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The map label for this gene is limC [H]

Identifier: 41409110

GI number: 41409110

Start: 3351014

End: 3351835

Strand: Reverse

Name: limC [H]

Synonym: MAP3012c

Alternate gene names: 41409110

Gene position: 3351835-3351014 (Counterclockwise)

Preceding gene: 41409111

Following gene: 41409109

Centisome position: 69.4

GC content: 70.68

Gene sequence:

>822_bases
ATGGGCGAATTCGACAACACGGTCGCCGTCGTCACCGGCGCCGCGCGCGGGCAGGGCCGCAGCCACGCCGTCGCGCTGGC
GCAGCAGGGCGCCGACGTCATCGTCGTCGATATCTGCGCCGACCTGCCGGCCATTCCCTACGCCCTGGGCACCGAGGCCG
AGCTCGCCGAAACCGTGCGGCTGGTCGAATCCGCGGGCCGCGCAGCGGTTCCGGTGATCGCCGACGTCCGCGACCTGCAG
GCGTTACGGGCCGGGGTGCAGGCGGGCATCGACCGGCTCGGCGACATCGACGTCGTCGTCGCCAACGCCGGGGTGGTGGC
CATCGGCGTCACCGAGGCCGAGTCCGAACCGGTGTTCAACACGATCGTGGACACCAACCTCAAGGGCGTGTGGCACACCA
TGCTGGCGACGGTGCCCTCGATCGTGCGCAAGGGCCGCGGCGGCTCGGTGGTGCTGGTCAGTTCGTCGCAGGGTCTGACC
GGGCGCGGCGGCGACGGCAGTGCGGCGATGTTCGCCTACGCCGCGTCCAAACACGGTGTGGTCGGCCTGATGCGCTCGGC
GGCGAATGCCTATGCGCCGCACAAGATTCGGGTGAACTCGGTACACCCGAGCGGGGTCGCGACGCCGATGATCCTCAACG
ATTTCGTGGTGAACCGGATGCTGGAGAATCCGAACCCGGCGCTGTCGCAGACCCTGCTGCCCGAGGTGCCGCTGGTCGAG
TCGCGCGACGTCACCGGGGCGGTGCTGTGGCTGGCCGGGCCGCGGTCACGCTACGTGACGGGGGTGGCCATCCCGGTGGA
CGCCGGCCACGTCGTCATGTGA

Upstream 100 bases:

>100_bases
GGCGCACCCCGCTGGCCTGCGATTACGACACGGCCGCGCGACTGGTGGCCTTCGCCGAGCGCGAGACCGGCACGGAACTG
AGGGTCTAGGGAGGTCGGCC

Downstream 100 bases:

>100_bases
GCGACGGGACTTCTCAGCCCCGGACGACCTTGCCGGCCTTAATGCACGAGGTGCACACGTTGAGGCGCTGCTTGTTGCCG
CCCGGACGGGCGACCGCGTG

Product: hypothetical protein

Products: NA

Alternate protein names: (4R,6S)-carveol dehydrogenase; CDH; Carveol dehydrogenase [H]

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MGEFDNTVAVVTGAARGQGRSHAVALAQQGADVIVVDICADLPAIPYALGTEAELAETVRLVESAGRAAVPVIADVRDLQ
ALRAGVQAGIDRLGDIDVVVANAGVVAIGVTEAESEPVFNTIVDTNLKGVWHTMLATVPSIVRKGRGGSVVLVSSSQGLT
GRGGDGSAAMFAYAASKHGVVGLMRSAANAYAPHKIRVNSVHPSGVATPMILNDFVVNRMLENPNPALSQTLLPEVPLVE
SRDVTGAVLWLAGPRSRYVTGVAIPVDAGHVVM

Sequences:

>Translated_273_residues
MGEFDNTVAVVTGAARGQGRSHAVALAQQGADVIVVDICADLPAIPYALGTEAELAETVRLVESAGRAAVPVIADVRDLQ
ALRAGVQAGIDRLGDIDVVVANAGVVAIGVTEAESEPVFNTIVDTNLKGVWHTMLATVPSIVRKGRGGSVVLVSSSQGLT
GRGGDGSAAMFAYAASKHGVVGLMRSAANAYAPHKIRVNSVHPSGVATPMILNDFVVNRMLENPNPALSQTLLPEVPLVE
SRDVTGAVLWLAGPRSRYVTGVAIPVDAGHVVM
>Mature_272_residues
GEFDNTVAVVTGAARGQGRSHAVALAQQGADVIVVDICADLPAIPYALGTEAELAETVRLVESAGRAAVPVIADVRDLQA
LRAGVQAGIDRLGDIDVVVANAGVVAIGVTEAESEPVFNTIVDTNLKGVWHTMLATVPSIVRKGRGGSVVLVSSSQGLTG
RGGDGSAAMFAYAASKHGVVGLMRSAANAYAPHKIRVNSVHPSGVATPMILNDFVVNRMLENPNPALSQTLLPEVPLVES
RDVTGAVLWLAGPRSRYVTGVAIPVDAGHVVM

Specific function: Catalyzes the oxidation of carveol to carvone, with a strong stereoselectivity since it efficiently converts only the (6S)-stereoisomers, of which (-)-(4R,6S)-trans-carveol is the better substrate. Displays a broad substrate specificity with a preference

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=276, Percent_Identity=32.9710144927536, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI4504505, Length=251, Percent_Identity=27.8884462151394, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI7705925, Length=263, Percent_Identity=28.5171102661597, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI31542939, Length=208, Percent_Identity=32.2115384615385, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI32483357, Length=268, Percent_Identity=27.9850746268657, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI40254986, Length=203, Percent_Identity=26.6009852216749, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI10190704, Length=266, Percent_Identity=25.9398496240602, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI5031737, Length=269, Percent_Identity=27.5092936802974, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI142976729, Length=228, Percent_Identity=23.2456140350877, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI87082100, Length=275, Percent_Identity=29.8181818181818, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789208, Length=271, Percent_Identity=29.1512915129151, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1787335, Length=267, Percent_Identity=28.0898876404494, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082160, Length=267, Percent_Identity=25.0936329588015, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1788459, Length=269, Percent_Identity=28.996282527881, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1787526, Length=275, Percent_Identity=28.3636363636364, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI2367175, Length=270, Percent_Identity=28.5185185185185, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787905, Length=273, Percent_Identity=25.6410256410256, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789057, Length=275, Percent_Identity=27.6363636363636, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1790717, Length=266, Percent_Identity=27.8195488721804, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1789378, Length=264, Percent_Identity=26.5151515151515, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788891, Length=232, Percent_Identity=28.448275862069, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=203, Percent_Identity=28.0788177339901, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=266, Percent_Identity=28.9473684210526, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17568967, Length=202, Percent_Identity=30.6930693069307, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=284, Percent_Identity=27.112676056338, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=269, Percent_Identity=28.6245353159851, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17567345, Length=208, Percent_Identity=25, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=283, Percent_Identity=24.7349823321555, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=292, Percent_Identity=28.0821917808219, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=284, Percent_Identity=27.112676056338, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=205, Percent_Identity=27.3170731707317, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17558628, Length=207, Percent_Identity=28.5024154589372, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=221, Percent_Identity=29.8642533936652, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=281, Percent_Identity=28.1138790035587, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=259, Percent_Identity=30.1158301158301, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324126, Length=268, Percent_Identity=26.4925373134328, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21357041, Length=278, Percent_Identity=29.136690647482, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI28571526, Length=279, Percent_Identity=30.1075268817204, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI23397609, Length=274, Percent_Identity=32.4817518248175, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24644339, Length=275, Percent_Identity=28.7272727272727, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24643142, Length=268, Percent_Identity=31.7164179104478, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI18859837, Length=219, Percent_Identity=29.2237442922374, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24639444, Length=267, Percent_Identity=29.5880149812734, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21357673, Length=203, Percent_Identity=25.1231527093596, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355319, Length=269, Percent_Identity=27.1375464684015, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24663911, Length=261, Percent_Identity=27.9693486590038, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 28093; Mature: 27961

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEFDNTVAVVTGAARGQGRSHAVALAQQGADVIVVDICADLPAIPYALGTEAELAETVR
CCCCCCEEEEEEECCCCCCCHHEEEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHH
LVESAGRAAVPVIADVRDLQALRAGVQAGIDRLGDIDVVVANAGVVAIGVTEAESEPVFN
HHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEECCCCCCCHH
TIVDTNLKGVWHTMLATVPSIVRKGRGGSVVLVSSSQGLTGRGGDGSAAMFAYAASKHGV
HHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCCH
VGLMRSAANAYAPHKIRVNSVHPSGVATPMILNDFVVNRMLENPNPALSQTLLPEVPLVE
HHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCC
SRDVTGAVLWLAGPRSRYVTGVAIPVDAGHVVM
CCCCCEEEEEEECCCCCEEEEEEEEECCCCCCC
>Mature Secondary Structure 
GEFDNTVAVVTGAARGQGRSHAVALAQQGADVIVVDICADLPAIPYALGTEAELAETVR
CCCCCEEEEEEECCCCCCCHHEEEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHH
LVESAGRAAVPVIADVRDLQALRAGVQAGIDRLGDIDVVVANAGVVAIGVTEAESEPVFN
HHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEECCCCCCCHH
TIVDTNLKGVWHTMLATVPSIVRKGRGGSVVLVSSSQGLTGRGGDGSAAMFAYAASKHGV
HHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCCH
VGLMRSAANAYAPHKIRVNSVHPSGVATPMILNDFVVNRMLENPNPALSQTLLPEVPLVE
HHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCC
SRDVTGAVLWLAGPRSRYVTGVAIPVDAGHVVM
CCCCCEEEEEEECCCCCEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10473585 [H]