYLEALINYEDRWFWRHPGVNPFSVARAAWQDLTAGRVISGGSTLT CEEECCEEHHHCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEECCCCHHH MQVARLLDPHSRTFGGKIRQLWRALQLEWHLSKRDILTLYLNRAPFGGTLQGIGAASWAY HHHHHHHCCCCCCCCHHHHHHHHHHHHEEECCCCCEEEEEEECCCCCCCCCCCCCCCCHH FGKPPARLSYADAALLAVLPQAPSRLRPDRWPARAEAARNKVLDRMAAQGVWPAETVRES CCCCCCCCCHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHC REEPVWLAPRQMPQLAPLFARMMLSKSQNDKIVTTLDAGLQRQLEDLARAWKGRLPARSS CCCCEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCC LAMIVVDHTDMSVRGWVGSVDLNDDSRFGHVDMVTAIRSPGSVLKPFVYGLALDDGLIHP EEEEEEECCCCEEECEEEEEECCCCCCCCCEEEHHHHCCCCHHHHHHHHHEEECCCCCCH ASLLQDVPRRTGDYRPGNFDSGFHGPVSMSDALVRSLNLPAVQVLEAYGPKRFAAKLRNV HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHC GLPLYLPAGAAPNLSLILGGAGARLDEMAAAYSAFARHGKAAKLRLQPDDPLSERPLMSP CCCEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCC GAAWIIRRIMADEAQPLPDNALPRIVPLAWKTGTSYGYRDAWAIGVNARYIIGIWTGRPD CHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCCEEEEEEEECCCC GTPVVGQFGFASAVPLLNQVNNLLLAHTGRLPEDPRPQAVSRGVICWPGGQTLPAGDSNC CCCEEECCCHHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHCCEEECCCCCCCCCCCHHH RRRLATWLLDDSQPPTLLLPEQEDINGIRFPVWLDDTGRRVAADCPQARAHTFIVWPRPL HHHHHHHHCCCCCCCEEECCCCCCCCCEEEEEEECCCCCEEECCCCCCCCCEEEEECCCC EPWLPPAERRSARLPAASDHCPPLQGNDAAPLMLSGVRDGAVIRQLPGQENVTLPVSTTG CCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHCCCCCCEEEEEECCC GKGRRWWFLNGEPVNGENNRLSLLLNIAGRYQLVVMDESGQVAAVNFELIR CCCCEEEEECCCCCCCCCCEEEEEEEECCCEEEEEECCCCCEEEEEEEEEC >Mature Secondary Structure MNGWRGKRGRWLWLAGAPLFIFLALWAADKLWPLPLNEVHPARVVVAHDGTPLWRFADAG CCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCC GIWRYPVTIEEVSPRYLEALINYEDRWFWRHPGVNPFSVARAAWQDLTAGRVISGGSTLT CEEECCEEHHHCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEECCCCHHH MQVARLLDPHSRTFGGKIRQLWRALQLEWHLSKRDILTLYLNRAPFGGTLQGIGAASWAY HHHHHHHCCCCCCCCHHHHHHHHHHHHEEECCCCCEEEEEEECCCCCCCCCCCCCCCCHH FGKPPARLSYADAALLAVLPQAPSRLRPDRWPARAEAARNKVLDRMAAQGVWPAETVRES CCCCCCCCCHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHC REEPVWLAPRQMPQLAPLFARMMLSKSQNDKIVTTLDAGLQRQLEDLARAWKGRLPARSS CCCCEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCC LAMIVVDHTDMSVRGWVGSVDLNDDSRFGHVDMVTAIRSPGSVLKPFVYGLALDDGLIHP EEEEEEECCCCEEECEEEEEECCCCCCCCCEEEHHHHCCCCHHHHHHHHHEEECCCCCCH ASLLQDVPRRTGDYRPGNFDSGFHGPVSMSDALVRSLNLPAVQVLEAYGPKRFAAKLRNV HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHC GLPLYLPAGAAPNLSLILGGAGARLDEMAAAYSAFARHGKAAKLRLQPDDPLSERPLMSP CCCEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCC GAAWIIRRIMADEAQPLPDNALPRIVPLAWKTGTSYGYRDAWAIGVNARYIIGIWTGRPD CHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCCEEEEEEEECCCC GTPVVGQFGFASAVPLLNQVNNLLLAHTGRLPEDPRPQAVSRGVICWPGGQTLPAGDSNC CCCEEECCCHHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHCCEEECCCCCCCCCCCHHH RRRLATWLLDDSQPPTLLLPEQEDINGIRFPVWLDDTGRRVAADCPQARAHTFIVWPRPL HHHHHHHHCCCCCCCEEECCCCCCCCCEEEEEEECCCCCEEECCCCCCCCCEEEEECCCC EPWLPPAERRSARLPAASDHCPPLQGNDAAPLMLSGVRDGAVIRQLPGQENVTLPVSTTG CCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHCCCCCCEEEEEECCC GKGRRWWFLNGEPVNGENNRLSLLLNIAGRYQLVVMDESGQVAAVNFELIR CCCCEEEEECCCCCCCCCCEEEEEEEECCCEEEEEECCCCCEEEEEEEEEC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10542235; 9205837; 9278503; 9841666 [H]