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The map label for this gene is ubiE [C]

Identifier: 41410303

GI number: 41410303

Start: 4673882

End: 4674508

Strand: Direct

Name: ubiE [C]

Synonym: MAP4205

Alternate gene names: 41410303

Gene position: 4673882-4674508 (Clockwise)

Preceding gene: 41410302

Following gene: 41410306

Centisome position: 96.77

GC content: 72.25

Gene sequence:

>627_bases
ATGAGATTCCGCAACGTGCTGTTCCCCTACGTGTACCGGTTCGGGCAGCCGGTGTTCGACCGGCTCTTCTACCACCGGTA
TCGGCGGCAGGCGATGAGTCACGCCACCGGGCGGCTGCTGATGGTCGGCCTGGGGCCGGGCACCGACCTGATGTTCCTGC
CCGCCGCGGTGACGTCGGTGGCGGCCGTGGAGCCCGAGGCGTCGTTTCGCCGGATGGCCGCCCGGCTGGCTGCGCGCCAC
GGGGTCGCGGTCGACGTGGTCGCGGGGTCCGGCGAGTCGATTCCCTTCCCGGACAACAGTTTCGACTCGGTGCACATCGG
GCTGGTGCTGTGCTCGGTGCGCGACGTGGCGGCCACCCTGGCCGAGATCCGCCGGGTGCTGGTGCCCGGGGGCAGGCTGG
TGGTGCTCGAGCATGTGCGCGGGGACGGGCTGACGGGCCGGCTGCAGGATCTGATCGCCCGGCCGTGGTCCTGGTTGGCC
GGCGGCTGCGAGCCCAACCGGCGGACCGGGGCGGCCATCGCCGCCGCCGGGTTCGACACCTCGATGCTGCGCAGCGTGCC
CCGCACCCCGGTGCCCTTCCCGTGCAAACCCCACCTGCAGGGATTCGCCGTGCTCAGTCCACGCTGA

Upstream 100 bases:

>100_bases
ATCTGCTGATGGGCATCGTGCGGTGGCGGTACCGGGTGGCCGTCTACGTGTCGTTGATGCGTGACGAATATCCGCCGTTC
CGAATGGATCTGGGCTCCCG

Downstream 100 bases:

>100_bases
CCGCCTCGATGATGTTCAGCCGCGCCGCCCGCCGCGCGGGCGGCACCGAACCGAGCAGGGTGATCCCCAGCGCCCCGGCG
GTGCAGGCAAGCGCCAGCGG

Product: hypothetical protein

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: Methyltransferase; Methyltransferase UbiE/COQ5 Family; SAM-Dependent Methyltransferase; UbiE/COQ5 Family Methlytransferase; Ubiquinone/Menaquinone Biosynthesis Methyltransferase UbiE; Methylase Involved In Ubiquinone/Menaquinone Biosynthesis; Generic Methyltransferase; Phosphatidylethanolamine N-Methyltransferase; Methyltransferase Domain Family; Methyltransferase Domain Family Protein; Sam Dependent Methyltransferase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MRFRNVLFPYVYRFGQPVFDRLFYHRYRRQAMSHATGRLLMVGLGPGTDLMFLPAAVTSVAAVEPEASFRRMAARLAARH
GVAVDVVAGSGESIPFPDNSFDSVHIGLVLCSVRDVAATLAEIRRVLVPGGRLVVLEHVRGDGLTGRLQDLIARPWSWLA
GGCEPNRRTGAAIAAAGFDTSMLRSVPRTPVPFPCKPHLQGFAVLSPR

Sequences:

>Translated_208_residues
MRFRNVLFPYVYRFGQPVFDRLFYHRYRRQAMSHATGRLLMVGLGPGTDLMFLPAAVTSVAAVEPEASFRRMAARLAARH
GVAVDVVAGSGESIPFPDNSFDSVHIGLVLCSVRDVAATLAEIRRVLVPGGRLVVLEHVRGDGLTGRLQDLIARPWSWLA
GGCEPNRRTGAAIAAAGFDTSMLRSVPRTPVPFPCKPHLQGFAVLSPR
>Mature_208_residues
MRFRNVLFPYVYRFGQPVFDRLFYHRYRRQAMSHATGRLLMVGLGPGTDLMFLPAAVTSVAAVEPEASFRRMAARLAARH
GVAVDVVAGSGESIPFPDNSFDSVHIGLVLCSVRDVAATLAEIRRVLVPGGRLVVLEHVRGDGLTGRLQDLIARPWSWLA
GGCEPNRRTGAAIAAAGFDTSMLRSVPRTPVPFPCKPHLQGFAVLSPR

Specific function: Methyltransferase Required For The Conversion Of Dimethylmenaquinone (Dmkh2) To Menaquinone (Mkh2) And The Conversion Of 2-Polyprenyl-6-Methoxy-1,4-Benzoquinol (Ddmqh2) To 2-Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol (Dmqh2). [C]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI89145417, Length=172, Percent_Identity=31.9767441860465, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI164663805, Length=209, Percent_Identity=29.6650717703349, Blast_Score=74, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.1.1.- [C]

Molecular weight: Translated: 22691; Mature: 22691

Theoretical pI: Translated: 11.31; Mature: 11.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFRNVLFPYVYRFGQPVFDRLFYHRYRRQAMSHATGRLLMVGLGPGTDLMFLPAAVTSV
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEHHHHHHHH
AAVEPEASFRRMAARLAARHGVAVDVVAGSGESIPFPDNSFDSVHIGLVLCSVRDVAATL
HHCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHH
AEIRRVLVPGGRLVVLEHVRGDGLTGRLQDLIARPWSWLAGGCEPNRRTGAAIAAAGFDT
HHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCCHHHHCCCCCCCCCCCCEEEECCCCH
SMLRSVPRTPVPFPCKPHLQGFAVLSPR
HHHHHCCCCCCCCCCCCCCCEEEEECCC
>Mature Secondary Structure
MRFRNVLFPYVYRFGQPVFDRLFYHRYRRQAMSHATGRLLMVGLGPGTDLMFLPAAVTSV
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEHHHHHHHH
AAVEPEASFRRMAARLAARHGVAVDVVAGSGESIPFPDNSFDSVHIGLVLCSVRDVAATL
HHCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHH
AEIRRVLVPGGRLVVLEHVRGDGLTGRLQDLIARPWSWLAGGCEPNRRTGAAIAAAGFDT
HHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCCHHHHCCCCCCCCCCCCEEEECCCCH
SMLRSVPRTPVPFPCKPHLQGFAVLSPR
HHHHHCCCCCCCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA