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The map label for this gene is uppS [C]

Identifier: 41408801

GI number: 41408801

Start: 3039934

End: 3040728

Strand: Reverse

Name: uppS [C]

Synonym: MAP2703c

Alternate gene names: 41408801

Gene position: 3040728-3039934 (Counterclockwise)

Preceding gene: 41408803

Following gene: 41408800

Centisome position: 62.96

GC content: 67.92

Gene sequence:

>795_bases
GTGTTCGTGGAAATCATTCCGCCGCGACTCAAGGAGCCGTTGTACCGCATCTATGAGATGCGGTTGCGCCAGGAGCTCGG
TGCCGCGAAGGCCGACCTGCCCCGCCACATCGCGGTGCTGTGTGACGGCAACCGGCGCTGGGCGCGCGACGCCGGGTACG
ACGACGTCAGCTACGGCTACCGGATGGGCGCGGTCAAGATCGCCGAGATGCTGCGCTGGTGTCAGGCAGCCGGCATCGAG
ATGACCACGGTGTACCTGCTTTCCACGGAGAACCTGCAGCGCGACCCCGACGAGCTGGCCGGGCTGATCGAAATCATCAC
CGACGTCGTCGAGGAGATCTGCGCGCCGGCCAACCGGTGGAGCGTGCGCACCGTCGGCGACCTCGAGCTGCTCGGCGAGG
AGCCGGCCCGCCGGCTGCGCGGCGCCGTGGAGTCCACCCCGGTCGAGGCGTCCTTCCACGTCAACGTCGCCGTCGGCTAC
GGCGGCCGGAGGGAGATCGTCGACGCCGTGCGCTCGCTGCTGAGCAAGGAACTGGCCAACGGGGCGACGGCCGAAGAGCT
GATCGACGCGGTCACCGTCGATGCGATCTCGGAAAACCTGTACACCTCGGGCCAACCCGATCCGGACCTGGTGATCCGCA
CCTCCGGTGAGCAACGGCTGTCGGGTTTTCTGCTGTGGCAAAGCGCCTACTCCGAGATGTGGTTCACCGAGGCGCACTGG
CCGGCCTTCCGCCGGGTCGACTTCCTGCGGGCGCTGCGCGACTACAGCCAGCGGCACCGCCGCTACGGCAAATAA

Upstream 100 bases:

>100_bases
CAGGAACGGCCGCGGCGCCGTCGCGAGCTGTGCGGCGACGGCCCGCACGACGCGGCCGAAATCAGCACCGGTGAAACGAT
CGCCGCTGGCAGTAGGGTGT

Downstream 100 bases:

>100_bases
CCCGCCGCCCGGAAGGCCTTAAGCACCCGTCGACCTGCGTGCCACACTTGGTGCATGGCTGCGCTGTCGGCGGTGGTGTT
CACGCTGAGCGCCTGGCTGG

Product: hypothetical protein

Products: NA

Alternate protein names: (2Z,6E)-farnesyl diphosphate synthase; Z-FPP synthase; Z-isoprenyl diphosphate synthase [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MFVEIIPPRLKEPLYRIYEMRLRQELGAAKADLPRHIAVLCDGNRRWARDAGYDDVSYGYRMGAVKIAEMLRWCQAAGIE
MTTVYLLSTENLQRDPDELAGLIEIITDVVEEICAPANRWSVRTVGDLELLGEEPARRLRGAVESTPVEASFHVNVAVGY
GGRREIVDAVRSLLSKELANGATAEELIDAVTVDAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHW
PAFRRVDFLRALRDYSQRHRRYGK

Sequences:

>Translated_264_residues
MFVEIIPPRLKEPLYRIYEMRLRQELGAAKADLPRHIAVLCDGNRRWARDAGYDDVSYGYRMGAVKIAEMLRWCQAAGIE
MTTVYLLSTENLQRDPDELAGLIEIITDVVEEICAPANRWSVRTVGDLELLGEEPARRLRGAVESTPVEASFHVNVAVGY
GGRREIVDAVRSLLSKELANGATAEELIDAVTVDAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHW
PAFRRVDFLRALRDYSQRHRRYGK
>Mature_264_residues
MFVEIIPPRLKEPLYRIYEMRLRQELGAAKADLPRHIAVLCDGNRRWARDAGYDDVSYGYRMGAVKIAEMLRWCQAAGIE
MTTVYLLSTENLQRDPDELAGLIEIITDVVEEICAPANRWSVRTVGDLELLGEEPARRLRGAVESTPVEASFHVNVAVGY
GGRREIVDAVRSLLSKELANGATAEELIDAVTVDAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHW
PAFRRVDFLRALRDYSQRHRRYGK

Specific function: Generates Z-farnesyl diphosphate (Z-FPP) from isopentenyl pyrophosphate (IPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family. Z-FPP synthase subfamily [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=234, Percent_Identity=34.1880341880342, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI45580738, Length=234, Percent_Identity=34.1880341880342, Blast_Score=133, Evalue=2e-31,
Organism=Escherichia coli, GI1786371, Length=231, Percent_Identity=34.1991341991342, Blast_Score=135, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71993029, Length=232, Percent_Identity=30.1724137931034, Blast_Score=123, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=218, Percent_Identity=33.9449541284404, Blast_Score=109, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6323748, Length=220, Percent_Identity=25.4545454545455, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI18857969, Length=236, Percent_Identity=34.7457627118644, Blast_Score=136, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.68 [H]

Molecular weight: Translated: 29962; Mature: 29962

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVEIIPPRLKEPLYRIYEMRLRQELGAAKADLPRHIAVLCDGNRRWARDAGYDDVSYGY
CEEEECCHHHHHHHHHHHHHHHHHHHCCHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHH
RMGAVKIAEMLRWCQAAGIEMTTVYLLSTENLQRDPDELAGLIEIITDVVEEICAPANRW
HHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
SVRTVGDLELLGEEPARRLRGAVESTPVEASFHVNVAVGYGGRREIVDAVRSLLSKELAN
CEEECCHHHHHCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHC
GATAEELIDAVTVDAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHW
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCC
PAFRRVDFLRALRDYSQRHRRYGK
HHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFVEIIPPRLKEPLYRIYEMRLRQELGAAKADLPRHIAVLCDGNRRWARDAGYDDVSYGY
CEEEECCHHHHHHHHHHHHHHHHHHHCCHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHH
RMGAVKIAEMLRWCQAAGIEMTTVYLLSTENLQRDPDELAGLIEIITDVVEEICAPANRW
HHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
SVRTVGDLELLGEEPARRLRGAVESTPVEASFHVNVAVGYGGRREIVDAVRSLLSKELAN
CEEECCHHHHHCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHC
GATAEELIDAVTVDAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHW
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCC
PAFRRVDFLRALRDYSQRHRRYGK
HHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]