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The map label for this gene is cobS

Identifier: 41408047

GI number: 41408047

Start: 2149984

End: 2150739

Strand: Direct

Name: cobS

Synonym: MAP1949

Alternate gene names: 41408047

Gene position: 2149984-2150739 (Clockwise)

Preceding gene: 41408046

Following gene: 41408051

Centisome position: 44.52

GC content: 78.97

Gene sequence:

>756_bases
GTGATGCGTTCGCTGGCAACGGCTTTCGCGTTCGGCACGGTGCTGCCCGTGCCGGCAGGCGGCCGCGGGCCGATGGGCCG
CGGCGCCATGACGGCGCTGCCGGTGGTGGGCCTCGCGCTGGGGGCGCTGGCCGCCGCCGTGGCGTGGGGCGGCGCGGTGG
TGTTCGGCCGGTCCAGCCCGCTGGGCGGGCTGCTCGCGGTGGCCGCGCTGCTGTTGATCACCCGCGGCCTGCACATCGAC
GGCGTCGCCGACACGGCCGACGGCCTGGGCTGCTACGGCCCCCCGGACCGCGCCCGGGCGGTGATGCGGGACGGCTCGAC
CGGACCGTTCGGCGTGGCCGCCGTCGTCGTGGTGGTGATGGCGCAGGCGCTGGCGTTCTCCGCGCTCGCGGCGGGGCGGC
CGGTTCCGGTCGGGGTGGCCGTGGCGGTGTTCGCCGGCCGGGTCGCCGCGGTGCTGGCCTGCCGCCGGACGGTGCCGGCG
GCCGCCGGCAGCTCGCTGGGCGCCACCGTCGCCGGCAGTCAGCCGGCGACGGTGGCGGCGGCCTGGGTCGCGGTGCTGCT
CGGCATGTCCCTGGTGGCCGGGCCGCGGCCGTGGCACGGACCGGTCGCGGTGCTGCTGGGCCTGGGCTGCGGCGGGGTGC
TGGTGCGGCACTGCGTGCGCCGCTTCGGCGGCATCAGCGGTGACGTGCTGGGCGCGGCGATCGAGCTGACCGCGACGGTG
AGCGCGGTAGCGCTCGCGGCCCTGGTGCGCGTCTAG

Upstream 100 bases:

>100_bases
GCGCCGCGCTGGCGCTGCCCATCGTGCGGGCCGCGGTGGCGGCCCTGTCGTCGATGGCGACCTTCGCCCAGGCCGGTGTG
TCCGACCCGTCCGCTCACCC

Downstream 100 bases:

>100_bases
CCCGGGTCGGCTCGGCTCGGCCGGCCGGCCGTGCCGGCTCGGCGGCTCAGCAACCCGCCGAGCGTGAAACTAGCTTCACG
GTCGGAGCCCAGCGTGAAAC

Product: cobalamin synthase

Products: GMP; adenosylcobalamin

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MMRSLATAFAFGTVLPVPAGGRGPMGRGAMTALPVVGLALGALAAAVAWGGAVVFGRSSPLGGLLAVAALLLITRGLHID
GVADTADGLGCYGPPDRARAVMRDGSTGPFGVAAVVVVVMAQALAFSALAAGRPVPVGVAVAVFAGRVAAVLACRRTVPA
AAGSSLGATVAGSQPATVAAAWVAVLLGMSLVAGPRPWHGPVAVLLGLGCGGVLVRHCVRRFGGISGDVLGAAIELTATV
SAVALAALVRV

Sequences:

>Translated_251_residues
MMRSLATAFAFGTVLPVPAGGRGPMGRGAMTALPVVGLALGALAAAVAWGGAVVFGRSSPLGGLLAVAALLLITRGLHID
GVADTADGLGCYGPPDRARAVMRDGSTGPFGVAAVVVVVMAQALAFSALAAGRPVPVGVAVAVFAGRVAAVLACRRTVPA
AAGSSLGATVAGSQPATVAAAWVAVLLGMSLVAGPRPWHGPVAVLLGLGCGGVLVRHCVRRFGGISGDVLGAAIELTATV
SAVALAALVRV
>Mature_251_residues
MMRSLATAFAFGTVLPVPAGGRGPMGRGAMTALPVVGLALGALAAAVAWGGAVVFGRSSPLGGLLAVAALLLITRGLHID
GVADTADGLGCYGPPDRARAVMRDGSTGPFGVAAVVVVVMAQALAFSALAAGRPVPVGVAVAVFAGRVAAVLACRRTVPA
AAGSSLGATVAGSQPATVAAAWVAVLLGMSLVAGPRPWHGPVAVLLGLGCGGVLVRHCVRRFGGISGDVLGAAIELTATV
SAVALAALVRV

Specific function: Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) [H]

COG id: COG0368

COG function: function code H; Cobalamin-5-phosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobS family [H]

Homologues:

Organism=Escherichia coli, GI1788301, Length=256, Percent_Identity=35.546875, Blast_Score=86, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003805 [H]

Pfam domain/function: PF02654 CobS [H]

EC number: 2.7.8.26

Molecular weight: Translated: 24306; Mature: 24306

Theoretical pI: Translated: 11.99; Mature: 11.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRSLATAFAFGTVLPVPAGGRGPMGRGAMTALPVVGLALGALAAAVAWGGAVVFGRSSP
CCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
LGGLLAVAALLLITRGLHIDGVADTADGLGCYGPPDRARAVMRDGSTGPFGVAAVVVVVM
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
AQALAFSALAAGRPVPVGVAVAVFAGRVAAVLACRRTVPAAAGSSLGATVAGSQPATVAA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHH
AWVAVLLGMSLVAGPRPWHGPVAVLLGLGCGGVLVRHCVRRFGGISGDVLGAAIELTATV
HHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
SAVALAALVRV
HHHHHHHHHCC
>Mature Secondary Structure
MMRSLATAFAFGTVLPVPAGGRGPMGRGAMTALPVVGLALGALAAAVAWGGAVVFGRSSP
CCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
LGGLLAVAALLLITRGLHIDGVADTADGLGCYGPPDRARAVMRDGSTGPFGVAAVVVVVM
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
AQALAFSALAAGRPVPVGVAVAVFAGRVAAVLACRRTVPAAAGSSLGATVAGSQPATVAA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHH
AWVAVLLGMSLVAGPRPWHGPVAVLLGLGCGGVLVRHCVRRFGGISGDVLGAAIELTATV
HHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
SAVALAALVRV
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: adenosylcobinamide-GDP; alpha-ribazole

Specific reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA