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The map label for this gene is hemC

Identifier: 41410101

GI number: 41410101

Start: 4463433

End: 4464380

Strand: Direct

Name: hemC

Synonym: MAP4003

Alternate gene names: 41410101

Gene position: 4463433-4464380 (Clockwise)

Preceding gene: 41410100

Following gene: 41410102

Centisome position: 92.41

GC content: 71.41

Gene sequence:

>948_bases
GTGATCCGGATAGGAACCCGGGGCAGCCTGCTGGCCACCACCCAGGCCGGGGGCGTCAGGGACGCCCTGATCGCCCGCGG
GCACCCGGCGGAACTGGTCACCATCACCACCGCGGGGGACCGGTCGTCGGGGCCCATCGAGTCGCTCGGGGTGGGAGTAT
TCACCACCGCCCTGCGCGAGGCCATCGAGGAGGGCCGGGTGGACGCCGCCGTGCACTCCCACAAGGACCTGCCGACCGCC
GACGATCCACGGTTTGCTGTGGCCGCCATCCCCGCCCGCAACGACCCACGGGACGCGGTGGTGGCCCGCGACGGCCTGGT
GCTCGCGGAGTTGCCACCCGGTTCGCTGGTGGGCACCTCGTCGCCGCGGCGGGCCGCGCAGCTTAGAGCATTGGGTCTCG
GTTTGGAAATCCGCCCCCTACGAGGCAACCTAGATACCAGGTTGAACAGGGTTAGCAGTGGTGATCTGGACGCGATCGTG
GTAGCCCGGGCGGGTCTGGCCCGGCTGGGTCGCCTCGGGGATGTCACCGAGACGCTCGAGCCGGTGCAGATGTTGCCGGC
ACCGGCTCAGGGCGCGCTCGCCGTCGAATGCCGAGCCGGGGACAGCCGGTTGGCCGCGGTGCTGGCGGAGCTGGACGATG
CCGACACGCGCGCGTCGGTCACCGCGGAGCGAGCCCTGCTGGCCGAACTGGAGGCCGGTTGCTCCGCACCGGTGGGCGCG
ATCGCCGAAGTGGTCGAGTCCATCGATGAGGACGGCCGGATCTTCGAAGAGCTGTCGCTGCGCGGTTGCGTGGCGGCGCT
GGACGGGTCCGACGTGATCCGCGCGTCCGGCATCGGCACTCCCGGTCGGGCCCGAGAGCTGGGGCTTTCGGTCGCCGCCG
AGCTGTTCGAGCTGGGCGCGCGCGAGTTGATGAGCGGAGCGCGGCACGACCCGGCGCGAGGAAATTAA

Upstream 100 bases:

>100_bases
ACCGCCGTCGACGCCGTCGCCGCGGGCGAATTGCCGGTCATAGCAACCGGATTCGACGCGGGCGCGCCGCAACAACCCAC
CGAGTAGCCGATTGGCGAAT

Downstream 100 bases:

>100_bases
GTGCGAGTTACCTGGGAGCGACAATGACGACGCGAGGGCGTAAGCCGACACCCGGCCGCATCACGTACGTGGGCTCCGGC
CCGGGTGACCCGGGACTGTT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MIRIGTRGSLLATTQAGGVRDALIARGHPAELVTITTAGDRSSGPIESLGVGVFTTALREAIEEGRVDAAVHSHKDLPTA
DDPRFAVAAIPARNDPRDAVVARDGLVLAELPPGSLVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIV
VARAGLARLGRLGDVTETLEPVQMLPAPAQGALAVECRAGDSRLAAVLAELDDADTRASVTAERALLAELEAGCSAPVGA
IAEVVESIDEDGRIFEELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVAAELFELGARELMSGARHDPARGN

Sequences:

>Translated_315_residues
MIRIGTRGSLLATTQAGGVRDALIARGHPAELVTITTAGDRSSGPIESLGVGVFTTALREAIEEGRVDAAVHSHKDLPTA
DDPRFAVAAIPARNDPRDAVVARDGLVLAELPPGSLVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIV
VARAGLARLGRLGDVTETLEPVQMLPAPAQGALAVECRAGDSRLAAVLAELDDADTRASVTAERALLAELEAGCSAPVGA
IAEVVESIDEDGRIFEELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVAAELFELGARELMSGARHDPARGN
>Mature_315_residues
MIRIGTRGSLLATTQAGGVRDALIARGHPAELVTITTAGDRSSGPIESLGVGVFTTALREAIEEGRVDAAVHSHKDLPTA
DDPRFAVAAIPARNDPRDAVVARDGLVLAELPPGSLVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIV
VARAGLARLGRLGDVTETLEPVQMLPAPAQGALAVECRAGDSRLAAVLAELDDADTRASVTAERALLAELEAGCSAPVGA
IAEVVESIDEDGRIFEELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVAAELFELGARELMSGARHDPARGN

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=346, Percent_Identity=37.2832369942197, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI66933009, Length=345, Percent_Identity=37.3913043478261, Blast_Score=173, Evalue=2e-43,
Organism=Escherichia coli, GI48994974, Length=310, Percent_Identity=43.8709677419355, Blast_Score=203, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6319996, Length=286, Percent_Identity=32.5174825174825, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI20130425, Length=284, Percent_Identity=41.1971830985916, Blast_Score=169, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 32478; Mature: 32478

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRIGTRGSLLATTQAGGVRDALIARGHPAELVTITTAGDRSSGPIESLGVGVFTTALRE
CEEECCCCCEEEECCCCCCHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
AIEEGRVDAAVHSHKDLPTADDPRFAVAAIPARNDPRDAVVARDGLVLAELPPGSLVGTS
HHHHCCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCCEEEEECCCCCEECCC
SPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLGDVTETLE
CCHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHH
PVQMLPAPAQGALAVECRAGDSRLAAVLAELDDADTRASVTAERALLAELEAGCSAPVGA
HHHHCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHH
IAEVVESIDEDGRIFEELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVAAELFELGA
HHHHHHHHCCCCHHHHHHHHHHHEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHH
RELMSGARHDPARGN
HHHHCCCCCCCCCCC
>Mature Secondary Structure
MIRIGTRGSLLATTQAGGVRDALIARGHPAELVTITTAGDRSSGPIESLGVGVFTTALRE
CEEECCCCCEEEECCCCCCHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
AIEEGRVDAAVHSHKDLPTADDPRFAVAAIPARNDPRDAVVARDGLVLAELPPGSLVGTS
HHHHCCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCCEEEEECCCCCEECCC
SPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLGDVTETLE
CCHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHH
PVQMLPAPAQGALAVECRAGDSRLAAVLAELDDADTRASVTAERALLAELEAGCSAPVGA
HHHHCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHH
IAEVVESIDEDGRIFEELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVAAELFELGA
HHHHHHHHCCCCHHHHHHHHHHHEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHH
RELMSGARHDPARGN
HHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA