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The map label for this gene is lldD [C]

Identifier: 41409584

GI number: 41409584

Start: 3874692

End: 3875870

Strand: Direct

Name: lldD [C]

Synonym: MAP3486

Alternate gene names: 41409584

Gene position: 3874692-3875870 (Clockwise)

Preceding gene: 41409583

Following gene: 41409588

Centisome position: 80.23

GC content: 69.8

Gene sequence:

>1179_bases
ATGGCCTTCGCCGAGTATCAGAACGAGCTCTACGACCAGTCGTTGCACGGCAACCAGCCGCAGTATCCGATCAGATTCGA
GGAGCTGGAGGCCAAGGCGTCGGCGGCGATGACCCCGAAGGTGCTGGGGTACGTCGCCGGCGGCGCCGGCGACGAGCACA
CCCAGCGGGCCAACTGCGAGGCGTTCAAGCGGTGGGGCTTGTACCCGCGGATGGGGATCGCCCCCGAACAGCGCGACATG
TCCGTCGAGCTGTTCGGCACCCGGTTCCCGTCGCCGATATTCATGGCGCCCATCGGCGTGATCGGGGTGTGCGACCCCGA
CGGCCACGGCGACCTGGCCTGCGTTCGGGCCTCGATCCGCACCGGCGTCCCGTTCTTCGTCGGCACGCTGTCGGCCGATC
CGATGGAGGACCTGGCCGACGAATTGGGCGACACCCCAGCGTTTTTCCAGCTCTACACCCCACCGGACCGCAAGATGGCC
GCCAGCCTGGTGCACCGGGCCGAGGCGGCCAGCTTCAGCGGCATCGCCGTCACCCTGGACACCTGGGTGACCGGCTGGCG
GCCCCGCGACCTGAGCGGCGGGAACTACCCCCAGGTGCCCAGCGGATGCCTGGCCAACTACACCAGCGATCCGGTTTTTC
GCGCCGGGTTGAGCCGCGGCGAAGACCCCACCGAGGCGGCGGTGCGCAAGCTGCCGATCTTCGGCGGGCCGTTCCGGTGG
GAGGACCTGGAATGGCTGCGGTCGCGGACCAGCCTGCCGCTGATGGCCAAGGGCATCTGCCACCCCGACGACGTGCGCCG
CGCCAAAGACATTGGGGTGGACGCCGTTTACTGCTCCAACCACGGCGGCCGGCAAGCCAACGGCGGGTTGCCCTGCCTGG
ACTGCCTGCCCGGGGTGGTCGAGGCGGCTGACGGGTTGCCGGTGCTGTTCGACTCGGGTGTGCGCAGCGGGGCCGACATC
GTCAAGGCGCTGGCGCTGGGGGCGACCGCGGTCGGCATCGGCCGCCCCTACGCCTACGGGCTGGCGCTCGGGGGCGTCGA
CGGCATCGTGCACGTGCTGCGCTCGCTGCTGGCCGAGGCCGACCTGATCATGGCCGTCGACGGCTACCCCTCGCTGAAGG
ACCTGACGCCGGACGCGCTTCGCCGCGTCGAACATGTTGCACCACAACGTTATTCGTAG

Upstream 100 bases:

>100_bases
CTTCGGCGGCCACAACGTCGCCATCGCCTTCGGACGGTACTGAACCCACCGTCGCGCCGGCCCTCGTTTGGTGATCCGAG
CAGAGGGTAAAGCAGCGACT

Downstream 100 bases:

>100_bases
CTTCCCTCCAAATACCACCTCCTTTGCCGGTAGCACAGCAGCAGCGCGCGTTCGCTTTCCAGCAGAACCTGCGCGCGGGC
GGTACGGCCCCCACCCTGAC

Product: hypothetical protein

Products: NA

Alternate protein names: Lactate oxidase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MAFAEYQNELYDQSLHGNQPQYPIRFEELEAKASAAMTPKVLGYVAGGAGDEHTQRANCEAFKRWGLYPRMGIAPEQRDM
SVELFGTRFPSPIFMAPIGVIGVCDPDGHGDLACVRASIRTGVPFFVGTLSADPMEDLADELGDTPAFFQLYTPPDRKMA
ASLVHRAEAASFSGIAVTLDTWVTGWRPRDLSGGNYPQVPSGCLANYTSDPVFRAGLSRGEDPTEAAVRKLPIFGGPFRW
EDLEWLRSRTSLPLMAKGICHPDDVRRAKDIGVDAVYCSNHGGRQANGGLPCLDCLPGVVEAADGLPVLFDSGVRSGADI
VKALALGATAVGIGRPYAYGLALGGVDGIVHVLRSLLAEADLIMAVDGYPSLKDLTPDALRRVEHVAPQRYS

Sequences:

>Translated_392_residues
MAFAEYQNELYDQSLHGNQPQYPIRFEELEAKASAAMTPKVLGYVAGGAGDEHTQRANCEAFKRWGLYPRMGIAPEQRDM
SVELFGTRFPSPIFMAPIGVIGVCDPDGHGDLACVRASIRTGVPFFVGTLSADPMEDLADELGDTPAFFQLYTPPDRKMA
ASLVHRAEAASFSGIAVTLDTWVTGWRPRDLSGGNYPQVPSGCLANYTSDPVFRAGLSRGEDPTEAAVRKLPIFGGPFRW
EDLEWLRSRTSLPLMAKGICHPDDVRRAKDIGVDAVYCSNHGGRQANGGLPCLDCLPGVVEAADGLPVLFDSGVRSGADI
VKALALGATAVGIGRPYAYGLALGGVDGIVHVLRSLLAEADLIMAVDGYPSLKDLTPDALRRVEHVAPQRYS
>Mature_391_residues
AFAEYQNELYDQSLHGNQPQYPIRFEELEAKASAAMTPKVLGYVAGGAGDEHTQRANCEAFKRWGLYPRMGIAPEQRDMS
VELFGTRFPSPIFMAPIGVIGVCDPDGHGDLACVRASIRTGVPFFVGTLSADPMEDLADELGDTPAFFQLYTPPDRKMAA
SLVHRAEAASFSGIAVTLDTWVTGWRPRDLSGGNYPQVPSGCLANYTSDPVFRAGLSRGEDPTEAAVRKLPIFGGPFRWE
DLEWLRSRTSLPLMAKGICHPDDVRRAKDIGVDAVYCSNHGGRQANGGLPCLDCLPGVVEAADGLPVLFDSGVRSGADIV
KALALGATAVGIGRPYAYGLALGGVDGIVHVLRSLLAEADLIMAVDGYPSLKDLTPDALRRVEHVAPQRYS

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=361, Percent_Identity=35.7340720221607, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI54234014, Length=362, Percent_Identity=30.6629834254144, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI7705393, Length=362, Percent_Identity=30.6629834254144, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1790033, Length=387, Percent_Identity=31.266149870801, Blast_Score=169, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI193208036, Length=341, Percent_Identity=34.3108504398827, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI32566217, Length=278, Percent_Identity=30.5755395683453, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323587, Length=367, Percent_Identity=30.5177111716621, Blast_Score=166, Evalue=4e-42,
Organism=Drosophila melanogaster, GI78707188, Length=353, Percent_Identity=34.8441926345609, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI281363140, Length=352, Percent_Identity=34.375, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI78707190, Length=352, Percent_Identity=34.375, Blast_Score=178, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.13.12.4 [H]

Molecular weight: Translated: 42122; Mature: 41991

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFAEYQNELYDQSLHGNQPQYPIRFEELEAKASAAMTPKVLGYVAGGAGDEHTQRANCE
CCHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHCCHH
AFKRWGLYPRMGIAPEQRDMSVELFGTRFPSPIFMAPIGVIGVCDPDGHGDLACVRASIR
HHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCEECCCCEEEEECCCCCCCHHHHHHHHH
TGVPFFVGTLSADPMEDLADELGDTPAFFQLYTPPDRKMAASLVHRAEAASFSGIAVTLD
CCCCEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEE
TWVTGWRPRDLSGGNYPQVPSGCLANYTSDPVFRAGLSRGEDPTEAAVRKLPIFGGPFRW
HHHCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHCCCCCCHHHHHHHHCCCCCCCCCC
EDLEWLRSRTSLPLMAKGICHPDDVRRAKDIGVDAVYCSNHGGRQANGGLPCLDCLPGVV
HHHHHHHHCCCCCHHHCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHH
EAADGLPVLFDSGVRSGADIVKALALGATAVGIGRPYAYGLALGGVDGIVHVLRSLLAEA
HHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHCCC
DLIMAVDGYPSLKDLTPDALRRVEHVAPQRYS
CEEEEECCCCCHHCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AFAEYQNELYDQSLHGNQPQYPIRFEELEAKASAAMTPKVLGYVAGGAGDEHTQRANCE
CHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHCCHH
AFKRWGLYPRMGIAPEQRDMSVELFGTRFPSPIFMAPIGVIGVCDPDGHGDLACVRASIR
HHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCEECCCCEEEEECCCCCCCHHHHHHHHH
TGVPFFVGTLSADPMEDLADELGDTPAFFQLYTPPDRKMAASLVHRAEAASFSGIAVTLD
CCCCEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEE
TWVTGWRPRDLSGGNYPQVPSGCLANYTSDPVFRAGLSRGEDPTEAAVRKLPIFGGPFRW
HHHCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHCCCCCCHHHHHHHHCCCCCCCCCC
EDLEWLRSRTSLPLMAKGICHPDDVRRAKDIGVDAVYCSNHGGRQANGGLPCLDCLPGVV
HHHHHHHHCCCCCHHHCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHH
EAADGLPVLFDSGVRSGADIVKALALGATAVGIGRPYAYGLALGGVDGIVHVLRSLLAEA
HHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHCCC
DLIMAVDGYPSLKDLTPDALRRVEHVAPQRYS
CEEEEECCCCCHHCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2324094; 3571231 [H]