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The map label for this gene is gabT [H]

Identifier: 57652339

GI number: 57652339

Start: 2677589

End: 2678926

Strand: Reverse

Name: gabT [H]

Synonym: SACOL2620

Alternate gene names: 57652339

Gene position: 2678926-2677589 (Counterclockwise)

Preceding gene: 57652342

Following gene: 57652337

Centisome position: 95.36

GC content: 37.97

Gene sequence:

>1338_bases
ATGAGTAAAGCACATCAATTAATTCAAGAGGATGAACATTATTTTGCGAAATCAGGACGTATTAAATATTATCCGTTAGT
GATTGATCATGGATATGGAGCAACATTGGTTGATATTGAGGGGAAGACATATATCGATTTGTTATCGAGTGCGAGTTCTC
AAAACGTAGGTCATGCACCTAGAGAAGTAACAGAAGCGATAAAGGCACAAGTTGATAAATTTATTCATTATACACCAGCA
TATATGTATCATGAACCGTTGGTACGTTTAGCTAAGAAGCTTTGTGAGATTGCACCTGGAGATTTTGAAAAAAGAGTGAC
CTTCGGATTAACCGGATCAGACGCAAATGATGGCATCATTAAATTTGCCAGAGCATATACAGGGCGTCCTTATATCATTA
GTTTCACTAATGCATATCATGGTTCAACTTTTGGCTCATTGTCTATGTCAGCTATTAGTTTAAATATGCGCAAACATTAT
GGTCCGTTATTGAATGGTTTTTATCATATTCCGTTTCCAGATAAATATCGTGGTATGTACGAGCAGCCACAAGCTAATTC
AGTAGAAGAATATTTAGCACCCTTAAAAGAAATGTTTGCGAAGTATGTACCTGCTGACGAAGTAGCATGTATTGTTATTG
AAACGATACAAGGCGATGGTGGACTTTTAGAACCAGTTCCAGGGTATTTTGAAGCGTTAGAAAAGATTTGTCGTGAACAT
GGTATTTTAATCGCTGTCGATGATATTCAACAAGGTTTTGGGAGAACAGGTACATGGAGTTCAGTCTCGCATTTTAATTT
TACGCCTGATTTAATCACTTTCGGAAAATCCTTAGCAGGTGGTATGCCTATGTCAGCAATTGTTGGACGCAAAGAGATTA
TGAATTGTTTAGAAGCACCAGCACATTTATTTACAACAGGTGCTAATCCAGTTAGTTGTGAAGCTGCATTAGCCACAATT
CAAATGATTGAAGATCAGTCGCTTCTTCAGGCTAGTGCGGAAAAAGGGGAATATGTTAGGAAACGAATGGATCAATGGGT
ATCTAAATACAATAGTGTAGGCGATGTTAGAGGTAAAGGTCTGAGCATTGGTATTGATATTGTTTCCGACAAAAAACTCA
AAACACGTGATGCCAGTGCGGCACTTAAAATTTGTAATTACTGCTTTGAGCATGGCGTAGTTATTATAGCTGTAGCAGGA
AATGTGTTGCGATTCCAACCGCCATTGGTAATAACATATGAGCAATTAGACACGGCGTTAAACACTATAGAAGATGCACT
GACTGCTTTGGAAGCAGGTAACTTAGATCAATATGACATATCTGGACAAGGTTGGTAA

Upstream 100 bases:

>100_bases
ATGACGGTATTTGAGCAGGATTTTAAATCGGATTTTATAATCGATTTAAGAGAGGCCACTTTGCTTGCACATTAATACTG
TCAATGGGAGGGGAATGTAT

Downstream 100 bases:

>100_bases
TAGCGATTATCTTAATATAAAATAAAAAATCATTTCCACATCTGGATGTTAATCAGATGGGAAATGATTTTTTTTATTTT
TTATTTTGGTGGGTGGTATT

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSKAHQLIQEDEHYFAKSGRIKYYPLVIDHGYGATLVDIEGKTYIDLLSSASSQNVGHAPREVTEAIKAQVDKFIHYTPA
YMYHEPLVRLAKKLCEIAPGDFEKRVTFGLTGSDANDGIIKFARAYTGRPYIISFTNAYHGSTFGSLSMSAISLNMRKHY
GPLLNGFYHIPFPDKYRGMYEQPQANSVEEYLAPLKEMFAKYVPADEVACIVIETIQGDGGLLEPVPGYFEALEKICREH
GILIAVDDIQQGFGRTGTWSSVSHFNFTPDLITFGKSLAGGMPMSAIVGRKEIMNCLEAPAHLFTTGANPVSCEAALATI
QMIEDQSLLQASAEKGEYVRKRMDQWVSKYNSVGDVRGKGLSIGIDIVSDKKLKTRDASAALKICNYCFEHGVVIIAVAG
NVLRFQPPLVITYEQLDTALNTIEDALTALEAGNLDQYDISGQGW

Sequences:

>Translated_445_residues
MSKAHQLIQEDEHYFAKSGRIKYYPLVIDHGYGATLVDIEGKTYIDLLSSASSQNVGHAPREVTEAIKAQVDKFIHYTPA
YMYHEPLVRLAKKLCEIAPGDFEKRVTFGLTGSDANDGIIKFARAYTGRPYIISFTNAYHGSTFGSLSMSAISLNMRKHY
GPLLNGFYHIPFPDKYRGMYEQPQANSVEEYLAPLKEMFAKYVPADEVACIVIETIQGDGGLLEPVPGYFEALEKICREH
GILIAVDDIQQGFGRTGTWSSVSHFNFTPDLITFGKSLAGGMPMSAIVGRKEIMNCLEAPAHLFTTGANPVSCEAALATI
QMIEDQSLLQASAEKGEYVRKRMDQWVSKYNSVGDVRGKGLSIGIDIVSDKKLKTRDASAALKICNYCFEHGVVIIAVAG
NVLRFQPPLVITYEQLDTALNTIEDALTALEAGNLDQYDISGQGW
>Mature_444_residues
SKAHQLIQEDEHYFAKSGRIKYYPLVIDHGYGATLVDIEGKTYIDLLSSASSQNVGHAPREVTEAIKAQVDKFIHYTPAY
MYHEPLVRLAKKLCEIAPGDFEKRVTFGLTGSDANDGIIKFARAYTGRPYIISFTNAYHGSTFGSLSMSAISLNMRKHYG
PLLNGFYHIPFPDKYRGMYEQPQANSVEEYLAPLKEMFAKYVPADEVACIVIETIQGDGGLLEPVPGYFEALEKICREHG
ILIAVDDIQQGFGRTGTWSSVSHFNFTPDLITFGKSLAGGMPMSAIVGRKEIMNCLEAPAHLFTTGANPVSCEAALATIQ
MIEDQSLLQASAEKGEYVRKRMDQWVSKYNSVGDVRGKGLSIGIDIVSDKKLKTRDASAALKICNYCFEHGVVIIAVAGN
VLRFQPPLVITYEQLDTALNTIEDALTALEAGNLDQYDISGQGW

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=420, Percent_Identity=30, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI226442705, Length=420, Percent_Identity=30, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI4557809, Length=427, Percent_Identity=29.7423887587822, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI226442709, Length=389, Percent_Identity=30.5912596401028, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI24119277, Length=422, Percent_Identity=28.436018957346, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI13994255, Length=428, Percent_Identity=28.2710280373832, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI284507298, Length=331, Percent_Identity=28.7009063444109, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI188536080, Length=432, Percent_Identity=26.1574074074074, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI38679950, Length=432, Percent_Identity=26.1574074074074, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI38679946, Length=432, Percent_Identity=26.1574074074074, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI1789016, Length=427, Percent_Identity=31.3817330210773, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1787560, Length=398, Percent_Identity=32.1608040201005, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI145693181, Length=406, Percent_Identity=32.7586206896552, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1788044, Length=408, Percent_Identity=29.4117647058824, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1789759, Length=403, Percent_Identity=28.5359801488834, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1786991, Length=427, Percent_Identity=26.6978922716628, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1786349, Length=305, Percent_Identity=28.1967213114754, Blast_Score=121, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI32564660, Length=435, Percent_Identity=30.1149425287356, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI25144271, Length=431, Percent_Identity=26.2180974477958, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI71992977, Length=426, Percent_Identity=27.9342723004695, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI25144274, Length=414, Percent_Identity=25.1207729468599, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17541228, Length=437, Percent_Identity=25.4004576659039, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323470, Length=442, Percent_Identity=29.4117647058824, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6324432, Length=423, Percent_Identity=27.4231678486998, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6324386, Length=354, Percent_Identity=26.271186440678, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6321456, Length=455, Percent_Identity=25.0549450549451, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI161085790, Length=425, Percent_Identity=33.4117647058824, Blast_Score=224, Evalue=8e-59,
Organism=Drosophila melanogaster, GI28574759, Length=426, Percent_Identity=33.0985915492958, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI21356575, Length=418, Percent_Identity=31.1004784688995, Blast_Score=188, Evalue=8e-48,
Organism=Drosophila melanogaster, GI21357415, Length=434, Percent_Identity=27.4193548387097, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI281366494, Length=438, Percent_Identity=24.2009132420091, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24667139, Length=438, Percent_Identity=24.2009132420091, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24667143, Length=438, Percent_Identity=24.2009132420091, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 49083; Mature: 48951

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAHQLIQEDEHYFAKSGRIKYYPLVIDHGYGATLVDIEGKTYIDLLSSASSQNVGHAP
CCHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCEEEEEECCCHHHHHHHCCCCCCCCCCH
REVTEAIKAQVDKFIHYTPAYMYHEPLVRLAKKLCEIAPGDFEKRVTFGLTGSDANDGII
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHH
KFARAYTGRPYIISFTNAYHGSTFGSLSMSAISLNMRKHYGPLLNGFYHIPFPDKYRGMY
HHHHHHCCCCEEEEECCCCCCCCCCCCEEHHHEEHHHHHCCHHHCCEEECCCCHHHCCCC
EQPQANSVEEYLAPLKEMFAKYVPADEVACIVIETIQGDGGLLEPVPGYFEALEKICREH
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHC
GILIAVDDIQQGFGRTGTWSSVSHFNFTPDLITFGKSLAGGMPMSAIVGRKEIMNCLEAP
CEEEEEECHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
AHLFTTGANPVSCEAALATIQMIEDQSLLQASAEKGEYVRKRMDQWVSKYNSVGDVRGKG
HHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LSIGIDIVSDKKLKTRDASAALKICNYCFEHGVVIIAVAGNVLRFQPPLVITYEQLDTAL
EEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCEEEECCCEEEEHHHHHHHH
NTIEDALTALEAGNLDQYDISGQGW
HHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKAHQLIQEDEHYFAKSGRIKYYPLVIDHGYGATLVDIEGKTYIDLLSSASSQNVGHAP
CHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCEEEEEECCCHHHHHHHCCCCCCCCCCH
REVTEAIKAQVDKFIHYTPAYMYHEPLVRLAKKLCEIAPGDFEKRVTFGLTGSDANDGII
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHH
KFARAYTGRPYIISFTNAYHGSTFGSLSMSAISLNMRKHYGPLLNGFYHIPFPDKYRGMY
HHHHHHCCCCEEEEECCCCCCCCCCCCEEHHHEEHHHHHCCHHHCCEEECCCCHHHCCCC
EQPQANSVEEYLAPLKEMFAKYVPADEVACIVIETIQGDGGLLEPVPGYFEALEKICREH
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHC
GILIAVDDIQQGFGRTGTWSSVSHFNFTPDLITFGKSLAGGMPMSAIVGRKEIMNCLEAP
CEEEEEECHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
AHLFTTGANPVSCEAALATIQMIEDQSLLQASAEKGEYVRKRMDQWVSKYNSVGDVRGKG
HHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LSIGIDIVSDKKLKTRDASAALKICNYCFEHGVVIIAVAGNVLRFQPPLVITYEQLDTAL
EEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCEEEECCCEEEEHHHHHHHH
NTIEDALTALEAGNLDQYDISGQGW
HHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]