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The map label for this gene is rfbD [H]

Identifier: 15922287

GI number: 15922287

Start: 1980639

End: 1981460

Strand: Direct

Name: rfbD [H]

Synonym: ST1970

Alternate gene names: 15922287

Gene position: 1980639-1981460 (Clockwise)

Preceding gene: 15922282

Following gene: 15922288

Centisome position: 73.5

GC content: 37.59

Gene sequence:

>822_bases
ATGCGAACACTAATAACTGGTGCATCGGGACAGTTAGGCATAGAACTCTCACGCTTACTCTCAGAAAGACATGAAGTAAT
AAAAGTCTACAATTCTTCAGAAATTCAAGGAGGTTACAAACTCGACCTTACCGATTTCCCGCGACTAGAGGACTTCATAA
TAAAGAAAAGACCAGACGTAATAATTAATGCAGCAGCAATGACTGACGTAGACAAATGCGAAATAGAGAAGGAGAAGGCA
TATAAAATAAACGCTGAGGCAGTTAGACACATAGTTAGAGCGGGAAAAGTAATAGATTCCTACATAGTCCACATCAGTAC
CGATTACGTGTTTGACGGAGAAAAAGGTAACTATAAAGAAGAAGATATACCTAATCCCATAAATTATTACGGTTTAAGCA
AGCTTTTAGGGGAAACATTTGCTCTACAAGATGATAGTTTAATAATCAGAACTTCTGGTATTTTTAGGAATAAGGGGTTT
CCAATTTACGTTTATAAAACTCTTAAGGAAGGGAAGACTGTATTCGCTTTTAAGGGCTATTACTCTCCTATCTCAGCAAG
AAAACTTGCTTCTGCAATACTTGAACTTTTAGAATTAAGAAAGACTGGGATCATTCACGTTGCCGGTGAGAGGATTTCAC
GTTTTGAATTAGCTTTAAAGATTAAGGAGAAGTTTAATTTACCGGGAGAAGTTAAAGAAGTTGATGAAGTTAGGGGGTGG
ATAGCTAAAAGGCCTTACGATTCCTCTCTCGATTCTTCAAGGGCTAGGAAAATACTTTCAACAGATTTTTACACATTGGA
TCTAGACGGTATGGTGGTGTGA

Upstream 100 bases:

>100_bases
TTTTAACTCTCGTATATCGAGAAATTTCAAAATGCAGTAAATACGTAATCACCTAGCTGATTTATAAAAGCTTTATATTC
TACATAGAAAATTATACTTA

Downstream 100 bases:

>100_bases
ATGGAGGCGGTAATTTTACACGGAGGTCAAGGTACTAGATTAAGGCCTTTAACTCACACTGGCCCTAAACAGTTAATAAA
AGTAGCGGGAAAGCCTGTTT

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MRTLITGASGQLGIELSRLLSERHEVIKVYNSSEIQGGYKLDLTDFPRLEDFIIKKRPDVIINAAAMTDVDKCEIEKEKA
YKINAEAVRHIVRAGKVIDSYIVHISTDYVFDGEKGNYKEEDIPNPINYYGLSKLLGETFALQDDSLIIRTSGIFRNKGF
PIYVYKTLKEGKTVFAFKGYYSPISARKLASAILELLELRKTGIIHVAGERISRFELALKIKEKFNLPGEVKEVDEVRGW
IAKRPYDSSLDSSRARKILSTDFYTLDLDGMVV

Sequences:

>Translated_273_residues
MRTLITGASGQLGIELSRLLSERHEVIKVYNSSEIQGGYKLDLTDFPRLEDFIIKKRPDVIINAAAMTDVDKCEIEKEKA
YKINAEAVRHIVRAGKVIDSYIVHISTDYVFDGEKGNYKEEDIPNPINYYGLSKLLGETFALQDDSLIIRTSGIFRNKGF
PIYVYKTLKEGKTVFAFKGYYSPISARKLASAILELLELRKTGIIHVAGERISRFELALKIKEKFNLPGEVKEVDEVRGW
IAKRPYDSSLDSSRARKILSTDFYTLDLDGMVV
>Mature_273_residues
MRTLITGASGQLGIELSRLLSERHEVIKVYNSSEIQGGYKLDLTDFPRLEDFIIKKRPDVIINAAAMTDVDKCEIEKEKA
YKINAEAVRHIVRAGKVIDSYIVHISTDYVFDGEKGNYKEEDIPNPINYYGLSKLLGETFALQDDSLIIRTSGIFRNKGF
PIYVYKTLKEGKTVFAFKGYYSPISARKLASAILELLELRKTGIIHVAGERISRFELALKIKEKFNLPGEVKEVDEVRGW
IAKRPYDSSLDSSRARKILSTDFYTLDLDGMVV

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=283, Percent_Identity=26.8551236749117, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI11034825, Length=283, Percent_Identity=26.8551236749117, Blast_Score=101, Evalue=6e-22,
Organism=Escherichia coli, GI1788352, Length=278, Percent_Identity=31.294964028777, Blast_Score=101, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 30955; Mature: 30955

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLITGASGQLGIELSRLLSERHEVIKVYNSSEIQGGYKLDLTDFPRLEDFIIKKRPDV
CCEEEECCCCCCCHHHHHHHHHHHHHEEEECCCCCCCCEEECCCCCCCHHHHHHCCCCCE
IINAAAMTDVDKCEIEKEKAYKINAEAVRHIVRAGKVIDSYIVHISTDYVFDGEKGNYKE
EEEEHHHCCCHHHHCCHHHCEEECHHHHHHHHHHHHHHHHEEEEEEECEEEECCCCCCCC
EDIPNPINYYGLSKLLGETFALQDDSLIIRTSGIFRNKGFPIYVYKTLKEGKTVFAFKGY
CCCCCCHHHHHHHHHHHHHHEECCCCEEEEECCEEECCCCEEEEEEECCCCCEEEEEECC
YSPISARKLASAILELLELRKTGIIHVAGERISRFELALKIKEKFNLPGEVKEVDEVRGW
CCCHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHEEEEHHHCCCCCCHHHHHHHHHH
IAKRPYDSSLDSSRARKILSTDFYTLDLDGMVV
HHCCCCCCCCCHHHHHHHHCCCEEEEECCCEEC
>Mature Secondary Structure
MRTLITGASGQLGIELSRLLSERHEVIKVYNSSEIQGGYKLDLTDFPRLEDFIIKKRPDV
CCEEEECCCCCCCHHHHHHHHHHHHHEEEECCCCCCCCEEECCCCCCCHHHHHHCCCCCE
IINAAAMTDVDKCEIEKEKAYKINAEAVRHIVRAGKVIDSYIVHISTDYVFDGEKGNYKE
EEEEHHHCCCHHHHCCHHHCEEECHHHHHHHHHHHHHHHHEEEEEEECEEEECCCCCCCC
EDIPNPINYYGLSKLLGETFALQDDSLIIRTSGIFRNKGFPIYVYKTLKEGKTVFAFKGY
CCCCCCHHHHHHHHHHHHHHEECCCCEEEEECCEEECCCCEEEEEEECCCCCEEEEEECC
YSPISARKLASAILELLELRKTGIIHVAGERISRFELALKIKEKFNLPGEVKEVDEVRGW
CCCHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHEEEEHHHCCCCCCHHHHHHHHHH
IAKRPYDSSLDSSRARKILSTDFYTLDLDGMVV
HHCCCCCCCCCHHHHHHHHCCCEEEEECCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609 [H]