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The map label for this gene is hemA

Identifier: 41410100

GI number: 41410100

Start: 4462040

End: 4463419

Strand: Direct

Name: hemA

Synonym: MAP4002

Alternate gene names: 41410100

Gene position: 4462040-4463419 (Clockwise)

Preceding gene: 41410099

Following gene: 41410101

Centisome position: 92.39

GC content: 72.97

Gene sequence:

>1380_bases
GTGAGCGTCTTGCTCTTCGGGGTTTCGCACCGTAGTGCGCCGGTCTCCGTCCTGGAACAACTCAGTATCGACGAATCCGA
TCACGGCAAGATCGTCGACCGGGTGTTGCAGTCCCCGCTGGTGACCGAGGCGATGGTGCTGTCGACATGCAACCGGGTCG
AGGTCTACGCGGTGGTGGACGCGTTCCACGGCGGGTTGGCCGTGATCGGGCAGGTGCTGTCGGACCACTCCGGGATGTCG
ATGTCCGACCTCACCAAATACGCCTACGTCCGGTACAGCGAGGCCGCCGTCGAGCACCTGTTCGCGGTGGCCAGCGGCCT
GGACTCGGCGGTGATCGGCGAGCAGCAGGTGCTCGGCCAGGTCCGCCGCGCGTACGCCACCGCCGAAACCAACCGCACCG
TGGGCCGGGTGCTGCACGAACTGGCCCAGCGCGCGCTGTCGGTGGGCAAGCGGGTGCACTCCGAGACCGCCATCGACGCC
GCCGGCGCCTCGGTGGTGTCGGTCGCCCTGGACATGGCCGACCGCCGGCTGGGCGGGCTGGCCGGCAAGACCGCCGTCCT
GGTCGGCGCCGGAGCGATGGGCGCCCTGGCCGCCGCGCACCTGTCCCGCGCCGGCATCGGGCAGGTCCACGTGCTCAACC
GGTCGCTGTCGCGGGCCCAACGGCTGGTCCGCAAGATCCGCGAAACCGGGGTGCGGGCCGACGCGCTGCCGCTGGAGCAC
CTGGCCGACGCGCTGGCCGGGGCCGACGTCGTGGTCAGCTGCACCGGCGCGGTCAGCCCGGTGGTCTCGCTGGCCGACGT
GCACCACGCGCTGGCCGCCGCCGGCCGCTCGGCCGCCGACGAGACCGCCCACCCGCTGGTGATCTGCGATCTGGGCATGC
CGCGCGACGTCGACCCGGCGGTGGCCGGGCTGCCCGGCGTCTGGGTGGTCGACGTGGACCGCGTGCAGCACGAGCCCTCG
GCGCACGCCGCGGCCGCCGACGTCGACGCCGCCCGCACCATCGTGGCCACCGAAGTCGCCGCCTACCTGGCCGGGCAGCG
GATGGCCGAGGTCACGCCGACGGTGACGGCGCTGCGCCAGCGCGCGGCCGACGTCGTCGAGGCCGAGCTGCTGCGGCTGG
ACAACCGGCTGCCCGGCCTCGACAGCGCCCACCGTGAAGAGGTGGCCCGCACCGTGCGTCGGGTGGTGGACAAGCTGCTG
CACGCCCCGACGGTGCGGATCAAACAGCTCGCCAGCGCCCCCGGCGGGGACAGCTACGCCGAGGCGTTGCGTGAGCTCTT
CGAACTCGACCAGACCGCCGTCGACGCCGTCGCCGCGGGCGAATTGCCGGTCATAGCAACCGGATTCGACGCGGGCGCGC
CGCAACAACCCACCGAGTAG

Upstream 100 bases:

>100_bases
GCTGCCAAACGATTATTTGGTAGCCCAGCTGATAAACGTTTACCGTGGACAGCAGTTCAGTTACTGGAGGAAGCAAGGGA
GCTGGCCAGGTGATGCTGCC

Downstream 100 bases:

>100_bases
CCGATTGGCGAATGTGATCCGGATAGGAACCCGGGGCAGCCTGCTGGCCACCACCCAGGCCGGGGGCGTCAGGGACGCCC
TGATCGCCCGCGGGCACCCG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSVLLFGVSHRSAPVSVLEQLSIDESDHGKIVDRVLQSPLVTEAMVLSTCNRVEVYAVVDAFHGGLAVIGQVLSDHSGMS
MSDLTKYAYVRYSEAAVEHLFAVASGLDSAVIGEQQVLGQVRRAYATAETNRTVGRVLHELAQRALSVGKRVHSETAIDA
AGASVVSVALDMADRRLGGLAGKTAVLVGAGAMGALAAAHLSRAGIGQVHVLNRSLSRAQRLVRKIRETGVRADALPLEH
LADALAGADVVVSCTGAVSPVVSLADVHHALAAAGRSAADETAHPLVICDLGMPRDVDPAVAGLPGVWVVDVDRVQHEPS
AHAAAADVDAARTIVATEVAAYLAGQRMAEVTPTVTALRQRAADVVEAELLRLDNRLPGLDSAHREEVARTVRRVVDKLL
HAPTVRIKQLASAPGGDSYAEALRELFELDQTAVDAVAAGELPVIATGFDAGAPQQPTE

Sequences:

>Translated_459_residues
MSVLLFGVSHRSAPVSVLEQLSIDESDHGKIVDRVLQSPLVTEAMVLSTCNRVEVYAVVDAFHGGLAVIGQVLSDHSGMS
MSDLTKYAYVRYSEAAVEHLFAVASGLDSAVIGEQQVLGQVRRAYATAETNRTVGRVLHELAQRALSVGKRVHSETAIDA
AGASVVSVALDMADRRLGGLAGKTAVLVGAGAMGALAAAHLSRAGIGQVHVLNRSLSRAQRLVRKIRETGVRADALPLEH
LADALAGADVVVSCTGAVSPVVSLADVHHALAAAGRSAADETAHPLVICDLGMPRDVDPAVAGLPGVWVVDVDRVQHEPS
AHAAAADVDAARTIVATEVAAYLAGQRMAEVTPTVTALRQRAADVVEAELLRLDNRLPGLDSAHREEVARTVRRVVDKLL
HAPTVRIKQLASAPGGDSYAEALRELFELDQTAVDAVAAGELPVIATGFDAGAPQQPTE
>Mature_458_residues
SVLLFGVSHRSAPVSVLEQLSIDESDHGKIVDRVLQSPLVTEAMVLSTCNRVEVYAVVDAFHGGLAVIGQVLSDHSGMSM
SDLTKYAYVRYSEAAVEHLFAVASGLDSAVIGEQQVLGQVRRAYATAETNRTVGRVLHELAQRALSVGKRVHSETAIDAA
GASVVSVALDMADRRLGGLAGKTAVLVGAGAMGALAAAHLSRAGIGQVHVLNRSLSRAQRLVRKIRETGVRADALPLEHL
ADALAGADVVVSCTGAVSPVVSLADVHHALAAAGRSAADETAHPLVICDLGMPRDVDPAVAGLPGVWVVDVDRVQHEPSA
HAAAADVDAARTIVATEVAAYLAGQRMAEVTPTVTALRQRAADVVEAELLRLDNRLPGLDSAHREEVARTVRRVVDKLLH
APTVRIKQLASAPGGDSYAEALRELFELDQTAVDAVAAGELPVIATGFDAGAPQQPTE

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=430, Percent_Identity=32.093023255814, Blast_Score=185, Evalue=5e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_MYCA1 (A0QLI1)

Other databases:

- EMBL:   CP000479
- RefSeq:   YP_883769.1
- ProteinModelPortal:   A0QLI1
- SMR:   A0QLI1
- STRING:   A0QLI1
- EnsemblBacteria:   EBMYCT00000011889
- GeneID:   4525577
- GenomeReviews:   CP000479_GR
- KEGG:   mav:MAV_4640
- TIGR:   MAV_4640
- eggNOG:   COG0373
- GeneTree:   EBGT00050000017163
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   A0QLI1
- ProtClustDB:   PRK00045
- BioCyc:   MAVI243243:MAV_4640-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 47934; Mature: 47803

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00747 GLUTR; PS00639 THIOL_PROTEASE_HIS

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLLFGVSHRSAPVSVLEQLSIDESDHGKIVDRVLQSPLVTEAMVLSTCNRVEVYAVVD
CCEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCEEEEEHHH
AFHGGLAVIGQVLSDHSGMSMSDLTKYAYVRYSEAAVEHLFAVASGLDSAVIGEQQVLGQ
HHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHH
VRRAYATAETNRTVGRVLHELAQRALSVGKRVHSETAIDAAGASVVSVALDMADRRLGGL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
AGKTAVLVGAGAMGALAAAHLSRAGIGQVHVLNRSLSRAQRLVRKIRETGVRADALPLEH
CCCCEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LADALAGADVVVSCTGAVSPVVSLADVHHALAAAGRSAADETAHPLVICDLGMPRDVDPA
HHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCHH
VAGLPGVWVVDVDRVQHEPSAHAAAADVDAARTIVATEVAAYLAGQRMAEVTPTVTALRQ
HHCCCCEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAADVVEAELLRLDNRLPGLDSAHREEVARTVRRVVDKLLHAPTVRIKQLASAPGGDSYA
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHH
EALRELFELDQTAVDAVAAGELPVIATGFDAGAPQQPTE
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SVLLFGVSHRSAPVSVLEQLSIDESDHGKIVDRVLQSPLVTEAMVLSTCNRVEVYAVVD
CEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCEEEEEHHH
AFHGGLAVIGQVLSDHSGMSMSDLTKYAYVRYSEAAVEHLFAVASGLDSAVIGEQQVLGQ
HHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHH
VRRAYATAETNRTVGRVLHELAQRALSVGKRVHSETAIDAAGASVVSVALDMADRRLGGL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
AGKTAVLVGAGAMGALAAAHLSRAGIGQVHVLNRSLSRAQRLVRKIRETGVRADALPLEH
CCCCEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LADALAGADVVVSCTGAVSPVVSLADVHHALAAAGRSAADETAHPLVICDLGMPRDVDPA
HHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCHH
VAGLPGVWVVDVDRVQHEPSAHAAAADVDAARTIVATEVAAYLAGQRMAEVTPTVTALRQ
HHCCCCEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAADVVEAELLRLDNRLPGLDSAHREEVARTVRRVVDKLLHAPTVRIKQLASAPGGDSYA
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHH
EALRELFELDQTAVDAVAAGELPVIATGFDAGAPQQPTE
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA