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The map label for this gene is fadD1_2

Identifier: 41410392

GI number: 41410392

Start: 4760970

End: 4762610

Strand: Direct

Name: fadD1_2

Synonym: MAP4294

Alternate gene names: 41410392

Gene position: 4760970-4762610 (Clockwise)

Preceding gene: 41410391

Following gene: 41410398

Centisome position: 98.58

GC content: 69.35

Gene sequence:

>1641_bases
ATGGCTGAGGACACGATCCAGGCGCTGCTGCGCAAACGGTGGTCCGACCCCGGTGTCGCGGTGAAATACGGTGACACGCA
ATGGAGTTGGGCCCAGTATCTGCGGGACGCGGCGGCCCGGGCCGCGGCCCTGCTGGGCGCCGCCGACCCGGGACGGCCGA
TGCACGTCGGCACCCTGCTGGGCAACACCCCCGAGATGCTGAGCCAGATGGCGGCGGCCGGCCTCGGCGGCTACGTGCTG
TGCGGGCTGAACACCACCCGGCGCGGCGAGGCGCTGGCCGCCGACGTTCGCCGCGCCGACTGCCAGTTCGTGGTCACCGA
CGCCGAACACCGGCCGCTGCTGGACGGCCTGGACCTTGTCGGCACGCAGATCCTGGACACCTCGACGCCGGACTGGGCCG
GGTTCGTCGACGCCGCCGGAGAGCTGACCCCACATCGGGATGTCGCCGCGATGGACCCGTTCATGATGATATTCACCTCG
GGCACCAGCGGAAACCCTAAGGCGGTGCAGGTATCCCATTTGATGGCGGTGTTCGCGGGGAGCAATCTGGTGCAGCGCTT
CGGGCTCACCGAACACGACACCTGCTACGTGTCGATGCCGCTGTTTCACTCCAACGCGGTGGTCGCGGGATGGGCGCCCG
CGGTGTGCTCGGGGGCCGCGATCGTGCCGGCGAAATTCTCGGCGCGCAACTTCCTCGACGACATCCGCCGCTACGGCGCC
ACCTACATGAACTACGTCGGCAAACCGCTGGCCTACGTGCTGGCCACCCCGGAGCGCGCCGACGATGCCGACAACCCGCT
GCGGGTGGCGTTCGGTAACGAGGCCAACGACAAGGACATCGAGGAGTTCGGCCGCTGGTTCGGTGTGCAGGTCGAGGACG
GCTTCGGGTCGACCGAGAACGCCGTCATCGTGATCCGCGAACCCGGCACCCCGAGGGGCTCGATCGGCCGGGGCATCGAC
GGGGTGGCGATCTACAACAGCGATACCGTCACCGAATGCCCCGTCGCCCGGTTCGACGCCGACGGCGCCCTGATCAACGC
CGACGAAGCGGTGGGCGAGTTGGTGAACACCGCCGGTTCCGGTTTCTTCACCGGCTACTACAACGACCCCGACGCCAACG
CCGAGCGCATGCGGCACGACATGTACTGGTCCGGCGACCTGGCCTACCGCGACGCCGACGGCTGGATCTACCTGGCCGGC
CGCACCGCGGACTGGATGCGGGTGGACGGCGAGAACCTCGCGGCCGCCCCCATCGAACGAATCCTGTTGCGGCACAGCGC
GATCAACCGCGTCGCGGTATACGCCGTGCCGGACGGGCATGTCGGCGATCAGGTGATGGCCGCCGTCGTCCTCAACGACG
GGGAAACCCTGACCCCGGCCGCGTTCGAGGCGTTCCTGGACGCACAGCCCGACCTGTCCCCCAAGGCCCGGCCGCGCTAT
GTCCGCATCGCCGCCGACCTGCCCAGCACCGCCACCCACAAAGTGCTGAAACGCCAACTGATCTCGCAGGGCACCGCGGT
AGCCGCCGGCGAGGTGCTCTGGGAGCGCGAGCCGCGCGGCACCGCCTACACGGTGGTGGCTAGCCCGGACTGCGGGGTGC
CCGGCGACGGATCTGCCCCTTCGACCGTCGCACCCGTTTGA

Upstream 100 bases:

>100_bases
TGGTGGGCGCATAGCCCGCCCGCCCGCCGCCGCTCGGCCGCTACTATAAGACGGACCGTCTCGTCTCGCAGGGCAGGCAT
AGTGAAGGTGGGGCCGACCG

Downstream 100 bases:

>100_bases
CCGGGTCGCGGCTGGTGCCGCCGGCGATCTCGTCGCGCAGCTGGGAGATGTTGGAGATCTCGGCGTACAGCCCGCGGATC
GCGTAGTCCAGCACGGCGAA

Product: acyl-CoA synthetase

Products: D-carnitinyl-CoA; crotonobetainyl-CoA; L-carnitinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MAEDTIQALLRKRWSDPGVAVKYGDTQWSWAQYLRDAAARAAALLGAADPGRPMHVGTLLGNTPEMLSQMAAAGLGGYVL
CGLNTTRRGEALAADVRRADCQFVVTDAEHRPLLDGLDLVGTQILDTSTPDWAGFVDAAGELTPHRDVAAMDPFMMIFTS
GTSGNPKAVQVSHLMAVFAGSNLVQRFGLTEHDTCYVSMPLFHSNAVVAGWAPAVCSGAAIVPAKFSARNFLDDIRRYGA
TYMNYVGKPLAYVLATPERADDADNPLRVAFGNEANDKDIEEFGRWFGVQVEDGFGSTENAVIVIREPGTPRGSIGRGID
GVAIYNSDTVTECPVARFDADGALINADEAVGELVNTAGSGFFTGYYNDPDANAERMRHDMYWSGDLAYRDADGWIYLAG
RTADWMRVDGENLAAAPIERILLRHSAINRVAVYAVPDGHVGDQVMAAVVLNDGETLTPAAFEAFLDAQPDLSPKARPRY
VRIAADLPSTATHKVLKRQLISQGTAVAAGEVLWEREPRGTAYTVVASPDCGVPGDGSAPSTVAPV

Sequences:

>Translated_546_residues
MAEDTIQALLRKRWSDPGVAVKYGDTQWSWAQYLRDAAARAAALLGAADPGRPMHVGTLLGNTPEMLSQMAAAGLGGYVL
CGLNTTRRGEALAADVRRADCQFVVTDAEHRPLLDGLDLVGTQILDTSTPDWAGFVDAAGELTPHRDVAAMDPFMMIFTS
GTSGNPKAVQVSHLMAVFAGSNLVQRFGLTEHDTCYVSMPLFHSNAVVAGWAPAVCSGAAIVPAKFSARNFLDDIRRYGA
TYMNYVGKPLAYVLATPERADDADNPLRVAFGNEANDKDIEEFGRWFGVQVEDGFGSTENAVIVIREPGTPRGSIGRGID
GVAIYNSDTVTECPVARFDADGALINADEAVGELVNTAGSGFFTGYYNDPDANAERMRHDMYWSGDLAYRDADGWIYLAG
RTADWMRVDGENLAAAPIERILLRHSAINRVAVYAVPDGHVGDQVMAAVVLNDGETLTPAAFEAFLDAQPDLSPKARPRY
VRIAADLPSTATHKVLKRQLISQGTAVAAGEVLWEREPRGTAYTVVASPDCGVPGDGSAPSTVAPV
>Mature_545_residues
AEDTIQALLRKRWSDPGVAVKYGDTQWSWAQYLRDAAARAAALLGAADPGRPMHVGTLLGNTPEMLSQMAAAGLGGYVLC
GLNTTRRGEALAADVRRADCQFVVTDAEHRPLLDGLDLVGTQILDTSTPDWAGFVDAAGELTPHRDVAAMDPFMMIFTSG
TSGNPKAVQVSHLMAVFAGSNLVQRFGLTEHDTCYVSMPLFHSNAVVAGWAPAVCSGAAIVPAKFSARNFLDDIRRYGAT
YMNYVGKPLAYVLATPERADDADNPLRVAFGNEANDKDIEEFGRWFGVQVEDGFGSTENAVIVIREPGTPRGSIGRGIDG
VAIYNSDTVTECPVARFDADGALINADEAVGELVNTAGSGFFTGYYNDPDANAERMRHDMYWSGDLAYRDADGWIYLAGR
TADWMRVDGENLAAAPIERILLRHSAINRVAVYAVPDGHVGDQVMAAVVLNDGETLTPAAFEAFLDAQPDLSPKARPRYV
RIAADLPSTATHKVLKRQLISQGTAVAAGEVLWEREPRGTAYTVVASPDCGVPGDGSAPSTVAPV

Specific function: Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI62865631, Length=491, Percent_Identity=27.6985743380855, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI13325055, Length=491, Percent_Identity=27.6985743380855, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI13236579, Length=369, Percent_Identity=28.1842818428184, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI227499619, Length=540, Percent_Identity=26.1111111111111, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI13325057, Length=375, Percent_Identity=28.5333333333333, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI38524616, Length=375, Percent_Identity=29.8666666666667, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI40807357, Length=396, Percent_Identity=28.2828282828283, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI156151445, Length=416, Percent_Identity=27.1634615384615, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI38505220, Length=511, Percent_Identity=26.027397260274, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI227499621, Length=308, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI115511026, Length=408, Percent_Identity=24.2647058823529, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI122937307, Length=512, Percent_Identity=23.6328125, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI58082049, Length=510, Percent_Identity=22.9411764705882, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI157311624, Length=507, Percent_Identity=21.6962524654832, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI157311622, Length=507, Percent_Identity=21.6962524654832, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI42544132, Length=384, Percent_Identity=24.4791666666667, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI8923896, Length=120, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI253970489, Length=120, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI221142682, Length=489, Percent_Identity=25.7668711656442, Blast_Score=135, Evalue=9e-33,
Organism=Escherichia coli, GI145693145, Length=354, Percent_Identity=26.5536723163842, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1786810, Length=519, Percent_Identity=25.8188824662813, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790505, Length=400, Percent_Identity=23.75, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1788107, Length=373, Percent_Identity=24.1286863270777, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115534440, Length=498, Percent_Identity=25.3012048192771, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17551278, Length=501, Percent_Identity=25.1497005988024, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17531443, Length=369, Percent_Identity=23.8482384823848, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI32563687, Length=361, Percent_Identity=24.0997229916898, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17559526, Length=376, Percent_Identity=23.936170212766, Blast_Score=85, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319699, Length=491, Percent_Identity=25.050916496945, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319515, Length=342, Percent_Identity=26.3157894736842, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323182, Length=437, Percent_Identity=24.9427917620137, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319264, Length=400, Percent_Identity=23.75, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI20130353, Length=481, Percent_Identity=26.8191268191268, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI28573631, Length=481, Percent_Identity=26.8191268191268, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI45552801, Length=527, Percent_Identity=25.6166982922201, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI45550496, Length=527, Percent_Identity=25.6166982922201, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24583465, Length=522, Percent_Identity=25.8620689655172, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24583463, Length=522, Percent_Identity=25.8620689655172, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI281364798, Length=522, Percent_Identity=25.8620689655172, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI18859661, Length=523, Percent_Identity=25.8126195028681, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24581924, Length=390, Percent_Identity=27.1794871794872, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21355181, Length=362, Percent_Identity=27.6243093922652, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24648260, Length=353, Percent_Identity=23.7960339943343, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24653035, Length=352, Percent_Identity=23.5795454545455, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356947, Length=357, Percent_Identity=25.2100840336134, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 58385; Mature: 58254

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEDTIQALLRKRWSDPGVAVKYGDTQWSWAQYLRDAAARAAALLGAADPGRPMHVGTLL
CCHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEC
GNTPEMLSQMAAAGLGGYVLCGLNTTRRGEALAADVRRADCQFVVTDAEHRPLLDGLDLV
CCCHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCHHHHHHH
GTQILDTSTPDWAGFVDAAGELTPHRDVAAMDPFMMIFTSGTSGNPKAVQVSHLMAVFAG
HHHHCCCCCCCCCHHHHCCCCCCCCCCCHHCCCEEEEEECCCCCCCCEEEHHHHHHHHHC
SNLVQRFGLTEHDTCYVSMPLFHSNAVVAGWAPAVCSGAAIVPAKFSARNFLDDIRRYGA
CHHHHHCCCCCCCEEEEEECEEECCEEEECCCHHHHCCCEEECCCCHHHHHHHHHHHHHH
TYMNYVGKPLAYVLATPERADDADNPLRVAFGNEANDKDIEEFGRWFGVQVEDGFGSTEN
HHHHHCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHEEEEEECCCCCCCC
AVIVIREPGTPRGSIGRGIDGVAIYNSDTVTECPVARFDADGALINADEAVGELVNTAGS
EEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCEEECCCCCEEECHHHHHHHHHHCCC
GFFTGYYNDPDANAERMRHDMYWSGDLAYRDADGWIYLAGRTADWMRVDGENLAAAPIER
CEEEEECCCCCCCHHHHHHHCEECCCEEEEECCCEEEEECCCCCEEEECCCCCCHHHHHH
ILLRHSAINRVAVYAVPDGHVGDQVMAAVVLNDGETLTPAAFEAFLDAQPDLSPKARPRY
HHHHHHCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCE
VRIAADLPSTATHKVLKRQLISQGTAVAAGEVLWEREPRGTAYTVVASPDCGVPGDGSAP
EEEEECCCCHHHHHHHHHHHHHCCCCEEHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCC
STVAPV
CCCCCC
>Mature Secondary Structure 
AEDTIQALLRKRWSDPGVAVKYGDTQWSWAQYLRDAAARAAALLGAADPGRPMHVGTLL
CHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEC
GNTPEMLSQMAAAGLGGYVLCGLNTTRRGEALAADVRRADCQFVVTDAEHRPLLDGLDLV
CCCHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCHHHHHHH
GTQILDTSTPDWAGFVDAAGELTPHRDVAAMDPFMMIFTSGTSGNPKAVQVSHLMAVFAG
HHHHCCCCCCCCCHHHHCCCCCCCCCCCHHCCCEEEEEECCCCCCCCEEEHHHHHHHHHC
SNLVQRFGLTEHDTCYVSMPLFHSNAVVAGWAPAVCSGAAIVPAKFSARNFLDDIRRYGA
CHHHHHCCCCCCCEEEEEECEEECCEEEECCCHHHHCCCEEECCCCHHHHHHHHHHHHHH
TYMNYVGKPLAYVLATPERADDADNPLRVAFGNEANDKDIEEFGRWFGVQVEDGFGSTEN
HHHHHCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHEEEEEECCCCCCCC
AVIVIREPGTPRGSIGRGIDGVAIYNSDTVTECPVARFDADGALINADEAVGELVNTAGS
EEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCEEECCCCCEEECHHHHHHHHHHCCC
GFFTGYYNDPDANAERMRHDMYWSGDLAYRDADGWIYLAGRTADWMRVDGENLAAAPIER
CEEEEECCCCCCCHHHHHHHCEECCCEEEEECCCEEEEECCCCCEEEECCCCCCHHHHHH
ILLRHSAINRVAVYAVPDGHVGDQVMAAVVLNDGETLTPAAFEAFLDAQPDLSPKARPRY
HHHHHHCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCE
VRIAADLPSTATHKVLKRQLISQGTAVAAGEVLWEREPRGTAYTVVASPDCGVPGDGSAP
EEEEECCCCHHHHHHHHHHHHHCCCCEEHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCC
STVAPV
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; D-carnitine; Coenzyme A; crotono-betaine; L-carnitine [C]

Specific reaction: Coenzyme A + D-carnitine = D-carnitinyl-CoA Coenzyme A + crotono-betaine = crotonobetainyl-CoA Coenzyme A + L-carnitine = L-carnitinyl-CoA [C]

General reaction: Ligases; Forming Carbon-Sulfur Bonds; Acid-Thiol Ligases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA