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The map label for this gene is pepB

Identifier: 41408051

GI number: 41408051

Start: 2154561

End: 2156108

Strand: Direct

Name: pepB

Synonym: MAP1953

Alternate gene names: 41408051

Gene position: 2154561-2156108 (Clockwise)

Preceding gene: 41408047

Following gene: 41408054

Centisome position: 44.61

GC content: 70.87

Gene sequence:

>1548_bases
ATGAGCACAGAACCCGGTTACGCCTCCCCCGTCGTCAACGTCGCCTCCTCGCTGCCCCGCCGCGCCGCCGCGTCCACCGT
GCTGATCGTGCCCGTCGTCTCCACCGGCGACGACGACAAGCCGGGCGCCGTCGTCGCGTCGGCCGGGTCGTTCCTGTCCT
CCGACGCGGTCGCCGAGATCGAATCCGGCCTGCGGGCGCTGGCGGCCACCGGCGGCGCCGAACAACTGCACCGGCTGGTG
GTGGGATCGCTGCCGGTGTCCAGCGTGCTGACCGTCGGCCTGGGCAAGCCGCGATCCGAGTGGCCGGCCGACACCGTCCG
CCGTGCCGCGGGGGTGGCCGCGCGGTCGCTGTCCAACACCGAGACGGTGTTCACCACGCTGGCGGCGCTGCCCGGCGAGG
GCGTGGCCTCGGCCGCCGTCGAGGGCCTGATCCTGGGCAGCTACCGGTTCACCGAATTCCGCAGCGCCAAGACCGCCCCG
AAAGACAAAGGGCTGCAAAAGATCACGGTGCTGGCCACCGCCAAGGACGCCAAGCAGGAGGTCGCGCACGGTGCGGCCGT
CGCGACCGCGGTCGCCACCGCCCGCGATCTGGTCAACACCCCGCCCAGTCACCTGTTTCCCGACGAATTCGCCAAGCGGG
CAAGGGCTTTGGGTGAGTCCGTCGGCCTCGAGGTGGAGGTGCTCGACGAGAAGGCGCTGCAAAAGGGCGGCTACGGAGGG
ATTCTGGGCGTCGGCCAGGGTTCGTCGCGCCCGCCGCGGCTGGTGCGGCTGATCCACCGCGGTTCGCGGCTGGCCAAGAA
ATCCAAGCAGGCGAAAAAGGTGGCGCTGGTCGGCAAGGGCGTCACCTTCGACACCGGCGGCATCTCGATCAAGCCGGCGG
CCTCGATGCATCACATGACCTCGGACATGGGCGGGGCCGCCGCCGTCATCGCCACCGTGGCGCTGGCCGCGCAGCTTCAG
CTGCCGATCGACGTGATCGCCACCGTGCCGATGGCGGAGAACATGCCGTCGGGCACCGCGCAGCGGCCCGGCGATGTGCT
GACGCAGTACGGCGGCACCACCGTCGAGGTGCAGAACACCGACGCCGAGGGCCGGCTGATTCTGGCCGACGCCATCGTGC
GGGCCTGCGAGGACAACCCGGACTACCTGATCGAGACCTCCACGCTGACCGGCGCGCAGACCGTCGCGCTGGGCGCCCGG
ATCCCCGGCGTGATGGGCAGCGACGAGTTCCGCGACCGGGTGGCGGCGATCTCGCAGCGGGTCGGTGAGAACGGCTGGCC
GATGCCGCTGCCCGACGAGCTCAAGGAGGACCTGAAGTCCACGGTGGCCGACCTGTCGAACATCAGCGGGCAGCGCTTCG
CCGGCATGCTGGTGGCCGGCGTGTTCCTGCGCGAGTTCATCGCCGACGGGGTGGGCTGGGCGCACATCGACGTGGCCGGC
CCGGCCTACAACACCGGCAGCCCGTGGGGTTATTCGCCCAAAGGCGCCACCGGGGTGCCGACGCGCACCATGTTCGCAGT
GCTCGAAGACATCGCCGCGAACGGCTAA

Upstream 100 bases:

>100_bases
GGTGATCAGGATCCAACCACCGCAACACGCGGCAACCTCACCCTGACACTGACTTCTCACCCTAGCCAGCCGCGACCGGC
GGACCGTTAGGGTGATGCGG

Downstream 100 bases:

>100_bases
GCGCCCCAGCACGATCCCGCCGCCCGCCCGAGCGTCATTCCGCCGCGCCCGTCGAGCGTCACGCCGCGCCCGTCGAGCGT
CACGCCGCGCCCGTCGAGCG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MSTEPGYASPVVNVASSLPRRAAASTVLIVPVVSTGDDDKPGAVVASAGSFLSSDAVAEIESGLRALAATGGAEQLHRLV
VGSLPVSSVLTVGLGKPRSEWPADTVRRAAGVAARSLSNTETVFTTLAALPGEGVASAAVEGLILGSYRFTEFRSAKTAP
KDKGLQKITVLATAKDAKQEVAHGAAVATAVATARDLVNTPPSHLFPDEFAKRARALGESVGLEVEVLDEKALQKGGYGG
ILGVGQGSSRPPRLVRLIHRGSRLAKKSKQAKKVALVGKGVTFDTGGISIKPAASMHHMTSDMGGAAAVIATVALAAQLQ
LPIDVIATVPMAENMPSGTAQRPGDVLTQYGGTTVEVQNTDAEGRLILADAIVRACEDNPDYLIETSTLTGAQTVALGAR
IPGVMGSDEFRDRVAAISQRVGENGWPMPLPDELKEDLKSTVADLSNISGQRFAGMLVAGVFLREFIADGVGWAHIDVAG
PAYNTGSPWGYSPKGATGVPTRTMFAVLEDIAANG

Sequences:

>Translated_515_residues
MSTEPGYASPVVNVASSLPRRAAASTVLIVPVVSTGDDDKPGAVVASAGSFLSSDAVAEIESGLRALAATGGAEQLHRLV
VGSLPVSSVLTVGLGKPRSEWPADTVRRAAGVAARSLSNTETVFTTLAALPGEGVASAAVEGLILGSYRFTEFRSAKTAP
KDKGLQKITVLATAKDAKQEVAHGAAVATAVATARDLVNTPPSHLFPDEFAKRARALGESVGLEVEVLDEKALQKGGYGG
ILGVGQGSSRPPRLVRLIHRGSRLAKKSKQAKKVALVGKGVTFDTGGISIKPAASMHHMTSDMGGAAAVIATVALAAQLQ
LPIDVIATVPMAENMPSGTAQRPGDVLTQYGGTTVEVQNTDAEGRLILADAIVRACEDNPDYLIETSTLTGAQTVALGAR
IPGVMGSDEFRDRVAAISQRVGENGWPMPLPDELKEDLKSTVADLSNISGQRFAGMLVAGVFLREFIADGVGWAHIDVAG
PAYNTGSPWGYSPKGATGVPTRTMFAVLEDIAANG
>Mature_514_residues
STEPGYASPVVNVASSLPRRAAASTVLIVPVVSTGDDDKPGAVVASAGSFLSSDAVAEIESGLRALAATGGAEQLHRLVV
GSLPVSSVLTVGLGKPRSEWPADTVRRAAGVAARSLSNTETVFTTLAALPGEGVASAAVEGLILGSYRFTEFRSAKTAPK
DKGLQKITVLATAKDAKQEVAHGAAVATAVATARDLVNTPPSHLFPDEFAKRARALGESVGLEVEVLDEKALQKGGYGGI
LGVGQGSSRPPRLVRLIHRGSRLAKKSKQAKKVALVGKGVTFDTGGISIKPAASMHHMTSDMGGAAAVIATVALAAQLQL
PIDVIATVPMAENMPSGTAQRPGDVLTQYGGTTVEVQNTDAEGRLILADAIVRACEDNPDYLIETSTLTGAQTVALGARI
PGVMGSDEFRDRVAAISQRVGENGWPMPLPDELKEDLKSTVADLSNISGQRFAGMLVAGVFLREFIADGVGWAHIDVAGP
AYNTGSPWGYSPKGATGVPTRTMFAVLEDIAANG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=436, Percent_Identity=36.2385321100917, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI47155554, Length=299, Percent_Identity=34.4481605351171, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1790710, Length=425, Percent_Identity=36.9411764705882, Blast_Score=238, Evalue=7e-64,
Organism=Escherichia coli, GI87082123, Length=386, Percent_Identity=34.4559585492228, Blast_Score=172, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17556903, Length=311, Percent_Identity=36.3344051446945, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17565172, Length=224, Percent_Identity=26.7857142857143, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24661038, Length=438, Percent_Identity=29.6803652968037, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI21355725, Length=439, Percent_Identity=29.3849658314351, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24662227, Length=417, Percent_Identity=27.8177458033573, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI21357381, Length=306, Percent_Identity=34.9673202614379, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI221379063, Length=306, Percent_Identity=34.9673202614379, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI221379062, Length=306, Percent_Identity=34.9673202614379, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI20129969, Length=422, Percent_Identity=30.0947867298578, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21355645, Length=425, Percent_Identity=28.2352941176471, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24662223, Length=425, Percent_Identity=28.2352941176471, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI161077148, Length=507, Percent_Identity=27.4161735700197, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI20130057, Length=507, Percent_Identity=27.4161735700197, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI19922386, Length=438, Percent_Identity=26.9406392694064, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI20129963, Length=420, Percent_Identity=27.8571428571429, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24646701, Length=216, Percent_Identity=34.2592592592593, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24646703, Length=216, Percent_Identity=34.2592592592593, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI21358201, Length=216, Percent_Identity=34.2592592592593, Blast_Score=85, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_MYCPA (Q73YK2)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_960887.1
- ProteinModelPortal:   Q73YK2
- SMR:   Q73YK2
- EnsemblBacteria:   EBMYCT00000039289
- GeneID:   2719675
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP1953
- NMPDR:   fig|262316.1.peg.1953
- GeneTree:   EBGT00050000016870
- HOGENOM:   HBG742580
- OMA:   ELHKPCE
- ProtClustDB:   PRK00913
- BRENDA:   3.4.11.1
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 53027; Mature: 52896

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 291-291 ACT_SITE 365-365

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEPGYASPVVNVASSLPRRAAASTVLIVPVVSTGDDDKPGAVVASAGSFLSSDAVAEI
CCCCCCCCCHHHHHHHHCCHHHHCCEEEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHH
ESGLRALAATGGAEQLHRLVVGSLPVSSVLTVGLGKPRSEWPADTVRRAAGVAARSLSNT
HHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCH
ETVFTTLAALPGEGVASAAVEGLILGSYRFTEFRSAKTAPKDKGLQKITVLATAKDAKQE
HHHHHHHHHCCCCCHHHHHHHHEEECCEEHHHHHCCCCCCCCCCCEEEEEEEECHHHHHH
VAHGAAVATAVATARDLVNTPPSHLFPDEFAKRARALGESVGLEVEVLDEKALQKGGYGG
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECHHHHHCCCCCC
ILGVGQGSSRPPRLVRLIHRGSRLAKKSKQAKKVALVGKGVTFDTGGISIKPAASMHHMT
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCEEECCCCEEECCCHHHHHHH
SDMGGAAAVIATVALAAQLQLPIDVIATVPMAENMPSGTAQRPGDVLTQYGGTTVEVQNT
HCCCHHHHHHHHHHHHHHHCCCHHHHEECCCCCCCCCCCCCCCHHHHHHCCCEEEEEECC
DAEGRLILADAIVRACEDNPDYLIETSTLTGAQTVALGARIPGVMGSDEFRDRVAAISQR
CCCCCEEHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHH
VGENGWPMPLPDELKEDLKSTVADLSNISGQRFAGMLVAGVFLREFIADGVGWAHIDVAG
HCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
PAYNTGSPWGYSPKGATGVPTRTMFAVLEDIAANG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STEPGYASPVVNVASSLPRRAAASTVLIVPVVSTGDDDKPGAVVASAGSFLSSDAVAEI
CCCCCCCCHHHHHHHHCCHHHHCCEEEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHH
ESGLRALAATGGAEQLHRLVVGSLPVSSVLTVGLGKPRSEWPADTVRRAAGVAARSLSNT
HHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCH
ETVFTTLAALPGEGVASAAVEGLILGSYRFTEFRSAKTAPKDKGLQKITVLATAKDAKQE
HHHHHHHHHCCCCCHHHHHHHHEEECCEEHHHHHCCCCCCCCCCCEEEEEEEECHHHHHH
VAHGAAVATAVATARDLVNTPPSHLFPDEFAKRARALGESVGLEVEVLDEKALQKGGYGG
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECHHHHHCCCCCC
ILGVGQGSSRPPRLVRLIHRGSRLAKKSKQAKKVALVGKGVTFDTGGISIKPAASMHHMT
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCEEECCCCEEECCCHHHHHHH
SDMGGAAAVIATVALAAQLQLPIDVIATVPMAENMPSGTAQRPGDVLTQYGGTTVEVQNT
HCCCHHHHHHHHHHHHHHHCCCHHHHEECCCCCCCCCCCCCCCHHHHHHCCCEEEEEECC
DAEGRLILADAIVRACEDNPDYLIETSTLTGAQTVALGARIPGVMGSDEFRDRVAAISQR
CCCCCEEHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHH
VGENGWPMPLPDELKEDLKSTVADLSNISGQRFAGMLVAGVFLREFIADGVGWAHIDVAG
HCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
PAYNTGSPWGYSPKGATGVPTRTMFAVLEDIAANG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA