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The map label for this gene is thiL

Identifier: 41409115

GI number: 41409115

Start: 3356381

End: 3357406

Strand: Reverse

Name: thiL

Synonym: MAP3017c

Alternate gene names: 41409115

Gene position: 3357406-3356381 (Counterclockwise)

Preceding gene: 41409117

Following gene: 41409114

Centisome position: 69.51

GC content: 74.95

Gene sequence:

>1026_bases
TTGTCTGTCGGGCCACTGTTACCCGGCTTCCCAGTATTGGCGGTCGGCCCGCCCGGGCGACAGCCCTATGGTGGTGGCGT
GCGGGACGAATCGACGCTGCGGCAACTCGGCGAATTCGCCGTCATCGACCGGCTGGTGGCCGGGCGCCGTCAGCCGGCCG
CGGTGACCCTCGGGCCCGGCGACGACGCCGCGCTGGTGACGACCGGCGACGGCCGCGTGGTGGTGTCGACCGACATGCTG
GTGCAGGACCGGCATTTCCGGCTCGACTGGTCGACGCCGCACGACATCGGCCGCAAGGCGATCGCGCAGAACGCCGCGGA
CATCGAGGCGATGGGCGCGCGGCCCACGGCGTTCGTGGTGGGCTTCGGCGCTCCCGGTCAGACCGCGGCAGCGCAGGTGG
ACGCGCTGGTGGACGGCATGTGGGACGAGGCGCAGCGGGTGGGGGCCGGCATCGCCGGCGGCGATCTGGTCAGCTGCCCG
CAGTGGGTCATCTCGGTCACCGCGCTCGGCGAGCTGGACGGGCGTTCCCCGGTGCGCCGCGCTGGCGCCGAACCCGGCTC
GCTGATCGCCGTGGCCGGCGACCTGGGCCGATCCGCGGCGGGATTTGACCTGTGGCGCAATCAGATTGGCGGGTTCGACG
AGCTGCGCCGCCGGCATGCGGTGCCGCAGCCGCCCTACGGCCAGGGTGCGGTGGCCGCGGCCGGGGGAGCGCAGGCGATG
ATCGACGTCTCCGACGGCCTGATCGCCGACCTGCGGCACGTCGCCGAGGCGTCCGGGGTGGGCATGGACGTGTCCACCGC
GGCGCTGGCCGCCGACCGTGACGCGGTGGCGGCCGCGGCGACCGCGGTGGGCGTCGACGCCTGGCCGTGGGTGCTGACCG
GCGGTGAGGACCACGCCCTGGTGGCCTGTTTCCCCGGGCCCGCGCCGGCCGGCTGGCGCATCATCGGGCGGGTTCTCGAC
GGCCCGGCCCGGGTGCTGGTCGACGAGCGGGAGTGGAGCGGCCCCGCCGGCTGGCAGTCGTACTAG

Upstream 100 bases:

>100_bases
CCCCGATCGTCGTCACCGCCAGCGCGACCGCGACCATGATCACCGCCCGCGGGGGCCCGCCGTCGGCCTCCGATTCGGTT
GCCACCGCCCGCGCACCTCC

Downstream 100 bases:

>100_bases
GGTGGCCCGGTGATCTCTAAGTGACCGATCCCGCGGCCGGCGGGGGCCGGCGATGACGGCGCGCCCGCTGAATGAACTCG
TCGAGCCCGGCTGGGCGCGT

Product: thiamine monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MSVGPLLPGFPVLAVGPPGRQPYGGGVRDESTLRQLGEFAVIDRLVAGRRQPAAVTLGPGDDAALVTTGDGRVVVSTDML
VQDRHFRLDWSTPHDIGRKAIAQNAADIEAMGARPTAFVVGFGAPGQTAAAQVDALVDGMWDEAQRVGAGIAGGDLVSCP
QWVISVTALGELDGRSPVRRAGAEPGSLIAVAGDLGRSAAGFDLWRNQIGGFDELRRRHAVPQPPYGQGAVAAAGGAQAM
IDVSDGLIADLRHVAEASGVGMDVSTAALAADRDAVAAAATAVGVDAWPWVLTGGEDHALVACFPGPAPAGWRIIGRVLD
GPARVLVDEREWSGPAGWQSY

Sequences:

>Translated_341_residues
MSVGPLLPGFPVLAVGPPGRQPYGGGVRDESTLRQLGEFAVIDRLVAGRRQPAAVTLGPGDDAALVTTGDGRVVVSTDML
VQDRHFRLDWSTPHDIGRKAIAQNAADIEAMGARPTAFVVGFGAPGQTAAAQVDALVDGMWDEAQRVGAGIAGGDLVSCP
QWVISVTALGELDGRSPVRRAGAEPGSLIAVAGDLGRSAAGFDLWRNQIGGFDELRRRHAVPQPPYGQGAVAAAGGAQAM
IDVSDGLIADLRHVAEASGVGMDVSTAALAADRDAVAAAATAVGVDAWPWVLTGGEDHALVACFPGPAPAGWRIIGRVLD
GPARVLVDEREWSGPAGWQSY
>Mature_340_residues
SVGPLLPGFPVLAVGPPGRQPYGGGVRDESTLRQLGEFAVIDRLVAGRRQPAAVTLGPGDDAALVTTGDGRVVVSTDMLV
QDRHFRLDWSTPHDIGRKAIAQNAADIEAMGARPTAFVVGFGAPGQTAAAQVDALVDGMWDEAQRVGAGIAGGDLVSCPQ
WVISVTALGELDGRSPVRRAGAEPGSLIAVAGDLGRSAAGFDLWRNQIGGFDELRRRHAVPQPPYGQGAVAAAGGAQAMI
DVSDGLIADLRHVAEASGVGMDVSTAALAADRDAVAAAATAVGVDAWPWVLTGGEDHALVACFPGPAPAGWRIIGRVLDG
PARVLVDEREWSGPAGWQSY

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=282, Percent_Identity=35.4609929078014, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 35035; Mature: 34904

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVGPLLPGFPVLAVGPPGRQPYGGGVRDESTLRQLGEFAVIDRLVAGRRQPAAVTLGPG
CCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
DDAALVTTGDGRVVVSTDMLVQDRHFRLDWSTPHDIGRKAIAQNAADIEAMGARPTAFVV
CCEEEEEECCCEEEEEECEEEECCEEEECCCCCHHHHHHHHHCCCCCHHHCCCCCEEEEE
GFGAPGQTAAAQVDALVDGMWDEAQRVGAGIAGGDLVSCPQWVISVTALGELDGRSPVRR
EECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEEHHHCCCCCCCHHHH
AGAEPGSLIAVAGDLGRSAAGFDLWRNQIGGFDELRRRHAVPQPPYGQGAVAAAGGAQAM
CCCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCEEECCCCEEE
IDVSDGLIADLRHVAEASGVGMDVSTAALAADRDAVAAAATAVGVDAWPWVLTGGEDHAL
EECCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCEE
VACFPGPAPAGWRIIGRVLDGPARVLVDEREWSGPAGWQSY
EEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
SVGPLLPGFPVLAVGPPGRQPYGGGVRDESTLRQLGEFAVIDRLVAGRRQPAAVTLGPG
CCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
DDAALVTTGDGRVVVSTDMLVQDRHFRLDWSTPHDIGRKAIAQNAADIEAMGARPTAFVV
CCEEEEEECCCEEEEEECEEEECCEEEECCCCCHHHHHHHHHCCCCCHHHCCCCCEEEEE
GFGAPGQTAAAQVDALVDGMWDEAQRVGAGIAGGDLVSCPQWVISVTALGELDGRSPVRR
EECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEEHHHCCCCCCCHHHH
AGAEPGSLIAVAGDLGRSAAGFDLWRNQIGGFDELRRRHAVPQPPYGQGAVAAAGGAQAM
CCCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCEEECCCCEEE
IDVSDGLIADLRHVAEASGVGMDVSTAALAADRDAVAAAATAVGVDAWPWVLTGGEDHAL
EECCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCEE
VACFPGPAPAGWRIIGRVLDGPARVLVDEREWSGPAGWQSY
EEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9202461; 9384377; 8419296 [H]