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The map label for this gene is pyrE

Identifier: 41409955

GI number: 41409955

Start: 4319840

End: 4320379

Strand: Direct

Name: pyrE

Synonym: MAP3857

Alternate gene names: 41409955

Gene position: 4319840-4320379 (Clockwise)

Preceding gene: 41409954

Following gene: 41409956

Centisome position: 89.44

GC content: 72.04

Gene sequence:

>540_bases
GTGGCCGAACCTGAGCTCGAGGAGCTGGCCGAGCTGGTGCGCCGGCTGTCGGTGGTGCACGGCCGGGTCACGCTGTCGTC
CGGCAAGGAGGCCGACTACTACGTCGACCTGCGCCGGGCCACCCTGCATCATCGCGCCTCGGCGTTGATCGGCAGGCTGA
TGCGCGAGCTGACCACCGACTGGGACTACGCGGTGGTCGGCGGCCTGACCCTGGGCGCCGACCCGGTGGCCACCGCCATC
ATGCACGCGCCGGGCCGCCCGATCGACGCCTTCGTGGTCCGCAAGTCGGCGAAAACCCATGGGCTGCAACGCCTTATCGA
AGGCTCGGAGGTCGCGGGCAAGCGGGTGCTGGTGGTCGAGGACACCAGCACCACCGGCAACTCTGCGCTCACCGCGGTGC
GCGCCGTCCAGCAGGCCGGCGGTCATGTGCTGGGGGTGGCCACCGTGGTGGACCGCGCCACCGGCGCCGCCGAGGCCATC
GAGGCCGAGGGGCTGCCCTACCGCAGCGTGCTCGGTCTCGCCGATCTGGGGCTGGGCTAA

Upstream 100 bases:

>100_bases
ATCAGCATTCCGGGCTTGCAGTACAAGGCGATCGTCGCCGCCGAGCGGCTGATCCCGCGCACCCTGATGCGGGCGATCAC
CAAACGAGTCGGTGGTGGCC

Downstream 100 bases:

>100_bases
TTGCATTGCTGCGCAAGGCTTCTCGCGATAGTGGCCTGCCTGCTGGCCTGCGTGACGGCCTGCTCGAACCCCCACCCCGC
GGCGCGCCCGTACGGCGCCC

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 179; Mature: 178

Protein sequence:

>179_residues
MAEPELEELAELVRRLSVVHGRVTLSSGKEADYYVDLRRATLHHRASALIGRLMRELTTDWDYAVVGGLTLGADPVATAI
MHAPGRPIDAFVVRKSAKTHGLQRLIEGSEVAGKRVLVVEDTSTTGNSALTAVRAVQQAGGHVLGVATVVDRATGAAEAI
EAEGLPYRSVLGLADLGLG

Sequences:

>Translated_179_residues
MAEPELEELAELVRRLSVVHGRVTLSSGKEADYYVDLRRATLHHRASALIGRLMRELTTDWDYAVVGGLTLGADPVATAI
MHAPGRPIDAFVVRKSAKTHGLQRLIEGSEVAGKRVLVVEDTSTTGNSALTAVRAVQQAGGHVLGVATVVDRATGAAEAI
EAEGLPYRSVLGLADLGLG
>Mature_178_residues
AEPELEELAELVRRLSVVHGRVTLSSGKEADYYVDLRRATLHHRASALIGRLMRELTTDWDYAVVGGLTLGADPVATAIM
HAPGRPIDAFVVRKSAKTHGLQRLIEGSEVAGKRVLVVEDTSTTGNSALTAVRAVQQAGGHVLGVATVVDRATGAAEAIE
AEGLPYRSVLGLADLGLG

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=159, Percent_Identity=28.3018867924528, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17508631, Length=155, Percent_Identity=30.3225806451613, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 18871; Mature: 18740

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEPELEELAELVRRLSVVHGRVTLSSGKEADYYVDLRRATLHHRASALIGRLMRELTTD
CCCCCHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WDYAVVGGLTLGADPVATAIMHAPGRPIDAFVVRKSAKTHGLQRLIEGSEVAGKRVLVVE
CCHHEECCEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
DTSTTGNSALTAVRAVQQAGGHVLGVATVVDRATGAAEAIEAEGLPYRSVLGLADLGLG
CCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
AEPELEELAELVRRLSVVHGRVTLSSGKEADYYVDLRRATLHHRASALIGRLMRELTTD
CCCCHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WDYAVVGGLTLGADPVATAIMHAPGRPIDAFVVRKSAKTHGLQRLIEGSEVAGKRVLVVE
CCHHEECCEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
DTSTTGNSALTAVRAVQQAGGHVLGVATVVDRATGAAEAIEAEGLPYRSVLGLADLGLG
CCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA