| Definition | Mycobacterium avium subsp. paratuberculosis K-10, complete genome. |
|---|---|
| Accession | NC_002944 |
| Length | 4,829,781 |
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The map label for this gene is ilvB [H]
Identifier: 41410306
GI number: 41410306
Start: 4677742
End: 4679547
Strand: Direct
Name: ilvB [H]
Synonym: MAP4208
Alternate gene names: 41410306
Gene position: 4677742-4679547 (Clockwise)
Preceding gene: 41410303
Following gene: 41410307
Centisome position: 96.85
GC content: 72.7
Gene sequence:
>1806_bases GTGAACCCATCGGCGGCCCGCCTCGTGTCTTCCCACATGCTCGGAAGGCACCGGGTGGTCGACCACATCGTCGGCCACCT CGCGGCGATCGGAACCGACCACCTCTTCGCGGTGGACGGCGCCAACATCGAGGACCTCTACGACGCGGCGCATTTCCGGC CGGAGCTCACCGCGGTGCTGGCCAAGCACGAGTTCTCCGCCGCCGCGATGGCCGACGGATACAGCCGAAGCGGAGCGGGA CTCGGGGTGGTGGCCGCGACCTCGGGCGGCGGATCGCTGAATCTCGTGGCCGGACTCGGCGAGTCGCTCGCCAGCCGGGT GCCGGTGCTGGCGCTGGTCGGCCAGCCCGCCGCCGCGCTGGACGGCCGGGGCAGCTTCCAGGACACCAGCGGCGCCAACG GATCGCTGGACGCCGGCGCGCTGTTCTCGGCGGTCTCGGTGTTCTGCCGGCGAGTGCAAACCCCCGACGACATTGTTTCG CTTCTGCCGCAGGCCATTTCGGCGGCGCGGGCCGGAGGCCCAGCGGTGCTGTTGTTGCCTAAGGACATTCAGCAGGCCCG GGTCGGCGTCGGCGAGCGCAACGGCCACGGCGCACCCGGCGGGCGAGTCGCGATTGCGGCGCAATGGCGGCCCCCGGCCG GCGACCCGCACCCGATCGCGGCGCAATTGCGCCGCGTGACCGGCGAGATCGCCATCATCGCCGGCGAACAGGTGGCCCGC GACGACGCCCGGGCCGAGCTCGAGGAGCTGCGCGCGCTGCTGGGGGCGCGGGTGGCCACCGTGCCGGACGCCAAGGACGT CGCCGGCGCACCCGGGCCGGACGGCCGGACGCTGGGAGTGACCGGTGTGATGGGCCACCGCAACGTGGCCGAGGCGGTGG CCCGCAGCGCGGTGTGCCTCATCGTCGGGACCCGGCTGGCGGTCACCGCGCGCAGCGGCCTGGACGACGCGCTGGCCGCG GTGCGCACCGTCTCGATCGGGTCGGCGCCGCCCTATCTCGCCTGCACCCACGTGCACACCGGCGACCTGCGCGGCTCGCT GCGGCTGCTGATCCGCGCGCTGCGCGGCCACCGGCGACCGGTCGCGCCGGCCGGGCAAGGCGGGGGCCGGCCGACCGAGC TGACGCCGCCGCCGTGCAGGGGGCCGGGGGTGCGCTACCGCGACGCGATGGCGGTGCTGGACGGCGTGCTGCCGCGCGGC GCCGACATCGTGGTCGACGCTGGCAACACCGGCGCGGTCGCGATCCACTGTCTGCCGGTGCGCCGCGACGGCCGGTTCGT CGTCGCGCTCGGCATGGGTGGCATGGGCTACAGCTTCGGGGCGGGGATCGGAATAGCGTTGGGGCGCAACAACAGTGGAC GCCCTGGCGGGCGCACCGTCGTCATCGCCGGGGACGGCGCGTTCTTCATGCACGGCATGGAGGTGCACACCGCCGTGCAA TACCGGCTACCGATGACGTTCGTGCTGTTCAACAACAACGCGCACGCCATGTGCGTGACCCGCGAGCAGCTGTTCTACGG CGACCGCTACAGCTACAACCGTTTTCGGCCCAGCCGGCTGGGCGCCGGGCTGGCCGCCATGTTCCCCGGCCTGACCTCGG TGGAGGTCGGCGACGTCGACGGGTTCGCCGCCGCGATGGCCGCGGCGCTCGATGTCGACGGCCCGGCGGTGGTCAGCGTC GAGTGCGCCGCCGACGAGATCCCGCCATTCGCCCCGTTTCTCACCACGTCGGCGGTCAAAGATGCTGCCGTCAAACAGAA TTCAGTTACAAAGGAGATCCGCACCAATGTCGCTGCCAGCGCTTGA
Upstream 100 bases:
>100_bases CCCACCCGGTACTCGCGCACCACGCCGGCCATTTCTATGGTCATCTAGGCACCACGGTGACGGCCGACGAACGGTTCACC GGCCCCGCCGCGCGACGATC
Downstream 100 bases:
>100_bases GGACATCGGCGACCTCATCGACGGGGTCACCCGCATCGAGACCAGCCCCCGGGAGAAGGCCACGCCGATCATCATGGACA TGATGCGGTCGGTGTACCCG
Product: hypothetical protein
Products: NA
Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]
Number of amino acids: Translated: 601; Mature: 601
Protein sequence:
>601_residues MNPSAARLVSSHMLGRHRVVDHIVGHLAAIGTDHLFAVDGANIEDLYDAAHFRPELTAVLAKHEFSAAAMADGYSRSGAG LGVVAATSGGGSLNLVAGLGESLASRVPVLALVGQPAAALDGRGSFQDTSGANGSLDAGALFSAVSVFCRRVQTPDDIVS LLPQAISAARAGGPAVLLLPKDIQQARVGVGERNGHGAPGGRVAIAAQWRPPAGDPHPIAAQLRRVTGEIAIIAGEQVAR DDARAELEELRALLGARVATVPDAKDVAGAPGPDGRTLGVTGVMGHRNVAEAVARSAVCLIVGTRLAVTARSGLDDALAA VRTVSIGSAPPYLACTHVHTGDLRGSLRLLIRALRGHRRPVAPAGQGGGRPTELTPPPCRGPGVRYRDAMAVLDGVLPRG ADIVVDAGNTGAVAIHCLPVRRDGRFVVALGMGGMGYSFGAGIGIALGRNNSGRPGGRTVVIAGDGAFFMHGMEVHTAVQ YRLPMTFVLFNNNAHAMCVTREQLFYGDRYSYNRFRPSRLGAGLAAMFPGLTSVEVGDVDGFAAAMAAALDVDGPAVVSV ECAADEIPPFAPFLTTSAVKDAAVKQNSVTKEIRTNVAASA
Sequences:
>Translated_601_residues MNPSAARLVSSHMLGRHRVVDHIVGHLAAIGTDHLFAVDGANIEDLYDAAHFRPELTAVLAKHEFSAAAMADGYSRSGAG LGVVAATSGGGSLNLVAGLGESLASRVPVLALVGQPAAALDGRGSFQDTSGANGSLDAGALFSAVSVFCRRVQTPDDIVS LLPQAISAARAGGPAVLLLPKDIQQARVGVGERNGHGAPGGRVAIAAQWRPPAGDPHPIAAQLRRVTGEIAIIAGEQVAR DDARAELEELRALLGARVATVPDAKDVAGAPGPDGRTLGVTGVMGHRNVAEAVARSAVCLIVGTRLAVTARSGLDDALAA VRTVSIGSAPPYLACTHVHTGDLRGSLRLLIRALRGHRRPVAPAGQGGGRPTELTPPPCRGPGVRYRDAMAVLDGVLPRG ADIVVDAGNTGAVAIHCLPVRRDGRFVVALGMGGMGYSFGAGIGIALGRNNSGRPGGRTVVIAGDGAFFMHGMEVHTAVQ YRLPMTFVLFNNNAHAMCVTREQLFYGDRYSYNRFRPSRLGAGLAAMFPGLTSVEVGDVDGFAAAMAAALDVDGPAVVSV ECAADEIPPFAPFLTTSAVKDAAVKQNSVTKEIRTNVAASA >Mature_601_residues MNPSAARLVSSHMLGRHRVVDHIVGHLAAIGTDHLFAVDGANIEDLYDAAHFRPELTAVLAKHEFSAAAMADGYSRSGAG LGVVAATSGGGSLNLVAGLGESLASRVPVLALVGQPAAALDGRGSFQDTSGANGSLDAGALFSAVSVFCRRVQTPDDIVS LLPQAISAARAGGPAVLLLPKDIQQARVGVGERNGHGAPGGRVAIAAQWRPPAGDPHPIAAQLRRVTGEIAIIAGEQVAR DDARAELEELRALLGARVATVPDAKDVAGAPGPDGRTLGVTGVMGHRNVAEAVARSAVCLIVGTRLAVTARSGLDDALAA VRTVSIGSAPPYLACTHVHTGDLRGSLRLLIRALRGHRRPVAPAGQGGGRPTELTPPPCRGPGVRYRDAMAVLDGVLPRG ADIVVDAGNTGAVAIHCLPVRRDGRFVVALGMGGMGYSFGAGIGIALGRNNSGRPGGRTVVIAGDGAFFMHGMEVHTAVQ YRLPMTFVLFNNNAHAMCVTREQLFYGDRYSYNRFRPSRLGAGLAAMFPGLTSVEVGDVDGFAAAMAAALDVDGPAVVSV ECAADEIPPFAPFLTTSAVKDAAVKQNSVTKEIRTNVAASA
Specific function: Valine and isoleucine biosynthesis; first step. [C]
COG id: COG0028
COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the TPP enzyme family [H]
Homologues:
Organism=Homo sapiens, GI21361361, Length=530, Percent_Identity=24.5283018867925, Blast_Score=82, Evalue=2e-15, Organism=Escherichia coli, GI1787096, Length=573, Percent_Identity=22.6876090750436, Blast_Score=85, Evalue=1e-17, Organism=Escherichia coli, GI87081685, Length=165, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=4e-16, Organism=Escherichia coli, GI1786717, Length=500, Percent_Identity=24, Blast_Score=80, Evalue=5e-16, Organism=Escherichia coli, GI1790104, Length=168, Percent_Identity=26.1904761904762, Blast_Score=64, Evalue=3e-11, Organism=Saccharomyces cerevisiae, GI6323755, Length=156, Percent_Identity=30.1282051282051, Blast_Score=71, Evalue=6e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012846 - InterPro: IPR012000 - InterPro: IPR012001 - InterPro: IPR000399 - InterPro: IPR011766 [H]
Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]
EC number: =2.2.1.6 [H]
Molecular weight: Translated: 61653; Mature: 61653
Theoretical pI: Translated: 8.49; Mature: 8.49
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 3.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNPSAARLVSSHMLGRHRVVDHIVGHLAAIGTDHLFAVDGANIEDLYDAAHFRPELTAVL CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCHHHHHHH AKHEFSAAAMADGYSRSGAGLGVVAATSGGGSLNLVAGLGESLASRVPVLALVGQPAAAL HHHCCCHHHHHCCCCCCCCCEEEEEEECCCCCEEEHHHCCHHHHHCCCEEEEECCCHHHC DGRGSFQDTSGANGSLDAGALFSAVSVFCRRVQTPDDIVSLLPQAISAARAGGPAVLLLP CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEC KDIQQARVGVGERNGHGAPGGRVAIAAQWRPPAGDPHPIAAQLRRVTGEIAIIAGEQVAR CCHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCEEEEECCHHHH DDARAELEELRALLGARVATVPDAKDVAGAPGPDGRTLGVTGVMGHRNVAEAVARSAVCL HHHHHHHHHHHHHHCCCEECCCCHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHCEEEE IVGTRLAVTARSGLDDALAAVRTVSIGSAPPYLACTHVHTGDLRGSLRLLIRALRGHRRP EEECEEEEEECCCCHHHHHHHHEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCC VAPAGQGGGRPTELTPPPCRGPGVRYRDAMAVLDGVLPRGADIVVDAGNTGAVAIHCLPV CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEEEE RRDGRFVVALGMGGMGYSFGAGIGIALGRNNSGRPGGRTVVIAGDGAFFMHGMEVHTAVQ CCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEECCEEEEECEEEEEEEE YRLPMTFVLFNNNAHAMCVTREQLFYGDRYSYNRFRPSRLGAGLAAMFPGLTSVEVGDVD EECCEEEEEECCCCEEEEEEHHHHHCCCCCCCCCCCHHHHCCCHHHHCCCCCEEEECCCC GFAAAMAAALDVDGPAVVSVECAADEIPPFAPFLTTSAVKDAAVKQNSVTKEIRTNVAAS HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC A C >Mature Secondary Structure MNPSAARLVSSHMLGRHRVVDHIVGHLAAIGTDHLFAVDGANIEDLYDAAHFRPELTAVL CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCHHHHHHH AKHEFSAAAMADGYSRSGAGLGVVAATSGGGSLNLVAGLGESLASRVPVLALVGQPAAAL HHHCCCHHHHHCCCCCCCCCEEEEEEECCCCCEEEHHHCCHHHHHCCCEEEEECCCHHHC DGRGSFQDTSGANGSLDAGALFSAVSVFCRRVQTPDDIVSLLPQAISAARAGGPAVLLLP CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEC KDIQQARVGVGERNGHGAPGGRVAIAAQWRPPAGDPHPIAAQLRRVTGEIAIIAGEQVAR CCHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCEEEEECCHHHH DDARAELEELRALLGARVATVPDAKDVAGAPGPDGRTLGVTGVMGHRNVAEAVARSAVCL HHHHHHHHHHHHHHCCCEECCCCHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHCEEEE IVGTRLAVTARSGLDDALAAVRTVSIGSAPPYLACTHVHTGDLRGSLRLLIRALRGHRRP EEECEEEEEECCCCHHHHHHHHEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCC VAPAGQGGGRPTELTPPPCRGPGVRYRDAMAVLDGVLPRGADIVVDAGNTGAVAIHCLPV CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEEEE RRDGRFVVALGMGGMGYSFGAGIGIALGRNNSGRPGGRTVVIAGDGAFFMHGMEVHTAVQ CCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEECCEEEEECEEEEEEEE YRLPMTFVLFNNNAHAMCVTREQLFYGDRYSYNRFRPSRLGAGLAAMFPGLTSVEVGDVD EECCEEEEEECCCCEEEEEEHHHHHCCCCCCCCCCCHHHHCCCHHHHCCCCCEEEECCCC GFAAAMAAALDVDGPAVVSVECAADEIPPFAPFLTTSAVKDAAVKQNSVTKEIRTNVAAS HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC A C
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8688087 [H]