Click here to switch to the map view.

The map label for this gene is dxs [C]

Identifier: 15922600

GI number: 15922600

Start: 2277950

End: 2278891

Strand: Direct

Name: dxs [C]

Synonym: ST2269

Alternate gene names: 15922600

Gene position: 2277950-2278891 (Clockwise)

Preceding gene: 15922599

Following gene: 15922601

Centisome position: 84.53

GC content: 35.35

Gene sequence:

>942_bases
ATGATGCAAAGAAGTACCTTACCAATGCGTGATACTTTCGGTAGATTATTAGCTGAATTGGGAGAGAAAAATAAAGATAT
AATAGTTATTACTGCAGATGTTGGAAACTCTACTAGAGCTATGTACTTTAGGGAGAAATTCCCAGACAGATATTTTAATG
TAGGTATTTCTGAGCAGGATATGGTTAATTTTGCTGCGGGCTTATCGGTTACTGGTTTTAAACCGATAGTCGTTGGGTTT
GCAATGTTTGTAATGAGAGCATGGGAGCAAATAAGAAACTCTATTGCTAGAATGAATTTAGATGTAAAAATAATGGTTAC
TCATTCTGGATATAGTGATAGTGGTGATGGTTCTAGTCATCAAGCCTTAGAGGATATAGCTTTAATGAGAGTGTTACCAA
ATATGAAAGTAATTATTCCAGCTGATTCGGAGGATGTAAAAAGGTCTTTACCAGTAGTAGTTAATGAACTTAGAGGTCCA
TTATATTATAGAATGGGAAGGGATTATACGCCAGTAATTACAGAAGGATTAGATTATGACTTTAAATTGGGCAAAGCTTA
CGTGTTAAGAGATGGAGAAGATTTAGCAATTATGGGTGCTGGAGTTGTTCTAGCTGATGCCTTAAAAGCTGCTGAGGAAT
TAGAAAAGATGGGTATAAGTGCTGCCGTTATAAACTTAATGAGTATAAAGCCTATTGACGAAGATTTAATAGAATATTAT
GCGAGAAAAACCGGGAGAATAATTACAATAGAAGAGCATTCTATATACGGTGGTATAGGTTCAGCTGTAGCTGAAGTTGT
AGTAAAGAAGTATCCAGTACCAATGAGATTCATTGGTGCTATTACCTTTGGAAGATCTGCTAGGAGCGAGAGAGATTTAC
TTGATTTCTATGGTATAAATTATAAGTCTATCTTAAATGCGGTTATGGAATTAGTGAAGTGA

Upstream 100 bases:

>100_bases
GCATTAAAGGCAAAGGCTCCGGTAGTTATTTTTGCTAAGACAAGAAGAGGTATGGGATTCAAGGCGATAGAAAATACTGA
AAAACAGAGGGCGAGTCCAG

Downstream 100 bases:

>100_bases
ATGAGTGCTGAAATTGATGAATTACGAAAAGAAATAGAAGCTATAGATAAACAAATATTAGAATTATTATCAAGAAGATT
AAAAATTTCTGCTAAAATAG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MMQRSTLPMRDTFGRLLAELGEKNKDIIVITADVGNSTRAMYFREKFPDRYFNVGISEQDMVNFAAGLSVTGFKPIVVGF
AMFVMRAWEQIRNSIARMNLDVKIMVTHSGYSDSGDGSSHQALEDIALMRVLPNMKVIIPADSEDVKRSLPVVVNELRGP
LYYRMGRDYTPVITEGLDYDFKLGKAYVLRDGEDLAIMGAGVVLADALKAAEELEKMGISAAVINLMSIKPIDEDLIEYY
ARKTGRIITIEEHSIYGGIGSAVAEVVVKKYPVPMRFIGAITFGRSARSERDLLDFYGINYKSILNAVMELVK

Sequences:

>Translated_313_residues
MMQRSTLPMRDTFGRLLAELGEKNKDIIVITADVGNSTRAMYFREKFPDRYFNVGISEQDMVNFAAGLSVTGFKPIVVGF
AMFVMRAWEQIRNSIARMNLDVKIMVTHSGYSDSGDGSSHQALEDIALMRVLPNMKVIIPADSEDVKRSLPVVVNELRGP
LYYRMGRDYTPVITEGLDYDFKLGKAYVLRDGEDLAIMGAGVVLADALKAAEELEKMGISAAVINLMSIKPIDEDLIEYY
ARKTGRIITIEEHSIYGGIGSAVAEVVVKKYPVPMRFIGAITFGRSARSERDLLDFYGINYKSILNAVMELVK
>Mature_313_residues
MMQRSTLPMRDTFGRLLAELGEKNKDIIVITADVGNSTRAMYFREKFPDRYFNVGISEQDMVNFAAGLSVTGFKPIVVGF
AMFVMRAWEQIRNSIARMNLDVKIMVTHSGYSDSGDGSSHQALEDIALMRVLPNMKVIIPADSEDVKRSLPVVVNELRGP
LYYRMGRDYTPVITEGLDYDFKLGKAYVLRDGEDLAIMGAGVVLADALKAAEELEKMGISAAVINLMSIKPIDEDLIEYY
ARKTGRIITIEEHSIYGGIGSAVAEVVVKKYPVPMRFIGAITFGRSARSERDLLDFYGINYKSILNAVMELVK

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=308, Percent_Identity=35.0649350649351, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI4507521, Length=308, Percent_Identity=35.0649350649351, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI225637463, Length=307, Percent_Identity=34.8534201954397, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI225637459, Length=307, Percent_Identity=34.8534201954397, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI225637461, Length=307, Percent_Identity=34.8534201954397, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI133778974, Length=304, Percent_Identity=34.8684210526316, Blast_Score=157, Evalue=8e-39,
Organism=Homo sapiens, GI4557353, Length=244, Percent_Identity=27.8688524590164, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI34101272, Length=244, Percent_Identity=27.8688524590164, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI291084858, Length=272, Percent_Identity=26.1029411764706, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI156564403, Length=278, Percent_Identity=25.5395683453237, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1786622, Length=278, Percent_Identity=34.1726618705036, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI48994911, Length=308, Percent_Identity=24.6753246753247, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1788808, Length=304, Percent_Identity=25.3289473684211, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17539652, Length=304, Percent_Identity=35.1973684210526, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17538422, Length=284, Percent_Identity=27.112676056338, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17506935, Length=238, Percent_Identity=27.3109243697479, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319698, Length=283, Percent_Identity=27.9151943462898, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6325331, Length=197, Percent_Identity=28.9340101522843, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319593, Length=196, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45551847, Length=313, Percent_Identity=31.3099041533546, Blast_Score=154, Evalue=5e-38,
Organism=Drosophila melanogaster, GI45550715, Length=313, Percent_Identity=31.3099041533546, Blast_Score=154, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24645119, Length=313, Percent_Identity=31.3099041533546, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24666278, Length=308, Percent_Identity=31.1688311688312, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21358145, Length=243, Percent_Identity=29.6296296296296, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24650940, Length=243, Percent_Identity=29.6296296296296, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI160714828, Length=263, Percent_Identity=26.2357414448669, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI160714832, Length=263, Percent_Identity=26.2357414448669, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 34892; Mature: 34892

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQRSTLPMRDTFGRLLAELGEKNKDIIVITADVGNSTRAMYFREKFPDRYFNVGISEQD
CCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEHHHHHCCHHHEECCCCHHH
MVNFAAGLSVTGFKPIVVGFAMFVMRAWEQIRNSIARMNLDVKIMVTHSGYSDSGDGSSH
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHH
QALEDIALMRVLPNMKVIIPADSEDVKRSLPVVVNELRGPLYYRMGRDYTPVITEGLDYD
HHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHCCCCCC
FKLGKAYVLRDGEDLAIMGAGVVLADALKAAEELEKMGISAAVINLMSIKPIDEDLIEYY
EECCCEEEEECCCCEEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHH
ARKTGRIITIEEHSIYGGIGSAVAEVVVKKYPVPMRFIGAITFGRSARSERDLLDFYGIN
HHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHCCC
YKSILNAVMELVK
HHHHHHHHHHHHC
>Mature Secondary Structure
MMQRSTLPMRDTFGRLLAELGEKNKDIIVITADVGNSTRAMYFREKFPDRYFNVGISEQD
CCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEHHHHHCCHHHEECCCCHHH
MVNFAAGLSVTGFKPIVVGFAMFVMRAWEQIRNSIARMNLDVKIMVTHSGYSDSGDGSSH
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHH
QALEDIALMRVLPNMKVIIPADSEDVKRSLPVVVNELRGPLYYRMGRDYTPVITEGLDYD
HHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHCCCCCC
FKLGKAYVLRDGEDLAIMGAGVVLADALKAAEELEKMGISAAVINLMSIKPIDEDLIEYY
EECCCEEEEECCCCEEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHH
ARKTGRIITIEEHSIYGGIGSAVAEVVVKKYPVPMRFIGAITFGRSARSERDLLDFYGIN
HHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHCCC
YKSILNAVMELVK
HHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]