Click here to switch to the map view.

The map label for this gene is purL [H]

Identifier: 57651678

GI number: 57651678

Start: 1086152

End: 1088341

Strand: Direct

Name: purL [H]

Synonym: SACOL1078

Alternate gene names: 57651678

Gene position: 1086152-1088341 (Clockwise)

Preceding gene: 57651677

Following gene: 57651679

Centisome position: 38.66

GC content: 35.16

Gene sequence:

>2190_bases
ATGTCTAAATTTATCGAACCAAGCGTTGAAGAAATTAAACTTGAAAAAGTATATCAAGATATGGGATTAAGTGATCAAGA
ATATGAAAAAGTTTGCGATATTTTAGGCAGACAACCTAACTTTACAGAAACAGGTATCTTTTCTGTTATGTGGAGTGAAC
ATTGCTCTTATAAACATTCTAAACCGTTTTTAAAGCAATTTCCTACGTCAGGTGACCATGTGCTTATGGGGCCTGGTGAA
GGTGCAGGGGTAGTCGATATAGGTGATAATCAAGCCGTAGTATTTAAAGTAGAGTCTCACAATCATCCATCAGCAATTGA
ACCATATCAAGGGGCTGCTACAGGCGTTGGTGGAATCATTCGTGACATTGTCTCTATTGGGGCTAGACCTATTAATTTGT
TAAACAGTCTTAGATTTGGAGAATTAGATAATAAACAAAACCAAAGATTACTTAAAGGTGTTGTAAAGGGTATCGGAGGT
TATGGTAACTGCATTGGTATTCCAACAACTGCTGGTGAAATCGAATTTGATGAACGTTATGATGGCAATCCACTTGTTAA
TGCAATGTGTGTTGGTGTTATCAATCACGACATGATTCAAAAAGGCACAGCAAAAGGTGTAGGTAATTCGGTCATTTATG
TTGGTTTGAAAACTGGTCGAGATGGTATTCATGGTGCTACTTTTGCATCTGAAGAATTGACGGAAGAAAGCGAAAGTAAA
CGACCTTCTGTACAAATCGGTGATCCATTTGTAGGTAAAAAATTAATGGAAGCAACACTTGAAGCAATTACATTTGATGA
ATTAGTTGGTATTCAAGATATGGGTGCTGCTGGTTTAACATCTTCATCGTCTGAAATGGCGGCAAAAGGTGGTAGTGGGT
TACATTTGAGATTAGAACAAGTGCCAACACGTGAGCCAGGTATTTCTCCTTATGAAATGATGCTTTCAGAAACTCAAGAA
CGTATGTTACTAGTTGTTGAAAAAGGTACTGAACAAAAATTCTTAGATTTATTTGATAAGCACGAATTGGATAGTGCTGT
TATAGGTGAAGTTACAGATACAAATCGTTTTGTTTTAACATATGATGACGAAGTTTATGCTGACATTCCAGTTGAACCAC
TAGCTGATGAAGCACCTGTATATATTTTAGAAGGAGAAGAAAAAGATTATAATACTTCTAAAAATGATTATACACACATC
GATGTTAAAGATACTTTCTTTAAATTACTTAAGCATCCGACTATAGCATCTAAACACTATTTATATGATCAATACGACCA
ACAAGTTGGTGCCAATACGATAATTAAGCCAGGACTTCAAGCATCGGTAGTACGTGTGGAAGGCACAAATAAGGCAATTG
CTTCAACAATTGATGGTGAAGCGCGTTATGTATATAACAATCCATATGAAGGTGGAAAGATGGTAGTAGCTGAAGCTTAT
CGAAATTTAATTGCCGTGGGTGCAACACCATTAGCAATGACAGATTGTTTAAATTATGGTTCTCCTGAAAAGAAAGAAAT
CTATCAACAGTTGATAGATTCAACGAAAGGTATGGCAGAAGCATGCGACATTCTTAAGACACCAGTAGTTTCTGGTAATG
TATCTTTATATAACGAAACGAAAGGTACTTCTATTTTCCCAACACCAGTTGTTGGAATGGTAGGTTTGATTGAAAATGTA
AATTATTTAAATGATTTTGAACCTCAAGTTGGAGATAAATTATATTTAATCGGTGATACTAAGGACGACTTTGGTGGTAG
TCAACTTGAAAAGTTAATTTATGGCAAAGTTAATCATGAATTTGAGTCATTAGATTTGAGTTCAGAAGTTGAAAAAGGTG
AATCAATCAAGACCGCTATTCGTGAAGGACTATTATCACATGTTCAAACAGTTGGTAAAGGTGGCTTACTGATTACCTTA
GCTAAACTAAGTGCGCATTACGGTTTAGGATTAAAATCTTCAATAGATATAACAAATGCACAATTGTTTAGTGAGACGCA
AGGCCGATATGTTGTTTCTGTTAAATCAGGTAAAACTTTAAATATTGATAATGCAATAGAAATTGGACTTTTAACAGATA
GTGATAATTTCAAGGTAACAACACCATATACAGAGATTAGTGAAAATGTTTCAGATATTAAACAAATATGGGAAGGGGCA
ATTGCTCAATGTTTAACTACTCAGGATTAA

Upstream 100 bases:

>100_bases
GGCATGATGCCACATCCTGAAAGAGCTTTAGAAACGTTGTTAGGTACTGATAGTGGTGTGAAATTATTTGAAGCGATGGT
AAAAAGTTGGAGGGAACAAC

Downstream 100 bases:

>100_bases
ACGAAGAATGTGGCGTGTTTGGTATTTGGAATCATCCTGAAGCAGCGCAACTAACATATATGGGACTTCATAGTTTGCAA
CATCGTGGTCAAGAAGGTGC

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 729; Mature: 728

Protein sequence:

>729_residues
MSKFIEPSVEEIKLEKVYQDMGLSDQEYEKVCDILGRQPNFTETGIFSVMWSEHCSYKHSKPFLKQFPTSGDHVLMGPGE
GAGVVDIGDNQAVVFKVESHNHPSAIEPYQGAATGVGGIIRDIVSIGARPINLLNSLRFGELDNKQNQRLLKGVVKGIGG
YGNCIGIPTTAGEIEFDERYDGNPLVNAMCVGVINHDMIQKGTAKGVGNSVIYVGLKTGRDGIHGATFASEELTEESESK
RPSVQIGDPFVGKKLMEATLEAITFDELVGIQDMGAAGLTSSSSEMAAKGGSGLHLRLEQVPTREPGISPYEMMLSETQE
RMLLVVEKGTEQKFLDLFDKHELDSAVIGEVTDTNRFVLTYDDEVYADIPVEPLADEAPVYILEGEEKDYNTSKNDYTHI
DVKDTFFKLLKHPTIASKHYLYDQYDQQVGANTIIKPGLQASVVRVEGTNKAIASTIDGEARYVYNNPYEGGKMVVAEAY
RNLIAVGATPLAMTDCLNYGSPEKKEIYQQLIDSTKGMAEACDILKTPVVSGNVSLYNETKGTSIFPTPVVGMVGLIENV
NYLNDFEPQVGDKLYLIGDTKDDFGGSQLEKLIYGKVNHEFESLDLSSEVEKGESIKTAIREGLLSHVQTVGKGGLLITL
AKLSAHYGLGLKSSIDITNAQLFSETQGRYVVSVKSGKTLNIDNAIEIGLLTDSDNFKVTTPYTEISENVSDIKQIWEGA
IAQCLTTQD

Sequences:

>Translated_729_residues
MSKFIEPSVEEIKLEKVYQDMGLSDQEYEKVCDILGRQPNFTETGIFSVMWSEHCSYKHSKPFLKQFPTSGDHVLMGPGE
GAGVVDIGDNQAVVFKVESHNHPSAIEPYQGAATGVGGIIRDIVSIGARPINLLNSLRFGELDNKQNQRLLKGVVKGIGG
YGNCIGIPTTAGEIEFDERYDGNPLVNAMCVGVINHDMIQKGTAKGVGNSVIYVGLKTGRDGIHGATFASEELTEESESK
RPSVQIGDPFVGKKLMEATLEAITFDELVGIQDMGAAGLTSSSSEMAAKGGSGLHLRLEQVPTREPGISPYEMMLSETQE
RMLLVVEKGTEQKFLDLFDKHELDSAVIGEVTDTNRFVLTYDDEVYADIPVEPLADEAPVYILEGEEKDYNTSKNDYTHI
DVKDTFFKLLKHPTIASKHYLYDQYDQQVGANTIIKPGLQASVVRVEGTNKAIASTIDGEARYVYNNPYEGGKMVVAEAY
RNLIAVGATPLAMTDCLNYGSPEKKEIYQQLIDSTKGMAEACDILKTPVVSGNVSLYNETKGTSIFPTPVVGMVGLIENV
NYLNDFEPQVGDKLYLIGDTKDDFGGSQLEKLIYGKVNHEFESLDLSSEVEKGESIKTAIREGLLSHVQTVGKGGLLITL
AKLSAHYGLGLKSSIDITNAQLFSETQGRYVVSVKSGKTLNIDNAIEIGLLTDSDNFKVTTPYTEISENVSDIKQIWEGA
IAQCLTTQD
>Mature_728_residues
SKFIEPSVEEIKLEKVYQDMGLSDQEYEKVCDILGRQPNFTETGIFSVMWSEHCSYKHSKPFLKQFPTSGDHVLMGPGEG
AGVVDIGDNQAVVFKVESHNHPSAIEPYQGAATGVGGIIRDIVSIGARPINLLNSLRFGELDNKQNQRLLKGVVKGIGGY
GNCIGIPTTAGEIEFDERYDGNPLVNAMCVGVINHDMIQKGTAKGVGNSVIYVGLKTGRDGIHGATFASEELTEESESKR
PSVQIGDPFVGKKLMEATLEAITFDELVGIQDMGAAGLTSSSSEMAAKGGSGLHLRLEQVPTREPGISPYEMMLSETQER
MLLVVEKGTEQKFLDLFDKHELDSAVIGEVTDTNRFVLTYDDEVYADIPVEPLADEAPVYILEGEEKDYNTSKNDYTHID
VKDTFFKLLKHPTIASKHYLYDQYDQQVGANTIIKPGLQASVVRVEGTNKAIASTIDGEARYVYNNPYEGGKMVVAEAYR
NLIAVGATPLAMTDCLNYGSPEKKEIYQQLIDSTKGMAEACDILKTPVVSGNVSLYNETKGTSIFPTPVVGMVGLIENVN
YLNDFEPQVGDKLYLIGDTKDDFGGSQLEKLIYGKVNHEFESLDLSSEVEKGESIKTAIREGLLSHVQTVGKGGLLITLA
KLSAHYGLGLKSSIDITNAQLFSETQGRYVVSVKSGKTLNIDNAIEIGLLTDSDNFKVTTPYTEISENVSDIKQIWEGAI
AQCLTTQD

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Escherichia coli, GI48994899, Length=826, Percent_Identity=23.6077481840194, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6321498, Length=570, Percent_Identity=23.859649122807, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 79537; Mature: 79405

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFIEPSVEEIKLEKVYQDMGLSDQEYEKVCDILGRQPNFTETGIFSVMWSEHCSYKHS
CCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCC
KPFLKQFPTSGDHVLMGPGEGAGVVDIGDNQAVVFKVESHNHPSAIEPYQGAATGVGGII
CCHHHHCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHH
RDIVSIGARPINLLNSLRFGELDNKQNQRLLKGVVKGIGGYGNCIGIPTTAGEIEFDERY
HHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEECCCC
DGNPLVNAMCVGVINHDMIQKGTAKGVGNSVIYVGLKTGRDGIHGATFASEELTEESESK
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHC
RPSVQIGDPFVGKKLMEATLEAITFDELVGIQDMGAAGLTSSSSEMAAKGGSGLHLRLEQ
CCCEEECCCHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCHHHHHCCCCCEEEEEEC
VPTREPGISPYEMMLSETQERMLLVVEKGTEQKFLDLFDKHELDSAVIGEVTDTNRFVLT
CCCCCCCCCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHCCCHHHCCCCCCCCEEEEE
YDDEVYADIPVEPLADEAPVYILEGEEKDYNTSKNDYTHIDVKDTFFKLLKHPTIASKHY
ECCCEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCCCH
LYDQYDQQVGANTIIKPGLQASVVRVEGTNKAIASTIDGEARYVYNNPYEGGKMVVAEAY
HHHHHHHHCCCCCEECCCCCEEEEEEECCCCHHHHCCCCCEEEEECCCCCCCEEEHHHHH
RNLIAVGATPLAMTDCLNYGSPEKKEIYQQLIDSTKGMAEACDILKTPVVSGNVSLYNET
HHHEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEECCEEEEECC
KGTSIFPTPVVGMVGLIENVNYLNDFEPQVGDKLYLIGDTKDDFGGSQLEKLIYGKVNHE
CCCEECCCHHHHHHHHHHCCCHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCC
FESLDLSSEVEKGESIKTAIREGLLSHVQTVGKGGLLITLAKLSAHYGLGLKSSIDITNA
HHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCCCCCCCHH
QLFSETQGRYVVSVKSGKTLNIDNAIEIGLLTDSDNFKVTTPYTEISENVSDIKQIWEGA
HHHHCCCCCEEEEECCCCEECCCCCEEEEEEECCCCEEEECCHHHHHCCHHHHHHHHHHH
IAQCLTTQD
HHHHHCCCC
>Mature Secondary Structure 
SKFIEPSVEEIKLEKVYQDMGLSDQEYEKVCDILGRQPNFTETGIFSVMWSEHCSYKHS
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCC
KPFLKQFPTSGDHVLMGPGEGAGVVDIGDNQAVVFKVESHNHPSAIEPYQGAATGVGGII
CCHHHHCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHH
RDIVSIGARPINLLNSLRFGELDNKQNQRLLKGVVKGIGGYGNCIGIPTTAGEIEFDERY
HHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEECCCC
DGNPLVNAMCVGVINHDMIQKGTAKGVGNSVIYVGLKTGRDGIHGATFASEELTEESESK
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHC
RPSVQIGDPFVGKKLMEATLEAITFDELVGIQDMGAAGLTSSSSEMAAKGGSGLHLRLEQ
CCCEEECCCHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCHHHHHCCCCCEEEEEEC
VPTREPGISPYEMMLSETQERMLLVVEKGTEQKFLDLFDKHELDSAVIGEVTDTNRFVLT
CCCCCCCCCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHCCCHHHCCCCCCCCEEEEE
YDDEVYADIPVEPLADEAPVYILEGEEKDYNTSKNDYTHIDVKDTFFKLLKHPTIASKHY
ECCCEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCCCH
LYDQYDQQVGANTIIKPGLQASVVRVEGTNKAIASTIDGEARYVYNNPYEGGKMVVAEAY
HHHHHHHHCCCCCEECCCCCEEEEEEECCCCHHHHCCCCCEEEEECCCCCCCEEEHHHHH
RNLIAVGATPLAMTDCLNYGSPEKKEIYQQLIDSTKGMAEACDILKTPVVSGNVSLYNET
HHHEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEECCEEEEECC
KGTSIFPTPVVGMVGLIENVNYLNDFEPQVGDKLYLIGDTKDDFGGSQLEKLIYGKVNHE
CCCEECCCHHHHHHHHHHCCCHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCC
FESLDLSSEVEKGESIKTAIREGLLSHVQTVGKGGLLITLAKLSAHYGLGLKSSIDITNA
HHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCCCCCCCHH
QLFSETQGRYVVSVKSGKTLNIDNAIEIGLLTDSDNFKVTTPYTEISENVSDIKQIWEGA
HHHHCCCCCEEEEECCCCEECCCCCEEEEEEECCCCEEEECCHHHHHCCHHHHHHHHHHH
IAQCLTTQD
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA