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The map label for this gene is ubiA [H]

Identifier: 15921811

GI number: 15921811

Start: 1512261

End: 1513166

Strand: Reverse

Name: ubiA [H]

Synonym: ST1518

Alternate gene names: 15921811

Gene position: 1513166-1512261 (Counterclockwise)

Preceding gene: 15921812

Following gene: 15921809

Centisome position: 56.15

GC content: 34.11

Gene sequence:

>906_bases
ATGAAAATTACGAGAATATACGTGAGACTTATGGCAATAAGTCTATCTAGGAAGTTAATTGACTATATTAAGCTTTCAAA
ACCTCGAGTTATTAGCCTCTTAGATCTCGCTGCTATTGCAGGATTTGTACTTGGTTTACCTAAAGCTATTAATATTACTT
CTATCATAGTGAGTTTTCTTGCCGTAATTATAGGAGGTAGCCTTGCATCTGGTGGAGGAATGATAATTAATGGAGGTCTT
GAGATAGAAAAAGATAAGAAAATGAAGAGAACTTCTTGGAGACCAACAGTAAAAGGAGAAGTAGGAAGAAAAGAGGCTTA
TGCAATAGGTTCAATATTTATAGTTGTTGGTACACTTATTGGTTTTCTTGCAAATCCTCTCACAGCCCTATTTATCGCTT
TAGGAGCTTTTATATATGTAGTTATTTACTCAATTTGGCTAAAACCAAGAACTTGGTGGAATATTGTGATTGGTGGTTTT
GCTGGAAGTGCGGCAGCATGGGCTGGTTTTGCAGCAAGTAGTGGTTCTTTCACATTATTGTCGTTTTTATTAGGCTTTTT
AATCTTTATGTGGACCCCAGGACACTTTTGGTCTTTAGCGTTAAGGTTCAGAGATGATTATAAAAATGCTGAAATTCCTA
TGTTACCAGTATTGACAGATGAGAGAACTTCTGCTAAAGCTATTGCTATATCAAATGCATTAATGGTACCATTTGCTTTA
CTAATAGGGTTATATGCTGGTTTAATATATTTGATTGTAAGTACAATAGTGTCCGCATTTCTACTATATGTATCAGTTAA
ACTTTATCTTAATCCTACAGCAGATGAAGCTTGGGAATCATTTAAATTATCCTCGCCTTATCTTGCAATAATCTTACTAA
CGTTAATTATAGTAAAACTTATTTAA

Upstream 100 bases:

>100_bases
AGTAAATGCTGCCTATGGAGCTTTATCTGATTTAATTCTTCTAAAGAGAGATTGCTTATGATTTTTCTCTATTTGTAATT
ATTTAAGAGAATATTTAAAT

Downstream 100 bases:

>100_bases
TACTTAAAGTTTTATTATTTTGTAATATTTTTAAAAACAAGATTAATATGGCATTGTGACTTTTAAATCGGCTTTATCAT
TGTTCGATATTATTATTTCA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MKITRIYVRLMAISLSRKLIDYIKLSKPRVISLLDLAAIAGFVLGLPKAINITSIIVSFLAVIIGGSLASGGGMIINGGL
EIEKDKKMKRTSWRPTVKGEVGRKEAYAIGSIFIVVGTLIGFLANPLTALFIALGAFIYVVIYSIWLKPRTWWNIVIGGF
AGSAAAWAGFAASSGSFTLLSFLLGFLIFMWTPGHFWSLALRFRDDYKNAEIPMLPVLTDERTSAKAIAISNALMVPFAL
LIGLYAGLIYLIVSTIVSAFLLYVSVKLYLNPTADEAWESFKLSSPYLAIILLTLIIVKLI

Sequences:

>Translated_301_residues
MKITRIYVRLMAISLSRKLIDYIKLSKPRVISLLDLAAIAGFVLGLPKAINITSIIVSFLAVIIGGSLASGGGMIINGGL
EIEKDKKMKRTSWRPTVKGEVGRKEAYAIGSIFIVVGTLIGFLANPLTALFIALGAFIYVVIYSIWLKPRTWWNIVIGGF
AGSAAAWAGFAASSGSFTLLSFLLGFLIFMWTPGHFWSLALRFRDDYKNAEIPMLPVLTDERTSAKAIAISNALMVPFAL
LIGLYAGLIYLIVSTIVSAFLLYVSVKLYLNPTADEAWESFKLSSPYLAIILLTLIIVKLI
>Mature_301_residues
MKITRIYVRLMAISLSRKLIDYIKLSKPRVISLLDLAAIAGFVLGLPKAINITSIIVSFLAVIIGGSLASGGGMIINGGL
EIEKDKKMKRTSWRPTVKGEVGRKEAYAIGSIFIVVGTLIGFLANPLTALFIALGAFIYVVIYSIWLKPRTWWNIVIGGF
AGSAAAWAGFAASSGSFTLLSFLLGFLIFMWTPGHFWSLALRFRDDYKNAEIPMLPVLTDERTSAKAIAISNALMVPFAL
LIGLYAGLIYLIVSTIVSAFLLYVSVKLYLNPTADEAWESFKLSSPYLAIILLTLIIVKLI

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=195, Percent_Identity=30.7692307692308, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786631, Length=265, Percent_Identity=28.6792452830189, Blast_Score=95, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71998235, Length=267, Percent_Identity=27.7153558052434, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6325085, Length=265, Percent_Identity=29.4339622641509, Blast_Score=89, Evalue=7e-19,
Organism=Drosophila melanogaster, GI19921064, Length=285, Percent_Identity=24.5614035087719, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 32862; Mature: 32862

Theoretical pI: Translated: 10.38; Mature: 10.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITRIYVRLMAISLSRKLIDYIKLSKPRVISLLDLAAIAGFVLGLPKAINITSIIVSFL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
AVIIGGSLASGGGMIINGGLEIEKDKKMKRTSWRPTVKGEVGRKEAYAIGSIFIVVGTLI
HHHHCCCCCCCCCEEEECCEEECCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GFLANPLTALFIALGAFIYVVIYSIWLKPRTWWNIVIGGFAGSAAAWAGFAASSGSFTLL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHCCCCCCCCHHHH
SFLLGFLIFMWTPGHFWSLALRFRDDYKNAEIPMLPVLTDERTSAKAIAISNALMVPFAL
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHH
LIGLYAGLIYLIVSTIVSAFLLYVSVKLYLNPTADEAWESFKLSSPYLAIILLTLIIVKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHH
I
C
>Mature Secondary Structure
MKITRIYVRLMAISLSRKLIDYIKLSKPRVISLLDLAAIAGFVLGLPKAINITSIIVSFL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
AVIIGGSLASGGGMIINGGLEIEKDKKMKRTSWRPTVKGEVGRKEAYAIGSIFIVVGTLI
HHHHCCCCCCCCCEEEECCEEECCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GFLANPLTALFIALGAFIYVVIYSIWLKPRTWWNIVIGGFAGSAAAWAGFAASSGSFTLL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHCCCCCCCCHHHH
SFLLGFLIFMWTPGHFWSLALRFRDDYKNAEIPMLPVLTDERTSAKAIAISNALMVPFAL
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHH
LIGLYAGLIYLIVSTIVSAFLLYVSVKLYLNPTADEAWESFKLSSPYLAIILLTLIIVKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHH
I
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]