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The map label for this gene is oxcA

Identifier: 41409621

GI number: 41409621

Start: 3923377

End: 3925161

Strand: Reverse

Name: oxcA

Synonym: MAP3523c

Alternate gene names: 41409621

Gene position: 3925161-3923377 (Counterclockwise)

Preceding gene: 41409623

Following gene: 41409618

Centisome position: 81.27

GC content: 71.88

Gene sequence:

>1785_bases
ATGGCTGGGCAGTACCCACACCCGCACGGCAGGAGTCGCCACATGTCCGCAACCTCGGCATCCGCCGGCCCGGCGCCGGA
ATCCGCACGGCTGATCGACGGCTTCCATCTGGTGGTGCAGGCGCTGCGGGCCAACGATGTCGCGACCATCTACGGCATCG
TCGGCATTCCGATCACCGACCTGGCCCGCGTCGCGCAGGCGTCGGGCATCCGCTACCTCGGCTTTCGGCAGGAGGCCTCG
GCCGGCAACGCGGCGGCGGCCGCGGGCTTCCTCACCCGTCGTCCCGGGGTGTGCCTGACCACGTCGGGACCCGGCTTCCT
CAACGCCCTGCCCGCGCTGGCGAACGCCACGACGAACTGCTTCCCGATGATCCAGATCTCCGGCTCGAGCGATCGGGCGC
TGGTCGATCTGCGCCGCGGCGATTACCAGGACCTCGACCAGCTGGACGCCGCAAGGCCTTTCGCGAAGGCGGCGTACCGG
ATCAACCGGGTCGACGACATCGGCCGCGGCGTCGCGCGCGCCGTGCGGACGGCGGTCTCCGGCCGCCCCGGCGGTGTCTA
CCTGGACATCCCCGGCGACGTCCTGGGCCAGGCCATGGACGCTTCGGCCGCCGCCGGCACGCTGTGGCGGGTCGTCGACC
CCGCCCCCCGCCAGCTGCCCGCGCCCGAGGCGGTCGATCGCGCGCTGGACGTTCTGGCCGACGCCCGGCGGCCGTTGATC
GTGCTGGGCAAGGGCGCGGCATACGCCCAGGCCGACAACGAGATTCGGCGATTCGTCGAGTCAACCGGGATTCCGTTCCT
GCCGATGTCGATGGCCAAGGGGCTGCTACCGGACGCGCACCCGCAGTCCGTCGCGGCCGCGCGGTCGCTGGCCATCGGGC
GCGCCGACGCGGTGCTGTTGGTCGGCGCCCGGTTGAATTGGCTTCTGGGACATGGGGAATCGCCGCAATGGTCGGCCGGC
GTCAAGTTCGTCCAGGTCGACATCGAGCCGTCGGAGTTCGACAGCAACCAGCAGATCGCCGCGCCGCTGGCCGGCGACAT
CGGCTCGGTGATGTCCGCGCTGTGCGACGCGCTGGCCGCCCGGCCGATCACCGTACCGGCGCGGTGGACCGAGGAACTGG
CCGAGCGCCGGGCCCACAACGACGCCAAGATGCGCGAGCGCCTCGCCGAGGACCCGCACCCGATGCGGTTCTACAACGCG
CTGGGCGCGATTCGCGCTGTGCTGCAAGACAACCGCGACGTCTACGTGGTCAACGAGGGAGCCAACGCGCTCGACCTGGC
CCGCAACGTCGTCGACATGGAACTGCCTCGGCACCGGCTCGACACCGGAACCTGGGGCGTGATGGGCATCGGCATGGGCT
TCGCCATCGGCGCCGCGGTCGAGACCGGTCGGCCGGTGGTCGCGATCGAGGGCGACAGCGCGTTCGGCTTCAGCGGGATG
GAGATCGAGACCATCTGCCGCTACCGCCTGCCGGTGACCGTCGTCATCCTCAACAACGGCGGTGTCTACCGCGGCGACGA
GGCCCCGCACGGGGATGACCCGGCGCCCACCGTGCTCAGCGCCCGGGCCCGCCACGAGCTGATCGCGGAGGCTTTCGGCG
GCAAGGGATATCACGTCAGCACGGCGGCCGAACTGCGGGCGGCGCTGACGGAGGCGATCGGCTCCGGCGGGCCGTCGCTG
ATCGACTGCGAGCTCGATCCGACCGCCGGGGTGGAAAGCGGCCACCTGGCCAACCGGAACCCGGCCAGCGCGGCGTCGCC
GGCCGCGGTCAGCGCCGGCGCGTGA

Upstream 100 bases:

>100_bases
CGACGCCGGCGGTCCCGGCGCTGACCTGCCGCGATAAACGTCGTGAATGGCCGGATAGCGCGTTCGACTTGGACACCTGA
CGGTCGGCGGGGTCATTGTG

Downstream 100 bases:

>100_bases
CGCCCAGCAGCTGCGCGTCGAAGAAGTCGTTCAGCTGCAGCCGGCCGGCGGACGCGGCCAGCGCCCGCGCGATCGGCGAG
CCGGGACCGTGCGACTTGGT

Product: putative oxalyl-CoA decarboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 594; Mature: 593

Protein sequence:

>594_residues
MAGQYPHPHGRSRHMSATSASAGPAPESARLIDGFHLVVQALRANDVATIYGIVGIPITDLARVAQASGIRYLGFRQEAS
AGNAAAAAGFLTRRPGVCLTTSGPGFLNALPALANATTNCFPMIQISGSSDRALVDLRRGDYQDLDQLDAARPFAKAAYR
INRVDDIGRGVARAVRTAVSGRPGGVYLDIPGDVLGQAMDASAAAGTLWRVVDPAPRQLPAPEAVDRALDVLADARRPLI
VLGKGAAYAQADNEIRRFVESTGIPFLPMSMAKGLLPDAHPQSVAAARSLAIGRADAVLLVGARLNWLLGHGESPQWSAG
VKFVQVDIEPSEFDSNQQIAAPLAGDIGSVMSALCDALAARPITVPARWTEELAERRAHNDAKMRERLAEDPHPMRFYNA
LGAIRAVLQDNRDVYVVNEGANALDLARNVVDMELPRHRLDTGTWGVMGIGMGFAIGAAVETGRPVVAIEGDSAFGFSGM
EIETICRYRLPVTVVILNNGGVYRGDEAPHGDDPAPTVLSARARHELIAEAFGGKGYHVSTAAELRAALTEAIGSGGPSL
IDCELDPTAGVESGHLANRNPASAASPAAVSAGA

Sequences:

>Translated_594_residues
MAGQYPHPHGRSRHMSATSASAGPAPESARLIDGFHLVVQALRANDVATIYGIVGIPITDLARVAQASGIRYLGFRQEAS
AGNAAAAAGFLTRRPGVCLTTSGPGFLNALPALANATTNCFPMIQISGSSDRALVDLRRGDYQDLDQLDAARPFAKAAYR
INRVDDIGRGVARAVRTAVSGRPGGVYLDIPGDVLGQAMDASAAAGTLWRVVDPAPRQLPAPEAVDRALDVLADARRPLI
VLGKGAAYAQADNEIRRFVESTGIPFLPMSMAKGLLPDAHPQSVAAARSLAIGRADAVLLVGARLNWLLGHGESPQWSAG
VKFVQVDIEPSEFDSNQQIAAPLAGDIGSVMSALCDALAARPITVPARWTEELAERRAHNDAKMRERLAEDPHPMRFYNA
LGAIRAVLQDNRDVYVVNEGANALDLARNVVDMELPRHRLDTGTWGVMGIGMGFAIGAAVETGRPVVAIEGDSAFGFSGM
EIETICRYRLPVTVVILNNGGVYRGDEAPHGDDPAPTVLSARARHELIAEAFGGKGYHVSTAAELRAALTEAIGSGGPSL
IDCELDPTAGVESGHLANRNPASAASPAAVSAGA
>Mature_593_residues
AGQYPHPHGRSRHMSATSASAGPAPESARLIDGFHLVVQALRANDVATIYGIVGIPITDLARVAQASGIRYLGFRQEASA
GNAAAAAGFLTRRPGVCLTTSGPGFLNALPALANATTNCFPMIQISGSSDRALVDLRRGDYQDLDQLDAARPFAKAAYRI
NRVDDIGRGVARAVRTAVSGRPGGVYLDIPGDVLGQAMDASAAAGTLWRVVDPAPRQLPAPEAVDRALDVLADARRPLIV
LGKGAAYAQADNEIRRFVESTGIPFLPMSMAKGLLPDAHPQSVAAARSLAIGRADAVLLVGARLNWLLGHGESPQWSAGV
KFVQVDIEPSEFDSNQQIAAPLAGDIGSVMSALCDALAARPITVPARWTEELAERRAHNDAKMRERLAEDPHPMRFYNAL
GAIRAVLQDNRDVYVVNEGANALDLARNVVDMELPRHRLDTGTWGVMGIGMGFAIGAAVETGRPVVAIEGDSAFGFSGME
IETICRYRLPVTVVILNNGGVYRGDEAPHGDDPAPTVLSARARHELIAEAFGGKGYHVSTAAELRAALTEAIGSGGPSLI
DCELDPTAGVESGHLANRNPASAASPAAVSAGA

Specific function: Oxalic acid catabolism; second step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=563, Percent_Identity=41.3854351687389, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI21361361, Length=504, Percent_Identity=30.5555555555556, Blast_Score=192, Evalue=9e-49,
Organism=Escherichia coli, GI1788716, Length=561, Percent_Identity=58.4670231729055, Blast_Score=664, Evalue=0.0,
Organism=Escherichia coli, GI1790104, Length=564, Percent_Identity=26.4184397163121, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI87081685, Length=541, Percent_Identity=24.7689463955638, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1786717, Length=490, Percent_Identity=28.5714285714286, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1787096, Length=538, Percent_Identity=23.7918215613383, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17531301, Length=547, Percent_Identity=39.3053016453382, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17531299, Length=547, Percent_Identity=39.3053016453382, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17542570, Length=565, Percent_Identity=28.8495575221239, Blast_Score=194, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6320816, Length=529, Percent_Identity=35.3497164461248, Blast_Score=316, Evalue=5e-87,
Organism=Saccharomyces cerevisiae, GI6323755, Length=579, Percent_Identity=22.1070811744387, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323073, Length=542, Percent_Identity=23.2472324723247, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323163, Length=506, Percent_Identity=22.1343873517787, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19922626, Length=558, Percent_Identity=38.1720430107527, Blast_Score=399, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017660
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.8 [H]

Molecular weight: Translated: 62266; Mature: 62135

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGQYPHPHGRSRHMSATSASAGPAPESARLIDGFHLVVQALRANDVATIYGIVGIPITD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHH
LARVAQASGIRYLGFRQEASAGNAAAAAGFLTRRPGVCLTTSGPGFLNALPALANATTNC
HHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCC
FPMIQISGSSDRALVDLRRGDYQDLDQLDAARPFAKAAYRINRVDDIGRGVARAVRTAVS
EEEEEECCCCCCEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GRPGGVYLDIPGDVLGQAMDASAAAGTLWRVVDPAPRQLPAPEAVDRALDVLADARRPLI
CCCCCEEEECCHHHHHHHHCCHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEE
VLGKGAAYAQADNEIRRFVESTGIPFLPMSMAKGLLPDAHPQSVAAARSLAIGRADAVLL
EEECCCCHHHHHHHHHHHHHHCCCCEECHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEE
VGARLNWLLGHGESPQWSAGVKFVQVDIEPSEFDSNQQIAAPLAGDIGSVMSALCDALAA
EECEEEEEEECCCCCCCCCCCEEEEEECCHHHCCCCCEECCCHHCCHHHHHHHHHHHHHC
RPITVPARWTEELAERRAHNDAKMRERLAEDPHPMRFYNALGAIRAVLQDNRDVYVVNEG
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCC
ANALDLARNVVDMELPRHRLDTGTWGVMGIGMGFAIGAAVETGRPVVAIEGDSAFGFSGM
CCHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCC
EIETICRYRLPVTVVILNNGGVYRGDEAPHGDDPAPTVLSARARHELIAEAFGGKGYHVS
CHHHHHHCCCCEEEEEECCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEC
TAAELRAALTEAIGSGGPSLIDCELDPTAGVESGHLANRNPASAASPAAVSAGA
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AGQYPHPHGRSRHMSATSASAGPAPESARLIDGFHLVVQALRANDVATIYGIVGIPITD
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHH
LARVAQASGIRYLGFRQEASAGNAAAAAGFLTRRPGVCLTTSGPGFLNALPALANATTNC
HHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCC
FPMIQISGSSDRALVDLRRGDYQDLDQLDAARPFAKAAYRINRVDDIGRGVARAVRTAVS
EEEEEECCCCCCEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GRPGGVYLDIPGDVLGQAMDASAAAGTLWRVVDPAPRQLPAPEAVDRALDVLADARRPLI
CCCCCEEEECCHHHHHHHHCCHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEE
VLGKGAAYAQADNEIRRFVESTGIPFLPMSMAKGLLPDAHPQSVAAARSLAIGRADAVLL
EEECCCCHHHHHHHHHHHHHHCCCCEECHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEE
VGARLNWLLGHGESPQWSAGVKFVQVDIEPSEFDSNQQIAAPLAGDIGSVMSALCDALAA
EECEEEEEEECCCCCCCCCCCEEEEEECCHHHCCCCCEECCCHHCCHHHHHHHHHHHHHC
RPITVPARWTEELAERRAHNDAKMRERLAEDPHPMRFYNALGAIRAVLQDNRDVYVVNEG
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCC
ANALDLARNVVDMELPRHRLDTGTWGVMGIGMGFAIGAAVETGRPVVAIEGDSAFGFSGM
CCHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCC
EIETICRYRLPVTVVILNNGGVYRGDEAPHGDDPAPTVLSARARHELIAEAFGGKGYHVS
CHHHHHHCCCCEEEEEECCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEC
TAAELRAALTEAIGSGGPSLIDCELDPTAGVESGHLANRNPASAASPAAVSAGA
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]