Click here to switch to the map view.

The map label for this gene is hom [H]

Identifier: 15921812

GI number: 15921812

Start: 1513206

End: 1514144

Strand: Reverse

Name: hom [H]

Synonym: ST1519

Alternate gene names: 15921812

Gene position: 1514144-1513206 (Counterclockwise)

Preceding gene: 15921813

Following gene: 15921811

Centisome position: 56.19

GC content: 33.65

Gene sequence:

>939_bases
GTGGGATGGAATGGTGAAGTTAGGTTGAAATTATTACTCTTTGGTTATGGAAATGTCGGAAAAGCATTTAGAAAATTACT
TCATGAAAAAAGATCTCCGGAGTTAAATGACGTAATAATTGGAGGAATAGTTACTAGAAGAGGAATAATGTTACAAGATA
AAGAAGACTTTACACCAGATCTTGAAGGAGACGTATTTAAAGCCTTTGAAAAAATTAAACCAGATATAATAGTTGATGTT
TCATCTGCAAATTATAACAATGGAGAACCTTCACTCTCTTTATATAAGGAAGCTATAAAAGATGGTGTAAATATAATAAC
TACAAATAAAGCTCCTTTAGCTTTAGCCTTTAACGAGATATTTTCTTTAGCTAGATCAAAAGGTGTAAAAATTGGTTTTC
AAGGAACTGTAATGAGCGGAACACCATCAATTAATCTATACAGAGTTTTACCAGGAAGTAGAGTGATAAAGATTAGGGGG
ATTCTAAATGGGACAACAAACTTCATATTGACCCTCATGAATAAAGGAGTAAGTTTCGAAGAGGCATTGAAAGAGGCTCA
AAGAAGAGGATATGCTGAAGAAGACCCTACATTAGACATTAACGGTTTTGATGCGGCAGCAAAAATAACTATTTTAGCCA
ACTTTATGATAGGAAATAGTGTGACGATTAAAGATGTAAAGTTTGAAGGCATAAATCGAGATTTACCAAAAAATGAAAAA
ATAAAGTTAATCGCGTATGCTGATGAAAAAGAAGTTTGGGTAAAGCCCCTTCCTATTTCTCAAGATGATCCTCTATATAA
TGTTGACGGTGTTGAAAACGCACTTGAGATTACTACAGATATTCAAAGTATTTTAATAAGAGGACCTGGTGCCGGACCAG
TAAATGCTGCCTATGGAGCTTTATCTGATTTAATTCTTCTAAAGAGAGATTGCTTATGA

Upstream 100 bases:

>100_bases
TTTTAATTGTTTCAGCTGGAGTACCGGGAGTTGAAAAAGATTTAGTATTTTATGCTGCTAAACTTACAGCAGAGTTATTA
GTTAAATATGCTAATGGAAA

Downstream 100 bases:

>100_bases
TTTTTCTCTATTTGTAATTATTTAAGAGAATATTTAAATATGAAAATTACGAGAATATACGTGAGACTTATGGCAATAAG
TCTATCTAGGAAGTTAATTG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MGWNGEVRLKLLLFGYGNVGKAFRKLLHEKRSPELNDVIIGGIVTRRGIMLQDKEDFTPDLEGDVFKAFEKIKPDIIVDV
SSANYNNGEPSLSLYKEAIKDGVNIITTNKAPLALAFNEIFSLARSKGVKIGFQGTVMSGTPSINLYRVLPGSRVIKIRG
ILNGTTNFILTLMNKGVSFEEALKEAQRRGYAEEDPTLDINGFDAAAKITILANFMIGNSVTIKDVKFEGINRDLPKNEK
IKLIAYADEKEVWVKPLPISQDDPLYNVDGVENALEITTDIQSILIRGPGAGPVNAAYGALSDLILLKRDCL

Sequences:

>Translated_312_residues
MGWNGEVRLKLLLFGYGNVGKAFRKLLHEKRSPELNDVIIGGIVTRRGIMLQDKEDFTPDLEGDVFKAFEKIKPDIIVDV
SSANYNNGEPSLSLYKEAIKDGVNIITTNKAPLALAFNEIFSLARSKGVKIGFQGTVMSGTPSINLYRVLPGSRVIKIRG
ILNGTTNFILTLMNKGVSFEEALKEAQRRGYAEEDPTLDINGFDAAAKITILANFMIGNSVTIKDVKFEGINRDLPKNEK
IKLIAYADEKEVWVKPLPISQDDPLYNVDGVENALEITTDIQSILIRGPGAGPVNAAYGALSDLILLKRDCL
>Mature_311_residues
GWNGEVRLKLLLFGYGNVGKAFRKLLHEKRSPELNDVIIGGIVTRRGIMLQDKEDFTPDLEGDVFKAFEKIKPDIIVDVS
SANYNNGEPSLSLYKEAIKDGVNIITTNKAPLALAFNEIFSLARSKGVKIGFQGTVMSGTPSINLYRVLPGSRVIKIRGI
LNGTTNFILTLMNKGVSFEEALKEAQRRGYAEEDPTLDINGFDAAAKITILANFMIGNSVTIKDVKFEGINRDLPKNEKI
KLIAYADEKEVWVKPLPISQDDPLYNVDGVENALEITTDIQSILIRGPGAGPVNAAYGALSDLILLKRDCL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=294, Percent_Identity=26.530612244898, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1790376, Length=340, Percent_Identity=22.0588235294118, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=149, Percent_Identity=33.5570469798658, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR022697
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 34285; Mature: 34154

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGWNGEVRLKLLLFGYGNVGKAFRKLLHEKRSPELNDVIIGGIVTRRGIMLQDKEDFTPD
CCCCCEEEEEEEEEECCCHHHHHHHHHHHHCCCCHHHEEEEHHHHHCCEEEECCCCCCCC
LEGDVFKAFEKIKPDIIVDVSSANYNNGEPSLSLYKEAIKDGVNIITTNKAPLALAFNEI
CCCHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCCEEHHHHHH
FSLARSKGVKIGFQGTVMSGTPSINLYRVLPGSRVIKIRGILNGTTNFILTLMNKGVSFE
HHHHHHCCCEEEECEEEECCCCCEEEEEECCCCEEEEEEEEECCHHHHHHHHHHCCCCHH
EALKEAQRRGYAEEDPTLDINGFDAAAKITILANFMIGNSVTIKDVKFEGINRDLPKNEK
HHHHHHHHCCCCCCCCEEEECCCCCCEEEEEEEEEEECCEEEEEEEEECCCCCCCCCCCC
IKLIAYADEKEVWVKPLPISQDDPLYNVDGVENALEITTDIQSILIRGPGAGPVNAAYGA
EEEEEEECCCCEEEECCCCCCCCCCEECCCCCHHHHHHHHHHHHEEECCCCCCCHHHHHH
LSDLILLKRDCL
HHHHHHHHHCCC
>Mature Secondary Structure 
GWNGEVRLKLLLFGYGNVGKAFRKLLHEKRSPELNDVIIGGIVTRRGIMLQDKEDFTPD
CCCCEEEEEEEEEECCCHHHHHHHHHHHHCCCCHHHEEEEHHHHHCCEEEECCCCCCCC
LEGDVFKAFEKIKPDIIVDVSSANYNNGEPSLSLYKEAIKDGVNIITTNKAPLALAFNEI
CCCHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCCEEHHHHHH
FSLARSKGVKIGFQGTVMSGTPSINLYRVLPGSRVIKIRGILNGTTNFILTLMNKGVSFE
HHHHHHCCCEEEECEEEECCCCCEEEEEECCCCEEEEEEEEECCHHHHHHHHHHCCCCHH
EALKEAQRRGYAEEDPTLDINGFDAAAKITILANFMIGNSVTIKDVKFEGINRDLPKNEK
HHHHHHHHCCCCCCCCEEEECCCCCCEEEEEEEEEEECCEEEEEEEEECCCCCCCCCCCC
IKLIAYADEKEVWVKPLPISQDDPLYNVDGVENALEITTDIQSILIRGPGAGPVNAAYGA
EEEEEEECCCCEEEECCCCCCCCCCEECCCCCHHHHHHHHHHHHEEECCCCCCCHHHHHH
LSDLILLKRDCL
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]