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The map label for this gene is strD [H]

Identifier: 15922288

GI number: 15922288

Start: 1981461

End: 1982495

Strand: Direct

Name: strD [H]

Synonym: ST1971

Alternate gene names: 15922288

Gene position: 1981461-1982495 (Clockwise)

Preceding gene: 15922287

Following gene: 15922289

Centisome position: 73.53

GC content: 39.52

Gene sequence:

>1035_bases
ATGGAGGCGGTAATTTTACACGGAGGTCAAGGTACTAGATTAAGGCCTTTAACTCACACTGGCCCTAAACAGTTAATAAA
AGTAGCGGGAAAGCCTGTTTCCCAGTGGGTTTTAGAACAGATAAGGGATTCTGGAATTAGAGACGTAGTGATAGTTTTAG
GTGATAATACCCCAAAGAGGGTTGTAGACTATTATGGTGATGGTAGTAAGTTTGGGGTAAATATTACCTATGTTTATCAA
GGTAAGGCAAGAGGTTTGGCAGACGCAGTATATAAAGTTAAGGATGTAGTATCTAAGAAGTTTTTGGTTTATTTAGGGGA
CAATCTTGTGCCTTACGATCTGAGGAAGTTTATGTCGTTTAAAGGCTCAGCTTCTATACTTTTGGCTAAGGTTGATAATC
CTAACCGTTTCGGAGTTGCTGTAATAAAAGAAAATAAGGTTGTGAAGTTGGTAGAGAAGCCTAAGGAACCTATTTCCGAT
TTAGCGTTAGTAGGTGTTTATGCATTTACTGACGAGATTTTTGAGGTTATTGAGAGTCTGAGACCTAGTTGGAGGGGGGA
ATTGGAGATAACTGATGCTATACAAGGCTTAATAGATGAAGGTAAAGAGGTTAATTACGAAATAGTCCAAGGGTGGTGGA
AGGATACTGGGACACCTAGGGACATATTGGAGGCTAATTCTTTTTTATTAGATAGGTATACTGAGAGGAGGATTGAAGGT
GATGTGGACAATTCTACTATAGACGGTAGGGTTATAGTGGAGAAGGGGACTGTGATAAAGAACTCGGTTATTAGGGGTCC
CGTATATATAGGTAGGGATAGTAAGATAGTGAATTCCTATGTTGGTCCTTTCACTTCAATAGGGGATTCGAGTCAAGTTG
TTGATAGTGAGGTTGAGTATAGTGTCATTTTGGATAATGTAAGGATTAAGGGGGTTTCACTTATGGATTCGTTAATAGGG
AACAATTCTGTCGTGGAGAAGGGAAATAGGTGGCAGAGGCTAATAATAGGTGAGAATTCTTCGGTGATATTATGA

Upstream 100 bases:

>100_bases
AGCTAAAAGGCCTTACGATTCCTCTCTCGATTCTTCAAGGGCTAGGAAAATACTTTCAACAGATTTTTACACATTGGATC
TAGACGGTATGGTGGTGTGA

Downstream 100 bases:

>100_bases
TAATTATTGGTGGTGCTGGTTTCATAGGCTCTGCGTTTGTAAGAGAGGTGAATAGGAGGGGAATTAAACCGGTTGTGATT
GATTTACTTACTTATGCCGG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MEAVILHGGQGTRLRPLTHTGPKQLIKVAGKPVSQWVLEQIRDSGIRDVVIVLGDNTPKRVVDYYGDGSKFGVNITYVYQ
GKARGLADAVYKVKDVVSKKFLVYLGDNLVPYDLRKFMSFKGSASILLAKVDNPNRFGVAVIKENKVVKLVEKPKEPISD
LALVGVYAFTDEIFEVIESLRPSWRGELEITDAIQGLIDEGKEVNYEIVQGWWKDTGTPRDILEANSFLLDRYTERRIEG
DVDNSTIDGRVIVEKGTVIKNSVIRGPVYIGRDSKIVNSYVGPFTSIGDSSQVVDSEVEYSVILDNVRIKGVSLMDSLIG
NNSVVEKGNRWQRLIIGENSSVIL

Sequences:

>Translated_344_residues
MEAVILHGGQGTRLRPLTHTGPKQLIKVAGKPVSQWVLEQIRDSGIRDVVIVLGDNTPKRVVDYYGDGSKFGVNITYVYQ
GKARGLADAVYKVKDVVSKKFLVYLGDNLVPYDLRKFMSFKGSASILLAKVDNPNRFGVAVIKENKVVKLVEKPKEPISD
LALVGVYAFTDEIFEVIESLRPSWRGELEITDAIQGLIDEGKEVNYEIVQGWWKDTGTPRDILEANSFLLDRYTERRIEG
DVDNSTIDGRVIVEKGTVIKNSVIRGPVYIGRDSKIVNSYVGPFTSIGDSSQVVDSEVEYSVILDNVRIKGVSLMDSLIG
NNSVVEKGNRWQRLIIGENSSVIL
>Mature_344_residues
MEAVILHGGQGTRLRPLTHTGPKQLIKVAGKPVSQWVLEQIRDSGIRDVVIVLGDNTPKRVVDYYGDGSKFGVNITYVYQ
GKARGLADAVYKVKDVVSKKFLVYLGDNLVPYDLRKFMSFKGSASILLAKVDNPNRFGVAVIKENKVVKLVEKPKEPISD
LALVGVYAFTDEIFEVIESLRPSWRGELEITDAIQGLIDEGKEVNYEIVQGWWKDTGTPRDILEANSFLLDRYTERRIEG
DVDNSTIDGRVIVEKGTVIKNSVIRGPVYIGRDSKIVNSYVGPFTSIGDSSQVVDSEVEYSVILDNVRIKGVSLMDSLIG
NNSVVEKGNRWQRLIIGENSSVIL

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=329, Percent_Identity=25.2279635258359, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI11761621, Length=329, Percent_Identity=25.2279635258359, Blast_Score=105, Evalue=4e-23,
Organism=Escherichia coli, GI1788351, Length=241, Percent_Identity=33.6099585062241, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1790224, Length=243, Percent_Identity=32.0987654320988, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1787488, Length=269, Percent_Identity=26.0223048327138, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=348, Percent_Identity=26.7241379310345, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17509979, Length=354, Percent_Identity=25.9887005649718, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320148, Length=346, Percent_Identity=28.9017341040462, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21355443, Length=350, Percent_Identity=26.2857142857143, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24644084, Length=350, Percent_Identity=26.2857142857143, Blast_Score=114, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 38205; Mature: 38205

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAVILHGGQGTRLRPLTHTGPKQLIKVAGKPVSQWVLEQIRDSGIRDVVIVLGDNTPKR
CCEEEEECCCCCEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHH
VVDYYGDGSKFGVNITYVYQGKARGLADAVYKVKDVVSKKFLVYLGDNLVPYDLRKFMSF
HHEECCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHCC
KGSASILLAKVDNPNRFGVAVIKENKVVKLVEKPKEPISDLALVGVYAFTDEIFEVIESL
CCCCEEEEEEECCCCCEEEEEEECCCEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RPSWRGELEITDAIQGLIDEGKEVNYEIVQGWWKDTGTPRDILEANSFLLDRYTERRIEG
CCCCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCC
DVDNSTIDGRVIVEKGTVIKNSVIRGPVYIGRDSKIVNSYVGPFTSIGDSSQVVDSEVEY
CCCCCCCCCEEEEECCCEEECCEEECCEEECCCCHHHHHHCCCCCCCCCCCHHHCCCCEE
SVILDNVRIKGVSLMDSLIGNNSVVEKGNRWQRLIIGENSSVIL
EEEEECEEEEHHHHHHHHHCCCCEECCCCCEEEEEEECCCCEEC
>Mature Secondary Structure
MEAVILHGGQGTRLRPLTHTGPKQLIKVAGKPVSQWVLEQIRDSGIRDVVIVLGDNTPKR
CCEEEEECCCCCEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHH
VVDYYGDGSKFGVNITYVYQGKARGLADAVYKVKDVVSKKFLVYLGDNLVPYDLRKFMSF
HHEECCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHCC
KGSASILLAKVDNPNRFGVAVIKENKVVKLVEKPKEPISDLALVGVYAFTDEIFEVIESL
CCCCEEEEEEECCCCCEEEEEEECCCEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RPSWRGELEITDAIQGLIDEGKEVNYEIVQGWWKDTGTPRDILEANSFLLDRYTERRIEG
CCCCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCC
DVDNSTIDGRVIVEKGTVIKNSVIRGPVYIGRDSKIVNSYVGPFTSIGDSSQVVDSEVEY
CCCCCCCCCEEEEECCCEEECCEEECCEEECCCCHHHHHHCCCCCCCCCCCHHHCCCCEE
SVILDNVRIKGVSLMDSLIGNNSVVEKGNRWQRLIIGENSSVIL
EEEEECEEEEHHHHHHHHHCCCCEECCCCCEEEEEEECCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]