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The map label for this gene is kasB_2

Identifier: 41409583

GI number: 41409583

Start: 3873375

End: 3874634

Strand: Direct

Name: kasB_2

Synonym: MAP3485

Alternate gene names: 41409583

Gene position: 3873375-3874634 (Clockwise)

Preceding gene: 41409582

Following gene: 41409584

Centisome position: 80.2

GC content: 68.17

Gene sequence:

>1260_bases
ATGACGGAGCTGGTTACCGGGGAAACGCTGCCGAACGTGGTCGTCACTGGCATCGCCATGACGACCGCGCTGGCGACTGA
CGCCGAGACCACCTGGAAGCTGTTGCTGGACAGTCAAAGTGGTATCCGCAAGCTCGAGGATTCCTTCGTCGAGGAGTTCG
ACCTGCCGGTGCGCATCGGCGGTCACCTGCTGGAGGATTTCGACGACGGGCTGACCCGGGCCGAGCGGCACCGGATGGGC
TACCTGCAGATGATGTCGACGGTGCTGGGCCGGCGGGTCTGGGAGAACGCCGGCTCGCCCGAAGTTGACAGTAACCGGCT
CATGGTGTCCATCGGTACCGGCCTGGGGTCATCCGAGGAAATGGTCTTCAGCTACGACGACATGCGCGCGCGGGGCATGA
AGGGGGTCTCGCCGCTGGCGGTGTCGAAGTACATGCCCGACGGCGCGGCCGTCGCGGTGGGCCTGGAACGGCACGCCAAG
GCCGGCGTGATCACGCCGGTGTCGGCGTGCGCGTCGGGCTCCGAGGGCATCGCCCAGGCGTGGCGCAACATCGTCTTCGG
CGAGGCCGACATCGCGATCTGCGGCGGTGTCGAGACGAAGATCGAGGCGGTGGCGATCGCGGCGTTCGCCCAGATGCGCA
TCGTGATGTCGACCAAGAACGACGACCCTGTCGGCGCCTGTCGCCCGTTCGACCGGGACCGCACCGGCTTCGTGTTCGGC
GAGGCCGGCGCGCTGATGGTGATCGAAACCGAGGAACACGCCAAGGCCCGCGGCGCCAACATCCTGGCCCGCATCATGGG
CGCCAGCATCACCTCCGACGGCTACCACATGGTCGCCCCGGACCCCAACGGCGAACGCGCCGGACACGCCATGAGCCGCG
CCATCCAGCTGGCCGGCCTGACGCCCGGCGACATCGATCACGTCAACGCGCACGCCACCGGCACCTCGGTGGGCGACGTG
GCCGAGAGCAAGGCCATCAACAACGCGCTGGGCCCGCACGGCGGCAACGCCGCCGTCTACGCCCCAAAGGCCGCGCTCGG
CCACTCGGTGGGCGCGGTCGGCGCGGTCGAGTCCATCCTGACCGTGCTGGCCCTGCGCGACCAGGTCGTCCCGCCCACCC
TGAACCTGGAAAACCTCGACCCCGAAATCGATTTGGACGTGGTGGCGGGCAAACCGCGACCGGGCAACTACCAGTACGCG
ATCAACAACTCGTTCGGCTTCGGCGGCCACAACGTCGCCATCGCCTTCGGACGGTACTGA

Upstream 100 bases:

>100_bases
CGCCGGTGACGTCGGCGGATTGTGTTTTCATGAAGATGGACGAGTGGGGGCGCGACGTCACGCGTGGACGGCTCCCGTCA
AGTGAAAGGTATCGAGTGTC

Downstream 100 bases:

>100_bases
ACCCACCGTCGCGCCGGCCCTCGTTTGGTGATCCGAGCAGAGGGTAAAGCAGCGACTATGGCCTTCGCCGAGTATCAGAA
CGAGCTCTACGACCAGTCGT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: Beta-ketoacyl-ACP synthase 2; KAS 2 [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MTELVTGETLPNVVVTGIAMTTALATDAETTWKLLLDSQSGIRKLEDSFVEEFDLPVRIGGHLLEDFDDGLTRAERHRMG
YLQMMSTVLGRRVWENAGSPEVDSNRLMVSIGTGLGSSEEMVFSYDDMRARGMKGVSPLAVSKYMPDGAAVAVGLERHAK
AGVITPVSACASGSEGIAQAWRNIVFGEADIAICGGVETKIEAVAIAAFAQMRIVMSTKNDDPVGACRPFDRDRTGFVFG
EAGALMVIETEEHAKARGANILARIMGASITSDGYHMVAPDPNGERAGHAMSRAIQLAGLTPGDIDHVNAHATGTSVGDV
AESKAINNALGPHGGNAAVYAPKAALGHSVGAVGAVESILTVLALRDQVVPPTLNLENLDPEIDLDVVAGKPRPGNYQYA
INNSFGFGGHNVAIAFGRY

Sequences:

>Translated_419_residues
MTELVTGETLPNVVVTGIAMTTALATDAETTWKLLLDSQSGIRKLEDSFVEEFDLPVRIGGHLLEDFDDGLTRAERHRMG
YLQMMSTVLGRRVWENAGSPEVDSNRLMVSIGTGLGSSEEMVFSYDDMRARGMKGVSPLAVSKYMPDGAAVAVGLERHAK
AGVITPVSACASGSEGIAQAWRNIVFGEADIAICGGVETKIEAVAIAAFAQMRIVMSTKNDDPVGACRPFDRDRTGFVFG
EAGALMVIETEEHAKARGANILARIMGASITSDGYHMVAPDPNGERAGHAMSRAIQLAGLTPGDIDHVNAHATGTSVGDV
AESKAINNALGPHGGNAAVYAPKAALGHSVGAVGAVESILTVLALRDQVVPPTLNLENLDPEIDLDVVAGKPRPGNYQYA
INNSFGFGGHNVAIAFGRY
>Mature_418_residues
TELVTGETLPNVVVTGIAMTTALATDAETTWKLLLDSQSGIRKLEDSFVEEFDLPVRIGGHLLEDFDDGLTRAERHRMGY
LQMMSTVLGRRVWENAGSPEVDSNRLMVSIGTGLGSSEEMVFSYDDMRARGMKGVSPLAVSKYMPDGAAVAVGLERHAKA
GVITPVSACASGSEGIAQAWRNIVFGEADIAICGGVETKIEAVAIAAFAQMRIVMSTKNDDPVGACRPFDRDRTGFVFGE
AGALMVIETEEHAKARGANILARIMGASITSDGYHMVAPDPNGERAGHAMSRAIQLAGLTPGDIDHVNAHATGTSVGDVA
ESKAINNALGPHGGNAAVYAPKAALGHSVGAVGAVESILTVLALRDQVVPPTLNLENLDPEIDLDVVAGKPRPGNYQYAI
NNSFGFGGHNVAIAFGRY

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=33.8129496402878, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=44.5205479452055, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI41872631, Length=254, Percent_Identity=28.3464566929134, Blast_Score=82, Evalue=6e-16,
Organism=Escherichia coli, GI1787337, Length=414, Percent_Identity=36.7149758454106, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1788663, Length=414, Percent_Identity=33.5748792270531, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71983541, Length=412, Percent_Identity=32.0388349514563, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=38.8679245283019, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17550940, Length=289, Percent_Identity=26.9896193771626, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI212642053, Length=379, Percent_Identity=25.065963060686, Blast_Score=88, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=447, Percent_Identity=31.5436241610738, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24644341, Length=423, Percent_Identity=34.2789598108747, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI19920632, Length=255, Percent_Identity=23.921568627451, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221330659, Length=255, Percent_Identity=23.921568627451, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24581345, Length=258, Percent_Identity=24.4186046511628, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 44086; Mature: 43955

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELVTGETLPNVVVTGIAMTTALATDAETTWKLLLDSQSGIRKLEDSFVEEFDLPVRIG
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEC
GHLLEDFDDGLTRAERHRMGYLQMMSTVLGRRVWENAGSPEVDSNRLMVSIGTGLGSSEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCC
MVFSYDDMRARGMKGVSPLAVSKYMPDGAAVAVGLERHAKAGVITPVSACASGSEGIAQA
EEEEECCHHHCCCCCCCCHHHHHCCCCCCEEEEEHHHHCCCCCCCHHHHHCCCCHHHHHH
WRNIVFGEADIAICGGVETKIEAVAIAAFAQMRIVMSTKNDDPVGACRPFDRDRTGFVFG
HHHHCCCCCCEEEECCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCEEEEE
EAGALMVIETEEHAKARGANILARIMGASITSDGYHMVAPDPNGERAGHAMSRAIQLAGL
CCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCC
TPGDIDHVNAHATGTSVGDVAESKAINNALGPHGGNAAVYAPKAALGHSVGAVGAVESIL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECHHHHCCCCCHHHHHHHHH
TVLALRDQVVPPTLNLENLDPEIDLDVVAGKPRPGNYQYAINNSFGFGGHNVAIAFGRY
HHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEECCCCCCCCCEEEEEECCC
>Mature Secondary Structure 
TELVTGETLPNVVVTGIAMTTALATDAETTWKLLLDSQSGIRKLEDSFVEEFDLPVRIG
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEC
GHLLEDFDDGLTRAERHRMGYLQMMSTVLGRRVWENAGSPEVDSNRLMVSIGTGLGSSEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCC
MVFSYDDMRARGMKGVSPLAVSKYMPDGAAVAVGLERHAKAGVITPVSACASGSEGIAQA
EEEEECCHHHCCCCCCCCHHHHHCCCCCCEEEEEHHHHCCCCCCCHHHHHCCCCHHHHHH
WRNIVFGEADIAICGGVETKIEAVAIAAFAQMRIVMSTKNDDPVGACRPFDRDRTGFVFG
HHHHCCCCCCEEEECCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCEEEEE
EAGALMVIETEEHAKARGANILARIMGASITSDGYHMVAPDPNGERAGHAMSRAIQLAGL
CCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCC
TPGDIDHVNAHATGTSVGDVAESKAINNALGPHGGNAAVYAPKAALGHSVGAVGAVESIL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECHHHHCCCCCHHHHHHHHH
TVLALRDQVVPPTLNLENLDPEIDLDVVAGKPRPGNYQYAINNSFGFGGHNVAIAFGRY
HHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEECCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]