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The map label for this gene is guaAA

Identifier: 15920795

GI number: 15920795

Start: 566356

End: 566922

Strand: Direct

Name: guaAA

Synonym: ST0578

Alternate gene names: 15920795

Gene position: 566356-566922 (Clockwise)

Preceding gene: 15920793

Following gene: 15920797

Centisome position: 21.02

GC content: 33.69

Gene sequence:

>567_bases
GTGAAAATTGCTGTAATTTATTTTGGAGGTCAATATAATCACTTAATAGTCAAAGACTTAAAATATCTAGGTTTAAATGC
TGTTCTTATAACTCCAGAAAAACCGGTTGAAATTCTAAAAGATTATGATTGTATAATTTTTGGCGGAGGTCCTTATTCGG
TTATTACAGAGTTAAACAAAATGGGTAATGCTGTAGATTATGTCCTTAGAACTTCTCAACCTAAACTAGGCATCTGCTTA
GGTCATCAATTATTAGCAAAGGTTCTAGGTGGTGAAGTAACGAAGGCAACAAAACCAGAGTATGGATTAGTAAAAGTGAA
CATAAACGATGAAGATACCATCTTAAGAGGATTATCACCATCTATTAATGCCTGGGAAAGTCATACCGATGAAGTAATTT
CTCCACCTCAAGGGTTCAGAATTTTAGCAAATAGTGAAAATGCTAAAGTCCAAGCAATGGTAAATAAGGACAATACAATA
TTTGGAGTGCAGTTTCATCCAGAAGTTAAGCATACCGAAAAAGGCATAGAAGTATTTAAGAATTTCATAGAAGCTTGCAA
GAAATAG

Upstream 100 bases:

>100_bases
TACCATTTGCAGAAATAAGAGCAACGACTGCAGCCTTACATTCATTCATATTTATTTAATCTGACCCAAAGCTTATATTT
TTGAAAATGAACTTTCAAGT

Downstream 100 bases:

>100_bases
TTATGTAATTTTATCCTCATTAGCTTCCTTAATCTTTTGCATAACTTTAGGAGGTAATGCATAATCCTCTCTTCTCTCGT
TTATTTTACCTAGTAATACA

Product: GMP synthase subunit A

Products: NA

Alternate protein names: Glutamine amidotransferase

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MKIAVIYFGGQYNHLIVKDLKYLGLNAVLITPEKPVEILKDYDCIIFGGGPYSVITELNKMGNAVDYVLRTSQPKLGICL
GHQLLAKVLGGEVTKATKPEYGLVKVNINDEDTILRGLSPSINAWESHTDEVISPPQGFRILANSENAKVQAMVNKDNTI
FGVQFHPEVKHTEKGIEVFKNFIEACKK

Sequences:

>Translated_188_residues
MKIAVIYFGGQYNHLIVKDLKYLGLNAVLITPEKPVEILKDYDCIIFGGGPYSVITELNKMGNAVDYVLRTSQPKLGICL
GHQLLAKVLGGEVTKATKPEYGLVKVNINDEDTILRGLSPSINAWESHTDEVISPPQGFRILANSENAKVQAMVNKDNTI
FGVQFHPEVKHTEKGIEVFKNFIEACKK
>Mature_188_residues
MKIAVIYFGGQYNHLIVKDLKYLGLNAVLITPEKPVEILKDYDCIIFGGGPYSVITELNKMGNAVDYVLRTSQPKLGICL
GHQLLAKVLGGEVTKATKPEYGLVKVNINDEDTILRGLSPSINAWESHTDEVISPPQGFRILANSENAKVQAMVNKDNTI
FGVQFHPEVKHTEKGIEVFKNFIEACKK

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0518

COG function: function code F; GMP synthase - Glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=183, Percent_Identity=31.1475409836066, Blast_Score=94, Evalue=6e-20,
Organism=Escherichia coli, GI1788854, Length=193, Percent_Identity=30.5699481865285, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1789760, Length=114, Percent_Identity=32.4561403508772, Blast_Score=70, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71992717, Length=190, Percent_Identity=30, Blast_Score=83, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI133901714, Length=190, Percent_Identity=30, Blast_Score=83, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71992710, Length=190, Percent_Identity=30, Blast_Score=83, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6323873, Length=188, Percent_Identity=35.6382978723404, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI281365319, Length=192, Percent_Identity=31.7708333333333, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAAA_SULTO (Q974T4)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_376464.1
- ProteinModelPortal:   Q974T4
- SMR:   Q974T4
- GeneID:   1458523
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST0578
- NMPDR:   fig|273063.1.peg.632
- HOGENOM:   HBG292341
- OMA:   GQYVHRI
- ProtClustDB:   PRK00758
- BioCyc:   STOK273063:ST0578-MONOMER
- BRENDA:   6.3.5.2
- HAMAP:   MF_01510
- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR004739
- PRINTS:   PR00097
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase

EC number: =6.3.5.2

Molecular weight: Translated: 20828; Mature: 20828

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 79-79 ACT_SITE 166-166 ACT_SITE 168-168

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAVIYFGGQYNHLIVKDLKYLGLNAVLITPEKPVEILKDYDCIIFGGGPYSVITELNK
CEEEEEEECCCCCEEHHHHHHHCCCEEEEECCCCCHHHHCCCCEEEECCCCHHHHHHHHH
MGNAVDYVLRTSQPKLGICLGHQLLAKVLGGEVTKATKPEYGLVKVNINDEDTILRGLSP
HCCCEEEEEECCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHEECCCC
SINAWESHTDEVISPPQGFRILANSENAKVQAMVNKDNTIFGVQFHPEVKHTEKGIEVFK
CCCCCCCCCCHHCCCCCCCEEEECCCCCEEEEEEECCCEEEEEEECCCCHHHHHHHHHHH
NFIEACKK
HHHHHHCC
>Mature Secondary Structure
MKIAVIYFGGQYNHLIVKDLKYLGLNAVLITPEKPVEILKDYDCIIFGGGPYSVITELNK
CEEEEEEECCCCCEEHHHHHHHCCCEEEEECCCCCHHHHCCCCEEEECCCCHHHHHHHHH
MGNAVDYVLRTSQPKLGICLGHQLLAKVLGGEVTKATKPEYGLVKVNINDEDTILRGLSP
HCCCEEEEEECCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHEECCCC
SINAWESHTDEVISPPQGFRILANSENAKVQAMVNKDNTIFGVQFHPEVKHTEKGIEVFK
CCCCCCCCCCHHCCCCCCCEEEECCCCCEEEEEEECCCEEEEEEECCCCHHHHHHHHHHH
NFIEACKK
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479